Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.260613
S. Rashwan, M. Bahr, Heba Abdelazeem
: Background : During the induction of general anesthesia, fentanyl is a widely used analgesic. Fentanyl induced cough (FIC) might be a serious complication .Tramadol is a centrally acting codeine analogue, which has an antitussive effect as well as an NMDA antagonist effect. Our study aims to evaluate result of the pre-operative administration of 2 different doses of tramadol I.V. on Incidence and severity of fentanyl-induced cough were compared to placebo. Methodology : In a prospective, double-blind randomized sample, 150 ASA (I - II) patients between the ages of 20 & 60 who were scheduled for elective surgeries under general anaesthesia were assigned to one of three groups: End Result : There was a substantial reduction in the number of cases of FIC in tramadol treated groups, compared to the placebo group being (8(16%)) for group T1 and (7(14%)) for group T 2 compared to the group S (18(36%)) with p value (0.019) & (0.022) respectively, When group T1 was compared to group T2, there was no statistically significant difference with p value of ( 0.736 ). In terms of the quality of the FIC; 11 from 18 in group S , 6 from 8 in group T1 and 4 from 7 in group T2 exhibited a mild type, 6 from 18 in group S , 2 from 8 in group T1 and 3 from 7 in group T2 exhibited mild type, and 1 from 18 in group S showed severe form without the presence of patients in T1 and T2 groups exhibited severe type. There was no substantial difference between the 3 group in terms of the postoperative nausea and vomiting. Conclusion: The Tramadol with different doses; 1mg / kg and 2mg / kg IV 15 minutes. Before anesthesia induction can reduce the incidence & severity of fentanyl-induced cough compared to placebo, but there is no significant distinction between the 2 doses concerning to the incidence & severity of cough.
背景:芬太尼是全麻诱导过程中广泛使用的镇痛药。芬太尼诱发的咳嗽(FIC)可能是严重的并发症。曲马多是一种中枢作用的可待因类似物，具有止咳作用和NMDA拮抗剂作用。本研究旨在评价术前给予2种不同剂量曲马多静脉注射对芬太尼致咳嗽发生率和严重程度的影响，并与安慰剂进行比较。方法:在一项前瞻性双盲随机抽样研究中，150名年龄在20 ~ 60岁之间的ASA (I - II)患者在全身麻醉下计划进行择期手术，被分为三组:与安慰剂组相比，曲马多治疗组FIC病例数明显减少，T1组为8例(16%)，T2组为7例(14%)，S组为18例(36%)，p值分别为0.019和0.022,T1组与T2组比较，差异无统计学意义，p值为0.736。在FIC的质量方面;S组18例中有11例，T1组8例中有6例，T2组7例中有4例为轻度型，S组18例中有6例，T1组8例中有2例，T2组7例中有3例为轻度型，S组18例中有1例为重度型，T1组和T2组均无患者。三组患者术后恶心、呕吐情况无明显差异。结论:不同剂量曲马多;1mg / kg和2mg / kg静脉注射15分钟。与安慰剂相比，麻醉前诱导可以降低芬太尼引起的咳嗽的发生率和严重程度，但两种剂量在咳嗽的发生率和严重程度上没有显著差异。
{"title":"The effect of two doses of tramadol hydrochloride on fentanyl induced Cough: A double-blinded, randomized, controlled study","authors":"S. Rashwan, M. Bahr, Heba Abdelazeem","doi":"10.21608/ejmr.2022.260613","DOIUrl":"https://doi.org/10.21608/ejmr.2022.260613","url":null,"abstract":": Background : During the induction of general anesthesia, fentanyl is a widely used analgesic. Fentanyl induced cough (FIC) might be a serious complication .Tramadol is a centrally acting codeine analogue, which has an antitussive effect as well as an NMDA antagonist effect. Our study aims to evaluate result of the pre-operative administration of 2 different doses of tramadol I.V. on Incidence and severity of fentanyl-induced cough were compared to placebo. Methodology : In a prospective, double-blind randomized sample, 150 ASA (I - II) patients between the ages of 20 & 60 who were scheduled for elective surgeries under general anaesthesia were assigned to one of three groups: End Result : There was a substantial reduction in the number of cases of FIC in tramadol treated groups, compared to the placebo group being (8(16%)) for group T1 and (7(14%)) for group T 2 compared to the group S (18(36%)) with p value (0.019) & (0.022) respectively, When group T1 was compared to group T2, there was no statistically significant difference with p value of ( 0.736 ). In terms of the quality of the FIC; 11 from 18 in group S , 6 from 8 in group T1 and 4 from 7 in group T2 exhibited a mild type, 6 from 18 in group S , 2 from 8 in group T1 and 3 from 7 in group T2 exhibited mild type, and 1 from 18 in group S showed severe form without the presence of patients in T1 and T2 groups exhibited severe type. There was no substantial difference between the 3 group in terms of the postoperative nausea and vomiting. Conclusion: The Tramadol with different doses; 1mg / kg and 2mg / kg IV 15 minutes. Before anesthesia induction can reduce the incidence & severity of fentanyl-induced cough compared to placebo, but there is no significant distinction between the 2 doses concerning to the incidence & severity of cough.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86339742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.259455
S. Gomaa, R. Sheir, H. Farhan, T. Ahmed, Ahmed Abdelsattar
: The goal of this study was to explore the association between Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein and diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). The study included 90 participants, 60 patients with T2DM all recruited from Outpatients Clinic and Internal Medicine Inpatient Department, Beni-Suef University Hospital; and 30 apparently healthy controls. Patients were sub-divided into group I: 20 patients with no albuminuria, group II: 20 patients with microalbuminuria and group III: 20 patients with macroalbuminuria. All participants were subjected to full history taking, routine laboratory investigations and serum SH3YL1 analysis using enzyme-linked immunosorbent (ELISA) assay. Serum SH3YL1 was significantly higher in T2DM patients (5.69 ± 1.6 ng/ml) versus controls (3.76 ±0.80 ng/ml) (p<0.001).There was statistical significant difference with p <0.05 between cases of group I, and each of group II, and group III as regards SH3YL1 level with lowest mean among group I. There was statistical significant positive correlation between SH3YL1 level and each of fasting blood glucose, 2hours postprandial, glycated hemoglobin, urea, creatinine, albuminuria, total cholesterol and triglycerides. SH3YL1 showed sensitivity of (88.3%) and specificity of (53.3%) at cut off value (3.85 ng/mL) among T2DM patients versus controls (p<0.001). Moreover, sensitivity of (70%, 90%, and 90%) and specificity of (56.7%, 70%, and 86.7%) at cutoff (4 ng/mL, 4.45 ng/mL, and 4.65 ng/mL) was found among groups I, II and III versus control group (p= 0.01, <0.001 and <0.001), respectively. In conclusion, SH3YL1 serum level revealed statistically significant increase among T2DM patients and showed statistical difference between the studied no albuminuria, microalbuminuria and macroalbuminuria groups. Our study suggests SH3YL1 as a promising diagnostic and prognostic marker among DN patients.
{"title":"Assessment of SH3YL1 protein as a marker for diabetic nephropathy in type 2 diabetes mellitus","authors":"S. Gomaa, R. Sheir, H. Farhan, T. Ahmed, Ahmed Abdelsattar","doi":"10.21608/ejmr.2022.259455","DOIUrl":"https://doi.org/10.21608/ejmr.2022.259455","url":null,"abstract":": The goal of this study was to explore the association between Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein and diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). The study included 90 participants, 60 patients with T2DM all recruited from Outpatients Clinic and Internal Medicine Inpatient Department, Beni-Suef University Hospital; and 30 apparently healthy controls. Patients were sub-divided into group I: 20 patients with no albuminuria, group II: 20 patients with microalbuminuria and group III: 20 patients with macroalbuminuria. All participants were subjected to full history taking, routine laboratory investigations and serum SH3YL1 analysis using enzyme-linked immunosorbent (ELISA) assay. Serum SH3YL1 was significantly higher in T2DM patients (5.69 ± 1.6 ng/ml) versus controls (3.76 ±0.80 ng/ml) (p<0.001).There was statistical significant difference with p <0.05 between cases of group I, and each of group II, and group III as regards SH3YL1 level with lowest mean among group I. There was statistical significant positive correlation between SH3YL1 level and each of fasting blood glucose, 2hours postprandial, glycated hemoglobin, urea, creatinine, albuminuria, total cholesterol and triglycerides. SH3YL1 showed sensitivity of (88.3%) and specificity of (53.3%) at cut off value (3.85 ng/mL) among T2DM patients versus controls (p<0.001). Moreover, sensitivity of (70%, 90%, and 90%) and specificity of (56.7%, 70%, and 86.7%) at cutoff (4 ng/mL, 4.45 ng/mL, and 4.65 ng/mL) was found among groups I, II and III versus control group (p= 0.01, <0.001 and <0.001), respectively. In conclusion, SH3YL1 serum level revealed statistically significant increase among T2DM patients and showed statistical difference between the studied no albuminuria, microalbuminuria and macroalbuminuria groups. Our study suggests SH3YL1 as a promising diagnostic and prognostic marker among DN patients.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77068759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.252258
A. Mabrouk, M. Khamis, M. Meabed, Rehab Abd El-Kareem
: The aim of current study was to detect prevalence and clinical presentation of iron deficiency anemia (IDA) in primary school children in Beni-Suef and to assess their risk factors. This cross-sectional survey was conducted on randomly selected primary school children with microcytic hypochromic anemia of both genders aged from 6 years – 12 years in Beni- suef governorate. The prevalence of IDA was 26.6% among children 6-12 years of age. Socioeconomic factors (such as mother education, residence, nutritional status, parasitic infection and recurrent infection) and poor dietary habits are the main contributing factors of IDA among the children studied. It is alarming that the prevalence of IDA is high among children 6–12years of age. Screening for IDA should be directed at high-risk groups and school programs should be implemented to improve awareness of healthy food habits.
{"title":"Iron Deficiency Anemia in Primary School Children in Beni-Suef (Prevalence and Clinical Spectrum)","authors":"A. Mabrouk, M. Khamis, M. Meabed, Rehab Abd El-Kareem","doi":"10.21608/ejmr.2022.252258","DOIUrl":"https://doi.org/10.21608/ejmr.2022.252258","url":null,"abstract":": The aim of current study was to detect prevalence and clinical presentation of iron deficiency anemia (IDA) in primary school children in Beni-Suef and to assess their risk factors. This cross-sectional survey was conducted on randomly selected primary school children with microcytic hypochromic anemia of both genders aged from 6 years – 12 years in Beni- suef governorate. The prevalence of IDA was 26.6% among children 6-12 years of age. Socioeconomic factors (such as mother education, residence, nutritional status, parasitic infection and recurrent infection) and poor dietary habits are the main contributing factors of IDA among the children studied. It is alarming that the prevalence of IDA is high among children 6–12years of age. Screening for IDA should be directed at high-risk groups and school programs should be implemented to improve awareness of healthy food habits.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78511545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.252813
M. Salem, Mona Othman, A. Faheem, Khaled El Hadidy
: Diabetes mellitus (DM) is increasing worldwide especially in developing countries. Increasing age, BMI, weight, martial period and family history for diabetes are highly prone to gestational diabetes mellitus. The aim of this work is to estimate prevalence of GDM among pregnant females in Bani-Suef governorate and its hazards on mother and offspring. Our present study was included 1000 pregnant females were followed and their outcomes with estimated gestational age between 24th and 28th week. At first a proforma containing general information was fulfilled, Then the study population were divided into two groups . 1 st group was screened by Random Blood Sugar (RBS) while 2 nd group was screened by a standardized 2h -75 Oral Glucose Tolerance Test (OGTT) according to WHO guidelines of GDM. Our study detected the prevalence of GDM was 2.6%. There was statistically significance of increasing age and BMI, positive family history of DM and positive history of twin pregnancy. There was no statistically significance as regards history of PCO, past history of GDM and past history of macrocosmic baby. We recommend the early screening before 24th week of gestation, for GDM regardless of any other risk factors and those women with increased BMI, age, weight and positive history of diabetes mellitus has to be considered as high-risk group. All GDM diagnosed women should be closely monitored for glycemic control for good maternal and fetal outcome.
{"title":"The prevalance of gestational diabetes mellitus among pregnant females in Beni-Suef governorate and its hazards on the maternal and fetal outcome .","authors":"M. Salem, Mona Othman, A. Faheem, Khaled El Hadidy","doi":"10.21608/ejmr.2022.252813","DOIUrl":"https://doi.org/10.21608/ejmr.2022.252813","url":null,"abstract":": Diabetes mellitus (DM) is increasing worldwide especially in developing countries. Increasing age, BMI, weight, martial period and family history for diabetes are highly prone to gestational diabetes mellitus. The aim of this work is to estimate prevalence of GDM among pregnant females in Bani-Suef governorate and its hazards on mother and offspring. Our present study was included 1000 pregnant females were followed and their outcomes with estimated gestational age between 24th and 28th week. At first a proforma containing general information was fulfilled, Then the study population were divided into two groups . 1 st group was screened by Random Blood Sugar (RBS) while 2 nd group was screened by a standardized 2h -75 Oral Glucose Tolerance Test (OGTT) according to WHO guidelines of GDM. Our study detected the prevalence of GDM was 2.6%. There was statistically significance of increasing age and BMI, positive family history of DM and positive history of twin pregnancy. There was no statistically significance as regards history of PCO, past history of GDM and past history of macrocosmic baby. We recommend the early screening before 24th week of gestation, for GDM regardless of any other risk factors and those women with increased BMI, age, weight and positive history of diabetes mellitus has to be considered as high-risk group. All GDM diagnosed women should be closely monitored for glycemic control for good maternal and fetal outcome.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75579423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.236208
N. Abdallah, Nourhan Selim, Lamia Mahmoud, Shaimaa Abdelkreem, A. Ibrahim
: Background: Epidermal growth factor (EGF) is a mitogen for hepatocytes, and plays a critical role in liver tissue regeneration. Many signaling pathways especially pathways that regulate the physiological processes such as tumor cells growth, differentiation, migration, apoptosis, and angiogenesis had been studied in the era of HCC development such as the EGF signal pathway. During the past few years, there have been enormous efforts to understand the structure and life cycle of hepatitis C virus (HCV) as well as to develop specific medications targeting different viral proteins such as NS3/4A protease, NS5B polymerase, and NS5A replication complex. The discovery of direct acting antiviral agents (DAAs) represented a revolution in the management of chronic hepatitis C virus infection Objectives: to investigate polymorphism of the gene encoding EGF in HCV-induced liver cirrhosis whether receiving antiviral treatment or not. Methods: Sixty Egyptian patients were enrolled in the study. Twenty patients pre-diagnosed as HCV-induced liver cirrhosis and received antiviral treatment in the form of Daklatasvir, Sofosbuvir and Ribavirin for 3 months and sustained virological response (SVR) was obtained, 20 patients diagnosed as HCV-induced liver cirrhosis and not receiving treatment yet, and 20 healthy person of matched age and sex as control group). Genotyping for EGF gene was performed by real time PCR. Results: With regards to polymorphism of EGF gene there are three genotypes; A/A, A/G and G/G that were detected in the three studied groups. The frequency of EGF gene polymorphism in HCV control group, the frequency was (AA 65 %, AG 15%, GG 20%). Upon examining the allelic discrimination, A allele was present in 35% of HCV patient who received treatment versus 32.5% of HCV patient who did not receive treatment and 72.5% of control group. On the other hand, G allele was present in 65% of HCV patients who received treatment versus 67.5% of HCV patients who did not receive treatment and 17.5% of control group. Conclusion: No significant effect of antiviral treatment on EGF gene.
背景:表皮生长因子(Epidermal growth factor, EGF)是肝细胞的丝裂原，在肝组织再生中起关键作用。许多信号通路，特别是调控肿瘤细胞生长、分化、迁移、凋亡、血管生成等生理过程的信号通路，如EGF信号通路，在HCC发展时代已被研究。在过去的几年里，人们在了解丙型肝炎病毒(HCV)的结构和生命周期以及开发针对不同病毒蛋白(如NS3/4A蛋白酶、NS5B聚合酶和NS5A复制复合体)的特异性药物方面付出了巨大的努力。直接作用抗病毒药物(DAAs)的发现代表了慢性丙型肝炎病毒感染治疗的一场革命目的:探讨编码EGF基因在丙型肝炎诱导的肝硬化中是否接受抗病毒治疗的多态性。方法:60例埃及患者入组研究。20例预诊断为丙型肝炎肝硬化并接受达他韦、索非布韦和利巴韦林抗病毒治疗3个月且持续病毒学应答(SVR)的患者，20例诊断为丙型肝炎肝硬化但尚未接受治疗的患者，20例年龄和性别匹配的健康人作为对照组。采用实时聚合酶链反应(real - time PCR)进行EGF基因分型。结果:EGF基因多态性可分为三种基因型;A/A、A/G、G/G。HCV对照组EGF基因多态性频率为(AA 65%， AG 15%， GG 20%)。在检测等位基因歧视时，接受治疗的HCV患者中有35%存在A等位基因，未接受治疗的HCV患者中有32.5%，对照组中有72.5%。另一方面，65%接受治疗的HCV患者存在G等位基因，而未接受治疗的HCV患者为67.5%，对照组为17.5%。结论:抗病毒治疗对EGF基因无明显影响。
{"title":"Study of Epidermal Growth Factor Gene Polymorphism in Hepatitis C Virus Induced Liver Cirrhosis with or without Treatment","authors":"N. Abdallah, Nourhan Selim, Lamia Mahmoud, Shaimaa Abdelkreem, A. Ibrahim","doi":"10.21608/ejmr.2022.236208","DOIUrl":"https://doi.org/10.21608/ejmr.2022.236208","url":null,"abstract":": Background: Epidermal growth factor (EGF) is a mitogen for hepatocytes, and plays a critical role in liver tissue regeneration. Many signaling pathways especially pathways that regulate the physiological processes such as tumor cells growth, differentiation, migration, apoptosis, and angiogenesis had been studied in the era of HCC development such as the EGF signal pathway. During the past few years, there have been enormous efforts to understand the structure and life cycle of hepatitis C virus (HCV) as well as to develop specific medications targeting different viral proteins such as NS3/4A protease, NS5B polymerase, and NS5A replication complex. The discovery of direct acting antiviral agents (DAAs) represented a revolution in the management of chronic hepatitis C virus infection Objectives: to investigate polymorphism of the gene encoding EGF in HCV-induced liver cirrhosis whether receiving antiviral treatment or not. Methods: Sixty Egyptian patients were enrolled in the study. Twenty patients pre-diagnosed as HCV-induced liver cirrhosis and received antiviral treatment in the form of Daklatasvir, Sofosbuvir and Ribavirin for 3 months and sustained virological response (SVR) was obtained, 20 patients diagnosed as HCV-induced liver cirrhosis and not receiving treatment yet, and 20 healthy person of matched age and sex as control group). Genotyping for EGF gene was performed by real time PCR. Results: With regards to polymorphism of EGF gene there are three genotypes; A/A, A/G and G/G that were detected in the three studied groups. The frequency of EGF gene polymorphism in HCV control group, the frequency was (AA 65 %, AG 15%, GG 20%). Upon examining the allelic discrimination, A allele was present in 35% of HCV patient who received treatment versus 32.5% of HCV patient who did not receive treatment and 72.5% of control group. On the other hand, G allele was present in 65% of HCV patients who received treatment versus 67.5% of HCV patients who did not receive treatment and 17.5% of control group. Conclusion: No significant effect of antiviral treatment on EGF gene.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77235626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.241699
Mohamed Aabdallah, Taymour Ibrahim, Khadiga Abugabal, Ahmed Abosief
Introduction: Most studies that linked varicocele (Vx) with male infertility focused mainly on the testis affection, yet it was suggested that Vx can disturb also the epididymis that plays a central role in sperm maturation. Higher concentrations of L-Carnitine (LC) were reported in the human epididymis but few studies have investigated the relationship of seminal LC with male infertility associated with Vx. This study aimed to assess seminal plasma L-Carnitine (LC) levels in infertile oligoathenoteratozoospermic (OAT) patients with varicocele (Vx). Methods: Overall, 86 men were investigated. They were divided into; infertile OAT patients with Vx (n=45), infertile OAT patients without Vx (n=21), and fertile men (n=20) as controls. These cases were subjected to history taking, clinical examination, and semen analysis. Seminal LC levels were estimated by the colorimetric method. Results: The mean seminal plasma LC levels were significantly lower in infertile OAT patients with Vx (216.3 ± 57.1 ng/ml) compared to infertile OAT patients without Vx (252.9 ± 62.9 ng/ml, P= 0.01), or fertile men (382.8 ± 63.6 ng/ml, P=0.001). Besides, the mean seminal plasma LC level exhibited significant decreases in infertile OAT patients of Vx grade III compared to Vx grade II cases, and in infertile OAT patients of bilateral Vx compared with unilateral Vx cases. Collectively, there was a significant positive correlation between seminal LC levels with sperm concentration, motility, and normal forms. Conclusion: Seminal LC levels are expressively reduced in infertile OAT patients with Vx influenced by an escalation of its grade and bilaterality. Egyptian Journal of Medical Research (EJMR), Volume 3, Issue2, 2022 244
{"title":"Assessment of Seminal L-Carnitine in Infertile Men with Varicocele","authors":"Mohamed Aabdallah, Taymour Ibrahim, Khadiga Abugabal, Ahmed Abosief","doi":"10.21608/ejmr.2022.241699","DOIUrl":"https://doi.org/10.21608/ejmr.2022.241699","url":null,"abstract":"Introduction: Most studies that linked varicocele (Vx) with male infertility focused mainly on the testis affection, yet it was suggested that Vx can disturb also the epididymis that plays a central role in sperm maturation. Higher concentrations of L-Carnitine (LC) were reported in the human epididymis but few studies have investigated the relationship of seminal LC with male infertility associated with Vx. This study aimed to assess seminal plasma L-Carnitine (LC) levels in infertile oligoathenoteratozoospermic (OAT) patients with varicocele (Vx). Methods: Overall, 86 men were investigated. They were divided into; infertile OAT patients with Vx (n=45), infertile OAT patients without Vx (n=21), and fertile men (n=20) as controls. These cases were subjected to history taking, clinical examination, and semen analysis. Seminal LC levels were estimated by the colorimetric method. Results: The mean seminal plasma LC levels were significantly lower in infertile OAT patients with Vx (216.3 ± 57.1 ng/ml) compared to infertile OAT patients without Vx (252.9 ± 62.9 ng/ml, P= 0.01), or fertile men (382.8 ± 63.6 ng/ml, P=0.001). Besides, the mean seminal plasma LC level exhibited significant decreases in infertile OAT patients of Vx grade III compared to Vx grade II cases, and in infertile OAT patients of bilateral Vx compared with unilateral Vx cases. Collectively, there was a significant positive correlation between seminal LC levels with sperm concentration, motility, and normal forms. Conclusion: Seminal LC levels are expressively reduced in infertile OAT patients with Vx influenced by an escalation of its grade and bilaterality. Egyptian Journal of Medical Research (EJMR), Volume 3, Issue2, 2022 244","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80646117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.244692
Khaled H. Mohamed, H. Taha, M. Kamel, H. Farhan
Objective: The aim of this study is to assess the level of serum bone sialoprotein as a diagnostic biomarker in cases of diabetic bone diseases and its relation to diabetic microvascular complications. Methods: A total of 60 subjects; 30 diabetic patients type II with micro-vascular complications (retinopathy and/or nephropathy) as a case group and 30 healthy individuals serve as control group was recruited in this case–control study from diabetes and endocrinology clinic and internal medicine department in Beni Suef university hospital. The biochemical and metabolic parameters and bone turnover marker will be assessed in all patients. Results: Serum bone sialoprotein (BSP) was found to be significantly higher in diabetic patients with microvascular complication compared to normal control group. Moreover, bone sialoprotein (BSP) was positively correlated to osteoporosis of lumbar spine. Conclusion: Bone sialoprotein increase could be used as a biomarker of diabetic bone disease diagnosis and could be a predictor of spinal osteoporotic fractures in diabetic patients.
{"title":"Bone Sialoprotein Level in Osteoporotic Diabetic Patients type II with Microvascular Complication","authors":"Khaled H. Mohamed, H. Taha, M. Kamel, H. Farhan","doi":"10.21608/ejmr.2022.244692","DOIUrl":"https://doi.org/10.21608/ejmr.2022.244692","url":null,"abstract":"Objective: The aim of this study is to assess the level of serum bone sialoprotein as a diagnostic biomarker in cases of diabetic bone diseases and its relation to diabetic microvascular complications. Methods: A total of 60 subjects; 30 diabetic patients type II with micro-vascular complications (retinopathy and/or nephropathy) as a case group and 30 healthy individuals serve as control group was recruited in this case–control study from diabetes and endocrinology clinic and internal medicine department in Beni Suef university hospital. The biochemical and metabolic parameters and bone turnover marker will be assessed in all patients. Results: Serum bone sialoprotein (BSP) was found to be significantly higher in diabetic patients with microvascular complication compared to normal control group. Moreover, bone sialoprotein (BSP) was positively correlated to osteoporosis of lumbar spine. Conclusion: Bone sialoprotein increase could be used as a biomarker of diabetic bone disease diagnosis and could be a predictor of spinal osteoporotic fractures in diabetic patients.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87221628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: This study was conducted to is to assess the role of microdebrider assisted turbinoplasty in children with hypertrophic inferior turbinate in the long-lasting reduction of the turbinate size, preservation of the turbinate mucosal surface, maintenance of the function and complications, the study was designed as a prospective cohort series study. The study was held in Beni-Suef specialized hospital and in Beni-Suef university. This study included 40 patients in childhood period of (9 to 15) years old with hypertrophic inferior turbinate were diagnosed and all patients were be treated by Microdibreder assisted turbinoplasty. This study revealed that the maximum time for debriding the turbinate was 30 minutes and the minimum time was 20 with an average 22.5 minutes. During the operation 5 patients had mucosal tears (25%) and only in 2 patients (5%) suction electrocautery was used to achieve hemostasis. In 4 patients, bony turbinate was thick (10%) and n 36 patients it was thin (90%). There was a significant improvement of the nasal obstruction and other symptoms of hypertrophy. This study concluded that Microdebrider is the best technique used to improve nasal obstruction caused by hypertrophic inferior turbinate in children by decreasing its size with the ability to preserve the entire turbinal mucosa, except for a notch in the anterior pole of the turbinate. Keeping its functional structures intact, the turbinate can remain fully normal after the procedure.
{"title":"Microdebrider-Assisted Turbinoplasty in Children with Hypertrophic Inferior Turbinate","authors":"Ashraf Khalid, Mohamed Abdel Monaem, Khalid Abdelmoaty, Abdelrhman Mouhamed","doi":"10.21608/ejmr.2022.238824","DOIUrl":"https://doi.org/10.21608/ejmr.2022.238824","url":null,"abstract":": This study was conducted to is to assess the role of microdebrider assisted turbinoplasty in children with hypertrophic inferior turbinate in the long-lasting reduction of the turbinate size, preservation of the turbinate mucosal surface, maintenance of the function and complications, the study was designed as a prospective cohort series study. The study was held in Beni-Suef specialized hospital and in Beni-Suef university. This study included 40 patients in childhood period of (9 to 15) years old with hypertrophic inferior turbinate were diagnosed and all patients were be treated by Microdibreder assisted turbinoplasty. This study revealed that the maximum time for debriding the turbinate was 30 minutes and the minimum time was 20 with an average 22.5 minutes. During the operation 5 patients had mucosal tears (25%) and only in 2 patients (5%) suction electrocautery was used to achieve hemostasis. In 4 patients, bony turbinate was thick (10%) and n 36 patients it was thin (90%). There was a significant improvement of the nasal obstruction and other symptoms of hypertrophy. This study concluded that Microdebrider is the best technique used to improve nasal obstruction caused by hypertrophic inferior turbinate in children by decreasing its size with the ability to preserve the entire turbinal mucosa, except for a notch in the anterior pole of the turbinate. Keeping its functional structures intact, the turbinate can remain fully normal after the procedure.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80584721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.238885
Hazem Haron, Abdel-Aziz El Bayoumi Abdel Aleem, Doaa Hassanin
: Background: Dry eye is described as a multifactorial disorder of the tear film that occurs due to excessive tear evaporation or tears insufficiency, and so leads to ocular discomfort sensation and ocular tissue damage with time. Objectives: The aim of this study was to assess the incidence of dry eye disease after uncomplicated phacoemulsification surgery at patients with no pre-existed dry eye. Patients and Methods: This hospital-based cross-sectional study was conducted to assess the incidence of dry eye at 50 eyes of 50 patients who underwent uncomplicated phacoemulsification surgery, with age more than 40 years old. It is measured by dry eye tests ST1, TBUT, and OSDI questionnaire. Results: This study showed that 22% of the patients who underwent uncomplicated phacoemulsification surgery suffered from dry eye with significant results at 1st week postoperative that improved over time. Also, it showed a significant association between microscopic light exposure time (during surgery) and increasing the incidence of dry eye postoperatively. Conclusion: There was a statistically significant drop in the results of the schirmer test1 and TBUT post phacoemulsification surgery, but with no clinical significance, as they still at the normal range. The tear film assessment results at 22% of the patients, at the 1st week post-operative, were out of the normal range at TBUT, OSDI tests and were borderline at ST1. These results improved over time to return to the normal values within 12 week postoperatively.
{"title":"The Incidence of Dry Eye Disease after Uncomplicated Phacoemulsification Surgery","authors":"Hazem Haron, Abdel-Aziz El Bayoumi Abdel Aleem, Doaa Hassanin","doi":"10.21608/ejmr.2022.238885","DOIUrl":"https://doi.org/10.21608/ejmr.2022.238885","url":null,"abstract":": Background: Dry eye is described as a multifactorial disorder of the tear film that occurs due to excessive tear evaporation or tears insufficiency, and so leads to ocular discomfort sensation and ocular tissue damage with time. Objectives: The aim of this study was to assess the incidence of dry eye disease after uncomplicated phacoemulsification surgery at patients with no pre-existed dry eye. Patients and Methods: This hospital-based cross-sectional study was conducted to assess the incidence of dry eye at 50 eyes of 50 patients who underwent uncomplicated phacoemulsification surgery, with age more than 40 years old. It is measured by dry eye tests ST1, TBUT, and OSDI questionnaire. Results: This study showed that 22% of the patients who underwent uncomplicated phacoemulsification surgery suffered from dry eye with significant results at 1st week postoperative that improved over time. Also, it showed a significant association between microscopic light exposure time (during surgery) and increasing the incidence of dry eye postoperatively. Conclusion: There was a statistically significant drop in the results of the schirmer test1 and TBUT post phacoemulsification surgery, but with no clinical significance, as they still at the normal range. The tear film assessment results at 22% of the patients, at the 1st week post-operative, were out of the normal range at TBUT, OSDI tests and were borderline at ST1. These results improved over time to return to the normal values within 12 week postoperatively.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79652644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ejmr.2022.231672
Nahed Abdelazeem, Abdelaziz El Refaiee, Shimaa A Othman
: The goal of this study is to measure serum level of I Kappa B in patients with psoriasis in comparison with healthy controls. 50 psoriatic patients and 40 age & gender matched apparently healthy controls were included in the study, patients were classified according to Psoriasis Area & Surface Index (PASI) score and serum samples for all participants were taken to measure I Kappa B level for each. The level of serum I Kappa B was found to be significantly lower in the patients (3.96 ±1.96) than in controls (11.02 ±2.22). This difference was of statistical significance (p-value =0.001).
{"title":"I-KappaB Expression in Patient with Psoriasis Vulgaris","authors":"Nahed Abdelazeem, Abdelaziz El Refaiee, Shimaa A Othman","doi":"10.21608/ejmr.2022.231672","DOIUrl":"https://doi.org/10.21608/ejmr.2022.231672","url":null,"abstract":": The goal of this study is to measure serum level of I Kappa B in patients with psoriasis in comparison with healthy controls. 50 psoriatic patients and 40 age & gender matched apparently healthy controls were included in the study, patients were classified according to Psoriasis Area & Surface Index (PASI) score and serum samples for all participants were taken to measure I Kappa B level for each. The level of serum I Kappa B was found to be significantly lower in the patients (3.96 ±1.96) than in controls (11.02 ±2.22). This difference was of statistical significance (p-value =0.001).","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75126052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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