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Comparison between AJCC 8th edition gastric and esophageal ypTNM classification system in Siewert II esophagogastric junction adenocarcinomas: A retrospective study based on Eastern and Western Data Siewert II 食管胃交界腺癌中 AJCC 第 8 版胃和食管 ypTNM 分类系统的比较:基于东西方数据的回顾性研究。
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-28 DOI: 10.1016/j.ejso.2024.108730

Introduction

Multimodal therapy has become the standard treatment for curable upper gastrointestinal cancers. However, it remains unclear which 8th edition AJCC post-neoadjuvant therapy pathological classification system, esophageal (ypTNM-EC) or gastric (ypTNM-GC), can predict the overall survival (OS) of patients with Siewert II adenocarcinomas better.

Methods

Patients diagnosed with Siewert II adenocarcinomas receiving neoadjuvant therapy plus curative resection at the University Medical Center Utrecht (UMC Utrecht) and the Peking University Cancer Hospital (PUCH) between the 2001 and 2022 were included in this study. The patients from two institutions were analyzed separately. Predictive univariable and multivariable Cox models based on ypTNM-EC and ypTNM-GC were constructed. The C-index and calibration curves were used to compare the predictive abilities of ypTNM-EC and ypTNM-GC Cox models.

Results

A total of 125 patients from UMCU and 145 from PUCH were included. There was no significant difference in the C-index between the ypTNM-EC and the ypTNM-GC univariable and multivariable Cox models in the UMC Utrecht (p-value = 0.883; p-value=0.681) and PUCH (p-value = 0.808; p-value=0.548) cohorts, and no significant difference was observed between their calibration curves in the two cohorts.

Conclusion

The AJCC 8th edition ypTNM prognostic classification systems for esophageal and gastric cancer demonstrated no difference in predicting OS for patients with Siewert II adenocarcinomas both in the Western and Eastern data. The ypTNM-GC, with fewer stage groups, may offer greater convenience for clinical application.
简介多模式疗法已成为可治愈的上消化道癌症的标准治疗方法。然而,食管癌(ypTNM-EC)和胃癌(ypTNM-GC)哪一种第 8 版 AJCC 新辅助治疗后病理分类系统能更好地预测 Siewert II 型腺癌患者的总生存期(OS),目前仍不清楚:本研究纳入了2001年至2022年间在乌得勒支大学医学中心(UMC Utrecht)和北京大学肿瘤医院(PUCH)接受新辅助治疗加根治性切除术的Siewert II腺癌患者。两家医院的患者分别进行了分析。根据 ypTNM-EC 和 ypTNM-GC 建立了单变量和多变量 Cox 预测模型。用C指数和校准曲线比较了ypTNM-EC和ypTNM-GC Cox模型的预测能力:结果:共纳入了 125 名来自 UMCU 的患者和 145 名来自 PUCH 的患者。在乌特勒支联大(p-value = 0.883;p-value=0.681)和普切(p-value = 0.808;p-value=0.548)队列中,ypTNM-EC 和 ypTNM-GC 单变量和多变量 Cox 模型的 C 指数无明显差异,在两个队列中,它们的校准曲线也无明显差异:结论:AJCC第8版ypTNM食管癌和胃癌预后分类系统在预测Siewert II腺癌患者的OS方面在西方和东方数据中均无差异。ypTNM-GC 的分期组别较少,可能更便于临床应用。
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引用次数: 0
Real-life effectiveness of prehabilitation to improve postoperative outcomes in patients with colorectal cancer approaching surgery: A systematic review and meta-analyses of observational studies versus randomized controlled trials 改善即将接受手术的结直肠癌患者术后预后的康复训练的实际效果:观察性研究与随机对照试验的系统回顾和荟萃分析。
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-28 DOI: 10.1016/j.ejso.2024.108708

Introduction

Current evidence synthesis of prehabilitation studies in colorectal surgery is based on results of randomized controlled trials (RCT). Although RCTs are the gold standard for effectiveness research, observational studies probably better reflect real-life practice. The aims of the current study were to compare observational studies to RCTs regarding the association between prehabilitation and postoperative outcomes, and characteristics of included patients and interventions.

Methods

A systematic search was conducted in PubMed, Embase, and CINAHL (until September 2023). Observational studies and RCTs investigating prehabilitation before colorectal surgery and reporting postoperative complications and/or length of stay (LoS) were included. Two reviewers independently assessed the risk of bias using the Cochrane Risk of Bias 2 tool for RCTs and the Cochrane ROBINS-I tool for observational studies. Meta(regression)-analyses were performed for postoperative complications and LoS.

Results

Pooled results showed a statistically significant reduction in postoperative complications (OR 0.54; 95 % confidence interval (CI) 0.40 to 0.72) and LoS (mean difference (MD) −1.34 CI -2.57 to −0.12) after prehabilitation in observational studies but not in RCTs (complications OR 0.95; CI 0.53 to 1.72; LoS MD 0.16 CI -0.52 to 0.83). Patients included in observational studies were older and more often had an ASA score ≥3. In a meta-regression analysis, these characteristics were not statistically significantly associated with the main outcomes.

Conclusion

Observational studies in a real-life setting showed that prehabilitation can reduce postoperative complications and LoS. To further explore the real-life effectiveness of prehabilitation, specific observational study designs, like a target emulation trial could be used.
简介:目前对结直肠手术术前康复研究的证据综述是基于随机对照试验(RCT)的结果。尽管随机对照试验是有效性研究的黄金标准,但观察性研究可能更能反映现实生活中的实践。本研究的目的是比较观察性研究和随机对照试验在术前康复与术后结果之间的关系,以及纳入的患者和干预措施的特点:方法:在 PubMed、Embase 和 CINAHL(截至 2023 年 9 月)上进行了系统检索。方法:在PubMed、Embed和CINAHL(截至2023年9月)上进行了系统性检索,纳入了调查结直肠手术前康复的观察性研究和RCT,并报告了术后并发症和/或住院时间(LoS)。两名审稿人使用 Cochrane Risk of Bias 2 工具独立评估了 RCT 的偏倚风险,并使用 Cochrane ROBINS-I 工具评估了观察性研究的偏倚风险。对术后并发症和LoS进行了元(回归)分析:汇总结果显示,在观察性研究中,术前康复后术后并发症(OR 0.54;95 % 置信区间(CI)0.40 至 0.72)和 LoS(平均差(MD)-1.34 CI -2.57 至 -0.12)显著减少,但在研究性试验中却没有显著减少(并发症 OR 0.95;CI 0.53 至 1.72;LoS MD 0.16 CI -0.52 至 0.83)。纳入观察性研究的患者年龄较大,ASA评分≥3分的患者较多。在一项荟萃回归分析中,这些特征与主要结果没有显著的统计学关联:结论:现实生活中的观察性研究表明,术前康复可减少术后并发症和LoS。为了进一步探索术前康复在现实生活中的有效性,可以采用特定的观察性研究设计,如目标模拟试验。
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引用次数: 0
Comment on “A nomogram for predicting colorectal cancer liver metastasis using circulating tumor cells from the first drainage vein” 就 "利用第一引流静脉的循环肿瘤细胞预测结直肠癌肝转移的提名图 "发表评论
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-28 DOI: 10.1016/j.ejso.2024.108729
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引用次数: 0
Comparison of robotic versus laparoscopic total gastrectomy for gastric cancer: A single-center retrospective cohort study in a Japanese high-volume center 胃癌机器人与腹腔镜全胃切除术的比较:日本一家大容量中心的单中心回顾性队列研究。
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-28 DOI: 10.1016/j.ejso.2024.108706

Background

Robotic-assisted surgery has become increasingly popular worldwide in recent years. This study aimed to compare the surgical outcomes of robotic total gastrectomy (RTG) and laparoscopic total gastrectomy (LTG) to figure out the advantages of RTG.

Methods

The eligible cases in this study were patients who underwent RTG or LTG for gastric adenocarcinoma at our hospital from January 2014 to December 2022. Propensity score matching (PSM) was employed to balance the underlying selection bias. Then, surgical outcomes of patients were analyzed to be compared.

Results

Overall, 255 patients (LTG: 178, RTG: 77) were included in this study. After PSM, 73 patients in each arm were assigned for analysis. Operation time was longer in the RTG than in the LTG (373 vs 336 min, p < 0.01). However, the RTG was associated with shorter postoperative hospital stays (8 vs 9 days, p = 0.04) and lower incidence of grade 3 or higher postoperative complications (1 % vs 11 %, p = 0.03). More lymph nodes were harvested in the RTG (59 vs 47, p < 0.01).

Conclusions

Although RTG requires longer operation time, it has the potential to provide advantages to the patient such as quicker recovery, reduction in postoperative complication, or more yield number of lymph nodes. Regarding survival outcomes, further analysis with enough follow-up is needed.
背景:近年来,机器人辅助手术在全球日益流行。本研究旨在比较机器人全胃切除术(RTG)和腹腔镜全胃切除术(LTG)的手术效果,以找出RTG的优势:本研究的合格病例为2014年1月至2022年12月期间在我院接受RTG或LTG治疗的胃腺癌患者。采用倾向评分匹配法(PSM)来平衡潜在的选择偏倚。然后,对患者的手术结果进行分析比较:本研究共纳入 255 例患者(LTG:178 例,RTG:77 例)。经过PSM后,两组各有73名患者被分配进行分析。RTG 的手术时间长于 LTG(373 分钟对 336 分钟,P 结论:虽然 RTG 需要更长的手术时间,但 LTG 的手术时间更短:虽然 RTG 需要更长的手术时间,但它有可能为患者带来更多好处,如更快恢复、减少术后并发症或获得更多淋巴结。至于生存结果,还需要进一步的分析和足够的随访。
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引用次数: 0
Clinical trials involving rare gynaecological cancers. 涉及罕见妇科癌症的临床试验。
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-27 DOI: 10.1016/j.ejso.2024.108726
Klejda Harasani, Aleksandar Čelebić, Irina Tripac, Jean Calleja-Agius

Clinical trials that investigate therapies for rare gynaecological cancers (RGC) are essential to provide evidence-based data towards new effective and safe treatments, however, they present unique challenges. The main objective of this narrative review is to summarize completed phase III clinical trials investigating therapies for RGC and to discuss the outcomes of these trials. PRISMA guidelines were used to report the steps of the review. We searched the WHO's International Clinical Trials Registry Platform, clinicaltrials.gov and PubMed/Medline for publications reporting results from clinical trials on RGC including at least one medication. From 31 identified phase III clinical trials, 13 were still ongoing, four were terminated and just eight (25.8 %) had posted results and/or publications. The latter completed trials were mostly multi-center and located in at least two continents, participants were mainly adults, and the recruitment period varied from about 2.5 to 10.5 years. Allocation was randomized with parallel assignment in 7 out of 8 trials, while only one trial had double masking. The most common primary outcome measure was progression-free survival (PFS), followed by overall survival (OS). Patient-reported outcomes were secondary outcome measures in four completed trials, assessing quality of life by various questionnaires. Most of the trials did not meet their primary endpoints. By highlighting the scarcity of clinical trials on RGC, our findings further emphasize the need for designing, conducting and sustaining phase III clinical trials to investigate innovative therapies for these conditions and report meaningful outcome measures.

研究罕见妇科癌症(RGC)疗法的临床试验对于提供循证数据以开发新的有效、安全疗法至关重要,但这些试验也面临着独特的挑战。本综述的主要目的是总结已完成的研究RGC疗法的III期临床试验,并讨论这些试验的结果。我们采用PRISMA指南来报告综述步骤。我们搜索了世界卫生组织的国际临床试验注册平台、clinicaltrials.gov 和 PubMed/Medline,以查找报告 RGC 临床试验结果的出版物,其中至少包括一种药物。在已确定的 31 项 III 期临床试验中,13 项仍在进行,4 项已终止,仅有 8 项(25.8%)公布了结果和/或发表了论文。后几项已完成的试验大多是多中心试验,至少分布在两个大洲,参与者主要是成年人,招募期从2.5年到10.5年不等。在 8 项试验中,有 7 项试验采用平行随机分配,只有一项试验采用双重掩蔽。最常见的主要结局指标是无进展生存期(PFS),其次是总生存期(OS)。在四项已完成的试验中,患者报告的结果是次要结果指标,通过各种问卷评估生活质量。大多数试验都没有达到主要终点。通过强调RGC临床试验的稀缺性,我们的研究结果进一步强调了设计、开展和维持III期临床试验的必要性,以研究治疗这些疾病的创新疗法并报告有意义的结果指标。
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引用次数: 0
Reply to Letter to the Editor “the association between physical activity and risk for breast cancer in US female adults: A cross-sectional study based on NHANES 2011–2020” 回复致编辑的信 "美国成年女性体育锻炼与乳腺癌风险之间的关系:基于 NHANES 2011-2020 的横断面研究"。
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-27 DOI: 10.1016/j.ejso.2024.108709
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引用次数: 0
Letter to the Editor “The association between physical activity and risk for breast cancer in US female adults: A cross-sectional study based on NHANES 2011–2020” 致编辑的信 "美国成年女性体育锻炼与乳腺癌风险之间的关系:基于 NHANES 2011-2020 的横断面研究"
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-26 DOI: 10.1016/j.ejso.2024.108710
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引用次数: 0
Prevalence and indicators of cure of Italian women with vulvar squamous cell carcinoma: A population-based study. 意大利妇女外阴鳞状细胞癌的发病率和治愈指标:一项基于人口的研究。
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-26 DOI: 10.1016/j.ejso.2024.108707
Lauro Bucchi, Fabiola Giudici, Federica Toffolutti, Angela De Paoli, Silvia Mancini, Mario Preti, Gemma Gatta, Stefano Ferretti, Emanuele Crocetti, Anna Rita Fiore, Ettore Bidoli, Adele Caldarella, Fabio Falcini, Alessio Gili, Francesco Cuccaro, Maria Letizia Gambino, Claudia Casella, Rossella Cavallo, Margherita Ferrante, Enrica Migliore, Giuliano Carrozzi, Antonino Musolino, Walter Mazzucco, Cinzia Gasparotti, Mario Fusco, Paola Ballotari, Giuseppe Sampietro, Lucia Mangone, William Mantovani, Giuseppe Cascone, Michael Mian, Federica Manzoni, Maria Teresa Pesce, Rocco Galasso, Francesca Bella, Pietro Seghini, Anna Clara Fanetti, Daniela Piras, Pasquala Pinna, Diego Serraino, Stefano Guzzinati, Luigino Dal Maso

Objective: Five-year net survival and conditional survival from vulvar squamous cell carcinoma (VSCC) patients in Italy have shown no progress during the past three decades. This study aims to estimate the complete prevalence and multiple indicators of cure.

Methods: Observed prevalence was estimated using 31 Italian cancer registries covering 47 % of Italian women. A subset of 22 cancer registries was used to estimate model-based long-term survival and indicators of cure, i.e., complete prevalence, cure fraction (CF), time to cure (TTC), proportion of 'already cured' patients, and cure prevalence.

Results: In 2018, VSCC patients alive in Italy (complete prevalence) were 6620 or 22 per 100,000 women. The cure fraction (the proportion of newly diagnosed patients who will not die of VSCC) did not change between 2000 and 2010 both for all patients (32 %) and in each age group. The time to cure (5-year conditional net survival >95 %) was 11 years for patients aged ≥44 years, but excess mortality remained for >15 years in the other age groups. This led to a negligible (5 %) proportion of 'already cured' patients (living longer than time to cure). The proportion of patients alive <2 years (21 %) was the same as that of patients surviving ≥15 years. The cure prevalence (patients who will not die of VSCC) was 64 %. A considerable proportion of patients will not be cured even among those who survived ≥5 years.

Conclusion: There is an urgent need to reshape the current vulvar care model in Italy.

目的:意大利外阴鳞状细胞癌(VSCC)患者的五年净生存率和条件生存率在过去三十年中没有取得任何进展。本研究旨在估算完整的患病率和多种治愈指标:方法:通过 31 个意大利癌症登记处对观察到的患病率进行估算,这些登记处覆盖了 47% 的意大利女性。22 个癌症登记处的子集用于估算基于模型的长期生存率和治愈指标,即完全患病率、治愈率(CF)、治愈时间(TTC)、"已治愈 "患者比例和治愈率:2018 年,意大利存活的 VSCC 患者(完全发病率)为 6620 人,即每 10 万名女性中有 22 人。2000年至2010年期间,所有患者的治愈率(32%)和各年龄组的治愈率(新诊断患者中不会死于VSCC的比例)均无变化。年龄≥44岁的患者的治愈时间(5年条件净存活率大于95%)为11年,但其他年龄组的超额死亡率仍大于15年。这导致 "已治愈 "患者的比例微乎其微(5%)(存活时间长于治愈时间)。存活患者的比例 结论:迫切需要重塑意大利目前的外阴护理模式。
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引用次数: 0
Reply to letter to the editor: Potential confounding factors in the analysis of postoperative outcomes. 回复致编辑的信:术后结果分析中的潜在混杂因素。
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-25 DOI: 10.1016/j.ejso.2024.108701
Yizhou Huang, Maohui Chen, Chun Chen, Bin Zheng
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引用次数: 0
Salvage lymphadenectomy or radiation therapy in prostate cancer patients with biochemical recurrence and PET positive lymph nodes after radical prostatectomy: A systematic review and pooled analysis 对根治性前列腺切除术后生化复发且 PET 淋巴结阳性的前列腺癌患者进行挽救性淋巴腺切除术或放疗:系统回顾和汇总分析
IF 3.5 2区 医学 Q2 ONCOLOGY Pub Date : 2024-09-22 DOI: 10.1016/j.ejso.2024.108704

Objective

To analyze the oncologic outcomes of biochemical recurrence (BCR) patients who received salvage treatment of lymph node dissection (LND) or radiation therapy (RT) for positron emission tomography (PET)-positive lymph node recurrences following radical prostatectomy (RP).

Methods

Research using the MEDLINE, Cochrane, and Web of Science databases was conducted until June 2023. Inclusion criteria were BCR patients that received salvage LND or RT for PET-positive lymph node recurrence following primary RP for prostate cancer. Studies with a follow-up period of less than 12 months were excluded.

Results

This study included 2476 patients (995 LND, 1481 RT) from 19 publications. The pooled incidences were 51.1 % and 74.3 % in PSA response, 69.8 % and 26.9 % in PSA progression, 41.5 % and 26.9 % in image progression, 41.5 % and 32.0 % in systemic progression, 0.9 % and 0.5 % in overall mortality, and 6.5 % and 1.3 % in cancer-specific mortality in LND and RT, respectively. Limitations include high heterogeneity.

Conclusion

Although heterogeneity is high across all studies, the pooled rates of PSA, image, and systemic progressions are higher in LND than in RT concerning BCR patients with PET-positive lymph nodes. For future trial designs in BCR, assessing the optimal timing of PSMA PET scans, concurrent systemic therapy, and salvage therapy type is imperative.
目的分析根治性前列腺切除术(RP)后因正电子发射断层扫描(PET)阳性淋巴结复发而接受淋巴结清扫(LND)或放疗(RT)挽救治疗的生化复发(BCR)患者的肿瘤治疗效果。方法使用 MEDLINE、Cochrane 和 Web of Science 数据库进行研究,直至 2023 年 6 月。纳入标准为前列腺癌根治术后因 PET 阳性淋巴结复发而接受 LND 或 RT 挽救治疗的 BCR 患者。结果本研究纳入了 19 篇文献中的 2476 例患者(995 例 LND,1481 例 RT)。在LND和RT中,PSA反应的总发生率分别为51.1%和74.3%,PSA进展的总发生率分别为69.8%和26.9%,影像进展的总发生率分别为41.5%和26.9%,全身进展的总发生率分别为41.5%和32.0%,总死亡率分别为0.9%和0.5%,癌症特异性死亡率分别为6.5%和1.3%。结论虽然所有研究的异质性都很高,但在PET阳性淋巴结的BCR患者中,LND的PSA、影像和全身进展汇总率高于RT。对于 BCR 的未来试验设计,评估 PSMA PET 扫描的最佳时机、同时进行的全身治疗和挽救治疗类型势在必行。
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引用次数: 0
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