Pub Date : 2024-08-19Epub Date: 2024-07-24DOI: 10.1016/j.cub.2024.06.074
Riley M Anderson, Andrew B Hennessy, Kiran Kowalski, André Kessler, Robert Bagchi, Michael S Singer
Seemingly small ecological changes can have large, ramifying effects that defy expectations. Such are keystone effects in ecosystems. Phloem-feeding insect herbivores can act as keystone species by altering community structure and species interactions via plant-mediated or ant-mediated mechanisms. Plant responses triggered by phloem feeders can disrupt tri-trophic interactions induced by leaf-chewing herbivores, while ants that tend phloem feeders can deter or prey on other arthropods. Here, we investigate how phloem-feeding herbivores change caterpillar-parasitoid interactions on Quercus alba (white oak) trees in natural forests. We factorially manipulated the presence of phloem-feeding insects as well as ant access on Q. alba branches over multiple years and sites and measured parasitism rates of co-occurring caterpillars. While 19.3% of caterpillars were parasitized when phloem feeders were removed, the presence of phloem feeders completely suppressed parasitism of caterpillars (0%). This stark pattern was consistent across the diverse community of phloem feeders and caterpillars. Our manipulation of ant access had no effect on parasitism of caterpillars, implicating a plant-mediated mechanism. We further assessed the mechanistic hypothesis that phloem feeders suppress plant emission of caterpillar-induced volatile compounds, which could disrupt host-location behavior by parasitoids of caterpillars. Phloem feeders indeed reduced concentrations of four volatile compounds, consistent with the putative plant volatile-mediated mechanism. Given the important role of parasitoids in controlling herbivore populations, this keystone effect of phloem feeders offers novel insight into community dynamics in forests and potentially other terrestrial ecosystems.
{"title":"Phloem-feeding insects create parasitoid-free space for caterpillars.","authors":"Riley M Anderson, Andrew B Hennessy, Kiran Kowalski, André Kessler, Robert Bagchi, Michael S Singer","doi":"10.1016/j.cub.2024.06.074","DOIUrl":"10.1016/j.cub.2024.06.074","url":null,"abstract":"<p><p>Seemingly small ecological changes can have large, ramifying effects that defy expectations. Such are keystone effects in ecosystems. Phloem-feeding insect herbivores can act as keystone species by altering community structure and species interactions via plant-mediated or ant-mediated mechanisms. Plant responses triggered by phloem feeders can disrupt tri-trophic interactions induced by leaf-chewing herbivores, while ants that tend phloem feeders can deter or prey on other arthropods. Here, we investigate how phloem-feeding herbivores change caterpillar-parasitoid interactions on Quercus alba (white oak) trees in natural forests. We factorially manipulated the presence of phloem-feeding insects as well as ant access on Q. alba branches over multiple years and sites and measured parasitism rates of co-occurring caterpillars. While 19.3% of caterpillars were parasitized when phloem feeders were removed, the presence of phloem feeders completely suppressed parasitism of caterpillars (0%). This stark pattern was consistent across the diverse community of phloem feeders and caterpillars. Our manipulation of ant access had no effect on parasitism of caterpillars, implicating a plant-mediated mechanism. We further assessed the mechanistic hypothesis that phloem feeders suppress plant emission of caterpillar-induced volatile compounds, which could disrupt host-location behavior by parasitoids of caterpillars. Phloem feeders indeed reduced concentrations of four volatile compounds, consistent with the putative plant volatile-mediated mechanism. Given the important role of parasitoids in controlling herbivore populations, this keystone effect of phloem feeders offers novel insight into community dynamics in forests and potentially other terrestrial ecosystems.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19Epub Date: 2024-07-30DOI: 10.1016/j.cub.2024.07.031
Rachakonda Sreekar, Lian Pin Koh, Aakash Lamba, Christos Mammides, Hoong Chen Teo, Adrian Dwiputra, Yiwen Zeng
Protected areas (PAs) play a crucial role in biodiversity conservation and climate change mitigation.1,2 However, ineffective management can lead to biodiversity loss and carbon emissions from deforestation.3,4,5,6 To address this issue and explore viable solutions, we assessed the impact of PA establishment on avoided deforestation in 80 Southeast Asian PAs using the synthetic control approach.7,8 Our results show that 36 PAs successfully prevented 78,910 ha of deforestation. However, the remaining 44 PAs lost 72,497 ha of forest, impacting the habitat of 226 threatened bird and mammal species. Effective management of these reserves could have potentially avoided up to 2.07 MtCO2e yr-1 in carbon emissions. We estimate that at least $17 million USD per year in additional funding is required to better manage these 44 ineffective PAs and reduce future emissions. Furthermore, we demonstrate that carbon markets have the potential to generate these funds by reducing carbon emissions from deforestation within protected areas. Our findings emphasize that improving PA management is an essential nature-based solution for conserving biodiversity and mitigating climate change.
{"title":"Conservation opportunities through improved management of recently established protected areas in Southeast Asia.","authors":"Rachakonda Sreekar, Lian Pin Koh, Aakash Lamba, Christos Mammides, Hoong Chen Teo, Adrian Dwiputra, Yiwen Zeng","doi":"10.1016/j.cub.2024.07.031","DOIUrl":"10.1016/j.cub.2024.07.031","url":null,"abstract":"<p><p>Protected areas (PAs) play a crucial role in biodiversity conservation and climate change mitigation.<sup>1</sup><sup>,</sup><sup>2</sup> However, ineffective management can lead to biodiversity loss and carbon emissions from deforestation.<sup>3</sup><sup>,</sup><sup>4</sup><sup>,</sup><sup>5</sup><sup>,</sup><sup>6</sup> To address this issue and explore viable solutions, we assessed the impact of PA establishment on avoided deforestation in 80 Southeast Asian PAs using the synthetic control approach.<sup>7</sup><sup>,</sup><sup>8</sup> Our results show that 36 PAs successfully prevented 78,910 ha of deforestation. However, the remaining 44 PAs lost 72,497 ha of forest, impacting the habitat of 226 threatened bird and mammal species. Effective management of these reserves could have potentially avoided up to 2.07 MtCO<sub>2</sub>e yr<sup>-1</sup> in carbon emissions. We estimate that at least $17 million USD per year in additional funding is required to better manage these 44 ineffective PAs and reduce future emissions. Furthermore, we demonstrate that carbon markets have the potential to generate these funds by reducing carbon emissions from deforestation within protected areas. Our findings emphasize that improving PA management is an essential nature-based solution for conserving biodiversity and mitigating climate change.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19DOI: 10.1016/j.cub.2024.07.027
Jonathon D Crystal
New research suggests that free-living blue and great tits remember foraging, including food type, location, and time since eating, even when event details were not known to be relevant for a subsequent assessment of memory, implicating the use of episodic memory in natural behavior.
{"title":"Comparative cognition: Free-living birds remember things past.","authors":"Jonathon D Crystal","doi":"10.1016/j.cub.2024.07.027","DOIUrl":"https://doi.org/10.1016/j.cub.2024.07.027","url":null,"abstract":"<p><p>New research suggests that free-living blue and great tits remember foraging, including food type, location, and time since eating, even when event details were not known to be relevant for a subsequent assessment of memory, implicating the use of episodic memory in natural behavior.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19Epub Date: 2024-07-24DOI: 10.1016/j.cub.2024.06.073
Anton Dvorzhak, Michael Brecht, Dietmar Schmitz
Social play is pervasive in juvenile mammals, yet it is poorly understood in terms of its underlying brain mechanisms. Specifically, we do not know why young animals are most playful and why most adults cease to social play. Here, we analyze the synaptic mechanisms underlying social play. We found that blocking the rat periaqueductal gray (PAG) interfered with social play. Furthermore, an age-related decrease of neural firing in the PAG is associated with a decrease in synaptic release of glycine. Most importantly, modulation of glycine concentration-apparently acting on the glycinergic binding site of the N-methyl-D-aspartate (NMDA) receptor-not only strongly modulates social play but can also reverse the age-related decline in social play. In conclusion, we demonstrate that social play critically depends on the neurotransmitter glycine within the PAG.
{"title":"Social play behavior is driven by glycine-dependent mechanisms.","authors":"Anton Dvorzhak, Michael Brecht, Dietmar Schmitz","doi":"10.1016/j.cub.2024.06.073","DOIUrl":"10.1016/j.cub.2024.06.073","url":null,"abstract":"<p><p>Social play is pervasive in juvenile mammals, yet it is poorly understood in terms of its underlying brain mechanisms. Specifically, we do not know why young animals are most playful and why most adults cease to social play. Here, we analyze the synaptic mechanisms underlying social play. We found that blocking the rat periaqueductal gray (PAG) interfered with social play. Furthermore, an age-related decrease of neural firing in the PAG is associated with a decrease in synaptic release of glycine. Most importantly, modulation of glycine concentration-apparently acting on the glycinergic binding site of the N-methyl-D-aspartate (NMDA) receptor-not only strongly modulates social play but can also reverse the age-related decline in social play. In conclusion, we demonstrate that social play critically depends on the neurotransmitter glycine within the PAG.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19DOI: 10.1016/j.cub.2024.06.054
Sergio M Pellis, Jackson R Ham
Play behavior is typically most frequent in immature animals and then declines by adulthood. New research reveals a brain mechanism that may underlie this age-related decline in play.
{"title":"Play behavior: Why do adults play less than juveniles?","authors":"Sergio M Pellis, Jackson R Ham","doi":"10.1016/j.cub.2024.06.054","DOIUrl":"https://doi.org/10.1016/j.cub.2024.06.054","url":null,"abstract":"<p><p>Play behavior is typically most frequent in immature animals and then declines by adulthood. New research reveals a brain mechanism that may underlie this age-related decline in play.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19DOI: 10.1016/j.cub.2024.07.024
Magdalena Maria Brislinger-Engelhardt, Peter Walentek
Multiciliated cells produce over a hundred motile cilia anchored to the membrane by modified centrioles. Recent work has characterized an alternative cell cycle used by this post-mitotic cell type to generate additional centrioles without undergoing cell division.
{"title":"Multiciliogenesis: Tricking the cell-cycle machinery to build hundreds of cilia.","authors":"Magdalena Maria Brislinger-Engelhardt, Peter Walentek","doi":"10.1016/j.cub.2024.07.024","DOIUrl":"https://doi.org/10.1016/j.cub.2024.07.024","url":null,"abstract":"<p><p>Multiciliated cells produce over a hundred motile cilia anchored to the membrane by modified centrioles. Recent work has characterized an alternative cell cycle used by this post-mitotic cell type to generate additional centrioles without undergoing cell division.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19Epub Date: 2024-08-07DOI: 10.1016/j.cub.2024.07.019
Anna C van der Heijden, Ysbrand D van der Werf, Odile A van den Heuvel, Lucia M Talamini, Hein J F van Marle
Post-traumatic stress disorder (PTSD) is a psychiatric disorder with traumatic memories at its core. Post-treatment sleep may offer a unique time window to increase therapeutic efficacy through consolidation of therapeutically modified traumatic memories. Targeted memory reactivation (TMR) enhances memory consolidation by presenting reminder cues (e.g., sounds associated with a memory) during sleep. Here, we applied TMR in PTSD patients to strengthen therapeutic memories during sleep after one treatment session with eye movement desensitization and reprocessing (EMDR). PTSD patients received either slow oscillation (SO) phase-targeted TMR, using modeling-based closed-loop neurostimulation (M-CLNS) with EMDR clicks as a reactivation cue (n = 17), or sham stimulation (n = 16). Effects of TMR on sleep were assessed through high-density polysomnography. Effects on treatment outcome were assessed through subjective, autonomic, and fMRI responses to script-driven imagery (SDI) of the targeted traumatic memory and overall PTSD symptom level. Compared to sham stimulation, TMR led to stimulus-locked increases in SO and spindle dynamics, which correlated positively with PTSD symptom reduction in the TMR group. Given the role of SOs and spindles in memory consolidation, these findings suggest that TMR may have strengthened the consolidation of the EMDR-treatment memory. Clinically, TMR vs. sham stimulation resulted in a larger reduction of avoidance level during SDI. TMR did not disturb sleep or trigger nightmares. Together, these data provide first proof of principle that TMR may be a safe and viable future treatment augmentation strategy for PTSD. The required follow-up studies may implement multi-night TMR or TMR during REM sleep to further establish the clinical effect of TMR for traumatic memories.
{"title":"Targeted memory reactivation to augment treatment in post-traumatic stress disorder.","authors":"Anna C van der Heijden, Ysbrand D van der Werf, Odile A van den Heuvel, Lucia M Talamini, Hein J F van Marle","doi":"10.1016/j.cub.2024.07.019","DOIUrl":"10.1016/j.cub.2024.07.019","url":null,"abstract":"<p><p>Post-traumatic stress disorder (PTSD) is a psychiatric disorder with traumatic memories at its core. Post-treatment sleep may offer a unique time window to increase therapeutic efficacy through consolidation of therapeutically modified traumatic memories. Targeted memory reactivation (TMR) enhances memory consolidation by presenting reminder cues (e.g., sounds associated with a memory) during sleep. Here, we applied TMR in PTSD patients to strengthen therapeutic memories during sleep after one treatment session with eye movement desensitization and reprocessing (EMDR). PTSD patients received either slow oscillation (SO) phase-targeted TMR, using modeling-based closed-loop neurostimulation (M-CLNS) with EMDR clicks as a reactivation cue (n = 17), or sham stimulation (n = 16). Effects of TMR on sleep were assessed through high-density polysomnography. Effects on treatment outcome were assessed through subjective, autonomic, and fMRI responses to script-driven imagery (SDI) of the targeted traumatic memory and overall PTSD symptom level. Compared to sham stimulation, TMR led to stimulus-locked increases in SO and spindle dynamics, which correlated positively with PTSD symptom reduction in the TMR group. Given the role of SOs and spindles in memory consolidation, these findings suggest that TMR may have strengthened the consolidation of the EMDR-treatment memory. Clinically, TMR vs. sham stimulation resulted in a larger reduction of avoidance level during SDI. TMR did not disturb sleep or trigger nightmares. Together, these data provide first proof of principle that TMR may be a safe and viable future treatment augmentation strategy for PTSD. The required follow-up studies may implement multi-night TMR or TMR during REM sleep to further establish the clinical effect of TMR for traumatic memories.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19DOI: 10.1016/j.cub.2024.06.059
Michael J W Boyle, Adam C Sharp, Maxwell V Barclay, Arthur Y C Chung, Robert M Ewers, Guillaume de Rougemont, Timothy C Bonebrake, Roger L Kitching, Nigel E Stork, Louise A Ashton
Insects are posited to be declining globally. This is particularly pertinent in tropical forests, which exhibit both the highest levels of biodiversity and the highest rates of biodiversity loss. However, for the hyper-diverse tropical insects there are scant data available to evidence declines. Understanding tropical insect diversity and its response to environmental change has therefore become a challenge, but it is estimated that 80% of tropical insect species remain undescribed1. Insect biodiversity predictions are based mostly on well-studied taxa and extrapolated to other groups, but no one knows whether resilience to environmental change varies between undescribed and described species. Here, we collected staphylinid beetles from unlogged and logged tropical forests in Borneo and investigated their responses to environmental change. Out of 252 morphospecies collected, 76% were undescribed. Undescribed species showed higher community turnover, reduced abundance and decreased probability of occurrence in logged forests. Thus the unknown components of tropical insect biodiversity are likely more impacted by human-induced environmental change. If these patterns are widespread, how accurate will assessments of insect declines in the tropics be?
{"title":"Tropical beetles more sensitive to impacts are less likely to be known to science.","authors":"Michael J W Boyle, Adam C Sharp, Maxwell V Barclay, Arthur Y C Chung, Robert M Ewers, Guillaume de Rougemont, Timothy C Bonebrake, Roger L Kitching, Nigel E Stork, Louise A Ashton","doi":"10.1016/j.cub.2024.06.059","DOIUrl":"https://doi.org/10.1016/j.cub.2024.06.059","url":null,"abstract":"<p><p>Insects are posited to be declining globally. This is particularly pertinent in tropical forests, which exhibit both the highest levels of biodiversity and the highest rates of biodiversity loss. However, for the hyper-diverse tropical insects there are scant data available to evidence declines. Understanding tropical insect diversity and its response to environmental change has therefore become a challenge, but it is estimated that 80% of tropical insect species remain undescribed<sup>1</sup>. Insect biodiversity predictions are based mostly on well-studied taxa and extrapolated to other groups, but no one knows whether resilience to environmental change varies between undescribed and described species. Here, we collected staphylinid beetles from unlogged and logged tropical forests in Borneo and investigated their responses to environmental change. Out of 252 morphospecies collected, 76% were undescribed. Undescribed species showed higher community turnover, reduced abundance and decreased probability of occurrence in logged forests. Thus the unknown components of tropical insect biodiversity are likely more impacted by human-induced environmental change. If these patterns are widespread, how accurate will assessments of insect declines in the tropics be?</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19DOI: 10.1016/j.cub.2024.06.024
Leah J Taylor-Kearney, Renée Z Wang, Patrick M Shih
Rubisco (D-ribulose 1,5-bisphosphate carboxylase/oxygenase) is the most abundant enzyme in the world, constituting up to half of the soluble protein content in plant leaves. Such is its ubiquity that its chemical fingerprint can be detected in the geological record spanning billions of years. Rubisco catalyses the conversion of inorganic CO2 into organic sugars, which underpin almost all of the biosphere, including our entire food chain. Due to its central role in the global carbon cycle, rubisco has been the subject of intense research for over 50 years. Rubisco is often considered inefficient due to its slow rate of carboxylation compared with other central metabolism enzymes, and its promiscuous oxygenase activity, which competes with the productive carboxylation reaction. It is hoped that engineering improved CO2 fixation will have significant advantages in agriculture and climate change mitigation. However, rubisco has proven difficult to engineer, with decades of efforts yielding limited results. Recent research has focused on reconstructing the evolutionary trajectory of rubisco to help elucidate its cryptic origins. Such evolutionary studies have led to a better understanding of both the origins of more complex rubisco forms and the broader relationship between rubisco's structure and function.
{"title":"Evolution and origins of rubisco.","authors":"Leah J Taylor-Kearney, Renée Z Wang, Patrick M Shih","doi":"10.1016/j.cub.2024.06.024","DOIUrl":"https://doi.org/10.1016/j.cub.2024.06.024","url":null,"abstract":"<p><p>Rubisco (D-ribulose 1,5-bisphosphate carboxylase/oxygenase) is the most abundant enzyme in the world, constituting up to half of the soluble protein content in plant leaves. Such is its ubiquity that its chemical fingerprint can be detected in the geological record spanning billions of years. Rubisco catalyses the conversion of inorganic CO<sub>2</sub> into organic sugars, which underpin almost all of the biosphere, including our entire food chain. Due to its central role in the global carbon cycle, rubisco has been the subject of intense research for over 50 years. Rubisco is often considered inefficient due to its slow rate of carboxylation compared with other central metabolism enzymes, and its promiscuous oxygenase activity, which competes with the productive carboxylation reaction. It is hoped that engineering improved CO<sub>2</sub> fixation will have significant advantages in agriculture and climate change mitigation. However, rubisco has proven difficult to engineer, with decades of efforts yielding limited results. Recent research has focused on reconstructing the evolutionary trajectory of rubisco to help elucidate its cryptic origins. Such evolutionary studies have led to a better understanding of both the origins of more complex rubisco forms and the broader relationship between rubisco's structure and function.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19DOI: 10.1016/j.cub.2024.06.061
Vincent Courdavault, Nicolas Papon
Our knowledge of the biosynthesis of medicinal compounds from plants remains limited. A new study has deciphered the complete metabolic pathway leading to the biosynthesis of the psychedelic mescaline in the cactus peyote, suggesting the development of biotechnological strategies for a sustainable supply of this important plant drug.
{"title":"Plant drugs: Transcending the mescaline biosynthesis.","authors":"Vincent Courdavault, Nicolas Papon","doi":"10.1016/j.cub.2024.06.061","DOIUrl":"https://doi.org/10.1016/j.cub.2024.06.061","url":null,"abstract":"<p><p>Our knowledge of the biosynthesis of medicinal compounds from plants remains limited. A new study has deciphered the complete metabolic pathway leading to the biosynthesis of the psychedelic mescaline in the cactus peyote, suggesting the development of biotechnological strategies for a sustainable supply of this important plant drug.</p>","PeriodicalId":11359,"journal":{"name":"Current Biology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}