Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.254009
Abd-ElAziz El-Rifaie, L. Rashed, M. Abdellatif, A. Mohamed
: There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons via investigating its potential role in the pathogenesis of this disease. A case control study for detection of Desmoglein-3 autoantibodies in serum of 40 lichen planus patients and 40 healthy controls using enzyme-linked immunosorbent assay (ELISA) technique.The patients and healthy controls were recruited from Dermatology outpatient clinic at Beni-Suef University hospital. The measurement of anti Dsg3 antibodies in LP patients was significantly higher as compared to normal control persons. The mean scores were 1361.37 ± 300.5 in oral LP & 2118.70 ± 584.37 in cutaneous LP vs. 66.98 ±70.95 in controls (p-value < 0.001). Desmoglein-3 auto-antibodies in LP may have a role in the pathogenesis of the disease. Further investigations are needed for detection of Dsg 3 auto-antibodies in LP skin biopsy or blood samples by other methods such as Immunofluorescence.
{"title":"Detection of Desmoglein-3 Auto-Antibodies in Patients with Lichen Planus","authors":"Abd-ElAziz El-Rifaie, L. Rashed, M. Abdellatif, A. Mohamed","doi":"10.21608/ejmr.2022.254009","DOIUrl":"https://doi.org/10.21608/ejmr.2022.254009","url":null,"abstract":": There is controversy about the role of auto anti-bodies against desmoglein 3 (Dsg 3) in the pathogenesis of lichen planus (LP). The goal of this study is to detect desmoglein-3 auto-antibodies in lichen planus patients comparted to normal control persons via investigating its potential role in the pathogenesis of this disease. A case control study for detection of Desmoglein-3 autoantibodies in serum of 40 lichen planus patients and 40 healthy controls using enzyme-linked immunosorbent assay (ELISA) technique.The patients and healthy controls were recruited from Dermatology outpatient clinic at Beni-Suef University hospital. The measurement of anti Dsg3 antibodies in LP patients was significantly higher as compared to normal control persons. The mean scores were 1361.37 ± 300.5 in oral LP & 2118.70 ± 584.37 in cutaneous LP vs. 66.98 ±70.95 in controls (p-value < 0.001). Desmoglein-3 auto-antibodies in LP may have a role in the pathogenesis of the disease. Further investigations are needed for detection of Dsg 3 auto-antibodies in LP skin biopsy or blood samples by other methods such as Immunofluorescence.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75850069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.260268
H. Khalil, Ahmed Gouda, E. Wahba
{"title":"Subfoveal Choroidal Thickness Changes Following Pars Plana Vitrectomy with Silicone Oil Endotamponade for Rhegmatogenous Retinal Detachment","authors":"H. Khalil, Ahmed Gouda, E. Wahba","doi":"10.21608/ejmr.2022.260268","DOIUrl":"https://doi.org/10.21608/ejmr.2022.260268","url":null,"abstract":"","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79422459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.254588
M. Abdel-Aziz, S. Fahmey, N. Ibrahim, A. Mabrouk
Staphylococcus aureus (S. aureus) remains one of the most frequently occurring community-acquired as well as hospital-acquired pathogens with high rates of hospital-acquired infections. S.aureus is an important pathogenic bacterium. It resides predominantly in the anterior nares, and extra-nasal sites including the skin, perineum, and pharynx, and less frequent in the gastrointestinal tract and the vagina. About 30% of the general population is nasal carriers of the bacterium. Infections caused by this organism could be exogenous or endogenous in origin, and they include impetigo, cellulitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS), septicemia, and pneumonia. Healthcare-associated infections by S. aureus are about 20% worldwide. S. aureus infection at NICU remains a major health challenge as colonized healthcare workers, patients, and contaminated surfaces serve as reservoir for infection. The incidence of healthcare-associated infections caused by S. aureus continues to increase worldwide. The goal of this study is to assess the nasal carriage of S. aureus isolated from neonates and health care workers (HCWs) in the NICU of Beni Suef University Hospital. Also, our study provides valuable insights documenting important factors that affect susceptibility and outcomes of neonatal sepsis which is a global public health issue.
{"title":"Staphylococcus Aureus Nasal Colonization in the Neonatal Intensive Care Unit of Beni-Suef University Hospital","authors":"M. Abdel-Aziz, S. Fahmey, N. Ibrahim, A. Mabrouk","doi":"10.21608/ejmr.2022.254588","DOIUrl":"https://doi.org/10.21608/ejmr.2022.254588","url":null,"abstract":"Staphylococcus aureus (S. aureus) remains one of the most frequently occurring community-acquired as well as hospital-acquired pathogens with high rates of hospital-acquired infections. S.aureus is an important pathogenic bacterium. It resides predominantly in the anterior nares, and extra-nasal sites including the skin, perineum, and pharynx, and less frequent in the gastrointestinal tract and the vagina. About 30% of the general population is nasal carriers of the bacterium. Infections caused by this organism could be exogenous or endogenous in origin, and they include impetigo, cellulitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS), septicemia, and pneumonia. Healthcare-associated infections by S. aureus are about 20% worldwide. S. aureus infection at NICU remains a major health challenge as colonized healthcare workers, patients, and contaminated surfaces serve as reservoir for infection. The incidence of healthcare-associated infections caused by S. aureus continues to increase worldwide. The goal of this study is to assess the nasal carriage of S. aureus isolated from neonates and health care workers (HCWs) in the NICU of Beni Suef University Hospital. Also, our study provides valuable insights documenting important factors that affect susceptibility and outcomes of neonatal sepsis which is a global public health issue.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83532292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.252809
S. El maraghi, Rania ElHossainy, M. Samy
: Background: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Similar to poly trauma, acute myocardial infarction, or stroke, early identification and appropriate management in the initial hours after sepsis develops improves outcomes. In a patient with septic shock, a fluid challenge will cause an increase in stroke volume; according to the Frank-Starling curve [1] .Relative hypovolemia has been described in the setting of septic shock. However, only 50 % of patients with hemodynamic instability are fluid responsive [2] . Purpose : Assessment of Fluid responsiveness in ventilated septic shock patients according to presence of LVOT obstruction and to judge the power of prediction of other hemodynamic parameters. Methods: A prospective observational study was carried out on 50 adult mechanically ventilated patients with septic shock. Two sets of measurements were performed before and immediately after volume expansion. Cardiac output (CO), stroke volume (SV), IVC distensibility index (dIVC), LVOT velocity ( m/s ,Mean and peak pressure gradient (mmHg) were measured by transthoracic echocardiography. Fluid challenge responders were defined as patients whose cardiac output was increased ≥15 %. The area under the receiver operating characteristic curve (AUC) was compared for each predictive parameter. Results: During the study period, LVOT obstruction was found in 18 patients (36 %). Mortality rate at 60 days was found to be higher in patients with LVOT than in patients without LVOT obstruction (75% versus 25%, p < 0.01). Around 90 % of patients with LVOT obstruction were fluid responders versus 60 % from patient without LVOT obstruction (P-value=0.04). IVC distensibility index predicts fluid responsiveness at a cutoff point 17% with a sensitivity 88% and specificity 83 %( p-value < 0.001 and AUC= 0.934) Conclusions: LVOT obstruction in the early phase of septic shock is not rare (more than one third of septic shock patients) and is associated with a high mortality rate.
{"title":"Assessment of dynamic left ventricular outflow track obstruction as fluid responsiveness marker in mechanically ventilated septic patients","authors":"S. El maraghi, Rania ElHossainy, M. Samy","doi":"10.21608/ejmr.2022.252809","DOIUrl":"https://doi.org/10.21608/ejmr.2022.252809","url":null,"abstract":": Background: Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Similar to poly trauma, acute myocardial infarction, or stroke, early identification and appropriate management in the initial hours after sepsis develops improves outcomes. In a patient with septic shock, a fluid challenge will cause an increase in stroke volume; according to the Frank-Starling curve [1] .Relative hypovolemia has been described in the setting of septic shock. However, only 50 % of patients with hemodynamic instability are fluid responsive [2] . Purpose : Assessment of Fluid responsiveness in ventilated septic shock patients according to presence of LVOT obstruction and to judge the power of prediction of other hemodynamic parameters. Methods: A prospective observational study was carried out on 50 adult mechanically ventilated patients with septic shock. Two sets of measurements were performed before and immediately after volume expansion. Cardiac output (CO), stroke volume (SV), IVC distensibility index (dIVC), LVOT velocity ( m/s ,Mean and peak pressure gradient (mmHg) were measured by transthoracic echocardiography. Fluid challenge responders were defined as patients whose cardiac output was increased ≥15 %. The area under the receiver operating characteristic curve (AUC) was compared for each predictive parameter. Results: During the study period, LVOT obstruction was found in 18 patients (36 %). Mortality rate at 60 days was found to be higher in patients with LVOT than in patients without LVOT obstruction (75% versus 25%, p < 0.01). Around 90 % of patients with LVOT obstruction were fluid responders versus 60 % from patient without LVOT obstruction (P-value=0.04). IVC distensibility index predicts fluid responsiveness at a cutoff point 17% with a sensitivity 88% and specificity 83 %( p-value < 0.001 and AUC= 0.934) Conclusions: LVOT obstruction in the early phase of septic shock is not rare (more than one third of septic shock patients) and is associated with a high mortality rate.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80476594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.255022
Hossam El Deen Khalil, A. Gouda, I.Y. Abd Allah
{"title":"Comparison between the Effect of Aflibercept (Eylea) and Ranibizumab (Lucentis) on Intraocular Pressure after 3rd Injection in Treatment of Diabetic Macular Edema","authors":"Hossam El Deen Khalil, A. Gouda, I.Y. Abd Allah","doi":"10.21608/ejmr.2022.255022","DOIUrl":"https://doi.org/10.21608/ejmr.2022.255022","url":null,"abstract":"","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72665487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.258995
Ashraf M. Khaled, A. Saeed, M. Abdeltawab, O. Ahmed
The goal of th study is to evaluate the role of high ‑ resolution computed tomography (HRCT) temporal bone in patients with active squamosal chronic otitis media (COM). 30 patients with active squamosal COM underwent preoperative HRCT temporal bone followed by surgery. Their intra ‑ operative findings were compared and correlated with the radiological findings, to calculate the predictive value of HRCT temporal bone. According to the present study, HRCT was highly sensitive for detecting mastoid pneumatization, soft tissue extension, ossicular erosion, tegmen and sigmoid sinus erosion, and less sensitive for fallopian canal erosion and lateral sinus fistula. It was specific for all these parameters.The present study concludes that HRCT can be recommended not only in cases suspected with potential complications but also in all cases of COM to know the extent of disease, varied pneumatization, and the presence of anatomical variations, which should alert the clinician and guide in surgical approach and treatment plan.
{"title":"Comparative Study between CT Findings and Intra-Operative Findings in Patients with CSOM (Attico-Antral Disease)","authors":"Ashraf M. Khaled, A. Saeed, M. Abdeltawab, O. Ahmed","doi":"10.21608/ejmr.2022.258995","DOIUrl":"https://doi.org/10.21608/ejmr.2022.258995","url":null,"abstract":"The goal of th study is to evaluate the role of high ‑ resolution computed tomography (HRCT) temporal bone in patients with active squamosal chronic otitis media (COM). 30 patients with active squamosal COM underwent preoperative HRCT temporal bone followed by surgery. Their intra ‑ operative findings were compared and correlated with the radiological findings, to calculate the predictive value of HRCT temporal bone. According to the present study, HRCT was highly sensitive for detecting mastoid pneumatization, soft tissue extension, ossicular erosion, tegmen and sigmoid sinus erosion, and less sensitive for fallopian canal erosion and lateral sinus fistula. It was specific for all these parameters.The present study concludes that HRCT can be recommended not only in cases suspected with potential complications but also in all cases of COM to know the extent of disease, varied pneumatization, and the presence of anatomical variations, which should alert the clinician and guide in surgical approach and treatment plan.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83706244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.252437
Merehan Hewidy, Mohammed Mohesen, Hamada Ashry A Ali
: Background: it is estimated that approximately 30% to 40% of implanted pregnancies resulted in spontaneous abortion during the first trimester, most of which occur in very early stage. Significant number of losses predominantly occurs very early in gestation, but once the embryonic heart activity appears the rate of spontaneous abortion gradually decreases to 2-5% . Methods: the present study was conducted at the Department of Obstetrics and Gynecology,6october Hospital during the period between February 2020 and august 2020 .46 cases at 5 weeks of pregnancy were subjected to transvaginal ultrasound and yolk sac size and shape were determined . Records of pregnant women were registered at 6, 9, 12 weeks of pregnancy. Aim Of The Work: to evaluate the value of yolk sac in prediction of pregnancy outcome . Results: Abnormal Shape of yolk sac was found in 11 cases, the mean YSD at 6 weeks in aborted cases was 3.5±1.8 and cases who continued pregnancy was 2.2 ±0.4 and this difference is statistically significant and cut off point at 6 weeks was 2.8 while there was no significant difference between YSD in aborted cases and in those who continued pregnancy at 9,12 weeks respectively. Conclusion: large size of yolk sac at 6 weeks of pregnancy and abnormal shape of yolk sac are predictor of poor pregnancy outcome.
{"title":"Size and Shape of yolk sac as a predictor of pregnancy outcome","authors":"Merehan Hewidy, Mohammed Mohesen, Hamada Ashry A Ali","doi":"10.21608/ejmr.2022.252437","DOIUrl":"https://doi.org/10.21608/ejmr.2022.252437","url":null,"abstract":": Background: it is estimated that approximately 30% to 40% of implanted pregnancies resulted in spontaneous abortion during the first trimester, most of which occur in very early stage. Significant number of losses predominantly occurs very early in gestation, but once the embryonic heart activity appears the rate of spontaneous abortion gradually decreases to 2-5% . Methods: the present study was conducted at the Department of Obstetrics and Gynecology,6october Hospital during the period between February 2020 and august 2020 .46 cases at 5 weeks of pregnancy were subjected to transvaginal ultrasound and yolk sac size and shape were determined . Records of pregnant women were registered at 6, 9, 12 weeks of pregnancy. Aim Of The Work: to evaluate the value of yolk sac in prediction of pregnancy outcome . Results: Abnormal Shape of yolk sac was found in 11 cases, the mean YSD at 6 weeks in aborted cases was 3.5±1.8 and cases who continued pregnancy was 2.2 ±0.4 and this difference is statistically significant and cut off point at 6 weeks was 2.8 while there was no significant difference between YSD in aborted cases and in those who continued pregnancy at 9,12 weeks respectively. Conclusion: large size of yolk sac at 6 weeks of pregnancy and abnormal shape of yolk sac are predictor of poor pregnancy outcome.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74961795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.251503
Asmaa Abd Elrahman, M. Meabed, Rehab M. Abd Elkareem, Yasmine Mohamed
: Background : Bone marrow failure is a group of disorders characterized by the inability of bone marrow to produce sufficient blood cells. They can be divided into inherited disorders, acquired disorders and diseases infiltrating bone marrow. Acute leukemia is a serious cause of bone marrow failure which needs early diagnosis and management . Purpose : To study for registry, and clinical spectrum of bone marrow failure in Beni-Suef university hospital to detect the magnitude of the problem . Patients and methods: It is cross sectional study over a period of six months from January 2019 to June 2019, in which patients with bone marrow failure (monocytopenia, bicytopenia or pancytopenia) from pediatric age group (0-13 years) who were admitted in the pediatric department in Beni-Suef university hospital were included and followed up. They were subjected to a detailed history, full examination and laboratory investigation; complete blood count, reticulocyte cont, bone marrow aspirate & biopsy, virology study and accordingly other investigations were done such as flow cytometry for cd55 & cd59, glucocerebrosidase enzyme assay, chromosomal breakage analysis and imaging. Results: Out of 22000 outpatients and 1700 inpatients,55 patients had diagnosed as bone marrow failure during six months duration with percentage of o.23%. The most frequent diagnosis of bone marrow failure was acute Leukemia (30.9 %), followed by Idiopathic aplastic anemia (27.3%) then Fanconi anaemia (21.8%). Conclusion: Bone marrow failure is not rare ,acute Leukemia should be considered strongly in the diagnosis of any case of bone marrow failure .
{"title":"Study for registry and clinical spectrum of bone marrow failure in pediatrics; single centre experience","authors":"Asmaa Abd Elrahman, M. Meabed, Rehab M. Abd Elkareem, Yasmine Mohamed","doi":"10.21608/ejmr.2022.251503","DOIUrl":"https://doi.org/10.21608/ejmr.2022.251503","url":null,"abstract":": Background : Bone marrow failure is a group of disorders characterized by the inability of bone marrow to produce sufficient blood cells. They can be divided into inherited disorders, acquired disorders and diseases infiltrating bone marrow. Acute leukemia is a serious cause of bone marrow failure which needs early diagnosis and management . Purpose : To study for registry, and clinical spectrum of bone marrow failure in Beni-Suef university hospital to detect the magnitude of the problem . Patients and methods: It is cross sectional study over a period of six months from January 2019 to June 2019, in which patients with bone marrow failure (monocytopenia, bicytopenia or pancytopenia) from pediatric age group (0-13 years) who were admitted in the pediatric department in Beni-Suef university hospital were included and followed up. They were subjected to a detailed history, full examination and laboratory investigation; complete blood count, reticulocyte cont, bone marrow aspirate & biopsy, virology study and accordingly other investigations were done such as flow cytometry for cd55 & cd59, glucocerebrosidase enzyme assay, chromosomal breakage analysis and imaging. Results: Out of 22000 outpatients and 1700 inpatients,55 patients had diagnosed as bone marrow failure during six months duration with percentage of o.23%. The most frequent diagnosis of bone marrow failure was acute Leukemia (30.9 %), followed by Idiopathic aplastic anemia (27.3%) then Fanconi anaemia (21.8%). Conclusion: Bone marrow failure is not rare ,acute Leukemia should be considered strongly in the diagnosis of any case of bone marrow failure .","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81056253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.259165
M. Elbatanouny, Osama Abdelaal, Mohammad Mohammad
Background : Microalbuminuria, used as a marker of endothelial dysfunction, is a predictor of mortality and of cardiovascular events. Microalbuminuria (MAB) in chronic obstructive lung disease (COPD) is attributed to generalized endothelial dysfunction as a result of systemic inflammation, which could be a significant marker for early cardiovascular abnormality. Objectives: Study the relationship between microalbuminuria and disease class in subjects with COPD classified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2018 “A, B, C, D” classification in absence of hypertension and diabetes ,and to Evaluate the clinical features that may predict cardiovascular risk in subjects with COPD. Setting: Chest Department and outpatient clinic, Beni-Suef University Hospital. Methods: Prospective Study included 60 patients who were diagnosed as COPD by Pulmonary function tests. All patients were subjected to clinical examination, Chest x ray, spirometry and Urinary albumin/creatinine ratio. Results: Urinary albumin/creatinine ratios were significantly higher in subjects who have more symptoms and high future risk (categories C, D) than in those with fewer symptoms and low future risk (categories A, B). A Significant differences were noted when the subjects were grouped based on PaO 2 (<65mmHg versus >65mmHg), PaCO 2 (<41mmHg versus >41mmHg), arterial oxygen saturation (<92% versus >92%), FEV1 (median split <60% versus >60%). There was a statistically significant strong negative correlation between the alb/creat ratio and FEV1% (r=-0.937, p=0.000), PaO 2 (r=-0.929, p=0.000) and SaO 2 (r=-0.934,p=0.000). There was a statistically significant strong positive correlation between the alb/creat ratio and Severity of Gold p=0.000), PaCO p=0.000) and of hospital There was a highly significant association between high level alb/creat ratio and the of pulmonary hypertension (P <0.001). Conclusions There is a strong correlation between microalbuminuria and the new version of A, B, C and D classification. Because the microalbuminuria simple, inexpensive, noninvasive, it can be routinely in COPD cases, especially those with many symptoms who are at higher risk, to early predict cardiovascular morbidity and mortality.
{"title":"Studying Microalbuminuria In Patients With COPD In Relation To The New Version Of Global Initiative For Chronic Obstructive Lung Disease","authors":"M. Elbatanouny, Osama Abdelaal, Mohammad Mohammad","doi":"10.21608/ejmr.2022.259165","DOIUrl":"https://doi.org/10.21608/ejmr.2022.259165","url":null,"abstract":"Background : Microalbuminuria, used as a marker of endothelial dysfunction, is a predictor of mortality and of cardiovascular events. Microalbuminuria (MAB) in chronic obstructive lung disease (COPD) is attributed to generalized endothelial dysfunction as a result of systemic inflammation, which could be a significant marker for early cardiovascular abnormality. Objectives: Study the relationship between microalbuminuria and disease class in subjects with COPD classified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2018 “A, B, C, D” classification in absence of hypertension and diabetes ,and to Evaluate the clinical features that may predict cardiovascular risk in subjects with COPD. Setting: Chest Department and outpatient clinic, Beni-Suef University Hospital. Methods: Prospective Study included 60 patients who were diagnosed as COPD by Pulmonary function tests. All patients were subjected to clinical examination, Chest x ray, spirometry and Urinary albumin/creatinine ratio. Results: Urinary albumin/creatinine ratios were significantly higher in subjects who have more symptoms and high future risk (categories C, D) than in those with fewer symptoms and low future risk (categories A, B). A Significant differences were noted when the subjects were grouped based on PaO 2 (<65mmHg versus >65mmHg), PaCO 2 (<41mmHg versus >41mmHg), arterial oxygen saturation (<92% versus >92%), FEV1 (median split <60% versus >60%). There was a statistically significant strong negative correlation between the alb/creat ratio and FEV1% (r=-0.937, p=0.000), PaO 2 (r=-0.929, p=0.000) and SaO 2 (r=-0.934,p=0.000). There was a statistically significant strong positive correlation between the alb/creat ratio and Severity of Gold p=0.000), PaCO p=0.000) and of hospital There was a highly significant association between high level alb/creat ratio and the of pulmonary hypertension (P <0.001). Conclusions There is a strong correlation between microalbuminuria and the new version of A, B, C and D classification. Because the microalbuminuria simple, inexpensive, noninvasive, it can be routinely in COPD cases, especially those with many symptoms who are at higher risk, to early predict cardiovascular morbidity and mortality.","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77714408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-01DOI: 10.21608/ejmr.2022.258992
Sherwet M. Shawky, Rasha S. Elbahrawe, Amira El-Bahie, L. Saleh, A. Taha, Sayed Abdelgayed
{"title":"Short-Term Health-Related Quality of Life After Hysterectomy Compared With Myomectomy for Symptomatic Leiomyomas.","authors":"Sherwet M. Shawky, Rasha S. Elbahrawe, Amira El-Bahie, L. Saleh, A. Taha, Sayed Abdelgayed","doi":"10.21608/ejmr.2022.258992","DOIUrl":"https://doi.org/10.21608/ejmr.2022.258992","url":null,"abstract":"","PeriodicalId":11524,"journal":{"name":"Egyptian Journal of Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88647392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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