Environmental toxicology and pharmacology最新文献_第4页

Assessment of early kidney function biomarkers and environmental exposure to contaminant mixtures in Mexican brick-making workers under precarious labor conditions 墨西哥制砖工人在不稳定劳动条件下早期肾功能生物标志物和环境污染混合物暴露的评估

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-06 DOI: 10.1016/j.etap.2025.104893

Reyes-Zavala Axel , Pérez-Vázquez Francisco Javier , Fernández-Macias Juan-Carlos , Barbier Olivier , Ortega-Romero Manolo , Saldaña-Villanueva Kelvin , Méndez-Rodríguez Karen Beatriz

Artisanal brick-making exposes workers to mixtures of environmental contaminants under precarious conditions. This study assessed exposure to PAHs, arsenic, fluoride, lead, and their associations with early kidney damage biomarkers in 109 adults from three brick-making communities in central Mexico. Urinary and blood concentrations of contaminants were measured using validated analytical methods, and renal biomarkers (CYS-C, B2M, OPN, KIM-1, NGAL) were quantified via multiplex ELISA. Median urinary concentrations of 1-OH-PYR (1.3–2.3 µmol/mol uCr), arsenic (20.8–45.3 µg/L), and fluoride (1.6–2.6 mg/g uCr) exceeded reference values in a substantial proportion of participants. Cystatin-C and osteopontin showed significant associations with arsenic, fluoride, and PAH metabolites, including nonlinear relationships. No consistent associations were found for NGAL or KIM-1. These findings provide evidence of early renal alterations related to environmental exposures and support the utility of early-effect biomarkers for public health surveillance in vulnerable populations exposed to nephrotoxic mixtures under informal occupational conditions.

手工制砖使工人在危险的条件下暴露于环境污染物的混合物中。本研究评估了来自墨西哥中部三个制砖社区的109名成年人暴露于多环芳烃、砷、氟化物、铅及其与早期肾损伤生物标志物的关系。采用验证的分析方法测量尿和血中污染物浓度，并通过多重ELISA定量肾脏生物标志物（CYS-C、B2M、OPN、KIM-1、NGAL）。在相当大比例的参与者中，1- o - pyr（1.3-2.3µmol/mol uCr）、砷（20.8-45.3 µg/L）和氟化物（1.6-2.6 mg/g uCr）的尿中浓度超过参考值。胱氨酸抑素c和骨桥蛋白与砷、氟化物和多环芳烃代谢产物有显著相关性，包括非线性关系。没有发现NGAL或KIM-1的一致关联。这些发现提供了与环境暴露相关的早期肾脏改变的证据，并支持在非正式职业条件下暴露于肾毒性混合物的弱势群体中，早期效应生物标志物在公共卫生监测中的效用。

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引用次数: 0

The effect of bisphenol PH and seven other bisphenol A alternatives on human haemostasis in vitro 双酚PH和其他7种双酚A替代品对体外人体止血的影响。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-04 DOI: 10.1016/j.etap.2025.104897

Marcel Hrubša , Alina Soloviova , Patrícia Harčárová , Catherine Gunaseelan , Zuzana Lomozová , Eduard Jirkovský , Alejandro Carazo , Marija Sollner Dolenc , Lucija Peterlin Mašič , Přemysl Mladěnka

Recognition of bisphenol A’s toxicity has meant substitution by new analogues, which are poorly investigated. We determined the impact of bisphenol A and 8 of its analogues on platelet aggregation, coagulation, and their toxicity to erythrocytes. Erythrocyte lysis assays revealed bisphenol toxicity towards both human and rat erythrocytes with high TC₅₀s > 100 μM. Bisphenol A and bisphenol PH acted as antiplatelet compounds. Bisphenol PH was particularly potent (IC₅₀ of 0.42 ± 0.14 μM; 0.16 ± 0.05 μg/ml) in arachidonic acid-based platelet aggregation. Mechanistically, bisphenol PH blocked cyclooxygenase 1, in a similar manner to the antiplatelet drug acetylsalicylic acid. In terms of the coagulation cascade, only weak effects were found for some of the selected compounds, and the tested bisphenols did not impact coagulation or demonstrate erythrocytic toxicity at biologically achievable concentrations. Contrarily, the negative impact of bisphenol PH on platelets, with a possible subsequent risk of bleeding, might have biological relevance.

对双酚A毒性的认识意味着新的类似物的替代，而这些类似物的研究很少。我们测定了双酚A及其类似物8对血小板聚集、凝血的影响及其对红细胞的毒性。红细胞溶解实验显示双酚对高tc50 ~ 100μM的人和大鼠红细胞均有毒性。双酚A和双酚PH具有抗血小板作用。双酚PH对花生四烯酸基血小板聚集作用特别强（IC50为0.42±0.14μM; 0.16±0.05μg/ml）。机制上，双酚PH阻断环加氧酶1，与抗血小板药物乙酰水杨酸类似。在凝血级联方面，一些选定的化合物只发现了微弱的作用，并且在生物可达到的浓度下，所测试的双酚类物质不影响凝血或表现出红细胞毒性。相反，双酚PH值对血小板的负面影响，以及随后可能出现的出血风险，可能具有生物学相关性。

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引用次数: 0

Hazard identification and ecological risk assessment of pesticide exposure in wildlife using GPS telemetry: Case study on endangered Carnaby’s Cockatoos 基于GPS遥测技术的野生动物农药暴露危害识别与生态风险评估——以濒危物种卡纳比凤头鹦鹉为例

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-04 DOI: 10.1016/j.etap.2025.104894

Zoë M. Kissane , Kristin S. Warren , Lian Yeap , Jill M. Shephard

Wildlife toxicology faces increasing threats from pesticide use, yet the impacts on biodiversity remain unclear, as current toxicity thresholds often rely on laboratory data that do not reflect environmental exposure. Here we present a two-step methodology integrating ecotoxicology and movement ecology to investigate pesticide exposure in endangered Carnaby’s cockatoos (Zanda latirostris). Using GPS telemetry and satellite tracking, this study identified pesticide exposure sites and quantified the likelihood and consequences of exposure. A total of 26 pesticides were detected in forage sources (agricultural seed), with 80 % of seed samples having one or more pesticides detected. The Maximum Residue Limit (MRL) was exceeded for multiple pesticides including imidacloprid, thiamethoxam, clothianidin, difenoconazole and metalaxyl. Results have highlighted the risks that granivorous birds face being exposed to insecticides, herbicides, and fungicides in agroecosystems. This methodology is broad in scope and applicable across species, providing the ecological realism missing in laboratory-based studies.

野生动物毒理学面临着农药使用日益增加的威胁，但对生物多样性的影响尚不清楚，因为目前的毒性阈值往往依赖于实验室数据，而不能反映环境暴露。本文采用生态毒理学和运动生态学相结合的两步法研究了濒危物种卡纳比凤头鹦鹉的农药暴露情况。利用GPS遥测和卫星跟踪，本研究确定了农药暴露地点，并量化了暴露的可能性和后果。饲料源（农业种子）共检出26种农药，80%的种子样品检出一种或多种农药。吡虫啉、噻虫嗪、噻虫胺、异虫康唑、甲螨灵等多种农药均超过最大残留限量。研究结果强调了肉禽在农业生态系统中暴露于杀虫剂、除草剂和杀菌剂所面临的风险。这种方法范围广泛，适用于各种物种，提供了实验室研究中缺少的生态现实性。

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引用次数: 0

Crotonaldehde oral exposure disrupt cardiac energy metabolism and induces oxidative stress via down-regulation of nrf-2 and up-regulation of PPARα Crotonaldehde口服暴露通过下调nrf-2和上调ppar - α来破坏心脏能量代谢，诱导氧化应激

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-04 DOI: 10.1016/j.etap.2025.104892

Olufemi I. Oluranti , Bernard O. Adele , Abayomi O. Ige , Elsie O. Adewoye

Alterations in cardiac energy metabolic pathways have been linked to cardiac dysfunction. This study investigated cardiac energy metabolism in male rats exposed to crotonaldehyde. Thirty-six male Wistar rats (150–170 g; n = 9) were grouped into 4 (I-IV): Control (normal saline 10 mL/kg), crotonaldehyde (0.75, 1.5, and 2.5 mg/kg, p.o) for 28 days. Levels of creatinine-kinase-myocardial-band, cardiac-troponin-I, glucose increased significantly, while triglyceride, free-fatty-acid, and insulin reduced significantly in all groups compared with control. Cardiac Pyruvate level, hexokinase and pyruvate dehydrogenase activities increased significantly in all crotonaldehyde-treated groups compared with control. Cardiac levels of malondialdehyde and hydrogen-peroxide increased significantly, while glutathione and nuclear-factor-erythroid-2-related-factor-2 reduced; superoxide-dismutase and catalase activities decreased following crotonaldehyde exposure compared with control. Cardiac glucose-transporter-4 and peroxisome-proliferator-activated-receptor-alpha expression increased in groups III and IV, while carnitine-palmitoyltransferase1β expression decreased in group II but increased in groups III and IV compared with control. Crotonaldehyde exposure exerts cardio-toxic effects by altering cardiac energy metabolism.

心脏能量代谢途径的改变与心功能障碍有关。本研究对暴露于巴豆醛的雄性大鼠心脏能量代谢进行了研究。36只雄性Wistar大鼠（150 ~ 170g, n=9）分为4组（I-IV组）：对照组（生理盐水10mL/kg），巴豆醛（0.75、1.5、2.5mg/kg, p.o） 28 d。与对照组相比，所有组的肌酐-激酶-心肌带、心肌肌钙蛋白- 1、葡萄糖水平均显著升高，而甘油三酯、游离脂肪酸和胰岛素水平均显著降低。与对照组相比，各巴豆醛处理组心脏丙酮酸水平、己糖激酶和丙酮酸脱氢酶活性均显著升高。心肌丙二醛和过氧化氢水平显著升高，谷胱甘肽和核因子-红细胞-2相关因子-2降低；与对照相比，暴露于巴豆醛后，超氧化物歧化酶和过氧化氢酶活性降低。心肌葡萄糖转运体-4和过氧化物酶体-增殖物活化受体- α的表达在III组和IV组增加，而肉毒碱-棕榈酰基转移酶1β的表达在II组减少，而在III组和IV组与对照组相比增加。巴豆醛暴露通过改变心脏能量代谢产生心脏毒性作用。

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引用次数: 0

Evaluation of THC-induced neurotoxicity via oxidative stress in undifferentiated SH-SY5Y cells 通过氧化应激评价四氢大麻酚诱导未分化SH-SY5Y细胞的神经毒性

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-03 DOI: 10.1016/j.etap.2025.104891

A. Sanz-Pérez , B.J. Anaya , A.I. Fraguas-Sánchez , D.R. Serrano , T. Pérez , P. Basilicata , M. Pieri , E. González-Burgos

The increasing global consumption of cannabis, particularly high-THC products, has raised public health concerns due to potential neurotoxic effects, although its association with oxidative stress remains a subject of debated. Some studies link THC-rich cannabis to increased oxidative damage, while others highlight antioxidant properties of cannabinoids. This study aimed to evaluate whether THC concentrations observed in real-world scenarios, specifically in the blood of drivers involved in traffic accidents, can induce neuronal damage through oxidative stress in vitro. Human undifferentiated SH-SY5Y neuroblastoma cells were exposed to 0.66, 20, 73.75, and 150 ng/mL THC. High concentrations (73.75 and 150 ng/mL) significantly reduced cell viability (to 76.5 % and 64.6 % at 48 h) and caused morphological changes. THC exposure increased ROS, peaking at 116.5 % at 150 ng/mL, disrupted glutathione balance (GSH/GSSG ratio decreased by 69.2 %), and moderately increased lipid peroxidation (34.5 %). Activities of antioxidant enzymes (CAT, SOD, GR, GPx) declined concentration-dependently. Additionally, nuclear condensation and mitochondrial membrane depolarization indicated early apoptosis. These findings suggest that high THC levels can trigger neurotoxicity via oxidative stress and mitochondrial dysfunction.

全球大麻消费量的增加，特别是高四氢大麻酚产品，由于潜在的神经毒性作用引起了公众健康关注，尽管其与氧化应激的关系仍然是一个有争议的主题。一些研究将富含四氢大麻酚的大麻与氧化损伤增加联系起来，而另一些研究则强调大麻素的抗氧化特性。本研究旨在评估在现实场景中观察到的四氢大麻酚浓度，特别是在交通事故中驾驶员的血液中，是否可以通过体外氧化应激诱导神经元损伤。人未分化SH-SY5Y神经母细胞瘤细胞分别暴露于0.66、20、73.75和150 ng/mL四氢大麻酚中。高浓度（73.75和150 ng/mL）显著降低细胞活力（48 h时分别为76.5 %和64.6 %），并引起形态学改变。THC暴露增加了ROS，在150 ng/mL时达到116.5 %的峰值，破坏了谷胱甘肽平衡（GSH/GSSG比值降低了69.2 %），适度增加了脂质过氧化（34.5% %）。抗氧化酶（CAT、SOD、GR、GPx）活性呈浓度依赖性下降。核凝聚和线粒体膜去极化提示细胞早期凋亡。这些发现表明，高THC水平可以通过氧化应激和线粒体功能障碍引发神经毒性。

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引用次数: 0

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 DOI: 10.1016/j.etap.2025.104879

Chloé ML. Argoul , Pierre-Louis Toutain , Sarah Berard , Nicole Picard-Hagen , Véronique Gayrard , Marlène Z. Lacroix

Understanding interspecies and structure-based differences in the toxicokinetics of perfluoroalkyl substances (PFAS) is important to explain their persistence and improve health risk assessment. Since renal clearance is the main elimination pathway, this study measured the free (protein-unbound) fraction (f_u) of PFAS in human and mouse plasma using the Dianorm^R system, selected for its robustness and rapid equilibrium. Sixteen PFAS were tested, including perfluoroalkyl carboxylic acids (PFCA), sulfonic acids (PFSA), and ether derivatives (PFECA). Mean f_u values ranged from 0.21 % (PFOS) to 50 % (PFPeA) in mice and from 0.02 % (PFHpS) to 8.5 % (PFPeA) in humans. Interspecies differences were most pronounced for short-chain PFAS and PFECA, but not observed for longer chains. A U-shaped relationship between f_u and molecular weight (MW) was found, with the lowest values near 400–500 g/mol. These results highlight plasma protein binding as a key determinant of PFAS persistence and provide predictive models linking f_u to MW.

了解全氟烷基物质（PFAS）毒性动力学的种间差异和基于结构的差异对于解释其持久性和改进健康风险评估具有重要意义。由于肾脏清除是主要的清除途径，本研究使用DianormR系统测量了人类和小鼠血浆中PFAS的游离（蛋白未结合）部分（fu），该系统因其稳健性和快速平衡而被选择。测试了16种PFAS，包括全氟烷基羧酸（PFCA）、磺酸（PFSA）和醚衍生物（PFECA）。小鼠的平均fu值从0.21 % （PFOS）到50 % （PFPeA）不等，人类的平均fu值从0.02 % （PFHpS）到8.5 % （PFPeA）不等。短链PFAS和PFECA的种间差异最明显，而长链PFAS和PFECA的种间差异不明显。fu与分子量（MW）呈u型关系，最小值在400 ~ 500 g/mol附近。这些结果强调血浆蛋白结合是PFAS持久性的关键决定因素，并提供了将fu与MW联系起来的预测模型。

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引用次数: 0

A novel in vivo toxicity profiling of solid lipid nanoparticles (SLNPs) in Vicia faba seedlings as a plant model 固体脂质纳米颗粒（SLNPs）在蚕豆幼苗中作为植物模型的体内毒性分析。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 DOI: 10.1016/j.etap.2025.104873

Aml M. Abo Al-Saoud , Mohammed Nagib A. Hasaneen , Ali Noory Fajer , Ibrahim S. Kamel

Solid lipid nanoparticles (SLNPs) are emerging as promising nanocarriers for various therapeutic agents being used in medicine or agriculture. However, understanding their toxic effects is crucial for their safe application in drug delivery systems. Therefore, this study aimed to evaluate the phytotoxic and cyto-genotoxic effects of SLNPs. SLNPs were synthesized at a concentration of 5 g/100 ml, coded as R and diluted for testing its toxicity using Vicia faba as a bioindicator. V. faba seedlings were exposed to five concentrations of SLNPs (R:5 g/100 ml; 0.5 R: 2.5 g/100 ml, 0.25 R: 1.25 g/100 ml, 0.125 R: 0.63 g/100 ml and 0.0625 R: 0.31 g/100 ml) and control (distilled water). Parameters such as root growth and histology, catalase enzyme activity, mitotic index, chromosomal anomalies and apoptosis percentages besides cell cycle progression were assessed. Results discovered a concentration-dependent increase in phototoxic effect revealed by significant inhibition percentages in root length (15.08 %–45.25 %) at high levels of SLNPs (0.5 R: 2.5 g/100 ml and R: 5 g/100 ml). Moreover, histological observation indicated that concentrations above the dilution of 0.125 R of SLNPs induces various histological alterations as reduced root diameter and filling the metaxylem with parenchyma cells which might impair the uptake and transport of solutes adversely affect plant health and life. Theses alterations might adopt the significant increases in catalase enzyme activity in root tissue in dose-dependent manner. Significant mitotic index and cell viability reduction and alterations in cell cycle distribution especially the obvious DNA synthesis phase arrest at the concentration of 5 g/100 ml and increased frequency of chromosomal anomalies suggesting SLNPs cyto-genotoxicity. These findings concluded that SLNPs of 5 g/100 ml is toxic can have adverse effects on V. faba plant health. Further studies needed in this regard.

固体脂质纳米颗粒（SLNPs）是一种有前景的纳米载体，可用于医学和农业的各种治疗药物。然而，了解它们的毒性作用对于它们在药物输送系统中的安全应用至关重要。因此，本研究旨在评估SLNPs的植物毒性和细胞遗传毒性作用。以蚕豆为生物指示剂，以5g/100ml的浓度合成SLNPs，编码为R，稀释后检测其毒性。将蚕豆幼苗暴露于5种浓度的SLNPs （R:5g/100ml、0.5R: 2.5g/100ml、0.25R: 1.25g/100ml、0.125R: 0.63g/100ml和0.0625R: 0.31g/100ml）和对照（蒸馏水）中。除细胞周期进展外，还评估了根系生长和组织学、过氧化氢酶活性、有丝分裂指数、染色体异常和凋亡百分比等参数。结果发现，高水平SLNPs （0.5R: 2.5g/100ml和R: 5g/100ml）对根长抑制率（15.08% ~ 45.25%）呈浓度依赖性增加。此外，组织学观察表明，浓度高于0.125R的SLNPs会引起根直径减小、薄壁细胞填充等组织学改变，从而影响植物对溶质的吸收和运输，对植物的健康和寿命产生不利影响。这些变化可能表现为根组织过氧化氢酶活性呈剂量依赖性的显著增加。有丝分裂指数和细胞活力显著降低，细胞周期分布发生改变，特别是在浓度为5g/100ml时DNA合成阶段明显停滞，染色体异常频率增加，提示SLNPs具有细胞遗传毒性。这些结果表明，5g/100ml的SLNPs具有毒性，对蚕豆植株健康有不良影响。这方面需要进一步的研究。

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引用次数: 0

Environmental fate of illicit drugs and new psychoactive substances in aquatic systems: Impact, critical insights, and future directions 水生系统中非法药物和新型精神活性物质的环境命运：影响、关键见解和未来方向

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 DOI: 10.1016/j.etap.2025.104880

Akshita Verma, Samuel Sunday Ogunsola, Kaylyn A. Keith, G.D. Thouli L. Jayawardana

Illicit drugs and novel psychoactive substances (NPS) in aquatic environments pose growing ecological and public health concerns due to their persistence and toxicity. Released mainly via wastewater and runoff, their transport and fate are influenced by microbial degradation, hydrology, and bioaccumulation. These compounds have been detected in freshwater and marine ecosystems, causing endocrine disruption and toxicity in aquatic organisms, with potential human exposure through water and food. Advances in high-resolution mass spectrometry (HRMS) have improved their detection, while treatment technologies such as advanced oxidation, membrane filtration, and bioremediation are being developed to remove these residues. This review integrates findings from environmental chemistry, ecotoxicology, and public health to assess the sources, behavior, impacts, and mitigation of illicit drugs and NPS in aquatic systems. It highlights the complexity of these contaminants and identifies critical knowledge gaps that must be addressed to support effective monitoring, risk assessment, and regulatory strategies.

水生环境中的非法药物和新型精神活性物质由于其持久性和毒性而日益引起生态和公共卫生问题。它们主要通过废水和径流释放，其运输和命运受到微生物降解、水文和生物积累的影响。这些化合物已在淡水和海洋生态系统中被检测到，对水生生物造成内分泌干扰和毒性，人类可能通过水和食物接触到这些化合物。高分辨率质谱法（HRMS）的进步改善了它们的检测，同时正在开发高级氧化、膜过滤和生物修复等处理技术来去除这些残留物。本综述综合了环境化学、生态毒理学和公共卫生方面的研究成果，以评估水生系统中非法药物和NPS的来源、行为、影响和缓解措施。它强调了这些污染物的复杂性，并确定了必须解决的关键知识空白，以支持有效的监测、风险评估和监管战略。

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引用次数: 0

Long-term impact of oral gestational PM10 exposure on morris water maze performance and hippocampal gene expression 妊娠期口服PM10暴露对Morris水迷宫表现和海马基因表达的长期影响

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 DOI: 10.1016/j.etap.2025.104874

Ruiz-Sobremazas Diego , Coca Mario , Morales-Navas Miguel , Nerea Rios Nieto , Rodulfo-Cárdenas Rocío , Colomina Maria Teresa , López-Granero Caridad , Sanchez-Santed Fernando , Perez-Fernandez Cristian

Environmental exposure to air pollution, specially to particulate matter (PM) during pregnancy, plays a significant role in increasing the risk of neurodevelopmental disorders such as autism. This study investigated the long-term impact of oral gestational PM exposure (200 µg/kg/day) on memory in aged rats using the Morris Water Maze (MWM). After completing MWM, hippocampal tissue was collected and analyzed for gene expression. Our findings indicate that gestational PM exposure caused no major developmental alterations, aside from slightly poorer performance in the adherence test. No differences were detected in standard MWM manipulations, however, PM-offspring showed reduced latency in the test session, suggesting a possible compulsive-like behavior. Additionally, hippocampal gene expression revealed downregulation of several genes, including NMDA and GABAergic subunits. These effects depended on exposure and sex. The behavioral effects might reflect cognitive inflexibility linked to gene alterations. Further research is needed to clarify these outcomes.

环境暴露于空气污染，特别是在怀孕期间暴露于颗粒物（PM），在增加自闭症等神经发育障碍的风险方面发挥着重要作用。本研究通过Morris水迷宫（MWM）研究了妊娠期口服PM（200µg/kg/天）对老年大鼠记忆的长期影响。完成MWM后，收集海马组织进行基因表达分析。我们的研究结果表明，除了在依从性测试中的表现稍差外，妊娠期暴露于PM没有引起重大的发育改变。在标准的MWM操作中没有检测到差异，然而，pm后代在测试过程中表现出减少的延迟，这表明可能存在强迫行为。此外，海马基因表达显示包括NMDA和gaba能亚基在内的多个基因下调。这些影响取决于暴露程度和性别。行为影响可能反映了与基因改变有关的认知不灵活性。需要进一步的研究来澄清这些结果。

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引用次数: 0

The agony of choice: Advancing sediment hazard assessment by using avoidance behaviour assays with Lumbriculus variegatus 选择的痛苦：利用变异蚓的回避行为分析推进沉积物危害评估。

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology

Pub Date : 2025-12-01 DOI: 10.1016/j.etap.2025.104871

Jacqueline Hilgendorf , Vânia Calisto , Diogo N. Cardoso , Joana Fernandes , Diana L.D. Lima , José N. Pinto , Ana Eduardo Rodrigues , Jesper G. Sørensen , Érika M.L. Sousa , Susana Loureiro

Sediments play a key role in chemical partitioning in aquatic ecosystems, acting as sinks for lipophilic and persistent compounds. However, sediment hazard assessment is limited, often underestimating risks by focusing on short-term, lethal endpoints. Behavioural assays, although underused for sediment-dwellers, can provide faster, more sensitive assessments. This study adapted soil avoidance methods for sediment, testing avoidance in Lumbriculus variegatus exposed to lead, bixafen, and fluoxetine. We compared survival with conventional one-compartment (contaminated sediment only) and two-compartment (contaminated vs. control) assays. The two-compartment test detected significant avoidance at concentrations up to 428 times lower than survival and showed effects when conventional assays failed to detect any (e.g., for bixafen). It revealed significant responses at environmentally relevant levels (0.19 mg/kg fluoxetine, 550 mg/kg lead) and provided insights into chemical sensing and non-monotonic dose–response curves. Two-compartment avoidance assays are rapid, sensitive, and relevant for future sediment hazard assessments with potential population-level implications.

沉积物在水生生态系统的化学分配中起着关键作用，作为亲脂性和持久性化合物的汇。然而，沉积物危害评估是有限的，往往低估了风险，专注于短期，致命的终点。行为分析虽然在沉积物居民中没有得到充分利用，但可以提供更快、更敏感的评估。本研究采用了泥沙避土方法，测试了暴露于铅、比沙芬和氟西汀的杂色蚓避土方法。我们比较了传统的单室（仅污染沉积物）和双室（污染与对照）试验的生存率。双室试验检测到明显的逃避，浓度高达生存的428倍，并且在常规试验未能检测到任何（例如，对bixafen）时显示出效果。它揭示了环境相关水平（0.19mg/kg氟西汀，550mg/kg铅）的显著响应，并提供了对化学感应和非单调剂量-响应曲线的见解。双室避免分析快速、敏感，与未来沉积物危害评估相关，具有潜在的人口水平影响。

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引用次数: 0