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Parathyroid adenoma in a 15-year-old girl with recurrent urolithiasis 15岁女孩复发性尿石症的甲状旁腺瘤
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.23
Patrycja Kucaba, Katarzyna Dziadzio-Gąsior, R. Podlasek, P. Bar, B. Korczowski
Introduction and aim. The incidence of urolithiasis in children has been growing steadily for several decades, and it accounts for an increasing percentage of hospitalizations. Kidney stones are deposits of various mineral salts. Most of them are composed of calcium, favored by hypercalcemia and hypercalciuria. Primary hyperparathyroidism is one of the reasons for increased calcium levels in the blood. Description of the case. A 15-year-old girl was hospitalized due to recurrent urolithiasis. Investigations revealed hypercalcemia with elevated parathyroid hormone. Ultrasound of the thyroid gland showed a local change near the lower pole of its right lobe, and Sestamibi nuclear scan confirmed the presence of the adenoma of the lower right parathyroid gland. Surgical removal of the parathyroid gland with the present adenoma was performed. Calcium and phosphate homeostasis parameters and the kidneys’ ultrasound image were without any significant deviations from the norm. Conclusion. After finding the cause of recurrent urolithiasis, the applied surgical treatment resolved all disease manifestations.
介绍和目的。几十年来,儿童尿石症的发病率一直在稳步增长,在住院治疗中所占的比例也在不断上升。肾结石是各种矿物盐的沉积。它们大多由钙组成,以高钙血症和高钙尿症为主。原发性甲状旁腺功能亢进是血液中钙含量升高的原因之一。案件描述。一名15岁女孩因复发性尿石症住院。调查显示高钙血症伴甲状旁腺激素升高。甲状腺超声示右叶下极附近局部改变,Sestamibi核扫描证实右下甲状旁腺腺瘤。手术切除甲状旁腺与目前的腺瘤。钙、磷酸盐稳态参数及肾脏超声图像均无明显偏离正常值。结论。在发现复发性尿石症的原因后,应用手术治疗解决了所有疾病的表现。
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引用次数: 0
Care dependency in radiation oncology patients and related factors – a descriptive study 放射肿瘤学患者的护理依赖及其相关因素的描述性研究
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.10
Rukiye Burucu, Zehra Alanyalı, Huriye Öztürk
Introduction and aim. The incidence of cancer is increasing on a daily basis. One of the methods used for treatment is radiotherapy. Owing to interventions during the radiotherapy process, the patient may experience care dependency. In this study, the aim was to investigate care dependence and related factors in radiation oncology patients. Material and methods. This was a descriptive and cross-sectional study. Data were collected between September 2020 and September 2021. In the collection of data, a sociodemographic information form and a Care Dependency Scale were used. The sample consisted of 52 people. Results. Number of participants was 52, mean age was 60.25±11.715, mean care dependency score (initial) 66.19±18.966, mean care addiction score (final) 66.27±22.795. Conclusion. The care dependency of patients hospitalized in the radiation oncology clinic is moderate. The care dependency of these patients decreased partially during their stay in the clinic. The patient’s inability to walk, speak and the presence of a companion affected the patient’s condition. By evaluating the care dependency levels of the patients, the awareness of the nurses about their patients can be increased. In addition, it may be appropriate to consider the care dependency levels of the patients for the nurse workforce planning to work in the oncology clinic.
介绍和目的。癌症的发病率每天都在增加。治疗方法之一是放射治疗。由于放疗过程中的干预,患者可能会出现护理依赖。本研究旨在探讨放射肿瘤患者的护理依赖及其相关因素。材料和方法。这是一项描述性和横断面研究。数据收集于2020年9月至2021年9月。在收集数据时,使用了社会人口学信息表和护理依赖量表。样本由52人组成。结果。受试者人数52人,平均年龄60.25±11.715岁,平均护理依赖评分(初始)66.19±18.966分,平均护理成瘾评分(终)66.27±22.795分。结论。放射肿瘤学门诊住院患者的护理依赖程度中等。这些患者在住院期间的护理依赖性部分下降。病人不能走路、说话和陪伴的存在影响了病人的病情。通过对患者护理依赖程度的评估,可以提高护士对患者的认识。此外,考虑病人的护理依赖程度可能是合适的,因为护士队伍计划在肿瘤诊所工作。
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引用次数: 0
The effect of weight loss on serum ceruloplasmin levels in obese patients 减肥对肥胖患者血清铜蓝蛋白水平的影响
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.5
Ece Yiğit, Ilknur Sayar
Introduction and aim. Serum ceruloplasmin level may be a biomarker associated with obesity and cardiovascular risk. We aimed to evaluate the effect of body weight lost by diet and exercise program on metabolic parameters and serum ceruloplasmin levels in obese patients. Material and methods. A total of 120 obese patients with BMI ≥30 kg/m 2 were enrolled in a 16-week balanced diet program with the goal of losing 10% or more of body weight while maintaining a daily energy deficit of 500-1000 kcal/day. Results. Mean weights of the patients decreased from 93.2±15.1 kg to 83.2±13.1 kg (p<0.001) and mean BMI decreased from 35.8±5.6 kg/m 2 to 31.9±4.9 kg/m 2 (p<0.001). Mean ceruloplasmin decreased from 25.2±4.7 mg/dL to 23.6±4.9 mg/dL (p<0.001), mean total cholesterol from 191.8±37.1 mg/dL to 153.8±28.7 mg/dL (p<0.001), mean LDL from 120.3±31.4 mg/dL to 91.1±27.7 mg/dL (p<0.001) and mean fasting blood glucose from 108.2±35 mg/dL to 103.3±81.1 mg/dL (p<0.001). There was a statistically significant and weak correlation between the change in ceruloplasmin and the change in BMI (p=0.016, R=0.233). There was a statistically significant and weak correlation between ceruloplasmin change and weight change (p=0.010, R=0.251). Conclusion. Obese patients’ serum ceruloplasmin levels were found to decrease with weight loss.
介绍和目的。血清铜蓝蛋白水平可能是与肥胖和心血管风险相关的生物标志物。我们的目的是评估饮食和运动减肥对肥胖患者代谢参数和血清铜蓝蛋白水平的影响。材料和方法。共有120名BMI≥30 kg/ m2的肥胖患者参加了为期16周的均衡饮食计划,目标是体重减轻10%或更多,同时保持每日能量赤字500-1000 kcal/天。结果。患者平均体重由93.2±15.1 kg降至83.2±13.1 kg (p<0.001),平均BMI由35.8±5.6 kg/ m2降至31.9±4.9 kg/ m2 (p<0.001)。平均铜蓝蛋白由25.2±4.7 mg/dL降至23.6±4.9 mg/dL (p<0.001),平均总胆固醇由191.8±37.1 mg/dL降至153.8±28.7 mg/dL (p<0.001),平均LDL由120.3±31.4 mg/dL降至91.1±27.7 mg/dL (p<0.001),平均空腹血糖由108.2±35 mg/dL降至103.3±81.1 mg/dL (p<0.001)。铜蓝蛋白的变化与BMI的变化有统计学意义,相关性较弱(p=0.016, R=0.233)。铜蓝蛋白变化与体重变化呈弱相关,差异有统计学意义(p=0.010, R=0.251)。结论。肥胖患者血清铜蓝蛋白水平随体重减轻而降低。
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引用次数: 0
Anemia – a scourge to maternal and child development in Bihar, India 贫血——印度比哈尔邦孕产妇和儿童发展的一大祸害
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.22
S. Nirala, R. Rao, B. Naik, S. Patil, M. Verma, C. Singh, S. Pandey
Introduction and aim. Anemia remains a leading contributor to years lived with disability (YLDs), being responsible for 50.3 million (5.82%) YLDs worldwide and 19.3 million (12.03%) YLDs in India, respectively. Results of the National Family Health Survey 2019-2021 (NFHS-5) suggest a high burden of anemia in India among women of reproductive age and children aged 6-59 months at the national level (57%, 67.1%), and in the state of Bihar, India (63.5%, 69.4%). Iron deficiency is the leading cause, accounting for more than half the cases. Anemia bodes harmful implications for both the mother and child, with long-lasting consequences for the latter. Anemia control programs have yielded little benefit despite efforts stretching over five decades. This narrative review aims to highlight the burden of anemia and the probable factors behind it among under-5 children and women of reproductive age in the Indian state of Bihar. Material and methods. The paper is a narrative review. The following databases were used to search and select literature: PubMed, Web of Science, Scopus, and Google Scholar. In addition, the websites of relevant government departments and national health programs were searched for pertinent material. Analysis of the literature. A multitude of reasons seem to be behind the unabated high prevalence in Bihar: low socioeconomic status, gender disparities, traditional customs and practices, food insecurity, lack of diverse diets, poor consumption, and no adherence to iron and folic acid (IFA) supplements, groundwater contamination with arsenic and fluoride, and supply chain mismanagement, all playing roles of varying degree. Conclusion. An all-encompassing approach and not merely the provision of IFA supplements are necessary to unravel the intricate web of factors that lead to anemia.
介绍和目的。贫血仍然是导致残疾年数(YLDs)的主要原因,在全球和印度分别造成5030万(5.82%)和1930万(12.03%)残疾年数。2019-2021年全国家庭健康调查(NFHS-5)的结果显示,印度育龄妇女和6-59个月儿童的贫血负担很高,在全国范围内(57%,67.1%),在印度比哈尔邦(63.5%,69.4%)。缺铁是主要原因,占一半以上的病例。贫血对母亲和孩子都有有害的影响,对后者有长期的影响。尽管经过了50多年的努力,贫血控制项目收效甚微。本综述旨在强调印度比哈尔邦5岁以下儿童和育龄妇女贫血的负担及其可能的原因。材料和方法。这篇论文是一篇叙述性评论。以下数据库用于检索和选择文献:PubMed, Web of Science, Scopus和Google Scholar。此外,我们还在相关政府部门和国家卫生项目的网站上搜索了相关资料。文献分析。造成比哈尔邦发病率居高不下的原因似乎有很多:低社会经济地位、性别差异、传统习俗和做法、粮食不安全、缺乏多样化饮食、消费不良、不坚持补充铁和叶酸(IFA)、地下水被砷和氟化物污染、供应链管理不善,所有这些都在不同程度上发挥了作用。结论。要解开导致贫血的错综复杂的因素网,有必要采取包罗万象的方法,而不仅仅是提供IFA补充剂。
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引用次数: 0
Pandemic awareness and caring behaviors of nurses working in intensive care unit – a multicenter study 重症监护室护士的流行病意识和护理行为——一项多中心研究
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.18
B. Demir, Sevda Türen, D. Doğan
Introduction and aim. In the COVID-19 pandemic, which is a global threat, the awareness levels of intensive care nurses who meet all the care needs of patients can affect the quality of care. In this study, pandemic awareness and care behaviors of nurses who undertook the patient’s care needs in intensive care units were examined. Material and methods. The research was carried out with 317 nurses working critical care units of 12 hospitals in different provinces. “Nurse Characteristics Form”, “Pandemic Awareness Scale” and “Caring Behaviors Inventory-24” were used as data collection tools. Data were collected between March and August 2022 in the middle of the COVID-19 pandemic process using an online survey. Results. It was determined that 75.4% of the participants were female and the mean age was 25.56±4.49. Pandemic awareness scale score was 3.04±0.62 (0.11-3.67) and caring behaviors inventory score was 5.48±0.84 (1.00-6.00). A significant, positive, weak relationship was found between nurses’ pandemic awareness and all sub-dimensions of caring behaviors (p≤ 0.05). Conclusion. It was seen that the caring behaviors of nurses with high pandemic awareness were also positively affected. Although it was the first time they had experienced the pandemic, nurses were found to have good caring behaviors.
介绍和目的。在COVID-19大流行这一全球性威胁中,满足患者所有护理需求的重症监护护士的意识水平会影响护理质量。在本研究中,研究了在重症监护室承担病人护理需求的护士的大流行意识和护理行为。材料和方法。研究人员对不同省份12家医院重症监护室的317名护士进行了调查。采用“护士特征表”、“流行病意识量表”和“关爱行为量表-24”作为数据收集工具。数据是在2022年3月至8月COVID-19大流行期间通过在线调查收集的。结果。75.4%的参与者为女性,平均年龄为25.56±4.49岁。流行病意识量表得分为3.04±0.62(0.11 ~ 3.67)分,关怀行为量表得分为5.48±0.84(1.00 ~ 6.00)分。护士流行病意识与护理行为各子维度呈显著、正、弱相关(p≤0.05)。结论。结果表明,具有高流行病意识的护士的护理行为也受到积极影响。虽然这是他们第一次经历大流行,但发现护士有良好的护理行为。
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引用次数: 0
The interaction of synbiotic of the environment and the endoecosystem as one of the mechanisms of action of balneotherapy 环境与内生态系统的相互作用是生物疗法的作用机制之一
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.26
I. Popovych, W. Zukow, V. Fil, H.Y. Kovalchuk, I. Bryndzia, O. Voloshyn, Iryna Y. Kopko, O. Lupak, T. Skrobach
Introduction and aim. Drinking mineral waters are one of the environmental factors that affect the condition of the human body. Of particular interest are therapeutic waters of the Naftussya type, which contain autochthonous microbes and organic oil-like substances and can be considered as a kind of ecosystem. On the other hand, gastrointestinal tract also is an ecosystem that associates a resident microbiota and cells of various phenotypes lining the epithelial wall. We assumed that one of the mechanisms of the therapeutic effect of Naftussya water is the interaction of external and internal ecosystems. This article is the first in a series in support of the hypothesis. Material and methods. The object of clinical-physiological observation were residents of the city of Truskavets’ (21 men aged 24-67 years and 8 women 33-76 years) with chronic pyelonephritis in remission. The objects of study: leukocyturia, bacteriuria, components of microbiota, phagocytosis function of neutrophils, leukocytary adaptation index, plasma and urine electrolytes and nitrogenous metabolites. Results. The weekly use of bioactive Naftussya water from the Opaka deposit causes a favorable normalizing effect on the stool microbiota: it increases the reduced content of Bifidobacteria and Lactobacilli, instead it reduces the increased content of pathogenic strains of Escherichia coli, as well as Klebsiela and Proteus. Reduction of dysbacteriosis is accompanied by an increase in the reduced bactericidal capacity of blood neutrophils against E. coli and Staphylococcus aureus, and reduction of bacteriuria and leukocyturia. At the same time, the elevated level of creatinine in the plasma decreases, instead, the decreased levels of sodium and chloride increase. As expected, the daily diuresis and excretion of urea, creatinine, phosphates, calcium, magnesium and chloride increases, but not sodium and uric acid, the concentrations of which in the urine decrease. The described physiologically beneficial effects are interpreted as adaptogenic, which is confirmed by an increase in the reduced leukocyte adaptation index. Conclusion. The healing effect of Naftussya bioactive water is the result of the interaction of external and internal ecosystems. The next article will consider the role of the nervous and endocrine systems in this interaction.
介绍和目的。饮用矿泉水是影响人体状况的环境因素之一。特别令人感兴趣的是纳夫图西亚类型的治疗水,它含有本地微生物和有机油样物质,可以被认为是一种生态系统。另一方面,胃肠道也是一个生态系统,它将常驻微生物群和各种表型的细胞联系在一起,排列在上皮壁上。我们假设Naftussya水的治疗效果的机制之一是外部和内部生态系统的相互作用。本文是支持这一假设的系列文章中的第一篇。材料和方法。临床生理观察对象为特鲁斯卡韦茨市慢性肾盂肾炎缓解期居民(男性21例,年龄24-67岁,女性8例,年龄33-76岁)。研究对象:白细胞尿、细菌尿、微生物群组成、中性粒细胞吞噬功能、白细胞适应指数、血浆和尿液电解质、含氮代谢物。结果。每周使用来自Opaka沉积物的生物活性Naftussya水对粪便微生物群产生了良好的正常化效果:它增加了双歧杆菌和乳酸杆菌的减少含量,相反它减少了大肠杆菌致病性菌株以及克雷伯氏菌和变形杆菌的增加含量。细菌失调的减少伴随着血液中性粒细胞对大肠杆菌和金黄色葡萄球菌杀菌能力的降低,以及细菌尿和白细胞尿的减少。同时,血浆中升高的肌酐水平降低,而降低的钠和氯化物水平升高。如预期的那样,尿中尿素、肌酐、磷酸盐、钙、镁和氯化物的每日利尿和排泄增加,但钠和尿酸没有增加,它们在尿液中的浓度下降。所描述的生理上的有益作用被解释为适应原性的,这被降低的白细胞适应指数的增加所证实。结论。Naftussya生物活性水的治疗效果是外部和内部生态系统相互作用的结果。下一篇文章将考虑神经系统和内分泌系统在这种相互作用中的作用。
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引用次数: 1
Global risks of endometriosis in women – an appraisal 女性子宫内膜异位症的全球风险评估
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.27
Chhandika Roy, N. Mondal
Introduction and aim. Endometriosis is a complex condition in which endometrium, tissue that resembles the uterine lining, develops outside the uterus. It is considered to be a chronic, estrogen-dependent, inflammatory gynecological disorder having multi-factorial origins. This review paper aims to consolidate recent information on ethnic differences, endometriosis risks, and the disease’s etiology in the global context. Material and methods. A systematic search was performed using a variety of international electronic databases, including “PubMed” and “DOAJ”, using the terms endometriosis, endometriosis and infertility, endometriosis and cancer, and treatment of endometriosis. Analysis of the literature. Endometriosis can appear anywhere in the body, including the umbilicus, the cecum and ileum of the digestive tract, the breast, the lungs, and the genitourinary organs. It is typically clinically asymptomatic with no obvious clinical manifestation and expensive treatment, which makes the diagnosis late. There is a complex interplay between socioeconomic status, family history, societal beliefs and laws, personal habits, reproductive and gynaecological conditions, and environmental influences in the development of endometriosis. Conclusion. Women with endometriosis should be given more attention, and specific resources in the healthcare system should be utilized to provide more efficient multidisciplinary healthcare and treatment.
介绍和目的。子宫内膜异位症是一种复杂的情况,子宫内膜,类似于子宫内膜的组织,在子宫外发育。它被认为是一种慢性,雌激素依赖,炎症性妇科疾病有多因素的起源。这篇综述的目的是在全球范围内整合关于种族差异、子宫内膜异位症风险和疾病病因的最新信息。材料和方法。使用包括“PubMed”和“DOAJ”在内的各种国际电子数据库进行系统检索,检索术语为子宫内膜异位症、子宫内膜异位症与不孕症、子宫内膜异位症与癌症以及子宫内膜异位症的治疗。文献分析。子宫内膜异位症可以出现在身体的任何部位,包括脐部、消化道盲肠和回肠、乳房、肺部和泌尿生殖器官。典型临床无明显临床表现,治疗费用昂贵,诊断较晚。在子宫内膜异位症的发展过程中,社会经济地位、家族史、社会信仰和法律、个人习惯、生殖和妇科状况以及环境影响之间存在复杂的相互作用。结论。应给予子宫内膜异位症妇女更多的关注,并应利用卫生保健系统的特定资源,提供更有效的多学科卫生保健和治疗。
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引用次数: 1
Progestins and combined oral contraceptives in the hormonal treatment of endometriosis – a review 孕激素联合口服避孕药治疗子宫内膜异位症综述
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.21
Kornelia Rojek
Introduction and aim. Endometriosis is a common inflammatory disease affecting 6-10% of women of reproductive age. It is defined as the growth of endometrial-like tissue outside the uterine cavity. Dysmenorrhea, pelvic pain, dyspareunia and infertility are the main symptoms of endometriosis patients. Endometriosis treatment methods can be broadly divided into surgical and pharmacological. Currently, hormonal drugs are often used for women with endometriosis to relieve bothersome symptoms. The aim of this article is to review new publications presenting the effectiveness as well as side effects of the use of progestins and combined oral contraceptives in the hormonal treatment of endometriosis. Material and methods. A review of the literature regarding progestins and combined oral contraceptives in the treatment of endometriosis was performed using the PubMed database. In the end, 67 articles were included in this review. Analysis of the literature. Progestins and combined oral contraceptives significantly reduce dysmenorrhea, dyspareunia and pelvic pain in women with endometriosis. However, there is a risk of potential side effects, which should be taken into account when choosing a therapy for each patient individually. Conclusion. Endometriosis is a chronic disease that has a significant impact on the health-related quality of life of patients. When choosing a treatment, many aspects should be considered, primarily the patient’s preferences, drug tolerance and safety. Further drug research is needed to determine the most effective treatment for endometriosis.
介绍和目的。子宫内膜异位症是一种常见的炎症性疾病,影响6-10%的育龄妇女。它被定义为子宫腔外生长的子宫内膜样组织。痛经、盆腔疼痛、性交困难、不孕症是子宫内膜异位症患者的主要症状。子宫内膜异位症的治疗方法大致可分为手术治疗和药物治疗。目前,激素药物常用于子宫内膜异位症患者,以缓解令人烦恼的症状。本文的目的是回顾新的出版物提出的有效性和副作用的使用黄体酮和联合口服避孕药在激素治疗子宫内膜异位症。材料和方法。使用PubMed数据库对有关孕激素和联合口服避孕药治疗子宫内膜异位症的文献进行了回顾。最终纳入67篇文献。文献分析。孕激素和联合口服避孕药可显著减少子宫内膜异位症患者的痛经、性交困难和盆腔疼痛。然而,存在潜在副作用的风险,在为每个患者单独选择治疗方法时应考虑到这一点。结论。子宫内膜异位症是一种慢性疾病,对患者的健康相关生活质量有重大影响。在选择一种治疗方法时,应考虑许多方面,主要是患者的偏好、药物耐受性和安全性。需要进一步的药物研究来确定子宫内膜异位症最有效的治疗方法。
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引用次数: 0
Effects of core-stabilization and trunk balance exercises on clinical parameters in patients with non-specific chronic low back pain – a randomized pilot study 核心稳定和躯干平衡运动对非特异性慢性腰痛患者临床参数的影响——一项随机先导研究
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.15
O. Fapojuwo, A. Akodu, Adurayemi Esther Ositelu
Introduction and aim. This study compared the efficacy of core stabilization (CSE) and trunk balance exercises (TBE) with flexibility training on pain-related disability (PRD), psychological status (PS) and fear avoidance belief (FAB) in patients with non-specific chronic low back pain (NSCLBP). Material and methods. Twenty-eight (28) participants diagnosed of NSCLBP were randomly assigned into CSE, TBE, and control groups (CG). Participants in CSE (n=10); TBE (n=8) and CG groups (n=10) received core stabilization exercise, trunk balance exercise and back care advice respectively. All participants received flexibility training in addition to treatment in their respective groups. Assessment of outcomes were done at baseline, end of 4 th and 8 th week. Results. There was significant improvement in all outcomes in the CSE, TBE and CG at 8 weeks; PRD (p=0.005, p=0.008, p=0.005), PS: depression (p=0.005, p=0.008, p=0.007); anxiety (p=0.005, p=0.007) and FAB about work (p=0.005, p=0.007, p=0.005); about physical activity (p=0.005, p=0.018, p=0.006). Comparison of outcomes between CSE and TBE groups showed no significant difference (p>0.05) Conclusion. Both CSE and TBE with flexibility training are effective in improving PRD, PS and FAB of patients with NSCLBP.
介绍和目的。本研究比较了核心稳定(CSE)和躯干平衡练习(TBE)与柔韧性训练对非特异性慢性腰痛(NSCLBP)患者疼痛相关残疾(PRD)、心理状态(PS)和恐惧回避信念(FAB)的影响。材料和方法。28名确诊为NSCLBP的参与者被随机分为CSE组、TBE组和对照组(CG)。CSE受试者(n=10);be组(n=8)和CG组(n=10)分别进行核心稳定训练、躯干平衡训练和背部护理建议。所有的参与者在各自小组的治疗之外都接受了柔韧性训练。在基线、第4周和第8周结束时进行结果评估。结果。8周时,CSE、TBE和CG的所有结果均有显著改善;PRD (p=0.005, p=0.008, p=0.005), PS:抑郁症(p=0.005, p=0.008, p=0.007);焦虑(p=0.005, p=0.007)和对工作的焦虑(p=0.005, p=0.007, p=0.005);关于体力活动(p=0.005, p=0.018, p=0.006)。CSE组与TBE组预后比较,差异无统计学意义(p>0.05)。CSE和TBE配合柔韧性训练均能有效改善非慢性粒细胞性bp患者的PRD、PS和FAB。
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引用次数: 0
p-Coumaric acid as a potent additive in blood storage solution 对香豆酸作为血液储存液的有效添加剂
Pub Date : 2023-06-01 DOI: 10.15584/ejcem.2023.2.24
Magdaline Christina Rajanand, Carl Hsieh, M. Pallavi, Ashabaree Nayak, M. John, Shivangi Malik, Vaishnavi Vempati, Yasmin Thacker Thacker, Vani Rajashekaraiah
Introduction and aim. Stored erythrocytes develop lesions involving changes in their structure and function reducing their efficacy. Oxidative Stress (OS) being one of the main causes of storage lesion, can be attenuated by antioxidants as additives in the storage solution. This study aims to evaluate the effect of p-Coumaric acid (CA) on erythrocytes during whole blood storage. Material and methods. Blood collected from Male Wistar rats was stored at 4°C in CPDA-1 solution for 21 days. Blood samples were stored with and without 1mM CA (CA 1) and 10 mM CA (CA 10). The erythrocytes were isolated every week during storage and the biomarkers for OS and antioxidant status were analysed. Results. Superoxide dismutase and catalase elevated on day 14. Conjugate dienes decreased in CA 10 on day 14. Thiobarbituric acid reactive substances increased on day 7 and decreased on day 14 in CA groups. Protein sulfhydryls decreased in controls and CA 1 on day 14 whereas, it was maintained in CA 10. Conclusion. Coumaric acid upregulated the antioxidant enzymes and protected the cells from oxidative damage. Thus, coumaric acid can be employed as a potent additive during storage and opens new avenues of employing it in similar OS situations in erythrocytes.
介绍和目的。储存的红细胞发生病变,包括其结构和功能的改变,降低了其功效。氧化应激是造成贮藏损伤的主要原因之一,在贮藏液中加入抗氧化剂可以减轻氧化应激。本研究旨在评价对香豆酸(CA)在全血储存过程中对红细胞的影响。材料和方法。雄性Wistar大鼠采集的血液在4°C CPDA-1溶液中保存21天。血液标本分别加入1mM CA (ca1)和不加入10mm CA (ca10)保存。储存期间每周分离红细胞,分析其OS和抗氧化状态的生物标志物。结果。第14天超氧化物歧化酶和过氧化氢酶升高。第14天ca10的共轭二烯含量下降。CA组硫代巴比妥酸活性物质在第7天升高,第14天降低。对照组和ca1的蛋白质巯基含量在第14天下降,而ca10则保持不变。结论。香豆酸上调抗氧化酶,保护细胞免受氧化损伤。因此,香豆酸可以作为一种有效的添加剂在储存过程中,并开辟了新的途径,在类似的情况下使用它在红细胞的OS。
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European Journal of Clinical and Experimental Medicine
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