Pub Date : 2023-09-29DOI: 10.33978/2307-3586-2023-19-35-68-72
L.D. Firsova
The stages of the evolution of theoretical ideas about psychosomatization in the development of diseases of upper digestive tract and practical issues of diagnosis and treatment of patients with functional disorders are discussed
讨论了上消化道疾病发展过程中心理化理论观点的演变阶段，以及诊断和治疗功能性障碍患者的实际问题
{"title":"Diseases of the Esophagus and Stomach: Evolution of Doctors' Attitude to Psychosomatic Aspects of Clinical Manifestations and Treatment","authors":"L.D. Firsova","doi":"10.33978/2307-3586-2023-19-35-68-72","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-35-68-72","url":null,"abstract":"The stages of the evolution of theoretical ideas about psychosomatization in the development of diseases of upper digestive tract and practical issues of diagnosis and treatment of patients with functional disorders are discussed","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.33978/2307-3586-2023-19-35-80-85
E.A. Sokolova, E. Vinnitskaya, S.N. Batskih, S. G. Khomeriki, T. Khaymenova
Antimitochondrial autoantibodies of the M2 subclass (AMA-M2) in primary biliary cholangitis (PBCh) under conditions of cholestasis are considered as one of the main criteria for diagnosis that does not require morphological confirmation. However, the detection of AMA-M2 in asymptomatic patients causes ambiguity of interpretation. Along with the assumption that such patients may have preclinical stage of PBCh, there is an opinion about the "healthy carrier" of AMA-M2. The article presents the clinical observation of a patient with the high AMA-M2 titer without significant clinical manifestations, the normal level of alkaline phosphatase, with changes in liver tissue characteristic of PBCh, revealed by the results of histological examination. Clinical observation demonstrates the need for liver biopsy for early detection of PBCh in AMA-M2-positive patients belonging to the risk group
{"title":"Primary Biliary Cholangitis with Normal Alkaline Phosphatase Level: Clinical Case and Literature Review","authors":"E.A. Sokolova, E. Vinnitskaya, S.N. Batskih, S. G. Khomeriki, T. Khaymenova","doi":"10.33978/2307-3586-2023-19-35-80-85","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-35-80-85","url":null,"abstract":"Antimitochondrial autoantibodies of the M2 subclass (AMA-M2) in primary biliary cholangitis (PBCh) under conditions of cholestasis are considered as one of the main criteria for diagnosis that does not require morphological confirmation. However, the detection of AMA-M2 in asymptomatic patients causes ambiguity of interpretation. Along with the assumption that such patients may have preclinical stage of PBCh, there is an opinion about the \"healthy carrier\" of AMA-M2. The article presents the clinical observation of a patient with the high AMA-M2 titer without significant clinical manifestations, the normal level of alkaline phosphatase, with changes in liver tissue characteristic of PBCh, revealed by the results of histological examination. Clinical observation demonstrates the need for liver biopsy for early detection of PBCh in AMA-M2-positive patients belonging to the risk group","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.33978/2307-3586-2023-19-35-86-91
I. Savina, E. Dubtsova, M. Kiryukova, D. Bordin, T.V. Zhurenkova, E. V. Parfenchikova, L. V. Vinokurova
Diagnostics of pancreatic diseases represents a difficult task for doctors in multiple fields. Autoimmune pancreatitis is one of the hardest to diagnose among other pancreatic diseases, as it is a rare disease and can mimic groove pancreatitis or pancreatic cancer. Similar manifestation, laboratory changes pattern, and data of imaging methods become peculiarities of differential diagnosis. The article presents a clinical case of difficulties in diagnosing autoimmune pancreatitis at its early stages.
{"title":"Diagnosis and Treatment of Autoimmune Pancreatitis","authors":"I. Savina, E. Dubtsova, M. Kiryukova, D. Bordin, T.V. Zhurenkova, E. V. Parfenchikova, L. V. Vinokurova","doi":"10.33978/2307-3586-2023-19-35-86-91","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-35-86-91","url":null,"abstract":"Diagnostics of pancreatic diseases represents a difficult task for doctors in multiple fields. Autoimmune pancreatitis is one of the hardest to diagnose among other pancreatic diseases, as it is a rare disease and can mimic groove pancreatitis or pancreatic cancer. Similar manifestation, laboratory changes pattern, and data of imaging methods become peculiarities of differential diagnosis. The article presents a clinical case of difficulties in diagnosing autoimmune pancreatitis at its early stages.","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"234 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.33978/2307-3586-2023-19-35-14-20
D. S. Bordin, S.V. Bykova, E. Sabelnikova, Yu.A. Kucheryavy
The article presents the overview of the results of the survey of 1,674 gastroenterologists from different regions of Russia on the criteria to select probiotic drugs in various clinical situations. The analysis of the data obtained made it possible to determine which factors influence the choice of probiotic drugs by doctors of the Russian Federation
{"title":"Criteria to Select Probiotics in the Russian Federation: the Result of a Survey of 1,674 Gastroenterologists","authors":"D. S. Bordin, S.V. Bykova, E. Sabelnikova, Yu.A. Kucheryavy","doi":"10.33978/2307-3586-2023-19-35-14-20","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-35-14-20","url":null,"abstract":"The article presents the overview of the results of the survey of 1,674 gastroenterologists from different regions of Russia on the criteria to select probiotic drugs in various clinical situations. The analysis of the data obtained made it possible to determine which factors influence the choice of probiotic drugs by doctors of the Russian Federation","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.33978/2307-3586-2023-19-35-30-40
E. Valitova, G.E. Baimakanova, M. V. Chebotareva, O. Berezina, D. S. Bordin
Bronchial asthma, chronic cough, laryngitis, erosion of tooth enamel are attributed to extra esophageal manifestations of gastroesophageal reflux disease (GERD). This form of GERD is characterized by the difficulty of establishing the diagnosis and high frequency of ineffective therapy. The article describes the main endoscopic signs of damage to the esophagus and larynx, presents normal pH-impedance reflux monitoring and criteria for pathological reflux into the esophagus and the lower third of the pharynx, as well as the possibilities of additional diagnostic methods – esophageal manometry and pepsin test. Treatment of patients with extra esophageal manifestations of GERD is a difficult task; the results of randomized placebo-controlled studies are contradictory. At the same time, empirical therapy is most effective in patients whose extra esophageal symptoms are combined with typical ones
{"title":"Upper Respiratory Tract Diseases as Extra Esophageal Manifestations of Gastroesophageal Reflux Disease: Current State of the Problem","authors":"E. Valitova, G.E. Baimakanova, M. V. Chebotareva, O. Berezina, D. S. Bordin","doi":"10.33978/2307-3586-2023-19-35-30-40","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-35-30-40","url":null,"abstract":"Bronchial asthma, chronic cough, laryngitis, erosion of tooth enamel are attributed to extra esophageal manifestations of gastroesophageal reflux disease (GERD). This form of GERD is characterized by the difficulty of establishing the diagnosis and high frequency of ineffective therapy. The article describes the main endoscopic signs of damage to the esophagus and larynx, presents normal pH-impedance reflux monitoring and criteria for pathological reflux into the esophagus and the lower third of the pharynx, as well as the possibilities of additional diagnostic methods – esophageal manometry and pepsin test. Treatment of patients with extra esophageal manifestations of GERD is a difficult task; the results of randomized placebo-controlled studies are contradictory. At the same time, empirical therapy is most effective in patients whose extra esophageal symptoms are combined with typical ones","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"235 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-29DOI: 10.33978/2307-3586-2023-19-35-60-66
A. N. Demchenko, A. Kagramanova, O. Knyazev, A. Parfenov
The article presents up-to-date data on the pathogenesis, classification and frequency of ophthalmic extraintestinal manifestations (OEM) of inflammatory bowel diseases (IBD). Early detection of OEM is an important aspect of the management of IBD patients, since timely and effective therapy of combined immuno-inflammatory pathology has a positive effect on the prognosis of the disease and reduces the disability of IBD patients. The article provides information on methods of diagnostic of ophthalmic manifestations of IBD and treatment of patients with combined immuno-inflammatory pathology. The close interaction of gastroenterologists and ophthalmologists is an important link in the implementation of multidisciplinary management of patients with IBD and autoimmune uveitis. The use of genetically engineered biological drugs helps to control the course of IBD and ophthalmic manifestations, which prevents the development of complications and improves the quality of life of patients
{"title":"Ophthalmic Manifestations of Inflammatory Bowel Diseases","authors":"A. N. Demchenko, A. Kagramanova, O. Knyazev, A. Parfenov","doi":"10.33978/2307-3586-2023-19-35-60-66","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-35-60-66","url":null,"abstract":"The article presents up-to-date data on the pathogenesis, classification and frequency of ophthalmic extraintestinal manifestations (OEM) of inflammatory bowel diseases (IBD). Early detection of OEM is an important aspect of the management of IBD patients, since timely and effective therapy of combined immuno-inflammatory pathology has a positive effect on the prognosis of the disease and reduces the disability of IBD patients. The article provides information on methods of diagnostic of ophthalmic manifestations of IBD and treatment of patients with combined immuno-inflammatory pathology. The close interaction of gastroenterologists and ophthalmologists is an important link in the implementation of multidisciplinary management of patients with IBD and autoimmune uveitis. The use of genetically engineered biological drugs helps to control the course of IBD and ophthalmic manifestations, which prevents the development of complications and improves the quality of life of patients","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.33978/2307-3586-2023-19-21-54-56
B. Lichterman, S. Styazhkina, T. Chernyshova, D. Shakirova
Endocrine surgery is not yet in the register of medical specialties, although there is already a group of surgeons specializing in this treatment of thyroid diseases. In May of this year, Izhevsk hosted the first plenum of the Board of the Association of Endocrine Surgeons, dedicated to the 90th anniversary of the Izhevsk State Medical Academy. In his welcoming speech, Doctor of Medical Sciences, Professor of the Department of Faculty Therapy with courses in Endocrinology and Hematology, Rector of the Izhevsk State Medical Academy Alexey SHKLYAEV called the plenum a landmark event that will definitely be useful to the surgical service of the republic. Surgeons and scientists from all regions of Russia took part in the event
{"title":"Current Problems and Issues of Endocrine Surgery: Based on the Materials of the First Plenum of the Association of Endocrine Surgeons, Held in the Udmurt Republic","authors":"B. Lichterman, S. Styazhkina, T. Chernyshova, D. Shakirova","doi":"10.33978/2307-3586-2023-19-21-54-56","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-21-54-56","url":null,"abstract":"Endocrine surgery is not yet in the register of medical specialties, although there is already a group of surgeons specializing in this treatment of thyroid diseases. In May of this year, Izhevsk hosted the first plenum of the Board of the Association of Endocrine Surgeons, dedicated to the 90th anniversary of the Izhevsk State Medical Academy. In his welcoming speech, Doctor of Medical Sciences, Professor of the Department of Faculty Therapy with courses in Endocrinology and Hematology, Rector of the Izhevsk State Medical Academy Alexey SHKLYAEV called the plenum a landmark event that will definitely be useful to the surgical service of the republic. Surgeons and scientists from all regions of Russia took part in the event","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86909455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.33978/2307-3586-2023-19-21-24-27
S. Styazhkina, A. Ledneva, A.A. Galieva
oxic thyroid adenoma (Plummer's disease) is a primary benign tumor disease of the thyroid gland, accompanied by autonomous hyperproduction of thyroid hormones. With a combination of Plummer's disease in one lobe and diffuse nodular goiter in the other lobe of the thyroid gland without compression syndrome, it is necessary to strive to perform hemithyroidectomy of the lobe with toxic adenoma. Two clinical examples of a combination of toxic adenoma of one lobe and diffuse nodular goiter of the other lobe of the thyroid gland with different surgical tactics are given
{"title":"The Combination of Toxic Adenoma and Diffuse Nodular Goiter: the Choice of Tactics of Surgical Treatment","authors":"S. Styazhkina, A. Ledneva, A.A. Galieva","doi":"10.33978/2307-3586-2023-19-21-24-27","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-21-24-27","url":null,"abstract":"oxic thyroid adenoma (Plummer's disease) is a primary benign tumor disease of the thyroid gland, accompanied by autonomous hyperproduction of thyroid hormones. With a combination of Plummer's disease in one lobe and diffuse nodular goiter in the other lobe of the thyroid gland without compression syndrome, it is necessary to strive to perform hemithyroidectomy of the lobe with toxic adenoma. Two clinical examples of a combination of toxic adenoma of one lobe and diffuse nodular goiter of the other lobe of the thyroid gland with different surgical tactics are given","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86835806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-25DOI: 10.33978/2307-3586-2023-19-8-50-54
Y. Kulygina, M. Osipenko
Inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS) are chronic bowel diseases affecting young people, leading to a decrease in working capacity and having a negative impact on the quality of life (QOL). The syndrome of excessive bacterial growth in the small intestine (SIBO) is often combined with organic and functional intestinal diseases, worsening the clinical picture and worsening the quality of life of patients. Recently, there has been an increase in the number of diagnosed cases of bacterial overgrowth syndrome in the small intestine, which is primarily due to the availability of hydrogen breathing tests (VDT), which facilitate the diagnostic process. Objective. QOL analysis of patients with IBD and IBS, depending on the presence or absence of SIBO. Material and methods. The study included 152 patients with IBD and 100 patients with IBS. All patients underwent VDT for the verification of Iron the "Gastro+" device using lactulose. To access QOL a general questionnaire for both groups of patients (SF-36) and were used specialized questionnaires IBD (IBD) and IBS-QOL (IBS). Results. The presence of SIBО in both IBD and IBS patients is associated with a decrease in quality of life indicators reflecting both physical and mental health. Corresponding changes on all scales were detected when using specific questionnaires (IBDQ and IBS-QOL) and on the part of most scales when using the SF-36 questionnaire, except for the "vitality" scale, the "social functioning" scale – in patients with IBD and the "general health" scale – in patients with IBS.
{"title":"Quality of Life in Patients with Inflammatory Bowel Diseases and Irritable Bowel Syndrome: What Is Common?","authors":"Y. Kulygina, M. Osipenko","doi":"10.33978/2307-3586-2023-19-8-50-54","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-8-50-54","url":null,"abstract":"Inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS) are chronic bowel diseases affecting young people, leading to a decrease in working capacity and having a negative impact on the quality of life (QOL). The syndrome of excessive bacterial growth in the small intestine (SIBO) is often combined with organic and functional intestinal diseases, worsening the clinical picture and worsening the quality of life of patients. Recently, there has been an increase in the number of diagnosed cases of bacterial overgrowth syndrome in the small intestine, which is primarily due to the availability of hydrogen breathing tests (VDT), which facilitate the diagnostic process. Objective. QOL analysis of patients with IBD and IBS, depending on the presence or absence of SIBO. Material and methods. The study included 152 patients with IBD and 100 patients with IBS. All patients underwent VDT for the verification of Iron the \"Gastro+\" device using lactulose. To access QOL a general questionnaire for both groups of patients (SF-36) and were used specialized questionnaires IBD (IBD) and IBS-QOL (IBS). Results. The presence of SIBО in both IBD and IBS patients is associated with a decrease in quality of life indicators reflecting both physical and mental health. Corresponding changes on all scales were detected when using specific questionnaires (IBDQ and IBS-QOL) and on the part of most scales when using the SF-36 questionnaire, except for the \"vitality\" scale, the \"social functioning\" scale – in patients with IBD and the \"general health\" scale – in patients with IBS.","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80068368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-25DOI: 10.33978/2307-3586-2023-19-8-34-41
M. M. Fedorin, M. Livzan, O. Gaus
Irritable bowel syndrome (IBS) in overweight and obese individuals is characterized by a more severe course than in patients with normal weight. The purpose. To assess the level of adipokines (leptin and adiponectin) in blood serum, the correlation of these laboratory markers with the clinical manifestations of IBS, quality of life, eating habits, and signs of anxiety and depression based on the results of using a special questionnaire in patients with IBS. Material and methods. An open cohort cross-sectional study was conducted with the inclusion of 175 participants aged 18 to 44 years (mean age 30.06 ± 6.15 years). Group 1 included 100 obese or overweight IBS patients aged 18 to 44 years (mean age 30.63 ± 6.37 years, BMI 25.88 ± 6.28 kg/m2). In group 1, subgroup 1A included 50 people with IBS associated with overweight or obesity. In subgroup 1B – 50 people suffering from IBS, with normal weight. Group 2 included 75 people without IBS, aged 19 to 43 years (mean age 29.31 ± 5.81 years, BMI 27.80 ± 6.20 kg/m2). Subgroup 2A included 50 non-IBS participants who were overweight or obese. Subgroup 2B included 25 apparently healthy participants. IBS symptoms were assessed using a 10-point scale. Using verified questionnaires, the severity of gastrointestinal symptoms, the presence of anxiety and depression, the level of specific anxiety, quality of life and eating habits were assessed. Results. IBS patients with overweight and obesity are characterized by higher levels of leptin and low levels of adiponectin than patients with normal weight (Mann – Whitney test, p < 0.05). Adipokine levels correlate with high cravings for sweet, fatty, starchy, and salty foods. A higher concentration of leptin is characteristic of patients suffering from IBS with a predominance of constipation (Mann – Whitney test, p < 0.05). High levels of leptin and low levels of adiponectin in overweight and obese IBS patients correlate with more severe symptoms of abdominal pain, flatulence, poor quality of life, and more frequent signs of anxiety and depression (Spirmen test p < 0.05, Mann – Whitney test, p < 0.05). Conclusion. The results obtained suggest a significant role of adipokines in the formation of more severe symptoms in IBS patients with overweight and obesity compared to patients with normal weight
{"title":"Associations of Leptin and Adiponectin in Irritable Bowel Syndrome Patients with Overweight and Obesity","authors":"M. M. Fedorin, M. Livzan, O. Gaus","doi":"10.33978/2307-3586-2023-19-8-34-41","DOIUrl":"https://doi.org/10.33978/2307-3586-2023-19-8-34-41","url":null,"abstract":"Irritable bowel syndrome (IBS) in overweight and obese individuals is characterized by a more severe course than in patients with normal weight. The purpose. To assess the level of adipokines (leptin and adiponectin) in blood serum, the correlation of these laboratory markers with the clinical manifestations of IBS, quality of life, eating habits, and signs of anxiety and depression based on the results of using a special questionnaire in patients with IBS. Material and methods. An open cohort cross-sectional study was conducted with the inclusion of 175 participants aged 18 to 44 years (mean age 30.06 ± 6.15 years). Group 1 included 100 obese or overweight IBS patients aged 18 to 44 years (mean age 30.63 ± 6.37 years, BMI 25.88 ± 6.28 kg/m2). In group 1, subgroup 1A included 50 people with IBS associated with overweight or obesity. In subgroup 1B – 50 people suffering from IBS, with normal weight. Group 2 included 75 people without IBS, aged 19 to 43 years (mean age 29.31 ± 5.81 years, BMI 27.80 ± 6.20 kg/m2). Subgroup 2A included 50 non-IBS participants who were overweight or obese. Subgroup 2B included 25 apparently healthy participants. IBS symptoms were assessed using a 10-point scale. Using verified questionnaires, the severity of gastrointestinal symptoms, the presence of anxiety and depression, the level of specific anxiety, quality of life and eating habits were assessed. Results. IBS patients with overweight and obesity are characterized by higher levels of leptin and low levels of adiponectin than patients with normal weight (Mann – Whitney test, p < 0.05). Adipokine levels correlate with high cravings for sweet, fatty, starchy, and salty foods. A higher concentration of leptin is characteristic of patients suffering from IBS with a predominance of constipation (Mann – Whitney test, p < 0.05). High levels of leptin and low levels of adiponectin in overweight and obese IBS patients correlate with more severe symptoms of abdominal pain, flatulence, poor quality of life, and more frequent signs of anxiety and depression (Spirmen test p < 0.05, Mann – Whitney test, p < 0.05). Conclusion. The results obtained suggest a significant role of adipokines in the formation of more severe symptoms in IBS patients with overweight and obesity compared to patients with normal weight","PeriodicalId":11400,"journal":{"name":"Effective Pharmacotherapy","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79354212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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