Environmental toxicology and pharmacology最新文献_第6页

Crotonaldehde oral exposure disrupt cardiac energy metabolism and induces oxidative stress via down-regulation of nrf-2 and up-regulation of PPARα Crotonaldehde口服暴露通过下调nrf-2和上调ppar - α来破坏心脏能量代谢，诱导氧化应激

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 Epub Date: 2025-12-04 DOI: 10.1016/j.etap.2025.104892

Olufemi I. Oluranti , Bernard O. Adele , Abayomi O. Ige , Elsie O. Adewoye

Alterations in cardiac energy metabolic pathways have been linked to cardiac dysfunction. This study investigated cardiac energy metabolism in male rats exposed to crotonaldehyde. Thirty-six male Wistar rats (150–170 g; n = 9) were grouped into 4 (I-IV): Control (normal saline 10 mL/kg), crotonaldehyde (0.75, 1.5, and 2.5 mg/kg, p.o) for 28 days. Levels of creatinine-kinase-myocardial-band, cardiac-troponin-I, glucose increased significantly, while triglyceride, free-fatty-acid, and insulin reduced significantly in all groups compared with control. Cardiac Pyruvate level, hexokinase and pyruvate dehydrogenase activities increased significantly in all crotonaldehyde-treated groups compared with control. Cardiac levels of malondialdehyde and hydrogen-peroxide increased significantly, while glutathione and nuclear-factor-erythroid-2-related-factor-2 reduced; superoxide-dismutase and catalase activities decreased following crotonaldehyde exposure compared with control. Cardiac glucose-transporter-4 and peroxisome-proliferator-activated-receptor-alpha expression increased in groups III and IV, while carnitine-palmitoyltransferase1β expression decreased in group II but increased in groups III and IV compared with control. Crotonaldehyde exposure exerts cardio-toxic effects by altering cardiac energy metabolism.

心脏能量代谢途径的改变与心功能障碍有关。本研究对暴露于巴豆醛的雄性大鼠心脏能量代谢进行了研究。36只雄性Wistar大鼠（150 ~ 170g, n=9）分为4组（I-IV组）：对照组（生理盐水10mL/kg），巴豆醛（0.75、1.5、2.5mg/kg, p.o） 28 d。与对照组相比，所有组的肌酐-激酶-心肌带、心肌肌钙蛋白- 1、葡萄糖水平均显著升高，而甘油三酯、游离脂肪酸和胰岛素水平均显著降低。与对照组相比，各巴豆醛处理组心脏丙酮酸水平、己糖激酶和丙酮酸脱氢酶活性均显著升高。心肌丙二醛和过氧化氢水平显著升高，谷胱甘肽和核因子-红细胞-2相关因子-2降低；与对照相比，暴露于巴豆醛后，超氧化物歧化酶和过氧化氢酶活性降低。心肌葡萄糖转运体-4和过氧化物酶体-增殖物活化受体- α的表达在III组和IV组增加，而肉毒碱-棕榈酰基转移酶1β的表达在II组减少，而在III组和IV组与对照组相比增加。巴豆醛暴露通过改变心脏能量代谢产生心脏毒性作用。

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引用次数: 0

Effects of consumer-grade and commercial acetamiprid formulations on the embryonic development of the South African clawed frog Xenopus laevis 消费级和商用醋氨虫制剂对南非爪蟾胚胎发育的影响

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/j.etap.2025.104905

Hannah Flach, Marlen Kerner, Mert Tosun, Paolina Maier, Petra Dietmann, Karin Botzenhart, Susanne J. Kühl

The insecticide acetamiprid is a neonicotinoid still approved for outdoor use worldwide. For active use, there are formulations that contain other often unpublished co-formulants in addition to acetamiprid. This study investigated effects of four different acetamiprid formulations (Careo Rosenspray, Careo, Mospilan, Danjiri) in a concentration range of 0.01–100 mg a.i./L on embryonic development of Xenopus laevis. The formulations led to an increase in embryo mortality with LC₅₀-values between 0.5 and 53.2 mg a.i./L depending on the formulation. At sublethal acetamiprid concentrations in Mospilan and Danjiri, the external appearance (body length, oedemas), the early neural development (eyes, heads, brains, cranial nerves) as well as the heart morphology and function were disturbed. Our results show that strict adherence to recommended handling and application conditions of acetamiprid formulations is essential to protect X. laevis. Therefore, pesticide risk assessment and approval renewal procedures must include commercially available combined formulations rather than solely evaluating the active ingredient.

扑热息痛是一种新烟碱类杀虫剂，在世界范围内仍被批准在室外使用。对于主动使用，除了扑热息痛外，还有含有其他通常未发表的共制剂的配方。研究了4种不同的醋氨虫制剂（Careo Rosenspray、Careo、Mospilan、Danjiri）在0.01 ~ 100 mg a.i./L浓度范围内对非洲爪蟾胚胎发育的影响。不同配方对胚胎死亡率的影响不同，lc50值在0.5 ~ 53.2 mg a.i./L之间。在Mospilan和Danjiri的亚致死浓度下，小鼠的外观（体长、水肿）、早期神经发育（眼睛、头部、大脑、脑神经）以及心脏形态和功能受到干扰。本研究结果表明，严格遵守对乙酰氨脒制剂推荐的处理和使用条件，对保护姬螨至关重要。因此，农药风险评估和批准更新程序必须包括商业上可获得的组合配方，而不是单独评估活性成分。

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引用次数: 0

Ecotoxicological impacts of imazethapyr herbicide on amphibian larvae: Evidence from Physalaemus cuvieri 吡咪唑吡酯除草剂对两栖动物幼虫的生态毒理学影响：来自居绒泡鼠的证据

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 Epub Date: 2025-11-26 DOI: 10.1016/j.etap.2025.104878

Alexandre Folador , Inete Cleide Bau , Guilherme Felicioni , Bruna Caprini , Aline Pompermaier , Wagner Antonio Tamagno , Carla Alves , Paulo Afonso Hartmann , Marilia Hartmann

Aquatic environments are amongst the ecosystems most impacted by pesticides, with amphibians being a particularly vulnerable group. This study investigated the cytotoxic, body condition and biochemical effects of a commercial formulation of imazethapyr-based herbicide (IBH), on Physalaemus cuvieri tadpoles at developmental stage 25 exposed to a broad concentration gradient (0–500 µg/L) for 14 days. Notably, even the lowest concentration (1 µg/L) significantly reduced body weight, body mass index, and scaled mass index, while inducing multiple erythrocyte nuclear abnormalities (ENAs). All tested concentrations caused these effects in ENAs (e.g., micronuclei, lobed nuclei) and impaired energy allocation patterns. IBH was also neurotoxic and induced oxidative stress at higher concentrations (400–500 µg/L). The cellular damage observed suggests the difficulty for tadpoles in maintaining energy reserves for growth and metamorphosis, as evidenced by significant body weight loss. Together, these results indicate that IBH is cytotoxic at environmentally relevant concentrations and may consequently compromise the health of P. cuvieri populations.

水生环境是受农药影响最大的生态系统之一，两栖动物是一个特别脆弱的群体。本研究研究了一种商业配方的吡唑乙酯除草剂（IBH）对处于发育25期的古绒螯蟹蝌蚪的细胞毒性、机体状况和生化影响，IBH的浓度梯度为0-500 µg/L。值得注意的是，即使是最低浓度（1 µg/L）也显著降低了体重、体重指数和比例质量指数，同时诱导了多个红细胞核异常（ENAs）。所有测试的浓度都对ENAs（例如微核、分叶核）造成这些影响，并损害能量分配模式。高浓度（400-500 µg/L） IBH还具有神经毒性并诱导氧化应激。观察到的细胞损伤表明，蝌蚪在维持生长和蜕变所需的能量储备方面存在困难，体重明显减轻就是证据。总之，这些结果表明IBH在环境相关浓度下具有细胞毒性，并可能因此损害P. cuvieri种群的健康。

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引用次数: 0

Histopathological and toxicogenomic evaluation of 1,4-dioxane toxicity after a 14-day repeated oral administration 14d重复口服1,4-二恶烷毒性的组织病理学和毒理学评价。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 Epub Date: 2025-11-25 DOI: 10.1016/j.etap.2025.104875

Hiroshi Honda , Kentaro Yamamoto , Mutsumi Shiraishi

1,4-dioxane (DON) has been widely used as a pharmaceutical ingredient, a solvent in organic synthesis reactions, and a stabilizer in chlorinated organic solvents. Although DON shows hepatocarcinogenicity in mice and rats, the mode of action has not fully been elucidated. Therefore, to understand the toxicological potential of DON in high doses after repeated oral administration and the adverse effects on the liver in terms of molecular mechanisms, we analyzed a results of repeated dose 14-day oral toxicity test integrating a gene expression analysis using DNA microarray. Rats were orally administered a dose of DON (0, 150, 500 and 1500 mg/kg/day) and examinations on hematology, blood biochemistry, organ weights and histopathology were conducted. Surplus liver was harvested to gene expression analysis to identify genes and molecular pathways related to the adverse effect of DON. As a result, centrilobular hypertrophy of hepatocytes (liver), tubular vacuolation/basophilic change (kidney), and vacuolation (pituitary posterior lobe) were observed as pathological findings. Gene expression analysis revealed genes related to oxidative stress, xenobiotic receptor response, immune response, and hepatocellular carcinoma were significantly enriched. Under middle dose group, DNA damage response related genes were not significantly enriched and histopathological change in liver was not observed suggesting a threshold. Continuous alteration of these gene expression profiles related to hepato-carcinogenesis may have an important role in the non-genotoxic mode of action of DON. Our results would be useful in further understanding the general toxicity of DON and in considering early changes in the liver which lead to carcinogenesis.

1,4-二氧六环（DON）作为药物成分、有机合成反应的溶剂和氯化有机溶剂的稳定剂已被广泛应用。虽然DON在小鼠和大鼠中显示出肝癌致癌性，但其作用方式尚未完全阐明。因此，为了从分子机制上了解高剂量反复口服DON的毒理学潜力和对肝脏的不良影响，我们对重复剂量14天口服毒性试验结果进行了分析，并结合DNA微阵列基因表达分析。大鼠分别口服DON(0、150、500和1500 mg/kg/d)，进行血液学、血液生化、脏器重量和组织病理学检查。收集剩余肝脏进行基因表达分析，以确定与DON不良反应相关的基因和分子途径。结果，病理表现为肝细胞小叶中心肥大，肾小管空泡化/嗜碱性改变，垂体后叶空泡化。基因表达分析显示，与氧化应激、外源受体反应、免疫反应和肝细胞癌相关的基因显著富集。中剂量组DNA损伤反应相关基因未显著富集，肝脏组织病理变化未见明显变化，提示存在阈值。这些与肝癌发生相关的基因表达谱的持续改变可能在DON的非遗传毒性作用模式中起重要作用。我们的结果将有助于进一步了解DON的一般毒性，并考虑导致癌变的肝脏早期变化。

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引用次数: 0

Mutual oral administration of wood/plastic smoke PM and heavy metals Pb2+/Cd2+: General toxicity effects and ACE2 expression in rats 木/塑烟雾PM与重金属Pb2+/Cd2+相互口服：大鼠一般毒性效应及ACE 2表达

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 Epub Date: 2025-11-26 DOI: 10.1016/j.etap.2025.104881

Nataliya Dziubenko , Iryna Byelinska , Taisa Dovbynchuk , Arsen Ishchuk , Viktoriia Velmyk , Mariia Korbush , Konstantin Paliienko , Liliia Kalynovska , Nataliya Krisanova , Nataliya Pozdnyakova , Tatiana Borisova , Ganna Tolstanova

Carbonaceous air pollution particulate matter (PM) and xenobiotic heavy metals, Pb²⁺ and Cd²⁺, are hazardous toxicants. PM-associated Pb²⁺ and Cd²⁺ are substantial metal components of PM_2.5. Here, we analysed general toxicity and ACE2 concentration/expression in rats after combined oral administration of water-suspended smoke PM preparations from wood (WS) or polypropylene (PS) and Pb²⁺/Cd²⁺. After combined exposure to Pb²⁺/Cd² and WS/PS, turnover of erythrocytes increased (an increase in volume of MCV erythrocytes). The combined effect of Cd²⁺ and PS had a lymphosuppressive effect. Pb²⁺/Cd²⁺ with WS/PS increased the level of myeloperoxidase activity in the mucous membrane of rat colon in all groups. ACE2 concentrations in the blood plasma were not changed in all groups. WS and PS reduced the intensity of positive staining of ACE2 receptors in the mucous membrane of the colon of rats. Therefore, multipollutant heavy metal- and PM-induced effects on general toxicity parameters and ACE2 concentration/expression were revealed.

碳质空气污染颗粒物（PM）和外源重金属Pb2+和Cd2+是有害毒物。与pm相关的Pb2+和Cd2+是PM2.5的主要金属成分。在这里，我们分析了大鼠在联合口服木材（WS）或聚丙烯（PS）和Pb2+/Cd2+的水悬浮烟雾PM制剂后的一般毒性和ACE2浓度/表达。同时暴露于Pb2+/Cd2和WS/PS后，红细胞周转增加（MCV红细胞体积增加）。Cd2+与PS联合作用具有淋巴抑制作用。Pb2+/Cd2+加WS/PS可提高各组大鼠结肠粘膜髓过氧化物酶活性。各组血浆中ACE2浓度无明显变化。WS和PS降低了大鼠结肠粘膜ACE2受体的阳性染色强度。因此，揭示了多污染物重金属和pm对一般毒性参数和ACE2浓度/表达的影响。

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引用次数: 0

Evaluation of THC-induced neurotoxicity via oxidative stress in undifferentiated SH-SY5Y cells 通过氧化应激评价四氢大麻酚诱导未分化SH-SY5Y细胞的神经毒性

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 Epub Date: 2025-12-03 DOI: 10.1016/j.etap.2025.104891

A. Sanz-Pérez , B.J. Anaya , A.I. Fraguas-Sánchez , D.R. Serrano , T. Pérez , P. Basilicata , M. Pieri , E. González-Burgos

The increasing global consumption of cannabis, particularly high-THC products, has raised public health concerns due to potential neurotoxic effects, although its association with oxidative stress remains a subject of debated. Some studies link THC-rich cannabis to increased oxidative damage, while others highlight antioxidant properties of cannabinoids. This study aimed to evaluate whether THC concentrations observed in real-world scenarios, specifically in the blood of drivers involved in traffic accidents, can induce neuronal damage through oxidative stress in vitro. Human undifferentiated SH-SY5Y neuroblastoma cells were exposed to 0.66, 20, 73.75, and 150 ng/mL THC. High concentrations (73.75 and 150 ng/mL) significantly reduced cell viability (to 76.5 % and 64.6 % at 48 h) and caused morphological changes. THC exposure increased ROS, peaking at 116.5 % at 150 ng/mL, disrupted glutathione balance (GSH/GSSG ratio decreased by 69.2 %), and moderately increased lipid peroxidation (34.5 %). Activities of antioxidant enzymes (CAT, SOD, GR, GPx) declined concentration-dependently. Additionally, nuclear condensation and mitochondrial membrane depolarization indicated early apoptosis. These findings suggest that high THC levels can trigger neurotoxicity via oxidative stress and mitochondrial dysfunction.

全球大麻消费量的增加，特别是高四氢大麻酚产品，由于潜在的神经毒性作用引起了公众健康关注，尽管其与氧化应激的关系仍然是一个有争议的主题。一些研究将富含四氢大麻酚的大麻与氧化损伤增加联系起来，而另一些研究则强调大麻素的抗氧化特性。本研究旨在评估在现实场景中观察到的四氢大麻酚浓度，特别是在交通事故中驾驶员的血液中，是否可以通过体外氧化应激诱导神经元损伤。人未分化SH-SY5Y神经母细胞瘤细胞分别暴露于0.66、20、73.75和150 ng/mL四氢大麻酚中。高浓度（73.75和150 ng/mL）显著降低细胞活力（48 h时分别为76.5 %和64.6 %），并引起形态学改变。THC暴露增加了ROS，在150 ng/mL时达到116.5 %的峰值，破坏了谷胱甘肽平衡（GSH/GSSG比值降低了69.2 %），适度增加了脂质过氧化（34.5% %）。抗氧化酶（CAT、SOD、GR、GPx）活性呈浓度依赖性下降。核凝聚和线粒体膜去极化提示细胞早期凋亡。这些发现表明，高THC水平可以通过氧化应激和线粒体功能障碍引发神经毒性。

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引用次数: 0

Corrigendum to “In vitro enantioselective inhibition of key human CYP450 enzymes by the chiral fungicide penconazole” [Environ. Toxicol. Pharmacol. 118 (2025) 104790] 手性杀菌剂戊康唑体外对人关键CYP450酶的对映选择性抑制的勘误[环境]。Toxicol。药理学杂志，118 (2025)104790 [j]。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 Epub Date: 2025-12-04 DOI: 10.1016/j.etap.2025.104890

Maike Felipe Santos Barbetta , Giovanni Stoppa Baviera , Icaro Salgado Perovani , Leandro Oka Duarte , Anderson Rodrigo Moraes de Oliveira

引用次数: 0

Integrated biomarker assessment of sublethal effects of a tebuconazole-based fungicide in Rhinella arenarum larvae 基于替布康唑的杀菌剂对砂鼻菌幼虫亚致死效应的综合生物标志物评估

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 DOI: 10.1016/j.etap.2025.104921

Mercedes Acquaroni, Cristina Pérez Coll, Gabriela Svartz

Agricultural intensification increases agrochemical use, exposing aquatic organisms to sublethal toxicants capable of disrupting key physiological pathways. This study assessed the biochemical and physiological responses of Rhinella arenarum larvae exposed to a commercial tebuconazole-based fungicide (Trigal®, 43 % active ingredient). Acute (96 h) exposures to 0.005, 0.01, and 0.05 mg/L were performed to evaluate biomarkers related to oxidative stress, neurotoxicity, and genotoxicity. The integrated biomarker response (IBR) index was used to combine these endpoints into a single global measure of physiological stress. Tebuconazole caused oxidative imbalance, with CAT, GST, and GSH activities inhibited by 20–60 % across all concentrations, while SOD increased 24 % at 0.05 mg/L. Lipid peroxidation and micronuclei frequency rose by 3-fold at 0.01–0.05 mg/L, indicating redox disruption and membrane damage. Significant BChE inhibition further evidenced neurophysiological impairment. The IBR index revealed a concentration-dependent increase, with the highest value observed at 0.05 mg/L, indicating a clear overall biological effect of exposure. Given the ecological role of amphibians as key components of food webs, these findings suggest that tebuconazole may impair larval performance and ultimately reduce recruitment in amphibian populations exposed to agricultural runoff.

农业集约化增加了农用化学品的使用，使水生生物暴露于能够破坏关键生理途径的亚致死毒物中。本研究评估了砂鼻菌（Rhinella arenum）幼虫暴露于一种商用苯丙唑类杀菌剂（Trigal®，43% %有效成分）后的生化和生理反应。急性（96 h）暴露于0.005、0.01和0.05 mg/L，以评估与氧化应激、神经毒性和遗传毒性相关的生物标志物。综合生物标志物反应（IBR）指数用于将这些终点合并为生理应激的单一全局测量。戊康唑引起氧化失衡，在所有浓度下，CAT、GST和GSH活性均被抑制20 - 60% %，而在0.05 mg/L浓度下，SOD活性升高24 %。在0.01 ~ 0.05 mg/L时，脂质过氧化和微核频率增加了3倍，表明氧化还原破坏和膜损伤。显著的BChE抑制进一步证明了神经生理损伤。IBR指数呈浓度依赖性增加，最高值为0.05 mg/L，表明暴露的整体生物学效应明显。鉴于两栖动物作为食物网关键组成部分的生态作用，这些研究结果表明，戊康唑可能会损害幼虫的表现，并最终减少暴露于农业径流的两栖动物种群的补充。

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引用次数: 0

Sublethal fipronil exposure impairs development and behavior in Drosophila melanogaster 亚致死氟虫腈暴露损害黑腹果蝇的发育和行为

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 Epub Date: 2025-12-24 DOI: 10.1016/j.etap.2025.104917

Heloísa Pereira Santos , Andressa Paladini , Cristiane Lenz Dalla Corte

The use of pesticides, particularly insecticides, is integral to modern agriculture. Fipronil, a widely used phenylpyrazole insecticide, is classified as a class II toxicant, indicating high toxicity by ingestion and contact. This study evaluated the morphometric and toxicological effects of fipronil on D. melanogaster development. Embryos were exposed orally from the embryonic stage to adulthood at 16, 40, 81, 163, 327, and 490 nM. The highest concentration reduced adult emergence from pupae, while survival decline at the three highest concentrations. Locomotor behavior was impaired at 81 nM in both sexes. Fipronil induced 24-h mortality in adult flies at concentrations ≥ 327 nM, with a median lethal concentration (LC₅₀) of 442 nM. Canonical variate analysis (CVA) revealed sex-dependent differences and shape changes at 16 and 40 nM compared with controls. Overall, these findings indicate fipronil toxicity in D. melanogaster and suggest that this model can help anticipate effects in other invertebrates.

农药，特别是杀虫剂的使用是现代农业不可缺少的一部分。氟虫腈是一种广泛使用的苯吡唑类杀虫剂，被列为II类有毒物质，表明摄入和接触具有高毒性。本研究评价了氟虫腈对黑腹大蠊发育的形态学和毒理学影响。胚胎在16、40、81、163、327和490 nM处从胚胎期到成年期经口暴露。最高浓度降低了成虫羽化，3个最高浓度降低了成虫存活率。运动行为在81 nM时受到损害。氟虫腈浓度≥ 327 nM时可致成蝇24 h死亡，中位致死浓度（LC50）为442 nM。典型变量分析（CVA）显示，与对照组相比，在16和40 nM时存在性别依赖性差异和形状变化。总的来说，这些发现表明氟虫腈对黑腹龙的毒性，并表明该模型可以帮助预测对其他无脊椎动物的影响。

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引用次数: 0

Urinary concentrations of di-butyl phthalate isomers and reproductive hormonal parameters in adult men: A systematic review with dose-response meta-analysis 成年男性尿中邻苯二甲酸二丁酯异构体浓度和生殖激素参数：一项剂量-反应荟萃分析的系统综述

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2026-01-01 Epub Date: 2025-12-09 DOI: 10.1016/j.etap.2025.104900

Tiberiu M. Nita , David Vernez , Pascal Wild , Nelly Pitteloud , Nancy B. Hopf

Background

Male reproductive decline has been linked to phthalate exposure. Di-butyl phthalate isomers (DnBP and DiBP) are endocrine disruptors with inconsistent evidence regarding effects on the hypothalamic-pituitary-gonadal/thyroid (HPG/T) axis.

Objective

To perform a dose-response meta-analysis of associations between DnBP and DiBP exposure and HPG/T-axis hormones.

Methods

Five databases were searched. The associations between urinary DBP metabolite concentrations (mono-n-butyl phthalate [MnBP], mono-iso-butyl phthalate [MiBP], or nonspecific DBP metabolites [∑DBPm]) and hormone levels (TT, fT, SHBG, LH, FSH, E2, INHB, and TSH) were analyzed using meta-regressions (unadjusted [UA], covariate-adjusted [CA], fertility-adjusted [FA]).

Results

From 10,410 records, 19 studies (N = 12,128) were considered. MiBP was negatively correlated with LH (UA: β=-0.117, p = 0.02; CA: β=-0.094, p = 0.012; FA: β=-0.125, p = 0.009), positively with E2 (CA: β=0.084, p = 0.045), and SHBG (CA: β=0.09, p = 0.034; FA: β=0.091, p = 0.015). MnBP was positively associated with TSH (UA: β=0.152, p = 0.001; CA: β=0.188, p = 0.006).

Conclusions

DBP-isomers exposure is associated with altered HPG/T-axis hormone levels.

男性生殖能力下降与邻苯二甲酸盐暴露有关。邻苯二甲酸二丁酯异构体（DnBP和DiBP）是内分泌干扰物，对下丘脑-垂体-性腺/甲状腺（HPG/T）轴的影响证据不一致。目的对DnBP和DiBP暴露与HPG/ t轴激素之间的关系进行剂量-反应荟萃分析。方法对5个数据库进行检索。尿DBP代谢物浓度（邻苯二甲酸单正丁酯[MnBP]、邻苯二甲酸单异丁酯[MiBP]或非特异性DBP代谢物[∑DBPm]）与激素水平（TT、fT、SHBG、LH、FSH、E2、INHB和TSH）之间的关系采用meta回归分析（未调整[UA]、协变量调整[CA]、生育调整[FA]）。结果从10410份记录中纳入19项研究（N= 12128）。MiBP与LH呈负相关（UA: β=-0.117, p=0.02; CA: β=-0.094, p=0.012; FA: β=-0.125, p=0.009），与E2 （CA: β=0.084, p=0.045）、SHBG （CA: β=0.09, p=0.034; FA: β=0.091, p=0.015）呈正相关。MnBP与TSH呈正相关（UA: β=0.152, p=0.001; CA: β=0.188, p=0.006）。结论sdbp异构体暴露与HPG/ t轴激素水平改变有关。

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引用次数: 0