Enrique Escorihuela, Alberto Concellón, Teresa Cardona, Giampaolo Zuccheri, Santiago Martín, José L. Serrano, Pilar Cea
Molecular Templates
Harnessing Langmuir-Blodgett nanoarchitectonic tools to create molecular platforms through supramolecular chemistry for orchestrating the arrangement of functional materials on surfaces. More details can be found in article 2301090 by José L. Serrano, Pilar Cea, and co-workers.
{"title":"Molecular Templates on Surfaces by Exploiting Supramolecular Chemistry in Langmuir–Blodgett Monolayers (Adv. Mater. Interfaces 18/2024)","authors":"Enrique Escorihuela, Alberto Concellón, Teresa Cardona, Giampaolo Zuccheri, Santiago Martín, José L. Serrano, Pilar Cea","doi":"10.1002/admi.202470045","DOIUrl":"https://doi.org/10.1002/admi.202470045","url":null,"abstract":"<p><b>Molecular Templates</b></p><p>Harnessing Langmuir-Blodgett nanoarchitectonic tools to create molecular platforms through supramolecular chemistry for orchestrating the arrangement of functional materials on surfaces. More details can be found in article 2301090 by José L. Serrano, Pilar Cea, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admi.202470045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141488755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingjie Tao, Ran Tian, Jiayuan Zhou, Kui Chu, Xuegang Chen, Wenshuai Gao, Guopeng Wang, Yuxuan Jiang, Kenji Watanabe, Takashi Taniguchi, Mingliang Tian, Xue Liu
At the interface of 2D heterostructures, the presence of defects and their manipulation play a crucial role in the interfacial charge transfer behavior, further influencing the device functionality and performance. In this study, the impact of deliberately introduced photo‐active defects in the h‐BN layer on the interfacial charge transfer and photoresponse performance of a metal‐insulator‐semiconductor type heterostructure device is explored. The formation and concentration of defects are qualitatively controlled using an inductive coupled plasma treatment method, as evidenced by enhanced h‐BN defect emission and more efficient optically induced doping of graphene at the graphene/h‐BN interface. Besides, the use of the h‐BN layer between graphene and WS2 not only suppresses charge carriers in the dark state, but also promotes the separation of photo‐generated electron‐hole pairs and interfacial charge transfer due to the existence of defect levels, leading to orders of magnitude improvement in the light on/off ratio and self‐driving performance of the heterostructure photodetector. This strategy of controlling defect states in the insulating layer provides a new approach to optimize the charge transfer processes at the 2D interfaces, so as to expand its potential applications in the fields of electronic and optoelectronic devices.
{"title":"Optically Active Defect Engineering via Plasma Treatment in a MIS‐Type 2D Heterostructure","authors":"Yingjie Tao, Ran Tian, Jiayuan Zhou, Kui Chu, Xuegang Chen, Wenshuai Gao, Guopeng Wang, Yuxuan Jiang, Kenji Watanabe, Takashi Taniguchi, Mingliang Tian, Xue Liu","doi":"10.1002/admi.202400288","DOIUrl":"https://doi.org/10.1002/admi.202400288","url":null,"abstract":"At the interface of 2D heterostructures, the presence of defects and their manipulation play a crucial role in the interfacial charge transfer behavior, further influencing the device functionality and performance. In this study, the impact of deliberately introduced photo‐active defects in the h‐BN layer on the interfacial charge transfer and photoresponse performance of a metal‐insulator‐semiconductor type heterostructure device is explored. The formation and concentration of defects are qualitatively controlled using an inductive coupled plasma treatment method, as evidenced by enhanced h‐BN defect emission and more efficient optically induced doping of graphene at the graphene/h‐BN interface. Besides, the use of the h‐BN layer between graphene and WS<jats:sub>2</jats:sub> not only suppresses charge carriers in the dark state, but also promotes the separation of photo‐generated electron‐hole pairs and interfacial charge transfer due to the existence of defect levels, leading to orders of magnitude improvement in the light on/off ratio and self‐driving performance of the heterostructure photodetector. This strategy of controlling defect states in the insulating layer provides a new approach to optimize the charge transfer processes at the 2D interfaces, so as to expand its potential applications in the fields of electronic and optoelectronic devices.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141529972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Md Ashiqur Rahman Laskar, Giuseppe Leonetti, Gianluca Milano, Ondřej Novotný, Jan Neuman, Sefaattin Tongay, Umberto Celano
Controlling nanoscale tip‐induced material removal is crucial for achieving atomic‐level precision in tomographic sensing with atomic force microscopy (AFM). While advances have enabled volumetric probing of conductive features with nanometer accuracy in solid‐state devices, materials, and photovoltaics, limitations in spatial resolution and volumetric sensitivity persist. This work identifies and addresses in‐plane and vertical tip‐sample junction leakage as sources of parasitic contrast in tomographic AFM, hindering real‐space 3D reconstructions. Novel strategies are proposed to overcome these limitations. First, the contrast mechanisms analyzing nanosized conductive features are explored when confining current collection purely to in‐plane transport, thus allowing reconstruction with a reduction in the overestimation of the lateral dimensions. Furthermore, an adaptive tip‐sample biasing scheme is demonstrated for the mitigation of a class of artefacts induced by the high electric field inside the thin oxide when volumetrically reduced. This significantly enhances vertical sensitivity by approaching the intrinsic limits set by quantum tunneling processes, allowing detailed depth analysis in thin dielectrics. The effectiveness of these methods is showcased in tomographic reconstructions of conductive filaments in valence change memory, highlighting the potential for application in nanoelectronics devices and bulk materials and unlocking new limits for tomographic AFM.
{"title":"Adaptive Scalpel Scanning Probe Microscopy for Enhanced Volumetric Sensing in Tomographic Analysis","authors":"Md Ashiqur Rahman Laskar, Giuseppe Leonetti, Gianluca Milano, Ondřej Novotný, Jan Neuman, Sefaattin Tongay, Umberto Celano","doi":"10.1002/admi.202400187","DOIUrl":"https://doi.org/10.1002/admi.202400187","url":null,"abstract":"Controlling nanoscale tip‐induced material removal is crucial for achieving atomic‐level precision in tomographic sensing with atomic force microscopy (AFM). While advances have enabled volumetric probing of conductive features with nanometer accuracy in solid‐state devices, materials, and photovoltaics, limitations in spatial resolution and volumetric sensitivity persist. This work identifies and addresses in‐plane and vertical tip‐sample junction leakage as sources of parasitic contrast in tomographic AFM, hindering real‐space 3D reconstructions. Novel strategies are proposed to overcome these limitations. First, the contrast mechanisms analyzing nanosized conductive features are explored when confining current collection purely to in‐plane transport, thus allowing reconstruction with a reduction in the overestimation of the lateral dimensions. Furthermore, an adaptive tip‐sample biasing scheme is demonstrated for the mitigation of a class of artefacts induced by the high electric field inside the thin oxide when volumetrically reduced. This significantly enhances vertical sensitivity by approaching the intrinsic limits set by quantum tunneling processes, allowing detailed depth analysis in thin dielectrics. The effectiveness of these methods is showcased in tomographic reconstructions of conductive filaments in valence change memory, highlighting the potential for application in nanoelectronics devices and bulk materials and unlocking new limits for tomographic AFM.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141509944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bong‐Geun Kim, Yu Rim Choi, Yerin Kim, Sang Bin Yoon, Sukyeong Hwang, Suk Joong Lee, Hyon Bin Na
Signal transducers are crucial in bioassay platforms for converting target detection into recordable signals. Commonly used color development for immunoassays involves enzymes and colorimetric substrates. However, due to cost and environmental issues, practical point‐of‐care testing requires alternative signal transducers. Growth‐induced extinction (absorption and scattering) of gold nanoclusters (AuNCs) is proposed as a novel approach for quantitative immunoassays. AuNCs devoid of localized surface plasmon resonance (LSPR) are used as seeds for growth reactions. Through reactions with a growth solution comprised of gold precursor and mild reductant, AuNCs of varying concentrations underwent controlled growth, resulting in nanoparticles of different sizes exhibiting distinct LSPR‐mediated extinction bands. Notably, the seed concentration exhibited a robust correlation with the resulting extinction of the grown particles on a small scale of 110 µL for a 96‐well microplate platform. To demonstrate this signal transduction mechanism, immunosorbent assays are performed using the conjugates of AuNC and detection antibody. The sandwich‐type assay successfully quantified a model antigen, human immunoglobulin G (hIgG), by monitoring LSPR wavelength and absorbance. This assay demonstrated a working range of 0.001–1 µg mL−1 and limit of detection of 1.19 ng mL−1. Signal transducers using the growth of AuNCs offer new alternative candidates for immunoassay platforms.
{"title":"Growth‐Induced Extinction Development of Gold Nanoclusters as Signal Transducers for Quantitative Immunoassays","authors":"Bong‐Geun Kim, Yu Rim Choi, Yerin Kim, Sang Bin Yoon, Sukyeong Hwang, Suk Joong Lee, Hyon Bin Na","doi":"10.1002/admi.202400211","DOIUrl":"https://doi.org/10.1002/admi.202400211","url":null,"abstract":"Signal transducers are crucial in bioassay platforms for converting target detection into recordable signals. Commonly used color development for immunoassays involves enzymes and colorimetric substrates. However, due to cost and environmental issues, practical point‐of‐care testing requires alternative signal transducers. Growth‐induced extinction (absorption and scattering) of gold nanoclusters (AuNCs) is proposed as a novel approach for quantitative immunoassays. AuNCs devoid of localized surface plasmon resonance (LSPR) are used as seeds for growth reactions. Through reactions with a growth solution comprised of gold precursor and mild reductant, AuNCs of varying concentrations underwent controlled growth, resulting in nanoparticles of different sizes exhibiting distinct LSPR‐mediated extinction bands. Notably, the seed concentration exhibited a robust correlation with the resulting extinction of the grown particles on a small scale of 110 µL for a 96‐well microplate platform. To demonstrate this signal transduction mechanism, immunosorbent assays are performed using the conjugates of AuNC and detection antibody. The sandwich‐type assay successfully quantified a model antigen, human immunoglobulin G (hIgG), by monitoring LSPR wavelength and absorbance. This assay demonstrated a working range of 0.001–1 µg mL<jats:sup>−1</jats:sup> and limit of detection of 1.19 ng mL<jats:sup>−1</jats:sup>. Signal transducers using the growth of AuNCs offer new alternative candidates for immunoassay platforms.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hoseong Han, Joel M. P. Scofield, Paul A. Gurr, Paul A. Webley, Greg G. Qiao
Increasing amounts of carbon dioxide (CO2) emissions in the atmosphere are a leading cause of climate change. Ultrathin film composite (UTFC) membranes have the potential to effectively reduce CO2 emissions from energy production and industrial processes. UTFC membranes typically require a gutter layer, to provide flat surfaces above the porous substrate for an ultrathin selective layer to be deposited. Removing the gutter layer, while maintaining compatibility with the support layer, can have substantial benefits of high gas permeation, cost‐effectiveness, and fewer manufacturing steps. However, achieving this faces significant challenges, due to limitations on the geometric design of gas pathways and incompatibility between the substrate and selective layers. Herein, zeolitic imidazolate framework‐8 (ZIF‐8) is used as an initiating core, and arms of poly(1,3‐dioxolane) dimethacrylate (PDXLMA), which possesses superior CO2/N2 selectivity, are used to create core‐shell nanoparticles. These two‐layered UTFC membranes are successfully produced from the nanoparticles via a simple drop‐spreading method. The importance of designing core‐shell structures is also investigated to achieve defect‐free two‐layered UTFC membranes and enable precision thickness control. The resulting membranes exhibit remarkable CO2 permeance of 3969 – 6035 GPU with CO2/N2 selectivity of 28.0–20.4, demonstrating their considerable performance improvement compared to the current three‐layered UTFC membranes.
{"title":"Unveiling the Potential: Core‐Shell Nanoparticles Assembly of Metal‐Organic Framework@poly(1,3‐dioxolane) Methacrylate for Gutter‐Layer‐Free Ultrathin Film Composite Membranes","authors":"Hoseong Han, Joel M. P. Scofield, Paul A. Gurr, Paul A. Webley, Greg G. Qiao","doi":"10.1002/admi.202400113","DOIUrl":"https://doi.org/10.1002/admi.202400113","url":null,"abstract":"Increasing amounts of carbon dioxide (CO<jats:sub>2</jats:sub>) emissions in the atmosphere are a leading cause of climate change. Ultrathin film composite (UTFC) membranes have the potential to effectively reduce CO<jats:sub>2</jats:sub> emissions from energy production and industrial processes. UTFC membranes typically require a gutter layer, to provide flat surfaces above the porous substrate for an ultrathin selective layer to be deposited. Removing the gutter layer, while maintaining compatibility with the support layer, can have substantial benefits of high gas permeation, cost‐effectiveness, and fewer manufacturing steps. However, achieving this faces significant challenges, due to limitations on the geometric design of gas pathways and incompatibility between the substrate and selective layers. Herein, zeolitic imidazolate framework‐8 (ZIF‐8) is used as an initiating core, and arms of poly(1,3‐dioxolane) dimethacrylate (PDXLMA), which possesses superior CO<jats:sub>2</jats:sub>/N<jats:sub>2</jats:sub> selectivity, are used to create core‐shell nanoparticles. These two‐layered UTFC membranes are successfully produced from the nanoparticles via a simple drop‐spreading method. The importance of designing core‐shell structures is also investigated to achieve defect‐free two‐layered UTFC membranes and enable precision thickness control. The resulting membranes exhibit remarkable CO<jats:sub>2</jats:sub> permeance of 3969 – 6035 GPU with CO<jats:sub>2</jats:sub>/N<jats:sub>2</jats:sub> selectivity of 28.0–20.4, demonstrating their considerable performance improvement compared to the current three‐layered UTFC membranes.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microneedle (MN) technology offers a powerful approach for transdermal delivery enabling painless injection and facilitating self‐administration without the need for professional assistance. However, the weak mechanical strength of MNs can lead to inefficient drug delivery and serious skin irritation if the MNs fracture during administration and leave fragments under the skin. Thus, the MNs need to be mechanically robust to avoid fracture during penetration through the skin while maintaining efficient drug delivery. Herein, the polymer‐based MNs with layer‐by‐layer (LbL) films of silica (SiO2) nanoparticles (NPs) and a polycation (poly(diallyldimethylammonium chloride) (PDADMAC)) followed by hydrothermal calcination are reinforced. The mechanical strength of the MNs is significantly improved after LbL assembly and shows lower threshold pressure to penetrate skins. Moreover, their drug loading and releasing properties are significantly enhanced due to an increase in the surface area and interfacial interaction. These SiO2 nanoparticle‐containing LbL thin films have great potential for the surface modification of 3D microstructured devices such as MNs, as evidenced by their enhanced mechanical strength and drug coating efficiency that result in a promising MN drug delivery model.
{"title":"Enhancing Penetration Performance and Drug Delivery of Polymeric Microneedles Using Silica Nanoparticle Coatings","authors":"Sohyun Kim, Hyewon Choi, Hyejoong Jeong, Wilfredo Méndez Ortiz, Hwayeong Cheon, Jae Yong Jeon, Jae Hyeon Lee, Jeong Hwan Han, Kathleen J. Stebe, Daeyeon Lee, Hyunsik Yoon","doi":"10.1002/admi.202400212","DOIUrl":"https://doi.org/10.1002/admi.202400212","url":null,"abstract":"Microneedle (MN) technology offers a powerful approach for transdermal delivery enabling painless injection and facilitating self‐administration without the need for professional assistance. However, the weak mechanical strength of MNs can lead to inefficient drug delivery and serious skin irritation if the MNs fracture during administration and leave fragments under the skin. Thus, the MNs need to be mechanically robust to avoid fracture during penetration through the skin while maintaining efficient drug delivery. Herein, the polymer‐based MNs with layer‐by‐layer (LbL) films of silica (SiO<jats:sub>2</jats:sub>) nanoparticles (NPs) and a polycation (poly(diallyldimethylammonium chloride) (PDADMAC)) followed by hydrothermal calcination are reinforced. The mechanical strength of the MNs is significantly improved after LbL assembly and shows lower threshold pressure to penetrate skins. Moreover, their drug loading and releasing properties are significantly enhanced due to an increase in the surface area and interfacial interaction. These SiO<jats:sub>2</jats:sub> nanoparticle‐containing LbL thin films have great potential for the surface modification of 3D microstructured devices such as MNs, as evidenced by their enhanced mechanical strength and drug coating efficiency that result in a promising MN drug delivery model.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zinc nitride (Zn3N2) is a promising semiconductor for a range of optoelectronic and energy conversion applications, offering a direct bandgap of 1.0 eV, large carrier mobilities, and abundant constituent elements. However, the material is prone to bulk oxidation in ambient environments, which has thus far impeded its practical deployment. While previous approaches have focused on stabilizing the material via integration of ZnO surface layers, these strategies introduce additional challenges regarding elevated processing temperatures and limited control of interface properties. In this study, it is shown that amorphous GaN thin films can serve as highly stable protection layers on Zn3N2 surfaces and can be deposited at the same growth temperature and in the same deposition system as the underlying semiconductor. The GaN‐capped Zn3N2 structures exhibit long‐term stability, surviving over 3 years of exposure to ambient conditions with no discernible alterations in composition, structure, or electrical properties. Notably, the amorphous GaN coatings can even impede Zn3N2 oxidation under prolonged aqueous exposure. Thus, this study offers a solution to stabilize Zn3N2 in ambient conditions, providing a viable pathway to its utilization in robust and high‐performance electronic devices, such as thin film transistors and solar energy conversion systems.
{"title":"Ultrastable Zn3N2 Thin Films via Integration of Amorphous GaN Protection Layers","authors":"Elise Sirotti, Stefan Böhm, Ian D. Sharp","doi":"10.1002/admi.202400214","DOIUrl":"https://doi.org/10.1002/admi.202400214","url":null,"abstract":"Zinc nitride (Zn<jats:sub>3</jats:sub>N<jats:sub>2</jats:sub>) is a promising semiconductor for a range of optoelectronic and energy conversion applications, offering a direct bandgap of 1.0 eV, large carrier mobilities, and abundant constituent elements. However, the material is prone to bulk oxidation in ambient environments, which has thus far impeded its practical deployment. While previous approaches have focused on stabilizing the material via integration of ZnO surface layers, these strategies introduce additional challenges regarding elevated processing temperatures and limited control of interface properties. In this study, it is shown that amorphous GaN thin films can serve as highly stable protection layers on Zn<jats:sub>3</jats:sub>N<jats:sub>2</jats:sub> surfaces and can be deposited at the same growth temperature and in the same deposition system as the underlying semiconductor. The GaN‐capped Zn<jats:sub>3</jats:sub>N<jats:sub>2</jats:sub> structures exhibit long‐term stability, surviving over 3 years of exposure to ambient conditions with no discernible alterations in composition, structure, or electrical properties. Notably, the amorphous GaN coatings can even impede Zn<jats:sub>3</jats:sub>N<jats:sub>2</jats:sub> oxidation under prolonged aqueous exposure. Thus, this study offers a solution to stabilize Zn<jats:sub>3</jats:sub>N<jats:sub>2</jats:sub> in ambient conditions, providing a viable pathway to its utilization in robust and high‐performance electronic devices, such as thin film transistors and solar energy conversion systems.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emin Uysal, Sabiha Gulce Yavas, Gokce Dicle Kalaycioglu, Mustafa Polat, Halil Kalipcilar, Nihal Aydogan
One of the most important issues in the design and preparation of drug delivery systems in the recent years is versatility which includes providing synergistic therapeutic effects and sustainability. This study uses a redox‐active ferrocenyl surfactant (FcN+(CH2CH3)3(CH2)10CH3, Fc(C11) where Fc is ferrocene) and pH responsive Zeolitic Imidazolate Framework‐8 (ZIF‐8) structures to form multifunctional assemblies (Fc(C11)‐AOT/Rhb@ZIF‐8/PDA) that can be used in several application including the drug delivery. The vesicles prepared using AOT‐FC(C11) constitute the core of the structure. Since the location of the ferrocene group in the molecule structure, which is next to head group, the surface of the vesicles is decorated with the ferrocene group which can act as a Fenton reaction catalyst. The polydopamine (PDA) covered ZIF‐8 are used to decorate the surface of the vesicles, creating a truly remarkable structure. The porous structure of ZIF‐8 as well as the core of the vesicles can accommodate drug molecules. With the added NIR‐responsive character upon PDA coating, this assembled structure can be used for phototermal therapy applications. The properties of this designed multifunctional and multi‐responsive system are studied at different pH and under NIR‐laser irradiation and show that it has potential to display a triple chemodynamic/ photothermal/ chemotherapeutic effect.
{"title":"Stimuli‐Responsive Nanoplatforms: ZIF‐8‐Decorated Ferrocenyl Surfactant‐Based Vesicles for Synergistic Therapeutic Applications","authors":"Emin Uysal, Sabiha Gulce Yavas, Gokce Dicle Kalaycioglu, Mustafa Polat, Halil Kalipcilar, Nihal Aydogan","doi":"10.1002/admi.202400169","DOIUrl":"https://doi.org/10.1002/admi.202400169","url":null,"abstract":"One of the most important issues in the design and preparation of drug delivery systems in the recent years is versatility which includes providing synergistic therapeutic effects and sustainability. This study uses a redox‐active ferrocenyl surfactant (FcN<jats:sup>+</jats:sup>(CH<jats:sub>2</jats:sub>CH<jats:sub>3</jats:sub>)<jats:sub>3</jats:sub>(CH<jats:sub>2</jats:sub>)<jats:sub>10</jats:sub>CH<jats:sub>3</jats:sub>, Fc(C<jats:sub>11</jats:sub>) where Fc is ferrocene) and pH responsive Zeolitic Imidazolate Framework‐8 (ZIF‐8) structures to form multifunctional assemblies (Fc(C<jats:sub>11</jats:sub>)‐AOT/Rhb@ZIF‐8/PDA) that can be used in several application including the drug delivery. The vesicles prepared using AOT‐FC(C<jats:sub>11</jats:sub>) constitute the core of the structure. Since the location of the ferrocene group in the molecule structure, which is next to head group, the surface of the vesicles is decorated with the ferrocene group which can act as a Fenton reaction catalyst. The polydopamine (PDA) covered ZIF‐8 are used to decorate the surface of the vesicles, creating a truly remarkable structure. The porous structure of ZIF‐8 as well as the core of the vesicles can accommodate drug molecules. With the added NIR‐responsive character upon PDA coating, this assembled structure can be used for phototermal therapy applications. The properties of this designed multifunctional and multi‐responsive system are studied at different pH and under NIR‐laser irradiation and show that it has potential to display a triple chemodynamic/ photothermal/ chemotherapeutic effect.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catarina Fernandes, Filippo Franceschini, Jorid Smets, Olivier Deschaume, Nurul Rusli, Carmen Bartic, Rob Ameloot, Kitty Baert, Jon Ustarroz, Irene Taurino
Bioresorbable electrochemical sensors remain mostly unexplored despite their ability to provide continuous in situ measurements of critical biomarkers. The primary challenge arises from the direct exposure of the electrodes’ thin metal films to biofluids, which poses difficulties in ensuring both proper operational lifetimes and sensing performance. Molybdenum (Mo) presents itself as a promising biometal due to its uniquely gradual dissolution in biofluids, facilitated by the formation of a slower‐dissolving MoOx surface layer. Consequently, carefully engineered MoOx films can endow transient electrochemical sensors with unparalleled stability during extended operational lifetimes. Herein an unprecedented sensor architecture achieved via the unique pairing of sputtered Mo and MoOx thin films, probed as a pH and dissolved oxygen sensor is reported. Compared to a bare Mo electrode, a bilayer Mo+MoOx electrode subjected to post‐deposition annealing (400 °C, 60 min, N2 environment) displayed a largely improved stability (>24 h) in solution and demonstrated predictable functionality during ongoing film dissolution at 37 °C. Collectively, this work establishes a pioneering strategy for the fabrication of reliable and clinically relevant implantable electrochemical sensors.
{"title":"A Fully‐Bioresorbable Nanostructured Molybdenum Oxide‐Based Electrode for Continuous Multi‐Analyte Electrochemical Sensing","authors":"Catarina Fernandes, Filippo Franceschini, Jorid Smets, Olivier Deschaume, Nurul Rusli, Carmen Bartic, Rob Ameloot, Kitty Baert, Jon Ustarroz, Irene Taurino","doi":"10.1002/admi.202400054","DOIUrl":"https://doi.org/10.1002/admi.202400054","url":null,"abstract":"Bioresorbable electrochemical sensors remain mostly unexplored despite their ability to provide continuous in situ measurements of critical biomarkers. The primary challenge arises from the direct exposure of the electrodes’ thin metal films to biofluids, which poses difficulties in ensuring both proper operational lifetimes and sensing performance. Molybdenum (Mo) presents itself as a promising biometal due to its uniquely gradual dissolution in biofluids, facilitated by the formation of a slower‐dissolving MoO<jats:sub>x</jats:sub> surface layer. Consequently, carefully engineered MoO<jats:sub>x</jats:sub> films can endow transient electrochemical sensors with unparalleled stability during extended operational lifetimes. Herein an unprecedented sensor architecture achieved via the unique pairing of sputtered Mo and MoO<jats:sub>x</jats:sub> thin films, probed as a pH and dissolved oxygen sensor is reported. Compared to a bare Mo electrode, a bilayer Mo+MoO<jats:sub>x</jats:sub> electrode subjected to post‐deposition annealing (400 °C, 60 min, N<jats:sub>2</jats:sub> environment) displayed a largely improved stability (>24 h) in solution and demonstrated predictable functionality during ongoing film dissolution at 37 °C. Collectively, this work establishes a pioneering strategy for the fabrication of reliable and clinically relevant implantable electrochemical sensors.","PeriodicalId":115,"journal":{"name":"Advanced Materials Interfaces","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141527653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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