Alok Pandey, R. Rajavel, Sandeep Chandraker, D. Dash
Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against swiss albino mice, anti-inflammatory activity against Wister albino rats. The compounds showed significant antibacterial activity against Staphylococcus aureus (gram-positive) bacteria and E. coli (gram-negative) bacteria.
{"title":"Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity","authors":"Alok Pandey, R. Rajavel, Sandeep Chandraker, D. Dash","doi":"10.1155/2012/145028","DOIUrl":"https://doi.org/10.1155/2012/145028","url":null,"abstract":"Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against swiss albino mice, anti-inflammatory activity against Wister albino rats. The compounds showed significant antibacterial activity against Staphylococcus aureus (gram-positive) bacteria and E. coli (gram-negative) bacteria.","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"2524-2531"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/145028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64295884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nitrate contamination of ground water resources has increased in Asia, Europe, United States, and various other parts of the world. This trend has raised concern as nitrates cause methemoglobinemia and cancer. Several treatment processes can remove nitrates from water with varying degrees of efficiency, cost, and ease of operation. Available technical data, experience, and economics indicate that biological denitrification is more acceptable for nitrate removal than reverse osmosis and ion exchange. This paper reviews the developments in the field of nitrate removal processes which can be effectively used for denitrifying ground water as well as industrial water.
{"title":"Nitrate Removal from Ground Water: A Review","authors":"Archna, Sur Sharma, R. Sobti","doi":"10.1155/2012/154616","DOIUrl":"https://doi.org/10.1155/2012/154616","url":null,"abstract":"Nitrate contamination of ground water resources has increased in Asia, Europe, United States, and various other parts of the world. This trend has raised concern as nitrates cause methemoglobinemia and cancer. Several treatment processes can remove nitrates from water with varying degrees of efficiency, cost, and ease of operation. Available technical data, experience, and economics indicate that biological denitrification is more acceptable for nitrate removal than reverse osmosis and ion exchange. This paper reviews the developments in the field of nitrate removal processes which can be effectively used for denitrifying ground water as well as industrial water.","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"1667-1675"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/154616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64296749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microbial protease represents the most important industrial enzymes, which have an active role in biotechnological processes. The objective of this study was to isolate new strain of Streptomyces that produce proteolytic enzymes with novel properties and the development of the low-cost medium. An alkaline protease producer strain NRC-15 was isolated from Egyptian soil sample. The cultural, morphological, physiological characters and chemotaxonomic evidence strongly indicated that the NRC-15 strain represents a novel species of the genus Streptomyces, hence the name Strptomyces pseudogrisiolus NRC-15. The culture conditions for higher protease production by NRC-15 were optimized with respect to carbon and nitrogen sources, metal ions, pH and temperature. Maximum protease production was obtained in the medium supplemented with 1% glucose, 1% yeast extract, 6% NaCl and 100 μmol/L of Tween 20, initial pH 9.0 at 50 °C for 96 h. The current results confirm that for this strain, a great ability to produce alkaline proteases, which supports the use of applications in industry.
{"title":"Optimization conditions of extracellular proteases production from a newly isolated streptomyces pseudogrisiolus NRC-15","authors":"E. Mostafa, M. Saad, H. Awad, M. Selim, H. Hassan","doi":"10.1155/2012/168540","DOIUrl":"https://doi.org/10.1155/2012/168540","url":null,"abstract":"Microbial protease represents the most important industrial enzymes, which have an active role in biotechnological processes. The objective of this study was to isolate new strain of Streptomyces that produce proteolytic enzymes with novel properties and the development of the low-cost medium. An alkaline protease producer strain NRC-15 was isolated from Egyptian soil sample. The cultural, morphological, physiological characters and chemotaxonomic evidence strongly indicated that the NRC-15 strain represents a novel species of the genus Streptomyces, hence the name Strptomyces pseudogrisiolus NRC-15. The culture conditions for higher protease production by NRC-15 were optimized with respect to carbon and nitrogen sources, metal ions, pH and temperature. Maximum protease production was obtained in the medium supplemented with 1% glucose, 1% yeast extract, 6% NaCl and 100 μmol/L of Tween 20, initial pH 9.0 at 50 °C for 96 h. The current results confirm that for this strain, a great ability to produce alkaline proteases, which supports the use of applications in industry.","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"949-961"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/168540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64298115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Some new Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 4-chlorobenzylidene-2-aminothiazole (CAT) and 2-nitrobenzylidene-2-aminothiazole (NAT) have been synthesized by conventional as well as microwave methods. These compounds have been characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, ESR, magnetic susceptibility, thermal, electrical conductivity and XRD analysis. The complexes are coloured and stable in air. Analytical data revealed that all the complexes exhibited 1:2 (metal:ligand) ratio with coordination number 4 or 6. FAB-mass and thermal data show degradation pattern of the complexes. The thermal behavior of metal complexes shows that the hydrated complexes loses water molecules of hydration in the first step; followed by decomposition of ligand molecules in the subsequent steps. The crystal system, lattice parameter, unit cell volume and number of molecules in unit cell in the lattice of complexes have been determined by XRD analysis. XRD patterns indicate crystalline nature for the complexes. The solid state electrical conductivity of the metal complexes has also been measured. Solid state electrical conductivity studies reflect semiconducting nature of the complexes. The Schiff base and metal complexes show a good activity against the Gram-positive bacteria; Staphylococcus aureus and Gram-negative bacteria; Escherichia coli and fungi Aspergillus niger and Candida albicans.
{"title":"Microwave Synthesis, Spectral, Thermal and Antimicrobial Studies of Some Co(II), Ni(II) and Cu(II) Complexes Containing 2-Aminothiazole Moiety","authors":"A. Mishra, H. Purwar, R. Jain, S. Gupta","doi":"10.1155/2012/106460","DOIUrl":"https://doi.org/10.1155/2012/106460","url":null,"abstract":"Some new Schiff base metal complexes of Co(II), Ni(II) and Cu(II) derived from 4-chlorobenzylidene-2-aminothiazole (CAT) and 2-nitrobenzylidene-2-aminothiazole (NAT) have been synthesized by conventional as well as microwave methods. These compounds have been characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, ESR, magnetic susceptibility, thermal, electrical conductivity and XRD analysis. The complexes are coloured and stable in air. Analytical data revealed that all the complexes exhibited 1:2 (metal:ligand) ratio with coordination number 4 or 6. FAB-mass and thermal data show degradation pattern of the complexes. The thermal behavior of metal complexes shows that the hydrated complexes loses water molecules of hydration in the first step; followed by decomposition of ligand molecules in the subsequent steps. The crystal system, lattice parameter, unit cell volume and number of molecules in unit cell in the lattice of complexes have been determined by XRD analysis. XRD patterns indicate crystalline nature for the complexes. The solid state electrical conductivity of the metal complexes has also been measured. Solid state electrical conductivity studies reflect semiconducting nature of the complexes. The Schiff base and metal complexes show a good activity against the Gram-positive bacteria; Staphylococcus aureus and Gram-negative bacteria; Escherichia coli and fungi Aspergillus niger and Candida albicans.","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"1655-1666"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/106460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64293434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The N-benzoylethylidene-2-aminobenzylamine (BEA) was used as a suitable ionophore in construction of neodymium ion selective electrode. The electrode with composition of 30% PVC, 58% solvent mediator (NB), 2% ionophore (BEA) and 10% anionic additive (OA) shows the best potentiometric response characteristics. The Nd3
{"title":"Neodymium(III) PVC Membrane Electrodchemical Sensor Based on N-benzoylethylidene-2-aminobenzylamine","authors":"H. Zamani, Mojdeh Zaferoni, S. Meghdadi","doi":"10.1155/2012/145812","DOIUrl":"https://doi.org/10.1155/2012/145812","url":null,"abstract":"The N-benzoylethylidene-2-aminobenzylamine (BEA) was used as a suitable ionophore in construction of neodymium ion selective electrode. The electrode with composition of 30% PVC, 58% solvent mediator (NB), 2% ionophore (BEA) and 10% anionic additive (OA) shows the best potentiometric response characteristics. The Nd3","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"1941-1950"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/145812","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64295560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lifetime exposure to trace metals, pesticides, polycyclic aromatic hydrocarbons (PAHs), trihalomethanes (THMs), and the other chemicals in drinking water through ingestion, and dermal contact may pose risks to human health. In this study, drinking water samples were collected from 50 sampling sites from Cankiri and its towns during 2010. The concentrations of all pollutants were analyzed, and then compared with permissible limits set by Turkish and WHO. For health risk assessment of trace metals, chronic daily intakes (CDIs) via ingestion and dermal contact, hazard quotient (HQ), and hazard index (HI) were calculated by using statistical formulas. For ingestion pathway, the maximum HQ values of As-non cancer in central Cankiri and Kursunlu town were higher than one. Considering dermal adsorption pathway, the mean and maximum HQ values were below one. HI values of As-non cancer in central Cankiri and Kursunlu town were also higher than one. Each trace metal (As-non cancer, B, Cd, Cr, Pb, and Sb) of the mean HI values were slightly below unity. Risks of As, PAHs, THMs, and benzene on human health were then evaluated using carcinogenic risk (CR). It is indicated that CRs of As and THMs were also found >10−5 in drinking water of Cankiri might exert potential carcinogenic risk for people. These assessments would point out required drinking water treatment strategy to ensure safety of consumers.
{"title":"Health Risk Assessment for Trace Metals, Polycyclic Aromatic Hydrocarbons and Trihalomethanes in Drinking Water of Cankiri, Turkey","authors":"E. Caylak","doi":"10.1155/2012/172135","DOIUrl":"https://doi.org/10.1155/2012/172135","url":null,"abstract":"Lifetime exposure to trace metals, pesticides, polycyclic aromatic hydrocarbons (PAHs), trihalomethanes (THMs), and the other chemicals in drinking water through ingestion, and dermal contact may pose risks to human health. In this study, drinking water samples were collected from 50 sampling sites from Cankiri and its towns during 2010. The concentrations of all pollutants were analyzed, and then compared with permissible limits set by Turkish and WHO. For health risk assessment of trace metals, chronic daily intakes (CDIs) via ingestion and dermal contact, hazard quotient (HQ), and hazard index (HI) were calculated by using statistical formulas. For ingestion pathway, the maximum HQ values of As-non cancer in central Cankiri and Kursunlu town were higher than one. Considering dermal adsorption pathway, the mean and maximum HQ values were below one. HI values of As-non cancer in central Cankiri and Kursunlu town were also higher than one. Each trace metal (As-non cancer, B, Cd, Cr, Pb, and Sb) of the mean HI values were slightly below unity. Risks of As, PAHs, THMs, and benzene on human health were then evaluated using carcinogenic risk (CR). It is indicated that CRs of As and THMs were also found >10−5 in drinking water of Cankiri might exert potential carcinogenic risk for people. These assessments would point out required drinking water treatment strategy to ensure safety of consumers.","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"1976-1991"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/172135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64298789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uranium adsorption by the synthesized compound of magnesium aluminum hydroxide hydrate – layered double hydrotalcite (STH)-like compounds was studied. The calcinated STH was proven to be a highly effective in U(VI) adsorption in pH range from 6.5 to 7. The time dependent experimental data were found to be fit to the pseudo-second-oder model. The equilibrium data have been modeled using Langmuir and Freundlich isotherms. The results showed that both model provide the best correlation with equilibrium data. The highest adsorption capacity, approximated 62.5 mg/g, was observed in the calcinated STH at 500 °C. The positive value of enthalpy change indicated that adsorption reaction of U(VI) on STH was endothermic process. The regeneration experiments of STH using 0.1M Na2CO3 solution was successfully demonstrated multiple times without any significant effect on the initial adsorption capacity.
{"title":"Adsorption of U(VI) from Aqueous Solution onto Hydrotalcite-Like Compounds","authors":"Nguyen Van Suc","doi":"10.1155/2012/182585","DOIUrl":"https://doi.org/10.1155/2012/182585","url":null,"abstract":"Uranium adsorption by the synthesized compound of magnesium aluminum hydroxide hydrate – layered double hydrotalcite (STH)-like compounds was studied. The calcinated STH was proven to be a highly effective in U(VI) adsorption in pH range from 6.5 to 7. The time dependent experimental data were found to be fit to the pseudo-second-oder model. The equilibrium data have been modeled using Langmuir and Freundlich isotherms. The results showed that both model provide the best correlation with equilibrium data. The highest adsorption capacity, approximated 62.5 mg/g, was observed in the calcinated STH at 500 °C. The positive value of enthalpy change indicated that adsorption reaction of U(VI) on STH was endothermic process. The regeneration experiments of STH using 0.1M Na2CO3 solution was successfully demonstrated multiple times without any significant effect on the initial adsorption capacity.","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"669-679"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/182585","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64299628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A reverse phase HPLC method is described for the determination of Dorzolamide in eye drops. Chromatography was carried on an Inertsil ODS 3V column using Acetonitrile : (0.02M) 1,Octane Sulphonic acid buffer (pH 3.5) (36:64 v/v) on isocratic mode at a flow rate of 1 mL/min with UV detection at 254 nm. The detector response was linear in the concentration range 4-720 µg/mL. The limit of detection and limit of quantification are found to be 0.7041 and 2.3483 µg/mL respectively. The method was validated as per the ICH guidelines. The proposed method is rapid, accurate and precise and can be applied for the routine analysis of dorzolamide in ophthalimic solutions.
{"title":"Validated LC Method for the Estimation of Dorzolamide HCl (Carbonic Anhydrase Inhibitor) in Ophthalmic Solutions","authors":"A. Narendra, D. Deepika, M. Annapurna","doi":"10.1155/2012/258261","DOIUrl":"https://doi.org/10.1155/2012/258261","url":null,"abstract":"A reverse phase HPLC method is described for the determination of Dorzolamide in eye drops. Chromatography was carried on an Inertsil ODS 3V column using Acetonitrile : (0.02M) 1,Octane Sulphonic acid buffer (pH 3.5) (36:64 v/v) on isocratic mode at a flow rate of 1 mL/min with UV detection at 254 nm. The detector response was linear in the concentration range 4-720 µg/mL. The limit of detection and limit of quantification are found to be 0.7041 and 2.3483 µg/mL respectively. The method was validated as per the ICH guidelines. The proposed method is rapid, accurate and precise and can be applied for the routine analysis of dorzolamide in ophthalimic solutions.","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"1238-1243"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/258261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64306103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Energies and structures of six different isomers resulted of complex between glycylglycine dipeptide and zinc cation were calculated at the BLYP and B3LYP levels of theory with 6-311G** and 6-311
{"title":"Effects of Zinc Binding on the Structure and Stability of Glycylglycine Dipeptide: A Computational Study","authors":"M. T. Baei, S. Z. Sayyad-Alangi","doi":"10.1155/2012/295846","DOIUrl":"https://doi.org/10.1155/2012/295846","url":null,"abstract":"Energies and structures of six different isomers resulted of complex between glycylglycine dipeptide and zinc cation were calculated at the BLYP and B3LYP levels of theory with 6-311G** and 6-311","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"1244-1250"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/295846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64310654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
New Salicylate derivatives of organoheterobimetallic-μ-oxoisopropoxide [Bu2SnO2Ti2(OPri)6] have been synthesized by the thermal condensation of μ-oxoisopropoxide compound with different salicylates in different molar ratios (1:1-1:4) yielded the compounds of the type [Bu2SnO2Ti2(OPri)6-n(RSal)n] (where n is 1-4 and RSal = Salicylate anion) respectively. The μ-oxoisopropoxide derivative has been characterized by elemental, liberated isopropanol, and spectral analysis (IR, 1H, 13C, and 119Sn NMR).
{"title":"Synthesis and Characterization of Salicylate Derivatives of Dibutyl Sn(IV)-Ti(IV)-μ-Oxoisopropoxide","authors":"R. Kumar","doi":"10.1155/2012/450821","DOIUrl":"https://doi.org/10.1155/2012/450821","url":null,"abstract":"New Salicylate derivatives of organoheterobimetallic-μ-oxoisopropoxide [Bu2SnO2Ti2(OPri)6] have been synthesized by the thermal condensation of μ-oxoisopropoxide compound with different salicylates in different molar ratios (1:1-1:4) yielded the compounds of the type [Bu2SnO2Ti2(OPri)6-n(RSal)n] (where n is 1-4 and RSal = Salicylate anion) respectively. The μ-oxoisopropoxide derivative has been characterized by elemental, liberated isopropanol, and spectral analysis (IR, 1H, 13C, and 119Sn NMR).","PeriodicalId":11519,"journal":{"name":"E-journal of Chemistry","volume":"9 1","pages":"1058-1063"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/450821","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64323406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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