Ejso最新文献

{"title":"Development and external validation of an AI-guided navigation system for the safe dissection plane in robot-assisted nipple sparing mastectomy","authors":"Woong Ki Park ,&nbsp;Namkee Oh ,&nbsp;Gyu-Seong Choi ,&nbsp;Bogeun Kim ,&nbsp;Ki Jo Kim ,&nbsp;Hee Jun Choi ,&nbsp;Jinsoo Rhu ,&nbsp;Jai Min Ryu","doi":"10.1016/j.ejso.2026.111392","DOIUrl":"10.1016/j.ejso.2026.111392","url":null,"abstract":"<div><h3>Purpose</h3><div>Robot-assisted nipple-sparing mastectomy (RANSM) has gained acceptance in selected patients; however, identifying the safe dissection plane remains technically challenging due to the absence of tactile feedback. Artificial intelligence (AI)–guided navigation may provide intraoperative assistance, yet no externally validated model has been reported for this procedure.</div></div><div><h3>Materials and methods</h3><div>This retrospective study developed and validated an AI-guided navigation system to identify the safe dissection plane during RANSM. Surgical video data from 37 procedures performed between January 2021 and December 2024 at two tertiary centers in South Korea were analyzed (internal dataset, n = 29; external dataset, n = 8). The safe dissection plane was annotated as the visual boundary between subcutaneous fat and glandular tissue. An AI segmentation model was trained using 5-fold cross-validation on the internal dataset and tested on the independent external dataset. Model performance was assessed using the Dice Similarity Coefficient (DSC), with intersection over union (IOU), sensitivity, precision, and specificity as secondary metrics.</div></div><div><h3>Results</h3><div>A total of 1996 internal and 293 external frames were analyzed. The model achieved a mean DSC of 74.0 % (±1.5 %), IOU: 60.0 % (±1.8 %), sensitivity: 79.7 % (±1.9 %), and precision: 71.5 % (±1.6 %) in internal validation. On external validation, the DSC was 70.8 %, IOU: 55.9 %, sensitivity: 73.1 %, precision: 72.2 %, and specificity: 96.8 %.</div></div><div><h3>Conclusion</h3><div>This study is the first to develop and externally validate an AI-guided navigation system for RANSM. The model demonstrated consistent performance across two institutions, suggesting potential to enhance surgical precision and safety. Larger prospective studies are warranted to confirm clinical utility.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 3","pages":"Article 111392"},"PeriodicalIF":2.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of perioperative circulating tumor DNA (ctDNA) in endometrial cancer with high-risk features: a prospective observational study","authors":"Luigi A. De Vitis ,&nbsp;Faye R. Harris ,&nbsp;Leah Grcevich ,&nbsp;Ilaria Capasso ,&nbsp;Stephen J. Murphy ,&nbsp;James B. Smadbeck ,&nbsp;Alexa F. McCune ,&nbsp;Mohamed F. Ali ,&nbsp;Giannoula Karagouga ,&nbsp;Sarah H. Johnson ,&nbsp;Dorsay Sadeghian ,&nbsp;Gabriella Schivardi ,&nbsp;Giuseppe Cucinella ,&nbsp;Evelyn A. Reynolds ,&nbsp;Grace M. Choong ,&nbsp;Lin Yang ,&nbsp;Alyssa M. Larish ,&nbsp;Michael T. Barrett ,&nbsp;Angela R. Emanuel ,&nbsp;Janet L. Schaefer-Klein ,&nbsp;Andrea Mariani","doi":"10.1016/j.ejso.2026.111388","DOIUrl":"10.1016/j.ejso.2026.111388","url":null,"abstract":"<div><h3>Introduction</h3><div>Although circulating tumor DNA (ctDNA) has emerged as a promising prognostic tool in various malignancies, evidence in endometrial cancer at high risk of recurrence is limited. This study evaluated the association of pre- and post-surgical ctDNA with advanced-stage disease, disease-free and overall survival in endometrial cancer with high-risk features.</div></div><div><h3>Material and methods</h3><div>This prospective observational study was conducted at Mayo Clinic (7/2016-6/2021). Patients with endometrial cancer at preoperative biopsy, confirmed by final pathology, were included. Blood samples were collected before and 10 weeks after surgery. Tumor-specific junctions identified in pathology specimens and blood samples were used to detect ctDNA. Associations between pre- and post-surgical ctDNA and advanced-stage disease, recurrence, and death were evaluated using logistic regression [odds ratio (OR) and 95 % confidence interval] and Cox proportional hazards [hazard ratio (HR) and 95 % confidence interval].</div></div><div><h3>Results</h3><div>Thirty-six patients were included: 6 (16.7 %) intermediate risk, 1 (2.8 %) high-intermediate risk, 28 (77.8 %) high risk, and 1 (2.8 %) advanced metastatic. Detection of pre- or post-surgical ctDNA was not significantly associated with advanced disease (pre-surgical OR 5.69 [0.88–66.02]; post-surgical OR 5.86 [0.83–72.68]). Pre-surgical ctDNA did not significantly predict recurrence (HR 0.99 [0.30–3.23]) or death (HR 3.23 [0.40–25.91]). In contrast, post-surgical ctDNA was associated with increased risk of recurrence (HR 3.32 [1.05–10.51]) and death (HR 5.97 [1.11–36.08]).</div></div><div><h3>Conclusion</h3><div>Post-surgical ctDNA detection was associated with poor outcomes in patients with endometrial cancer. These findings support the potential of ctDNA as a biomarker to personalize surveillance and guide post-surgical treatment strategies.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 3","pages":"Article 111388"},"PeriodicalIF":2.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inguinal “neoligament” reconstruction after groin soft tissue sarcoma resection: A novel surgical technique","authors":"Ferdinando Carlo Maria Cananzi ,&nbsp;Mattia Di Benedetto ,&nbsp;Vittoria D'Amato ,&nbsp;Laura Ruspi ,&nbsp;Federico Sicoli ,&nbsp;Salvatore Lorenzo Renne ,&nbsp;Vittorio Lorenzo Quagliuolo ,&nbsp;Laura Samà","doi":"10.1016/j.ejso.2026.111389","DOIUrl":"10.1016/j.ejso.2026.111389","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 3","pages":"Article 111389"},"PeriodicalIF":2.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron deficiency restrains short-term recovery in patients undergoing surgery for advanced ovarian cancer","authors":"Anna Norbeck ,&nbsp;Mihaela Asp ,&nbsp;Susanne Malander ,&nbsp;Päivi Kannisto","doi":"10.1016/j.ejso.2026.111390","DOIUrl":"10.1016/j.ejso.2026.111390","url":null,"abstract":"<div><h3>Background</h3><div>Patients with advanced ovarian cancer (AOC) who undergo primary and interval debulking surgery are often anemic at diagnosis, with iron deficiency being the most common cause. The aim was to investigate whether preoperative anemia and iron deficiency impact short-term recovery.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included 262 patients with AOC who underwent surgery at Skane University Hospital Lund, Sweden, between January 2020 and December 2023. Patients were divided into four groups, according to preoperative anemia and iron deficiency. Iron deficiency was defined as transferrin saturation (TSAT) &lt; 0.20. Severe complications were defined as Clavien–Dindo (CD) grade ≥3. Logistic regression analyses were used to investigate the difference between patients with and without iron deficiency.</div></div><div><h3>Results</h3><div>Among patients with iron deficiency anemia, 24 % of patients had more than 1 cm of residual tumor at the end of surgery, compared to 6–8 % of patients with no anemia and/or no iron deficiency, (<em>p 0.005</em>). The rate of severe complications (CD ≥ 3) was higher for patients with iron deficiency, odds ratio 2.47 (95 % CI 1.11–5.50), than for patients with no iron deficiency, adjusted for the Aletti score, operating time and hemoglobin (Hb) level. There was no difference between groups regarding length of hospital stay.</div></div><div><h3>Conclusion</h3><div>Patients with iron deficiency anemia, were less likely to undergo radical or optimal surgery. Severe postoperative complications were more common in patients with iron deficiency, with or without anemia. These analyses indicate that iron deficiency is associated with more advanced disease and complex surgical procedures.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 3","pages":"Article 111390"},"PeriodicalIF":2.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended thromboprophylaxis in enhanced recovery after surgery for colorectal cancer: a multicentre retrospective cohort study","authors":"S.T. Glazemakers ,&nbsp;S.H.J. Ketelaers ,&nbsp;H.B. Cornelisse ,&nbsp;F. de Wit ,&nbsp;I.T.A. Pereboom ,&nbsp;G. van der Sluis ,&nbsp;H. Smid-Nanninga ,&nbsp;H.D. de Boer ,&nbsp;I. Nielen ,&nbsp;S.W. Polle ,&nbsp;R. Bretveld ,&nbsp;E.B. van Duyn ,&nbsp;J. Tolenaar ,&nbsp;J.W.A. Burger ,&nbsp;J.G. Bloemen","doi":"10.1016/j.ejso.2025.111378","DOIUrl":"10.1016/j.ejso.2025.111378","url":null,"abstract":"<div><h3>Introduction</h3><div>The value of continuing thromboprophylaxis after hospital discharge (extended prophylaxis) following colorectal cancer surgery is uncertain in modern surgical practices.</div></div><div><h3>Methods</h3><div>A multicentre, retrospective cohort study was conducted across 6 ERAS-adherent centres in the Netherlands, including 2409 patients who underwent elective colorectal cancer surgery between January 2018 and August 2023. Patients were categorized based on their hospital's thromboprophylaxis regimen: thromboprophylaxis until discharge or extended prophylaxis continued after discharge. The primary outcome was 90-day cumulative incidence of symptomatic VTE, with log-rank tests for group comparisons. Secondary outcomes included major bleeding complications (Clavien-Dindo grade ≥ III), and factors associated with occurence of postoperative VTE or major bleeding complications.</div></div><div><h3>Results</h3><div>The median duration of thromboprophylaxis was 4 (IQR 2–6) days in the until-discharge group (n = 1260) and 28 (IQR 18–28) days in the extended-prophylaxis group (n = 1149). The overall incidence of symptomatic VTE was 0.2 %, with no significant difference observed between the two groups (0.2 % vs. 0.2 %; p = 0.925). Major bleeding complications occurred more frequently in the extended-prophylaxis group (1.0 % vs. 2.0 %; p = 0.049). Multivariate analysis demonstrated that extended thromboprophylaxis was independently associated with major bleeding complications (OR2.002, 95 %CI 1.007–3.980), but not with VTE incidence.</div></div><div><h3>Conclusion</h3><div>The overall incidence of symptomatic VTE following elective colorectal cancer surgery within ERAS protocols was low. Thromboprophylaxis regimens continued after discharge were not associated with lower incidence of postoperative VTE, but were associated with a higher frequency of postoperative major bleeding complications. These findings suggest that routine extended thromboprophylaxis may be reconsidered in modern colorectal cancer surgery.</div></div><div><h3>Clinical trial registration</h3><div>registration number W22.176.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 3","pages":"Article 111378"},"PeriodicalIF":2.9,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of the APTNM staging system: Integration of serum biomarkers with TNM classification for enhanced prognostic stratification following hepatectomy for hepatocellular carcinoma","authors":"Xin Li ,&nbsp;Yi-Fei Liu ,&nbsp;Chen-Yao Zhou ,&nbsp;Jun Lu ,&nbsp;Guo-Wei Wang ,&nbsp;Zi-Jie Tang ,&nbsp;Zi-Chao Tu ,&nbsp;Yong-Yi Zeng ,&nbsp;Wei Guo ,&nbsp;Ji-Li Li ,&nbsp;Jia-Hao Xu ,&nbsp;Chao Li ,&nbsp;Ming-Da Wang ,&nbsp;Feng Shen ,&nbsp;Fei Wu ,&nbsp;Tian Yang ,&nbsp;Eastern HepatoBiliary Alliance (EHBA) group","doi":"10.1016/j.ejso.2026.111384","DOIUrl":"10.1016/j.ejso.2026.111384","url":null,"abstract":"<div><h3>Background</h3><div>Current tumour-node-metastasis (TNM) staging for hepatocellular carcinoma (HCC) relies primarily on anatomical factors without incorporating tumour biological characteristics, limiting prognostic precision. This study aimed to develop and validate a novel staging system integrating serum biomarkers alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) with conventional TNM classification to enhance prognostic stratification following hepatectomy.</div></div><div><h3>Methods</h3><div>This multicentre cohort study included patients undergoing curative hepatectomy for HCC at six hospitals in China. The APTNM staging system was constructed by combining preoperative AFP (≥200 μg/L = 1 point), PIVKA-II (≥400 mAU/mL = 1 point), and AJCC 8th edition TNM stage (stages I–III = 1–3 points). Patients were classified as APTNM stage I (1 point), stage II (2–3 points), or stage III (4–5 points). Prognostic performance was evaluated using Kaplan-Meier analysis, multivariate Cox-regression, net reclassification improvement (NRI), and time-dependent receiver operating characteristic (ROC) curves.</div></div><div><h3>Results</h3><div>Among 660 HCC patients, the APTNM staging system demonstrated clear stratification for 5-year overall survival (OS) [stage I (n = 195), 47.7 %; stage II (n = 316), 28.1 %; stage III (n = 149), 15.3 %; <em>P</em> &lt; 0.001] and recurrence-free survival (RFS) (stage I, 29.4 %; stage II, 12.7 %; stage III, 0.0 %; <em>P</em> &lt; 0.001). Multivariate analysis confirmed APTNM staging as an independent predictor of both OS (stage II: HR 1.592, 95 % CI 1.209–2.096; stage III: HR 2.314, 1.668–3.211; both <em>P</em> &lt; 0.001) and RFS (stage II: 1.556, 1.230–1.969; stage III: 2.159, 1.623–2.872; both <em>P</em> &lt; 0.001). Time-dependent NRI values ranged from 0.20 to 0.26 for OS and 0.18–0.31 for RFS across 5-year follow-up, demonstrating substantial improvement over conventional TNM staging. Time-dependent ROC analysis consistently showed superior performance for the APTNM staging.</div></div><div><h3>Conclusions</h3><div>The APTNM staging system successfully integrates tumour biomarkers with anatomical factors, providing significantly enhanced prognostic stratification compared with conventional TNM staging. This biologically informed approach may facilitate more precise risk stratification and guide individualised postoperative surveillance and adjuvant therapy decisions for patients with HCC.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 2","pages":"Article 111384"},"PeriodicalIF":2.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elective surgery in rectal cancer: long term results of a German network comparison of open, laparoscopic, and robotic surgery","authors":"Thea Piso ,&nbsp;Michael Gerken ,&nbsp;Stefan Rolf Benz ,&nbsp;Monika Klinkhammer-Schalke ,&nbsp;Alois Fürst ,&nbsp;Melanie C. Langheinrich ,&nbsp;Saskia Thies ,&nbsp;Stefan Loth ,&nbsp;Constanze Schneider ,&nbsp;Fabian Reinwald ,&nbsp;Jacqueline Müller-Nordhorn ,&nbsp;Andrea Sackmann ,&nbsp;Sylke Ruth Zeissig ,&nbsp;Bianca Franke ,&nbsp;Vinzenz Völkel ,&nbsp;Moritz Schmelzle ,&nbsp;Ulf Kulik","doi":"10.1016/j.ejso.2026.111383","DOIUrl":"10.1016/j.ejso.2026.111383","url":null,"abstract":"<div><h3>Introduction</h3><div>Resection plays a pivotal role in the treatment of rectal cancer. The aim of this study is to compare the long-term outcomes of laparoscopic, open surgical and robotic approaches.</div></div><div><h3>Material and methods</h3><div>The study cohort contains data of 24,725 patients with rectal cancer and curative surgery between 2010 and 2022 from a pooled database of cancer registries of ten German federal states. Primary outcome was overall survival (OS). Secondary outcomes were cumulative loco-regional recurrence (CLR) and recurrence free survival (RFS) calculated via univariable and multivariable analyses, and matched-pair analyses.</div></div><div><h3>Results</h3><div>Of the 24,725 patients, 12,561 (50.8 %) were treated with open, 11,248 (45.5 %) with laparoscopic and 916 patients (3.7 %) with robotic-assisted resections. In multivariable Cox regression analysis, OS was higher in the minimal invasive surgery groups compared to the open surgery group with a HR of 0.775 (p &lt; 0.001) for the laparoscopic and HR of 0.768 (p = 0.006) for the robotic group. A comparison of robotic to open surgery regarding RFS showed a significant difference in favor of robotic surgery in multivariable Cox regression (HR 0.834, p = 0.046). The rate of CLR was lower in the robotic compared to the laparoscopic surgery group. Additionally, we found a lower conversion rate in the robotic group as compared to the laparoscopic group.</div></div><div><h3>Conclusion</h3><div>These findings from real-life data confirm current recommendations for minimal invasive rectal resection. There was a trend towards better outcomes after robotic compared to laparoscopic surgery. However, further studies are needed to investigate this issue and to provide definitive evidence.</div></div>","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 3","pages":"Article 111383"},"PeriodicalIF":2.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The European Quality Assurance scheme for Breast Cancer Services","authors":"Robert Mansel","doi":"10.1016/j.ejso.2025.111220","DOIUrl":"10.1016/j.ejso.2025.111220","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 ","pages":"Article 111220"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Prophylaxis in Template Prostate Biopsy under Local Anaesthetic","authors":"Jessica D'Souza,&nbsp;Omar Alabed Allat,&nbsp;Mohamed Alnoomani,&nbsp;Mohamed Noureldin,&nbsp;Govindaraj Rajkumar,&nbsp;Amr Emara,&nbsp;Richard Hindley","doi":"10.1016/j.ejso.2025.111285","DOIUrl":"10.1016/j.ejso.2025.111285","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 ","pages":"Article 111285"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-analysis on the prognostic impact of imaging detected Tumour Deposits","authors":"Harpreet Sekhon Inderjit Singh ,&nbsp;Amy Lord ,&nbsp;Nikhil Pawa ,&nbsp;Gina Brown","doi":"10.1016/j.ejso.2025.111286","DOIUrl":"10.1016/j.ejso.2025.111286","url":null,"abstract":"","PeriodicalId":11522,"journal":{"name":"Ejso","volume":"52 ","pages":"Article 111286"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145914915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}