Environmental toxicology and pharmacology最新文献_第2页

Association between exposure to per- and polyfluoroalkyl substances and missed miscarriage: A hospital-based case-control study in Shanghai, China 接触全氟和多氟烷基物质与流产漏诊之间的关系：中国上海医院病例对照研究》。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-11-16 DOI: 10.1016/j.etap.2024.104589

Beiying Wang, Wei Hong, Zhiping Wu, Xiaocui Li

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants linked to reproductive disruptions. This study investigated the relationship between PFAS exposure and missed miscarriage in a hospital-based, case-control study in Shanghai, China. There were 393 women in our research, including 198 cases and 195 controls. Concentrations of 30 PFAS in plasma were quantified using HPLC-MS/MS, and 15 PFAS were detected at a rate greater than 90 percent. PFOA, L-PFOS, and PFOS isomers were significantly higher in the cases than those in the controls. 13 PFAS showed significant positive associations with miscarriage risk after adjustment for confounders, particularly PFOA (OR: 2.99, 95 % CI: 1.96–4.68) and various PFOS isomers. BKMR analysis confirmed higher overall PFAS levels were associated with increased miscarriage risk. These findings highlight the potential reproductive toxicity of PFAS and underscore the need for further investigations and regulatory actions to mitigate PFAS exposure in pregnant women.

全氟和多氟烷基物质（PFAS）是与生殖干扰有关的持久性环境污染物。本研究在中国上海进行了一项基于医院的病例对照研究，调查了PFAS暴露与漏发流产之间的关系。研究共涉及 393 名妇女，包括 198 例病例和 195 例对照。我们使用 HPLC-MS/MS 对血浆中 30 种 PFAS 的浓度进行了定量，其中 15 种 PFAS 的检出率超过 90%。病例中的 PFOA、L-PFOS 和 PFOS 异构体含量明显高于对照组。在对混杂因素进行调整后，13 种 PFAS 与流产风险呈显著正相关，尤其是 PFOA（OR：2.99，95% CI：1.96-4.68）和各种 PFOS 异构体。BKMR分析证实，PFAS总体水平越高，流产风险越大。这些发现凸显了全氟辛烷磺酸对生殖系统的潜在毒性，并强调有必要开展进一步调查和采取监管行动，以减少孕妇接触全氟辛烷磺酸的机会。

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引用次数: 0

Effect of an insecticide, fungicide and plant growth regulator and their mixture on the survival of the springtail Folsomia candida and the potential reduction of toxicity by vitamins 杀虫剂、杀真菌剂和植物生长调节剂及其混合物对念珠绣春蜱存活的影响以及维生素的潜在减毒作用。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-11-13 DOI: 10.1016/j.etap.2024.104588

Pavla Pabiskova , Bruno Sopko , Elena Shcherbachenko , Tomas Erban

A pesticide-free model soil was pretreated with field-realistic doses/applications of the insecticide, Biscaya 240 OD; the fungicide Tilmor; the growth regulator, Atonik and their mixture. Because Folsomia candida is eyeless, unpigmented, avoids light, and prefers dark, wet and cold conditions, we grew and tested it in the dark and at 18°C. Survival of springtails added to soil at 50 % moisture was assessed after 28 days. The experiments were repeated three times in order to confirm the validity of the test and results. The mixture decreased the survival most significantly. Bayesian statistics showed that pesticide treatment had a greater effect than repeating the experiment. Further tests revealed that the negative effect of the mixture on springtail survival was effectively suppressed by the application of biotin (vitamin B7), whereas riboflavin (vitamin B2) had little effect. Vitamins can reduce the toxicity of agrochemicals in the soil through potential effects on soil biological activity.

在不含杀虫剂的模型土壤中预处理了田间实际剂量/应用的杀虫剂 Biscaya 240 OD、杀真菌剂 Tilmor、生长调节剂 Atonik 及其混合物。由于 Folsomia candida 无眼、无色素、避光，喜欢黑暗、潮湿和寒冷的环境，因此我们在黑暗和 18°C 的环境中对其进行了生长和测试。28 天后，我们对添加到含水量为 50%的土壤中的春尾虫的存活率进行了评估。实验重复了三次，以确认测试和结果的有效性。混合物对存活率的降低最为明显。贝叶斯统计表明，杀虫剂处理比重复实验的效果更大。进一步的测试表明，施用生物素（维生素 B7）可有效抑制混合物对春尾存活率的负面影响，而核黄素（维生素 B2）的作用则微乎其微。维生素可以通过对土壤生物活性的潜在影响来降低土壤中农用化学品的毒性。

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引用次数: 0

Spray paint-derived microplastics and incorporated substances as ecotoxicological contaminants in the neotropical bumblebee Bombus atratus 喷漆衍生的微塑料和掺杂物质是新热带熊蜂Bombus atratus体内的生态毒理学污染物。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-11-06 DOI: 10.1016/j.etap.2024.104586

Guilherme Andrade Neto Schmitz Boeing , Michele Provase , Elisabete Tsukada , Raquel F. Salla , Walter Ruggeri Waldman , Fábio Camargo Abdalla

While bumblebees may be exposed to microplastics (MPs), the effects on them are not well studied. Therefore, in this research, we assessed the cytotoxicity of pristine and photodegraded spray paint-derived MPs on the midgut, Malpighian tubules, and hepato-nephrocitic system cells of Bombus atratus workers exposed to 50 mg.L⁻¹ MPs for 96 hours. Histological and histochemical analyses revealed that pristine MPs caused subtle cellular changes, while the exposure to photodegraded MPs led to significant vacuolization, nuclear condensation, and pyknosis. These effects are possibly linked to the release of potentially toxic elements (PTEs) like Copper, Manganese, and Iron from photodegraded MPs, which exceeded Brazil's CONAMA safety limits. Photodegraded MPs also reduced body weight, disrupting homeostasis and potentially decreasing bumblebee’s fitness. These findings highlight the importance of studying the toxicity of environmentally realistic MPs, as plastic composition and weathering significantly influence their harmful effects.

虽然大黄蜂可能会接触到微塑料（MPs），但对其影响的研究并不多。因此，在这项研究中，我们评估了原始和光降解喷漆衍生的 MPs 对暴露于 50 mg.L-1 MPs 96 小时的大黄蜂工人的中肠、马氏管和肝肾系统细胞的细胞毒性。组织学和组织化学分析显示，原始 MPs 会导致细胞发生细微变化，而接触光降解 MPs 则会导致细胞明显空泡化、核凝结和细胞凋亡。这些影响可能与光降解 MPs 释放的潜在有毒元素（PTEs）有关，如铜、锰和铁，这些元素超过了巴西 CONAMA 的安全限制。光降解 MPs 还降低了体重，破坏了体内平衡，可能会降低大黄蜂的体能。这些发现凸显了研究现实环境中 MPs 的毒性的重要性，因为塑料成分和风化作用会对其有害影响产生重大影响。

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引用次数: 0

Pollen contaminated with a triple-action fungicide induced oxidative stress and reduced longevity though with less impact on lifespan in honey bees from well fed colonies 被三效杀真菌剂污染的花粉会诱发氧化应激并降低蜜蜂的寿命，但对喂养良好蜂群的蜜蜂寿命影响较小。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-11-04 DOI: 10.1016/j.etap.2024.104587

Thais R.R. Alves , Matheus F. Trivellato , Tainá A.L. Freitas , Aline Y. Kato , Cássia R.A. Gomes , Yara M.M. Ferraz , Jéssica A. Serafim , David De Jong , Evandro P. Prado , Eduardo F. Vicente , Ricardo O. Orsi , Gener T. Pereira , Camila A. Miranda , Fábio E. Mingatto , Daniel Nicodemo

Experiments were conducted to determine the effects of a triple-action fungicide on bees and whether improved nutrition can ameliorate eventual negative impacts. In cage tests, newly-emerged bees from well fed and from nutritionally-restricted honey bee colonies were fed for five days with pollen from sunflowers that had been sprayed or not with a commercial fungicide containing bixafen, prothioconazole and trifloxystrobin. Bees from well-fed colonies were significantly larger and consumed more uncontaminated pollen. They also exhibited increased glutathione peroxidase activity and higher concentrations of pyridine nucleotides, both of which are involved in antioxidase defense. However, pollen contaminated with fungicide led to an increase in lipoperoxidation, regardless of nutritional status. Bee longevity was reduced by both fungicide contamination of the pollen diet and poor nutritional condition. The fungicide adversely affected bees fed with contaminated pollen, though nutritional supplementation of the bee colonies that reared the bees partially compensated for these effects.

实验旨在确定三效杀真菌剂对蜜蜂的影响，以及改善营养是否能减轻最终的负面影响。在笼养试验中，用喷洒过或未喷洒过含有噻螨酮、丙硫菌唑和三唑酮的商用杀真菌剂的向日葵花粉喂养来自喂养良好和营养受限蜂群的新雏蜂五天。喂养充足的蜂群中的蜜蜂体型明显更大，消耗的无污染花粉也更多。它们还表现出谷胱甘肽过氧化物酶活性增强，吡啶核苷酸浓度升高，这两种物质都参与了抗氧化防御。然而，无论营养状况如何，受杀菌剂污染的花粉都会导致脂肪过氧化反应增加。花粉食物中的杀真菌剂污染和不良的营养状况都会缩短蜜蜂的寿命。用受污染的花粉喂养蜜蜂会受到杀真菌剂的不利影响，但对饲养蜜蜂的蜂群进行营养补充可部分弥补这些影响。

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引用次数: 0

Constructing an adverse outcome pathway framework for the impact of maternal exposure to PM2.5 on liver development and injury in offspring 构建母体暴露于 PM2.5 对后代肝脏发育和损伤影响的不良后果路径框架。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-11-01 DOI: 10.1016/j.etap.2024.104585

Kexin Zhang , Li Tian , Qinglin Sun , Jianong Lv , Ruiyang Ding , Yang Yu , Yang Li , Junchao Duan

Ambient fine particulate matter (PM_2.5) is a significant contributor to air pollution. PM_2.5 exposure poses a substantial hazard to public health. In recent years, the adverse effects of maternal PM_2.5 exposure on fetal health have gradually gained public attention. As the largest organ in the body, the liver has many metabolic and secretory functions. Liver development, as well as factors that interfere with its growth and function, are of concern. This review utilized the adverse outcome pathway (AOP) framework as the analytical approach to demonstrate the link between maternal PM_2.5 exposure and potential neonatal liver injury from the molecular to the population level. The excessive generation of reactive oxygen species (ROS), subsequent endoplasmic reticulum (ER) stress, and oxidative stress were regarded as the essential components in this framework, as they could trigger adverse developmental outcomes in the offspring through DNA damage, autophagy dysfunction, mitochondrial injury, and other pathways. To the best of our knowledge, this is the first article based on an AOP framework that elaborates on the influence of maternal exposure to PM_2.5 on liver injury occurrence and adverse effects on liver development in offspring. Therefore, this review offered mechanistic insights into the developmental toxicity of PM_2.5 in the liver, which provided a valuable basis for future studies and prevention strategies.

环境细颗粒物（PM2.5）是造成空气污染的重要因素。暴露于 PM2.5 会对公众健康造成巨大危害。近年来，母体暴露于PM2.5对胎儿健康的不良影响逐渐受到公众的关注。作为人体最大的器官，肝脏具有多种代谢和分泌功能。肝脏的发育以及干扰其生长和功能的因素都值得关注。本综述利用不良后果途径（AOP）框架作为分析方法，从分子到人群层面论证了母体接触 PM2.5 与新生儿潜在肝损伤之间的联系。活性氧（ROS）的过度生成、随后的内质网（ER）应激和氧化应激被认为是这一框架的重要组成部分，因为它们可能通过DNA损伤、自噬功能障碍、线粒体损伤和其他途径引发后代的不良发育结果。据我们所知，这是第一篇基于AOP框架阐述母体暴露于PM2.5对肝损伤发生的影响以及对后代肝脏发育不良影响的文章。因此，这篇综述从机理上揭示了PM2.5对肝脏发育的毒性，为今后的研究和预防策略提供了宝贵的依据。

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引用次数: 0

Microplastic contamination in the aquaculture icon Oreochromis mossambicus: Prevalence, characteristics, and comprehensive overview 水产养殖图标 Oreochromis mossambicus 中的微塑料污染：普遍性、特征和综合概述。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-10-31 DOI: 10.1016/j.etap.2024.104584

Pradeep Kumkar , Chandani R. Verma , Sachin M. Gosavi , Martin Lexa , Sanjay S. Kharat , Radek Rinn , Lukáš Kalous

The global production of plastics has surged to 368 million tonnes annually, leading to significant plastic waste accumulation, projected to reach 12,000 Mt by 2050, impacting aquatic ecosystems. Fish, crucial for their protein and nutrients, are particularly vulnerable to microplastic (MP) ingestion. As a major aquaculture producer and fish consumer, India faces rising plastic pollution in freshwater, which disrupts fish health and growth, posing a significant threat to the sustainability and productivity of aquaculture systems and potential health risks. This study focuses on Mozambique tilapia (Oreochromis mossambicus), valued for its widespread aquaculture use, rapid growth, and nutritional benefits. Our research reveals significant MP contamination (69.23 %) in Mozambique tilapia, with over 80 % from the Ulhas River and 60 % from the Bhima River contaminated and females showing higher susceptibility. These findings emphasise the need for further research on MP impacts on human health and the development of mitigation strategies.

全球塑料年产量激增至 3.68 亿吨，导致大量塑料废物堆积，预计到 2050 年将达到 12,000 兆吨，对水生生态系统造成影响。鱼类的蛋白质和营养至关重要，尤其容易摄入微塑料（MP）。作为一个主要的水产养殖生产国和水产品消费国，印度面临着日益严重的淡水塑料污染问题，这种污染会破坏鱼类的健康和生长，对水产养殖系统的可持续性和生产力构成重大威胁，并带来潜在的健康风险。本研究的重点是莫桑比克罗非鱼（Oreochromis mossambicus），该鱼类因其广泛的水产养殖用途、快速生长和营养价值而备受重视。我们的研究揭示了莫桑比克罗非鱼的重大 MP 污染（69.23%），其中乌尔哈斯河和比马河分别有 80% 和 60% 的罗非鱼受到污染，雌性罗非鱼的易感性更高。这些发现强调了进一步研究 MP 对人类健康的影响和制定缓解策略的必要性。

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引用次数: 0

Association of chronic arsenic exposure with cellular immune profile in MINIMat adolescents: A birth cohort in Bangladesh 慢性砷暴露与 MINIMat 青少年细胞免疫特征的关系：孟加拉国出生队列

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-10-30 DOI: 10.1016/j.etap.2024.104583

Farjana Haque , Evana Akhtar , Bikash Chandra Chanda , Anjuman Ara , Md.Ahsanul Haq , Protim Sarker , Maria Kippler , Yukiko Wagatsuma , Ondine S. von Ehrenstein , Rubhana Raqib

Chronic arsenic exposure is known to affect the immune system. We aimed to evaluate the association between arsenic exposure and immune cell profile in 15 years old adolescents (n=389) in rural Bangladesh, with chronic exposure to groundwater arsenic. Single blood and urine were collected. Urinary arsenic (U-As) concentration was measured using atomic absorption spectrometry. Peripheral blood mononuclear cells (PBMC) were analyzed by flow cytometry. Non-linear association was found between U-As (median, 24.9 µg/L) and immune cells with a cut-off at U-As 20 µg/L. U-As (<20 µg/L) were significantly associated with increases in CD8⁺T (21 %), na^ïve CD8⁺T (42 %) and early B cells (40 %), and classical monocytes (55 %), but reduction in CD3⁺T cells (37^%) and intermediate-monocytes (56 %). U-As (>20 µg/L) were associated with a 3 % reduction in memory B cells. Arsenic exposure was associated with altered immune cell profile in adolescents likely rendering them vulnerable to adverse health effects in later life.

众所周知，长期接触砷会影响免疫系统。我们的目的是评估长期暴露于地下水砷的孟加拉国农村地区 15 岁青少年（人数=389）的砷暴露与免疫细胞特征之间的关系。我们采集了单次血液和尿液。使用原子吸收光谱法测量尿砷（U-As）浓度。外周血单核细胞（PBMC）采用流式细胞术进行分析。结果发现，U-As（中位数，24.9 微克/升）与免疫细胞之间存在非线性关联，U-As 20 微克/升为分界线。U-As（+T细胞（21%）、幼稚CD8+T细胞（42%）、早期B细胞（40%）和典型单核细胞（55%），但CD3+T细胞（37%）和中间单核细胞（56%）减少。U-砷（>20 微克/升）与记忆 B 细胞减少 3% 有关。砷暴露与青少年免疫细胞谱的改变有关，可能使他们在以后的生活中容易受到不良健康影响。

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引用次数: 0

Regeneration of zebrafish retina following toxic injury 斑马鱼视网膜毒性损伤后的再生。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-10-29 DOI: 10.1016/j.etap.2024.104582

Alessandra La Pietra, Anna Rita Bianchi, Teresa Capriello, Teresa Mobilio, Annamaria Guagliardi, Anna De Maio, Ida Ferrandino

The structure of the zebrafish retina appears to be very similar to that of mammals, that is why it is used as a model for studying the eye. Indeed, the zebrafish retina can regenerate itself through mechanisms of Müller cell reprogramming. In this research, adult zebrafish were exposed to aluminum to cause damage in the retina and thus evaluate the regenerative capacity of the damaged tissue. Histological and histochemical analyses assessed the retinal structure and the neurodegenerative process, respectively. An expression analysis of PARPs was carried out to verify whether a potential oxidative DNA damage happens. In addition, some genes involved in the regeneration process (pax6a, pax2a, ngn1, and notch1a) were analyzed. The data confirmed the toxicity of aluminum which caused retinal neurodegeneration, but also highlighted the ability of zebrafish to regenerate the retinal structure, repairing the damage and confirming its use as a good model for translational studies.

斑马鱼视网膜的结构与哺乳动物非常相似，因此被用作研究眼睛的模型。事实上，斑马鱼视网膜可以通过Müller细胞重编程机制实现自我再生。在这项研究中，成年斑马鱼暴露于铝中，导致视网膜受损，从而评估受损组织的再生能力。组织学和组织化学分析分别评估了视网膜结构和神经退行性过程。对 PARPs 的表达进行了分析，以验证是否发生了潜在的 DNA 氧化损伤。此外，还分析了一些参与再生过程的基因（pax6a、pax2a、ngn1 和 notch1a）。这些数据证实了铝的毒性会导致视网膜神经变性，但同时也强调了斑马鱼再生视网膜结构、修复损伤的能力，并证实其可作为转化研究的良好模型。

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引用次数: 0

Evaluating the impact of gadolinium contamination on the marine bivalve Donax trunculus: Implications for environmental health 评估钆污染对海洋双壳类动物 Donax trunculus 的影响：对环境健康的影响。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-10-28 DOI: 10.1016/j.etap.2024.104580

Silvia Secco , Marta Cunha , Giovanni Libralato , Marco Trifuoggi , Antonella Giarra , Amadeu M.V.M. Soares , Rosa Freitas , Massimiliano Scalici

Gadolinium (Gd), commonly used in contrast agents for medical imaging, has been detected in hospital wastewater and aquatic environments, raising environmental concerns. This study examined the accumulation and cellular impacts of Gd in the clam species Donax trunculus, commonly used as bioindicator of contamination. Gadolinium accumulation in clams increased with exposure and over time. Biological responses varied with Gd levels: low concentrations (10 and 50 µg/L) led to low metabolic activity and glycogen content, but high antioxidant activities and lipid peroxidation levels (LPO); high concentrations (250 and 500 µg/L) resulted in increased metabolic activity, while antioxidant enzyme activity was inhibited and LPO levels were the lowest. Metabolic activity decreased after two weeks, suggesting limited long-term metabolic resilience. The study underscores D. trunculus as an effective early warning species for Gd pollution and highlights the ecological risks of rising Gd levels, emphasizing the need for environmental monitoring and regulation.

钆（Gd）常用于医学成像造影剂，在医院废水和水生环境中被检测到，引起了环境问题。这项研究考察了钆在蛤类物种 Donax trunculus 中的积累和对细胞的影响。钆在蛤蜊体内的积累随着接触时间的延长而增加。生物反应随 Gd 含量而变化：低浓度（10 和 50 微克/升）导致代谢活性和糖原含量低，但抗氧化活性和脂质过氧化水平（LPO）高；高浓度（250 和 500 微克/升）导致代谢活性增加，而抗氧化酶活性受到抑制，LPO 水平最低。新陈代谢活性在两周后下降，表明长期新陈代谢恢复能力有限。该研究强调了三疣梭子蟹是钆污染的有效预警物种，并突出了钆含量上升的生态风险，强调了环境监测和监管的必要性。

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引用次数: 0

Association of volatile organic compound exposure and metabolic syndrome 挥发性有机化合物暴露与代谢综合征的关系。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2024-10-24 DOI: 10.1016/j.etap.2024.104581

Hee Byung Koh, Jae Ho Chung, Sung Jin Moon

The cumulative toxicity of volatile organic compounds (VOCs) cause many medical diseases. We analyzed the evidence of association between VOCs and risk of metabolic syndrome in the Korean population using 1771 participants from the 2023 National Health and Nutrition Examination Survey. The creatinine-corrected urinary concentrations of BMA, 2-MHA, PGA, SPMA, 3-HPMA, BPMA and DHBMA were higher in the metabolic syndrome group than in the non-metabolic syndrome group. Urine N-Acetyl-S-(phenyl)-L-cysteine (SPMA) levels were significantly associated with metabolic syndrome after adjusting for confounders (odds ratio: 1.71). 2-MHA (OR 1.29, P=0.035) and SPMA (OR 2.84, P<0.001) were associated with the risk of elevated FBG impairment and SPMA (OR 1.57) was positively connected with the high blood pressure (P=0.016). In conclusion, the findings indicated significant association between the metabolic syndrome and a number of VOCs. Among them, there was a substantial positive correlation between the urinary SPMA levels and metabolic syndrome.

挥发性有机化合物（VOC）的累积毒性会引发多种疾病。我们利用 2023 年全国健康与营养调查的 1,771 名参与者，分析了韩国人群中挥发性有机化合物与代谢综合征风险之间的关联证据。代谢综合征组的 BMA、2-MHA、PGA、SPMA、3-HPMA、BPMA 和 DHBMA 的肌酐校正尿浓度高于非代谢综合征组。尿液中的 N-乙酰基-S-（苯基）-L-半胱氨酸（SPMA）水平在调整了混杂因素后与代谢综合征显著相关（几率比：1.71）。2-MHA（OR1.29，P=0.035）和 SPMA（OR2.84，P=0.035）与代谢综合征密切相关。

引用次数: 0