Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.239455
D. Morgan, R. Mohamed, Mahmoud Abdelkhalek, Asmaa Mohamed
: Background : Diabetes mellitus (DM) is a chronic metabolic disorder caused by an absolute or relative deficiency of insulin, an anabolic hormone. Insulin is produced by the beta cells of the islets of Langerhans located in the pancreas, and the absence, destruction, or other loss of these cells results in type 1 diabetes, so we aim to investigate the presence of a genetic association between single nucleotide polymorphism (SNP) and pediatric T1DM in a group of pediatric Egyptian patients. Patient and method: The study was a case control study conducted on 80 diabetic subjects aged 5-15 years recruited from the endocrine clinic Pediatrics, Beni-Suef University, and 76 apparently healthy controls with matched age and sex. All subjects were subjected to history taking, full clinical examination, laboratory tests (hemoglobin A1C, TSH, free T4, serum high density lipoprotein, serum low density lipoprotein, serum triglycerides) and SNP (rs34819629) was done by allelic discrimination technique using real time PCR. Results: In our study, the diabetic patients were 28 males (35.0%) and 52 females (65.0%), with a mean age of 10.0 ± 3.2 SD.AS for the control group they were 52 females (68.4%) and 24 males (31.6%) with a mean age 8.8 ± 2.8 SD and we found that Female cases affected more than males and No association was found in SNP (rs34819629) with Type 1 diabetes mellitus. Conclusion : Microalbuminuria was the most complication in our results and no association was found between SNP (rs34819629) and Type 1diabetes mellitus.
{"title":"Detection of Single Nucleotide Polymorphism (SNP) (rs34819629) and its Association with Pediatric Type 1 Diabetes Mellitus","authors":"D. Morgan, R. Mohamed, Mahmoud Abdelkhalek, Asmaa Mohamed","doi":"10.21608/ejmr.2022.239455","DOIUrl":"https://doi.org/10.21608/ejmr.2022.239455","url":null,"abstract":": Background : Diabetes mellitus (DM) is a chronic metabolic disorder caused by an absolute or relative deficiency of insulin, an anabolic hormone. Insulin is produced by the beta cells of the islets of Langerhans located in the pancreas, and the absence, destruction, or other loss of these cells results in type 1 diabetes, so we aim to investigate the presence of a genetic association between single nucleotide polymorphism (SNP) and pediatric T1DM in a group of pediatric Egyptian patients. Patient and method: The study was a case control study conducted on 80 diabetic subjects aged 5-15 years recruited from the endocrine clinic Pediatrics, Beni-Suef University, and 76 apparently healthy controls with matched age and sex. All subjects were subjected to history taking, full clinical examination, laboratory tests (hemoglobin A1C, TSH, free T4, serum high density lipoprotein, serum low density lipoprotein, serum triglycerides) and SNP (rs34819629) was done by allelic discrimination technique using real time PCR. Results: In our study, the diabetic patients were 28 males (35.0%) and 52 females (65.0%), with a mean age of 10.0 ± 3.2 SD.AS for the control group they were 52 females (68.4%) and 24 males (31.6%) with a mean age 8.8 ± 2.8 SD and we found that Female cases affected more than males and No association was found in SNP (rs34819629) with Type 1 diabetes mellitus. Conclusion : Microalbuminuria was the most complication in our results and no association was found between SNP (rs34819629) and Type 1diabetes mellitus.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83065657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.231679
Yasser Abdel-Hady, Mohamed Aly El-Wakil, Khaled Abd El-Meguid, Khadiga Abosaif
: The goal of this study is to investigate whether alterations of myocardial global longitudinal strain and high ‐ sensitive cardiac troponin could be detected early in patients receiving anthracycline chemotherapy & if it could predict future cardiac dysfunction. Methods: Thirty patients with cancer treated with Adriamycin were studied. Blood collection for measurement of high sensitive troponin and echocardiography were performed at baseline, three months & six months of chemotherapy. Global longitudinal strain (GLS), were calculated using speckle tracking echocardiography. Left ventricular ejection fraction was measured by M-mode echocardiography. Results: LVEF although reduced after treatment, remained within the normal range (65±3.6% at base line vs. 63±2.7% at three months vs. 62±2.6% at six months of treatment, p = 0.002).LVIDd & LVIDs was highest after 6 months of chemotherapy. GLS was significantly reduced after treatment (-20.56±1.9% vs. -18.2±2.2% at three months vs -17.1±2.1 at six months of treatment, p<0.001). Subclinical LV dysfunction (>15% reduction in GLS compared to before therapy) occurred in 43%. Serum hs ‐ cTnI levels increased significantly after 3 months of treatment with anthracycline (0.0088± 0.012, vs. 0.345 ± 0.5 after three months of treatment, p = 0.001).There was positive correlation between EF & GLS while a negative correlation was found between hscTnI & GLS. Hs ‐ cTnI assay may allow an early identification of cardiac damage and therefore provide a way to minimize cardiac related mortality and morbidity while undergoing chemotherapy and afterwards.
{"title":"Value of Left Ventricular Global Longitudinal Strain Assessed by Two-Dimensional Strain Imaging in Early Detection of Anthracycline Mediated Cardiotoxicity","authors":"Yasser Abdel-Hady, Mohamed Aly El-Wakil, Khaled Abd El-Meguid, Khadiga Abosaif","doi":"10.21608/ejmr.2022.231679","DOIUrl":"https://doi.org/10.21608/ejmr.2022.231679","url":null,"abstract":": The goal of this study is to investigate whether alterations of myocardial global longitudinal strain and high ‐ sensitive cardiac troponin could be detected early in patients receiving anthracycline chemotherapy & if it could predict future cardiac dysfunction. Methods: Thirty patients with cancer treated with Adriamycin were studied. Blood collection for measurement of high sensitive troponin and echocardiography were performed at baseline, three months & six months of chemotherapy. Global longitudinal strain (GLS), were calculated using speckle tracking echocardiography. Left ventricular ejection fraction was measured by M-mode echocardiography. Results: LVEF although reduced after treatment, remained within the normal range (65±3.6% at base line vs. 63±2.7% at three months vs. 62±2.6% at six months of treatment, p = 0.002).LVIDd & LVIDs was highest after 6 months of chemotherapy. GLS was significantly reduced after treatment (-20.56±1.9% vs. -18.2±2.2% at three months vs -17.1±2.1 at six months of treatment, p<0.001). Subclinical LV dysfunction (>15% reduction in GLS compared to before therapy) occurred in 43%. Serum hs ‐ cTnI levels increased significantly after 3 months of treatment with anthracycline (0.0088± 0.012, vs. 0.345 ± 0.5 after three months of treatment, p = 0.001).There was positive correlation between EF & GLS while a negative correlation was found between hscTnI & GLS. Hs ‐ cTnI assay may allow an early identification of cardiac damage and therefore provide a way to minimize cardiac related mortality and morbidity while undergoing chemotherapy and afterwards.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90179269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.238302
A. Mostaf, H. Haroun, S. Mohamed
: Aim of the work demonstrate the affection of the allergic conjunctivitis on the corneal surface and topography.Study has been undertaken to determine corneal topographic characteristics of patients with allergic conjunctivitis and compare the change in corneal topographic indices in allergic conjunctivitis subjects with normal subjects. Case – control study was carried out in Bani Suif Ophthalmic hospital among 204 eyes divided into two groups 102 diseased eyes with allergic conjunctivitis and 102 normal eyes age and gender matched normal subjects from July 01, 2018 to November 30, 2019. Patients with disease other than allergic conjunctivitis, previous history of corneal scars, dry eye, eye infections ,uveitis , history of surgery and unwilling to participate in the study were excluded. Age and gender matched subject with normal ocular finding were considered as a normal comparable group. The purpose and procedure of study were clearly explained to verbal consent was received from all subjects. Uncorrected and corrected distance visual acuity of each eye was assessed. Detailed anterior segment examination was carried out with the help of a Slit lamp biomicroscopy. Diagnosis of allergic conjunctivitis was made on the basis of the typical clinical history of severe itching and burning sensation with characteristic signs, including giant papillae on the upper palpebral conjunctiva, limbal infiltrates, and eosinophilic concretions (Horner–Trantas’_dots).
{"title":"Corneal Topographic Changes In Allergic Conjunctivitis","authors":"A. Mostaf, H. Haroun, S. Mohamed","doi":"10.21608/ejmr.2022.238302","DOIUrl":"https://doi.org/10.21608/ejmr.2022.238302","url":null,"abstract":": Aim of the work demonstrate the affection of the allergic conjunctivitis on the corneal surface and topography.Study has been undertaken to determine corneal topographic characteristics of patients with allergic conjunctivitis and compare the change in corneal topographic indices in allergic conjunctivitis subjects with normal subjects. Case – control study was carried out in Bani Suif Ophthalmic hospital among 204 eyes divided into two groups 102 diseased eyes with allergic conjunctivitis and 102 normal eyes age and gender matched normal subjects from July 01, 2018 to November 30, 2019. Patients with disease other than allergic conjunctivitis, previous history of corneal scars, dry eye, eye infections ,uveitis , history of surgery and unwilling to participate in the study were excluded. Age and gender matched subject with normal ocular finding were considered as a normal comparable group. The purpose and procedure of study were clearly explained to verbal consent was received from all subjects. Uncorrected and corrected distance visual acuity of each eye was assessed. Detailed anterior segment examination was carried out with the help of a Slit lamp biomicroscopy. Diagnosis of allergic conjunctivitis was made on the basis of the typical clinical history of severe itching and burning sensation with characteristic signs, including giant papillae on the upper palpebral conjunctiva, limbal infiltrates, and eosinophilic concretions (Horner–Trantas’_dots).","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90622408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.240903
H. Khalil, A. Ahmed, Hassan Mahfouz Eliwa
Background: Diabetic macular edema (DME) can occur at any stage of non-proliferative and proliferative diabetic retinopathy. It is characterized by a swelling of the macular area that normally accounts for high-resolution visual acuity (VA), and DME therefore leads to visual deterioration. Objective: To compare the effect of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by OCT. Patients and Methods: This was a prospective comparative study conducted on 32 Diabetic macular edema (DME); to compare the effect of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by OCT. Results: Pre-operative BCVA had a highly significant positive correlation with postoperative BCVA (p < 0.0001). DM duration had a highly significant negative correlation with postoperative BCVA (p = 0.0002). Logistic regression analysis shows that; after applying (Forward method) and entering some predictor variables; the decrease in DM duration; had an independent effect on increasing the probability of patient’s visual acuity improvement; with significant statistical difference (p = 0.042). By using ROC-curve analysis, Aflibercept and Ranibizumab usage showed non-significant predictive values in discrimination of improved patients from patients worsened ones (p > 0.05). Conclusion: Both aflibercept and ranibizumab improve visual acuity and decrease CMT in eyes with DME and moderate visual loss with no difference between the two drugs.
{"title":"Comparison of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by Optical Coherence Tomography","authors":"H. Khalil, A. Ahmed, Hassan Mahfouz Eliwa","doi":"10.21608/ejmr.2022.240903","DOIUrl":"https://doi.org/10.21608/ejmr.2022.240903","url":null,"abstract":"Background: Diabetic macular edema (DME) can occur at any stage of non-proliferative and proliferative diabetic retinopathy. It is characterized by a swelling of the macular area that normally accounts for high-resolution visual acuity (VA), and DME therefore leads to visual deterioration. Objective: To compare the effect of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by OCT. Patients and Methods: This was a prospective comparative study conducted on 32 Diabetic macular edema (DME); to compare the effect of Aflibercept (Eylea®) with Ranibizumab (Lucentis®) in treatment of diabetic macular edema by OCT. Results: Pre-operative BCVA had a highly significant positive correlation with postoperative BCVA (p < 0.0001). DM duration had a highly significant negative correlation with postoperative BCVA (p = 0.0002). Logistic regression analysis shows that; after applying (Forward method) and entering some predictor variables; the decrease in DM duration; had an independent effect on increasing the probability of patient’s visual acuity improvement; with significant statistical difference (p = 0.042). By using ROC-curve analysis, Aflibercept and Ranibizumab usage showed non-significant predictive values in discrimination of improved patients from patients worsened ones (p > 0.05). Conclusion: Both aflibercept and ranibizumab improve visual acuity and decrease CMT in eyes with DME and moderate visual loss with no difference between the two drugs.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84268886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.240113
Abd Elrahman Abd Elaleem, D. Ahmed, Mohamed Yasser Sayed Saif
: The current study was designed to evaluate the effect of oral linoleinec acid (omega 3 fatty acid) on patients who complained from dryness after Phacoemulsification. It was a Cross-Sectional study conducted first of April 2020 to end of February 2021 in the ophthalmology department at Beni-Suef University Hospital, and included 107 participants that had Phacoemulsification surgery, (60.7% males and 39.3% females), their age ranged from (48) to (71) with an average age of (62.07 ±6.03) years old. All participants were subjected to full clinical and laboratory investigations and received oral linoleinic acid capsules 1000 mg for 3 months after operation. Dry-eye markers including the ocular surface disease index (OSDI) and subjective symptom questionnaire, tear-film assessment using Schirmer testing 2, and break–up time test was sequentially evaluated preoperatively and postoperatively at 1st day,1st week, 1st month, 2nd month and 3rd month .Written Informed consent had been taken from all studied participants prior to beginning of the study. OSDI scores decreased significantly between baseline and three months post-operatively, YBUT scores increased significantly between baseline and three months post-operatively and Schirmer test scores increased significantly between baseline and three months post-operatively. Based on our results, oral omega-3 supplements could be safely added to the postoperative protocols following phacoemulsification to reduce the incidence of postoperative dry eye syndrome.
{"title":"Dry Eye Changes After Phacoemulsification After Using Oral Linoleinic Acid (Omega 3 Fatty Acids)","authors":"Abd Elrahman Abd Elaleem, D. Ahmed, Mohamed Yasser Sayed Saif","doi":"10.21608/ejmr.2022.240113","DOIUrl":"https://doi.org/10.21608/ejmr.2022.240113","url":null,"abstract":": The current study was designed to evaluate the effect of oral linoleinec acid (omega 3 fatty acid) on patients who complained from dryness after Phacoemulsification. It was a Cross-Sectional study conducted first of April 2020 to end of February 2021 in the ophthalmology department at Beni-Suef University Hospital, and included 107 participants that had Phacoemulsification surgery, (60.7% males and 39.3% females), their age ranged from (48) to (71) with an average age of (62.07 ±6.03) years old. All participants were subjected to full clinical and laboratory investigations and received oral linoleinic acid capsules 1000 mg for 3 months after operation. Dry-eye markers including the ocular surface disease index (OSDI) and subjective symptom questionnaire, tear-film assessment using Schirmer testing 2, and break–up time test was sequentially evaluated preoperatively and postoperatively at 1st day,1st week, 1st month, 2nd month and 3rd month .Written Informed consent had been taken from all studied participants prior to beginning of the study. OSDI scores decreased significantly between baseline and three months post-operatively, YBUT scores increased significantly between baseline and three months post-operatively and Schirmer test scores increased significantly between baseline and three months post-operatively. Based on our results, oral omega-3 supplements could be safely added to the postoperative protocols following phacoemulsification to reduce the incidence of postoperative dry eye syndrome.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88708111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.244269
A. Samir, H. Haroun, Hanan El Ghonemy, Rehab Abo El-Nor
Background: Posterior capsular opacification (PCO) is the most common delayed complication of cataract surgery with IOL implantation. The incidence of (pco) was reported to be 20.7% at two years and 28.7% at five years after cataract surgery. The purpose of our work is to evaluate the corneal endothelium after Nd:YAG laser capsuolotomy by specular microscope. Patients and Methods: The study included 60 patients, age ranging from 18 to 65 years. This is a descriptive longitudinal study. This study conducted in “Memorial institute of ophthalmic research in Giza”. Results: Nd:YAG laser used to perform posterior capsulotomies on patients that had undergone extracapsular cataract extraction. Only 7 (11.7%) patients had visual acuity improved to 0.3 less improvement in visual acuity. Vision was improved in all patients at least by one line. Visual outcome was not affected by complication. We did not document rise of IOP in any of our patient IOP after operation. Conclusion: Diminution of vision 2-3 years after successful cataract surgery became the chief complaint this is due to posterior capsule opicification, several advances and research has been done to prevent PCO by improving the surgical techniques, better IOL materials and design, use of therapeutic drugs but Nd:YAG laser capsulotomy is considered safe and with a low risk of complication.
{"title":"Effect of ND: YAG Laser Capsulotomy on Corneal Endothelium","authors":"A. Samir, H. Haroun, Hanan El Ghonemy, Rehab Abo El-Nor","doi":"10.21608/ejmr.2022.244269","DOIUrl":"https://doi.org/10.21608/ejmr.2022.244269","url":null,"abstract":"Background: Posterior capsular opacification (PCO) is the most common delayed complication of cataract surgery with IOL implantation. The incidence of (pco) was reported to be 20.7% at two years and 28.7% at five years after cataract surgery. The purpose of our work is to evaluate the corneal endothelium after Nd:YAG laser capsuolotomy by specular microscope. Patients and Methods: The study included 60 patients, age ranging from 18 to 65 years. This is a descriptive longitudinal study. This study conducted in “Memorial institute of ophthalmic research in Giza”. Results: Nd:YAG laser used to perform posterior capsulotomies on patients that had undergone extracapsular cataract extraction. Only 7 (11.7%) patients had visual acuity improved to 0.3 less improvement in visual acuity. Vision was improved in all patients at least by one line. Visual outcome was not affected by complication. We did not document rise of IOP in any of our patient IOP after operation. Conclusion: Diminution of vision 2-3 years after successful cataract surgery became the chief complaint this is due to posterior capsule opicification, several advances and research has been done to prevent PCO by improving the surgical techniques, better IOL materials and design, use of therapeutic drugs but Nd:YAG laser capsulotomy is considered safe and with a low risk of complication.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90695777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.232221
Laura Khalil, O. Botrous, M. Mohammed, Gehad Mohamed Abo elhassan
: The goal of this study is to study the association of circulating level of Irisin with the anthropometric and metabolic parameters in normal weight, overweight and obese children. It’s a cross sectional study conducted on 69 children, grouped into 3 groups ; normal weight (BMI<85th), overweight (BMI≥85th), and obese group (BMI≥ 95th percentile for age and sex) (39 males and 30 females), (20 normal weight, 13 overweight, 36 obese children). aged 6-18 years. All are recruited from Endocrinology Pediatric clinic in Beni Suef University. All participants were subjected to history taking and clinical examination, anthropometric assessment (weight, height, pubertal assessment, waist circumference and hip circumference) and laboratory tests (Serum Irisin, serum cholesterol, serum high density lipoprotein, serum triglycerides, serum fasting insulin, serum fasting glucose, oral glucose tolerance test). Insulin resistance and sensitivity were assessed by calculating HOMA-IR. The obese group of 36 children (52.2%) had a higher level of Irisin than the normal weight and the overweight groups (P-value<0.001). The obese group had a significant higher prevalence of metabolic syndrome regarding the MSC Cook's and the MSC deFerranti criteria. The obese group had a significant linear positive correlation between the Irisin level and BP, BMI, cholesterol level, fasting insulin, fasting glucose, the number of criteria of Metabolic Syndrome as regards International Diabetic Federation and the HOMA IR score. Results revealed that Irisin as well as HOMA-IR can predict presence of metabolic syndrome with high sensitivity and specificity at different levels.
{"title":"Study the association of circulating level of Irisin with the anthropometric and metabolic parameters in normal weight, overweight and obese children","authors":"Laura Khalil, O. Botrous, M. Mohammed, Gehad Mohamed Abo elhassan","doi":"10.21608/ejmr.2022.232221","DOIUrl":"https://doi.org/10.21608/ejmr.2022.232221","url":null,"abstract":": The goal of this study is to study the association of circulating level of Irisin with the anthropometric and metabolic parameters in normal weight, overweight and obese children. It’s a cross sectional study conducted on 69 children, grouped into 3 groups ; normal weight (BMI<85th), overweight (BMI≥85th), and obese group (BMI≥ 95th percentile for age and sex) (39 males and 30 females), (20 normal weight, 13 overweight, 36 obese children). aged 6-18 years. All are recruited from Endocrinology Pediatric clinic in Beni Suef University. All participants were subjected to history taking and clinical examination, anthropometric assessment (weight, height, pubertal assessment, waist circumference and hip circumference) and laboratory tests (Serum Irisin, serum cholesterol, serum high density lipoprotein, serum triglycerides, serum fasting insulin, serum fasting glucose, oral glucose tolerance test). Insulin resistance and sensitivity were assessed by calculating HOMA-IR. The obese group of 36 children (52.2%) had a higher level of Irisin than the normal weight and the overweight groups (P-value<0.001). The obese group had a significant higher prevalence of metabolic syndrome regarding the MSC Cook's and the MSC deFerranti criteria. The obese group had a significant linear positive correlation between the Irisin level and BP, BMI, cholesterol level, fasting insulin, fasting glucose, the number of criteria of Metabolic Syndrome as regards International Diabetic Federation and the HOMA IR score. Results revealed that Irisin as well as HOMA-IR can predict presence of metabolic syndrome with high sensitivity and specificity at different levels.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86765515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.238694
Fatma Abbas, M. A. Abd El Kader, Mohamed M.El-wakil, Ahmad Shaban
: Sensitivitytosalvage chemotherapy is one of the strongest predictors of OS and PFS after high-dose therapy with autologous bone marrow or peripheral blood stem cell transplantation (ABMT) in relapsed or refractory non-Hodgkin’slymphoma. Consequently, efforts have been focused on developing salvage chemotherapy protocols aiming at improving response rate for this particular group of patients. (6). Response rates to conventional chemotherapy are generally greater than 50%; however, Most NHL patients eventually relapse. Relapse of NHL may occur several months to years after the initial remission; however, the majority of relapses for aggressive patients. Numerous salvage chemotherapy regimens have been used to treat relapsed or refractory DLBCL.The majority are based on agents that demonstrate non cross resistance to those used in primary therapy. Studies on salvage therapy have generally included all patients with aggressive lymphoma and are not restricted to DLBCtechniques(5). An ideal salvage therapy regimen for use prior to ASCT should have a high response rate, low hematologic, andnonhematologictoxicity.(3)
{"title":"Efficacy and toxicity of gemcitabine/ dexamethasone / carboplatin versus ESHAP protocol in treatment of relapsed/ refractory Non-Hodgkin’s lymphomas (NHL)","authors":"Fatma Abbas, M. A. Abd El Kader, Mohamed M.El-wakil, Ahmad Shaban","doi":"10.21608/ejmr.2022.238694","DOIUrl":"https://doi.org/10.21608/ejmr.2022.238694","url":null,"abstract":": Sensitivitytosalvage chemotherapy is one of the strongest predictors of OS and PFS after high-dose therapy with autologous bone marrow or peripheral blood stem cell transplantation (ABMT) in relapsed or refractory non-Hodgkin’slymphoma. Consequently, efforts have been focused on developing salvage chemotherapy protocols aiming at improving response rate for this particular group of patients. (6). Response rates to conventional chemotherapy are generally greater than 50%; however, Most NHL patients eventually relapse. Relapse of NHL may occur several months to years after the initial remission; however, the majority of relapses for aggressive patients. Numerous salvage chemotherapy regimens have been used to treat relapsed or refractory DLBCL.The majority are based on agents that demonstrate non cross resistance to those used in primary therapy. Studies on salvage therapy have generally included all patients with aggressive lymphoma and are not restricted to DLBCtechniques(5). An ideal salvage therapy regimen for use prior to ASCT should have a high response rate, low hematologic, andnonhematologictoxicity.(3)","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86801246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.239081
Ahmed Ibrahim, L. Rashed, Antoun Ghaly, Mohamed Ahmed
: Background and Aim: The most common form of primary liver cancer in adults is hepatocellular carcinoma (HCC), and it is the most common cause of death in people with cirrhosis. The mammalian Sir2 family or sirtuins is formed of a cluster of highly conserved proteins triggering nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase activity which target histone and non-histone substrates including enzymes, transcription regulators, tumor suppressors, cell signaling proteins and DNA repair proteins. Seven human sirtuins have been identified and named SIRT1-7. SIRT1 has been regarded as a tumor promoter due to its increased expression in some types of cancers and its role in the inactivation of proteins involved in tumor suppression and DNA damage repair. We aimed to estimate the level of SIRT-1 in the blood of HBV, HCV, and HCC patients, to investigate the possible role of SIRT-1 in the pathogenesis of HCC and to determine the role of SIRT-1 as a tumor marker or pomoter compared to other markers like α-feto protein. Subjects and Methods: This study was performed in Internal Medicine department Beni-Suef Hospital. Our study included 160 individuals; divided into four groups; group A (healthy control), group B (HBV patients), group C (HCV patients) and group D (HCC patients). The serum level of SIRT-1 was assessed and compared in all groups and correlate its level as a tumor marker with the other marker α-fetoprotein. Results: There was significant increase in SIRT-1 levels in HBV, HCV and HCC group as compared to chronic noncancerous viral liver parenchyma diseases, so it may be included in pathogenesis of HCC. SIRT-1 may have matchable specificity and sensitivity as AFP in HCC patients.
{"title":"Comparative Study of SIRT1 Expression in Hepatitis B Virus, Hepatitis C Virus, and Hepatocellular Carcinoma Patients","authors":"Ahmed Ibrahim, L. Rashed, Antoun Ghaly, Mohamed Ahmed","doi":"10.21608/ejmr.2022.239081","DOIUrl":"https://doi.org/10.21608/ejmr.2022.239081","url":null,"abstract":": Background and Aim: The most common form of primary liver cancer in adults is hepatocellular carcinoma (HCC), and it is the most common cause of death in people with cirrhosis. The mammalian Sir2 family or sirtuins is formed of a cluster of highly conserved proteins triggering nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase activity which target histone and non-histone substrates including enzymes, transcription regulators, tumor suppressors, cell signaling proteins and DNA repair proteins. Seven human sirtuins have been identified and named SIRT1-7. SIRT1 has been regarded as a tumor promoter due to its increased expression in some types of cancers and its role in the inactivation of proteins involved in tumor suppression and DNA damage repair. We aimed to estimate the level of SIRT-1 in the blood of HBV, HCV, and HCC patients, to investigate the possible role of SIRT-1 in the pathogenesis of HCC and to determine the role of SIRT-1 as a tumor marker or pomoter compared to other markers like α-feto protein. Subjects and Methods: This study was performed in Internal Medicine department Beni-Suef Hospital. Our study included 160 individuals; divided into four groups; group A (healthy control), group B (HBV patients), group C (HCV patients) and group D (HCC patients). The serum level of SIRT-1 was assessed and compared in all groups and correlate its level as a tumor marker with the other marker α-fetoprotein. Results: There was significant increase in SIRT-1 levels in HBV, HCV and HCC group as compared to chronic noncancerous viral liver parenchyma diseases, so it may be included in pathogenesis of HCC. SIRT-1 may have matchable specificity and sensitivity as AFP in HCC patients.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91283248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.240191
G. Taha, Aya Ahmed, A. Mabrouk, Noha Abdel kader
The goal of this study was to investigate a possible association of chemokine 12 plasma level and its association to ITP , This was a prospective, observational, case-control study which was conducted on 60 patients with ITP with age ranging from 1 -18 years old together with 90 healthy controls. The plasma level of chemokine 12 in pediatric ITP patients and healthy controls were determined using enzyme linked immunosorbent assay (ELISA) The detection limit for this assay was 1.5 pg per ml. Patients were subjected also to lab investigation in the form of CBC and BM aspirate and There was a high plasma level of chemokine 12 in cases than controls (p value <0.05). Furthermore, cases with high plasma level of chemokine 12 were more susceptible for steroid dependency than controls (p<0.05) otherwise, no significant differences between plasma level of chemokine 12 among cases as regard clinical picture , history data , ITP course.
{"title":"Chemokine 12 plasma level in pediatric patients with Immune Thrombocytopenic purpura and its relation to Disease Activity","authors":"G. Taha, Aya Ahmed, A. Mabrouk, Noha Abdel kader","doi":"10.21608/ejmr.2022.240191","DOIUrl":"https://doi.org/10.21608/ejmr.2022.240191","url":null,"abstract":"The goal of this study was to investigate a possible association of chemokine 12 plasma level and its association to ITP , This was a prospective, observational, case-control study which was conducted on 60 patients with ITP with age ranging from 1 -18 years old together with 90 healthy controls. The plasma level of chemokine 12 in pediatric ITP patients and healthy controls were determined using enzyme linked immunosorbent assay (ELISA) The detection limit for this assay was 1.5 pg per ml. Patients were subjected also to lab investigation in the form of CBC and BM aspirate and There was a high plasma level of chemokine 12 in cases than controls (p value <0.05). Furthermore, cases with high plasma level of chemokine 12 were more susceptible for steroid dependency than controls (p<0.05) otherwise, no significant differences between plasma level of chemokine 12 among cases as regard clinical picture , history data , ITP course.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90866456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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