Pub Date : 2024-03-30DOI: 10.15584/ejcem.2024.1.19
Sudha K., Jerin James, P. Natarajan, Sundara Pandian Subramanian
Introduction and aim. Cadaveric dissection is the mainstay of learning anatomy by medical students. Even though newer teaching learning methodologies have been implemented to facilitate learning anatomy, cadaveric dissection remains the most preferred method by students. The objective of this study was to analyze the student perspective of different aspects of learning anatomy with their positive and negative experiences and to get a better understanding of their opinions and their experience. Material and methods. In this cross-sectional study, a pretested and validated questionnaire was used to collect information from the students after approval from the Institutional Ethics Committee. Informed consent was obtained from every student prior to their participation in the study. Results. Three hundred seventy-seven students took part in this study and the response rate obtained was 63.5%. The majority of the students stated that cadaveric dissection has helped them in learning basic anatomy and had deepened their under standing of complexity of human body and has helped in better performance in clinical applications. The smell of formalde hyde and eye irritation was cited as the major reasons for finding dissection sessions challenging. Most of the students agreed that counselling before dissection sessions will help to alleviate the emotional reactions to cadavers. Conclusion. The students unanimously agreed that cadaveric dissection sessions are the best way to learn basic anatomy com plemented with newer teaching tools like prosection and computer-based approaches. However, the problems encountered by the students like smell and irritation of formaldehyde need to be addressed with usage of alternative techniques.
{"title":"Unveiling challenges in cadaveric dissection for medical education – a study of student perspectives","authors":"Sudha K., Jerin James, P. Natarajan, Sundara Pandian Subramanian","doi":"10.15584/ejcem.2024.1.19","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.19","url":null,"abstract":"Introduction and aim. Cadaveric dissection is the mainstay of learning anatomy by medical students. Even though newer teaching learning methodologies have been implemented to facilitate learning anatomy, cadaveric dissection remains the most preferred method by students. The objective of this study was to analyze the student perspective of different aspects of learning anatomy with their positive and negative experiences and to get a better understanding of their opinions and their experience. Material and methods. In this cross-sectional study, a pretested and validated questionnaire was used to collect information from the students after approval from the Institutional Ethics Committee. Informed consent was obtained from every student prior to their participation in the study. Results. Three hundred seventy-seven students took part in this study and the response rate obtained was 63.5%. The majority of the students stated that cadaveric dissection has helped them in learning basic anatomy and had deepened their under standing of complexity of human body and has helped in better performance in clinical applications. The smell of formalde hyde and eye irritation was cited as the major reasons for finding dissection sessions challenging. Most of the students agreed that counselling before dissection sessions will help to alleviate the emotional reactions to cadavers. Conclusion. The students unanimously agreed that cadaveric dissection sessions are the best way to learn basic anatomy com plemented with newer teaching tools like prosection and computer-based approaches. However, the problems encountered by the students like smell and irritation of formaldehyde need to be addressed with usage of alternative techniques.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"32 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.15584/ejcem.2024.1.12
A. B. Ahmed, Purbajit Chetia
Introduction and aim. Rheumatoid arthritis (RA) causes pain, inflammation, and deformities in numerous joints. Monoamine oxidase B (MOA-B) inhibitor selegiline exhibits anti-inflammatory characteristics and has the propensity to scavenge free radicals. Therefore, the aim of this research comprises of assessing the effect of selegiline on proinflammatory cytokines in RAW 264.7 macrophages as well as its capacity to improve various arthritic parameters in rats with lipopolysaccharide (LPS) accelerated complete Freund’s adjuvant (CFA) induced RA. Material and methods. In RAW 264.7 cells (lipopolysaccharide accelerated), nitric oxide (NO), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and prostaglandin E2 (PGE2 ) were determined after treat ment with selegiline. Different arthritic parameters were analyzed after administration of selegiline in LPS accelerated CFA-induced arthritis in rats. Results. LPS escalates NO, TNF-α, IL-6, iNOS, and PGE2 quantities in the RAW 264.7 cells, which was minimized by selegiline at 100 µg/mL and 150 µg/mL respectively. In rats, CFA induction causes a decrease in body weight, elevation of paw volume, splenic index, and arthritic index, which are further accelerated by LPS. 20 mg/kg of selegiline managed all these arthritic parameters effectively, including TNF-α, IL-6, and a few other biochemical parameters. Conclusion. Selegiline may be beneficial in RA extenuating joint and cartilage damage, and modulating inflammatory responses.
导言和目的。类风湿性关节炎（RA）会导致许多关节疼痛、发炎和畸形。单胺氧化酶 B（MOA-B）抑制剂西格列汀具有抗炎特性和清除自由基的倾向。因此，本研究旨在评估西格列汀对 RAW 264.7 巨噬细胞中的促炎细胞因子的影响，以及其改善脂多糖（LPS）加速完全弗氏佐剂（CFA）诱导的大鼠 RA 的各种关节炎参数的能力。材料与方法使用西格列汀治疗后，测定 RAW 264.7 细胞（脂多糖加速）中的一氧化氮（NO）、肿瘤坏死因子α（TNF-α）、白细胞介素 6（IL-6）、诱导型一氧化氮合酶（iNOS）和前列腺素 E2（PGE2）。在 LPS 加速 CFA 诱导的大鼠关节炎中使用西格列汀后，对不同的关节炎参数进行了分析。结果显示LPS 使 RAW 264.7 细胞中的 NO、TNF-α、IL-6、iNOS 和 PGE2 数量增加，西格列汀分别以 100 微克/毫升和 150 微克/毫升的剂量将其降到最低。在大鼠体内，CFA 诱导会导致体重下降、爪体积增大、脾指数和关节炎指数升高，而 LPS 会进一步加速这些变化。20 毫克/千克的西格列汀可有效控制所有这些关节炎指标，包括 TNF-α、IL-6 和其他一些生化指标。结论西格列汀对减轻关节和软骨损伤、调节炎症反应可能有益。
{"title":"Selegiline modulates inflammatory indicators in RAW 264.7 macrophages and LPS-aggravated CFA-induced rheumatoid arthritis in rats","authors":"A. B. Ahmed, Purbajit Chetia","doi":"10.15584/ejcem.2024.1.12","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.12","url":null,"abstract":"Introduction and aim. Rheumatoid arthritis (RA) causes pain, inflammation, and deformities in numerous joints. Monoamine oxidase B (MOA-B) inhibitor selegiline exhibits anti-inflammatory characteristics and has the propensity to scavenge free radicals. Therefore, the aim of this research comprises of assessing the effect of selegiline on proinflammatory cytokines in RAW 264.7 macrophages as well as its capacity to improve various arthritic parameters in rats with lipopolysaccharide (LPS) accelerated complete Freund’s adjuvant (CFA) induced RA. Material and methods. In RAW 264.7 cells (lipopolysaccharide accelerated), nitric oxide (NO), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and prostaglandin E2 (PGE2 ) were determined after treat ment with selegiline. Different arthritic parameters were analyzed after administration of selegiline in LPS accelerated CFA-induced arthritis in rats. Results. LPS escalates NO, TNF-α, IL-6, iNOS, and PGE2 quantities in the RAW 264.7 cells, which was minimized by selegiline at 100 µg/mL and 150 µg/mL respectively. In rats, CFA induction causes a decrease in body weight, elevation of paw volume, splenic index, and arthritic index, which are further accelerated by LPS. 20 mg/kg of selegiline managed all these arthritic parameters effectively, including TNF-α, IL-6, and a few other biochemical parameters. Conclusion. Selegiline may be beneficial in RA extenuating joint and cartilage damage, and modulating inflammatory responses.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"41 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuying Ren, Fangming Deng, Zhongdong Du, Xiaodong Yang, Lijian Xie, Hong Wang, Fuyong Jiao
Introduction and aim. Kawasaki disease (KD) is an acute vasculitis with unknown etiology, usually occurring in chil dren under 5 years old. This article will summarize the three consensuses formulated in China about KD. Material and methods. English databases for consensus search include UpToDate, BMJ Clinical Evidence, National Guideline Clearinghouse, Joanna Briggs Institute Library, Cochrane Library, and PubMed, etc.; Chinese databases in clude China Biomedical Literature Service, China Knowledge Network, Wanfang database, etc. All literature searches ended on February 28, 2022. Analysis of the literature. KD is a common acquired heart disease in children and can lead to severe complications such as coronary injury. However, intravenous immunoglobulin (IVIG) combined with oral aspirin (Asp) is currently recognized as the most effective treatment in KD acute stage and the first-line treatment to prevent cardiovascular complications. Glucocorticoid (GC) is mainly used for KD patients with a high risk of coronary artery aneurysm (CAA), no immunoglobulin response, and confirmed CAA. There are already consensus guidelines on diagnosing and treat ing KD in different countries. This article summarizes the relevant expert consensus on aspirin, glucocorticoids and IVIG for the treatment of Kawasaki disease in China. Conclusion. Still, there are inconsistent opinions in the literature on the mechanism, optimal timing, and dosage of medication for KD.
{"title":"Consensus Committee of experts on Kawasaki Disease and Chinese Journal of Contemporary Pediatrics – the expert consensuses on intravenous immunoglobulin, aspirin, and glucocorticoid","authors":"Shuying Ren, Fangming Deng, Zhongdong Du, Xiaodong Yang, Lijian Xie, Hong Wang, Fuyong Jiao","doi":"10.15584/ejcem.2024.1.8","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.8","url":null,"abstract":"Introduction and aim. Kawasaki disease (KD) is an acute vasculitis with unknown etiology, usually occurring in chil dren under 5 years old. This article will summarize the three consensuses formulated in China about KD. Material and methods. English databases for consensus search include UpToDate, BMJ Clinical Evidence, National Guideline Clearinghouse, Joanna Briggs Institute Library, Cochrane Library, and PubMed, etc.; Chinese databases in clude China Biomedical Literature Service, China Knowledge Network, Wanfang database, etc. All literature searches ended on February 28, 2022. Analysis of the literature. KD is a common acquired heart disease in children and can lead to severe complications such as coronary injury. However, intravenous immunoglobulin (IVIG) combined with oral aspirin (Asp) is currently recognized as the most effective treatment in KD acute stage and the first-line treatment to prevent cardiovascular complications. Glucocorticoid (GC) is mainly used for KD patients with a high risk of coronary artery aneurysm (CAA), no immunoglobulin response, and confirmed CAA. There are already consensus guidelines on diagnosing and treat ing KD in different countries. This article summarizes the relevant expert consensus on aspirin, glucocorticoids and IVIG for the treatment of Kawasaki disease in China. Conclusion. Still, there are inconsistent opinions in the literature on the mechanism, optimal timing, and dosage of medication for KD.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"1 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.15584/ejcem.2024.1.29
S. H. Ahmed, T. Shaikh, Summaiyya Waseem, Maha Zahid, Khabab Abbasher Hussien Mohamed Ahmed, Irfan Ullah, Md Al Hasibuzzaman
Introduction and aim. Industrialization and elevated greenhouse gas emissions pose significant threats to the environment, raising atmospheric carbon dioxide levels and leading to climate change. Climate change may impact human health either directly via increasing extreme weather frequency and altering disease patterns or indirectly via social institutions and disrupted global supply chain resulting in consequences like undernutrition Material and methods. This review conducted a comprehensive literature search on PubMed, Google Scholar, and Cochrane Library, from inception to September 2022, using relevant keywords. Analysis of the literature. Massive flooding in South Asia is leading to a surge in water-related diseases. Cholera outbreaks have occurred in countries like Pakistan, India, and Bangladesh following floods, and waterborne diseases like typhoid, rota virus, hepatitis A, and leptospirosis are prevalent in flood-affected regions. Additionally, Cryptosporidium, Campylobacter, Shigella, and Polio outbreaks are reported. Water-scarce diseases, including scabies, impetigo, and cellulitis, are also on the rise in flood-affected areas. Water-based diseases, such as dracunculiasis, schistosomiasis, and Leishmaniasis, pose significant risks. Vector-borne diseases, including malaria, dengue, and Leishmaniasis, are becoming more prevalent due to flooded areas providing breeding grounds for disease vectors like mosquitoes and sandflies. These diseases are now more common in flood-af fected regions, affecting millions of people. Conclusion. Urgent measures are needed, including early warning systems, resilient infrastructure, drainage maintenance, and stricter land-use regulations, to reduce the impact of these natural disasters. International cooperation and immediate action at national and global levels are essential to mitigate the health crises caused by flooding and other natural disasters.
{"title":"Water-related diseases following flooding in South Asian countries – a healthcare crisis","authors":"S. H. Ahmed, T. Shaikh, Summaiyya Waseem, Maha Zahid, Khabab Abbasher Hussien Mohamed Ahmed, Irfan Ullah, Md Al Hasibuzzaman","doi":"10.15584/ejcem.2024.1.29","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.29","url":null,"abstract":"Introduction and aim. Industrialization and elevated greenhouse gas emissions pose significant threats to the environment, raising atmospheric carbon dioxide levels and leading to climate change. Climate change may impact human health either directly via increasing extreme weather frequency and altering disease patterns or indirectly via social institutions and disrupted global supply chain resulting in consequences like undernutrition Material and methods. This review conducted a comprehensive literature search on PubMed, Google Scholar, and Cochrane Library, from inception to September 2022, using relevant keywords. Analysis of the literature. Massive flooding in South Asia is leading to a surge in water-related diseases. Cholera outbreaks have occurred in countries like Pakistan, India, and Bangladesh following floods, and waterborne diseases like typhoid, rota virus, hepatitis A, and leptospirosis are prevalent in flood-affected regions. Additionally, Cryptosporidium, Campylobacter, Shigella, and Polio outbreaks are reported. Water-scarce diseases, including scabies, impetigo, and cellulitis, are also on the rise in flood-affected areas. Water-based diseases, such as dracunculiasis, schistosomiasis, and Leishmaniasis, pose significant risks. Vector-borne diseases, including malaria, dengue, and Leishmaniasis, are becoming more prevalent due to flooded areas providing breeding grounds for disease vectors like mosquitoes and sandflies. These diseases are now more common in flood-af fected regions, affecting millions of people. Conclusion. Urgent measures are needed, including early warning systems, resilient infrastructure, drainage maintenance, and stricter land-use regulations, to reduce the impact of these natural disasters. International cooperation and immediate action at national and global levels are essential to mitigate the health crises caused by flooding and other natural disasters.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"49 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.15584/ejcem.2024.1.16
Haris Chandra Mishra, Jyotiranjan Mohapatra, Sashibhusan Dash, Sanghamitra Dash
Introduction and aim. Corrosive strictures of the upper cervical esophagus and hypopharynx are hard to treat in the operating room because there is a high chance of aspiration during swallowing after a high-up or proximal esophageal anastomosis. In this cases, we aimed to evaluate the role of intraoperative dilatation of the proximal hypopharyngeal and cervical esophageal stumps during surgery. Material and methods. Patients who underwent surgery and had upper cervical esophageal and hypopharyngeal strictures from corrosive substance ingestion were included. Results. Out of total 27 patients, 10 had a cricopharyngeal or proximal cervical esophageal stricture with a long segment tho racic esophageal stricture that was treated with intra-operative dilatation (IOD) of the proximal hypopharyngeal stump. IOD was done in two cases with Hegar’s dilator and in three cases with wire-guided Savary Gillard dilators. In 74% (20/27) of the cases, the colon was frequently used as an esophageal substitute, while the stomach was only used in 10 cases. On follow-up, none of them developed repeated aspirations or required a tracheotomy. Conclusion. IOD of the proximal hypopharyngeal and cervical esophageal stumps during surgery for corrosive upper cervi cal esophageal or cricopharyngeal strictures helps to save the proximal stump and avoid frequent hospital stays and multiple surgeries.
{"title":"Surgical management of upper cervical esophagus stricture caused by ingestion of corrosive substances – a single-center experience","authors":"Haris Chandra Mishra, Jyotiranjan Mohapatra, Sashibhusan Dash, Sanghamitra Dash","doi":"10.15584/ejcem.2024.1.16","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.16","url":null,"abstract":"Introduction and aim. Corrosive strictures of the upper cervical esophagus and hypopharynx are hard to treat in the operating room because there is a high chance of aspiration during swallowing after a high-up or proximal esophageal anastomosis. In this cases, we aimed to evaluate the role of intraoperative dilatation of the proximal hypopharyngeal and cervical esophageal stumps during surgery. Material and methods. Patients who underwent surgery and had upper cervical esophageal and hypopharyngeal strictures from corrosive substance ingestion were included. Results. Out of total 27 patients, 10 had a cricopharyngeal or proximal cervical esophageal stricture with a long segment tho racic esophageal stricture that was treated with intra-operative dilatation (IOD) of the proximal hypopharyngeal stump. IOD was done in two cases with Hegar’s dilator and in three cases with wire-guided Savary Gillard dilators. In 74% (20/27) of the cases, the colon was frequently used as an esophageal substitute, while the stomach was only used in 10 cases. On follow-up, none of them developed repeated aspirations or required a tracheotomy. Conclusion. IOD of the proximal hypopharyngeal and cervical esophageal stumps during surgery for corrosive upper cervi cal esophageal or cricopharyngeal strictures helps to save the proximal stump and avoid frequent hospital stays and multiple surgeries.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"38 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.15584/ejcem.2024.1.28
Hajar Belhaj, H. Barouaca, Dia Eddine Oudghiri, Lamiri Abderrahmane, Mohammed Mostakim, Abderrahim Timihiri, H. Ahyayauch, S. Younes
Introduction and aim. Diabetes-related distress is a prevalent issue that affects many patients, leading to challenges in ad hering to treatment plans and lifestyle modifications. By implementing therapeutic education programs, healthcare providers seek to enhance patients’ understanding of their condition, coping mechanisms, and treatment adherence. This study aims to explore the impact of therapeutic education on diabetes-related distress and therapeutic adherence among individuals diag nosed with type 2 diabetes. Material and methods. This quasi-experimental study involved 40 patients with type 2 diabetes receiving therapeutic educa tion during 6 Months from March 24 to September 30, 2022. Diabetes-related distress and adherence were assessed before and after the intervention using the Diabetes Distress Scale (DDS-17) and glycated hemoglobin (HbA1c) levels. Results. Wilcoxon signed rank tests revealed statistically significant improvements for all measures after the intervention. Patients showed improved DDS-17 scores (p<0.001) across all dimensions, and lower HbA1c levels (p<0.001). Pre- and post-inter vention mean difference across all measures show that the greatest improvements were seen in emotional distress (1.37) and treatment-related distress (1.2). Conclusion. Therapeutic education had a positive impact on therapeutic adherence and diabetes-related distress. It should be an integral part of type 2 diabetes care protocols in Morocco.
{"title":"The influence of therapeutic education on diabetes-related distress and therapeutic adherence among patients with type 2 diabetes in Tetouan, Morocco","authors":"Hajar Belhaj, H. Barouaca, Dia Eddine Oudghiri, Lamiri Abderrahmane, Mohammed Mostakim, Abderrahim Timihiri, H. Ahyayauch, S. Younes","doi":"10.15584/ejcem.2024.1.28","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.28","url":null,"abstract":"Introduction and aim. Diabetes-related distress is a prevalent issue that affects many patients, leading to challenges in ad hering to treatment plans and lifestyle modifications. By implementing therapeutic education programs, healthcare providers seek to enhance patients’ understanding of their condition, coping mechanisms, and treatment adherence. This study aims to explore the impact of therapeutic education on diabetes-related distress and therapeutic adherence among individuals diag nosed with type 2 diabetes. Material and methods. This quasi-experimental study involved 40 patients with type 2 diabetes receiving therapeutic educa tion during 6 Months from March 24 to September 30, 2022. Diabetes-related distress and adherence were assessed before and after the intervention using the Diabetes Distress Scale (DDS-17) and glycated hemoglobin (HbA1c) levels. Results. Wilcoxon signed rank tests revealed statistically significant improvements for all measures after the intervention. Patients showed improved DDS-17 scores (p<0.001) across all dimensions, and lower HbA1c levels (p<0.001). Pre- and post-inter vention mean difference across all measures show that the greatest improvements were seen in emotional distress (1.37) and treatment-related distress (1.2). Conclusion. Therapeutic education had a positive impact on therapeutic adherence and diabetes-related distress. It should be an integral part of type 2 diabetes care protocols in Morocco.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"39 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. A. Gabal, Amina Badr Eldin, M. A. Elserwy, Mostafa Adel Mohammed
Introduction and aim. With increasing ultrasound US assessment opportunities for tight rheumatoid arthritis (RA) management, more simplified accurate US-assessment is desired in clinical practice. Aim of the work is assessing modified vs simplified ultrasound 6-joint scores relevance in assessing rheumatoid arthritis disease activity. Material and methods. Fifty-five RA patients were subjected to detailed history, clinical, and musculoskeletal examination with disease activity assessment by clinical disease activity index, simple disease activity index and disease activity score in 28 joints. Com plete blood count, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, anti-cyclic citrullinated peptide antibodies were done. Patients underwent US examination (gray-scale and power Doppler) for wrist, 2nd and 3rd metacarpophalangeal and knee joints bilaterally. Synovitis composite score was added. Two US indices were constructed: simplified S6 and modified M6 joint scores. Results. Statistical significant positive correlations were high between S6/M6 score parameters (total, grey-scale (GS), power doppler (PD), Composite) and disease activity markers. Both M6 and S6 scores differentiated mild-moderate and moderate-severe disease activity patients. However, only S6 score differentiated remission from mild disease activity patients. Conclusion. Ultrasound 6-joint scores (especially simplified S6) were rapid, easy and sensitive ultrasound tools assessing rheu matoid arthritis disease activity in clinical practice.
引言和目的。随着超声 US 评估用于类风湿性关节炎（RA）严格管理的机会越来越多，临床实践中需要更简化、更准确的 US 评估。这项工作的目的是评估在评估类风湿性关节炎疾病活动性时，改良与简化超声 6 关节评分的相关性。材料和方法。对 55 名类风湿性关节炎患者进行了详细的病史、临床和肌肉骨骼检查，并通过临床疾病活动度指数、简易疾病活动度指数和 28 个关节的疾病活动度评分评估疾病活动度。还进行了全血细胞计数、红细胞沉降率、C 反应蛋白、类风湿因子、抗环瓜氨酸肽抗体检查。患者接受双侧腕关节、第 2 和第 3 掌指关节以及膝关节的 US 检查（灰度和动力多普勒）。滑膜炎综合评分。建立了两个 US 指数：简化 S6 关节评分和改良 M6 关节评分。结果。S6/M6评分参数（总分、灰度（GS）、功率多普勒（PD）、综合评分）与疾病活动性指标之间具有统计学意义的高度正相关。M6 和 S6 评分都能区分轻度-中度和中度-重度疾病活动患者。然而，只有 S6 评分能区分缓解期和轻度疾病活动期患者。结论是在临床实践中，6关节超声评分（尤其是简化的S6评分）是评估类风湿关节炎疾病活动性的快速、简便和灵敏的超声工具。
{"title":"Simplified vs modified (reduced) ultrasound 6 joint score in assessing disease activity in rheumatoid arthritis patients","authors":"M. A. Gabal, Amina Badr Eldin, M. A. Elserwy, Mostafa Adel Mohammed","doi":"10.15584/ejcem.2024.1.4","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.4","url":null,"abstract":"Introduction and aim. With increasing ultrasound US assessment opportunities for tight rheumatoid arthritis (RA) management, more simplified accurate US-assessment is desired in clinical practice. Aim of the work is assessing modified vs simplified ultrasound 6-joint scores relevance in assessing rheumatoid arthritis disease activity. Material and methods. Fifty-five RA patients were subjected to detailed history, clinical, and musculoskeletal examination with disease activity assessment by clinical disease activity index, simple disease activity index and disease activity score in 28 joints. Com plete blood count, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, anti-cyclic citrullinated peptide antibodies were done. Patients underwent US examination (gray-scale and power Doppler) for wrist, 2nd and 3rd metacarpophalangeal and knee joints bilaterally. Synovitis composite score was added. Two US indices were constructed: simplified S6 and modified M6 joint scores. Results. Statistical significant positive correlations were high between S6/M6 score parameters (total, grey-scale (GS), power doppler (PD), Composite) and disease activity markers. Both M6 and S6 scores differentiated mild-moderate and moderate-severe disease activity patients. However, only S6 score differentiated remission from mild disease activity patients. Conclusion. Ultrasound 6-joint scores (especially simplified S6) were rapid, easy and sensitive ultrasound tools assessing rheu matoid arthritis disease activity in clinical practice.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"28 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.15584/ejcem.2024.1.25
Suchetana Goswami
Introduction and aim. Traumatic dental injuries (TDIs) in children can have aesthetic, functional, and psychological conse quences. This retrospective study aimed to investigate the epidemiology and patterns of TDIs in a hospital-based population. Material and methods. Patient records from the Department of pediatric and Preventive Dentistry in a dental college and hospital in Kolkata, India, were reviewed. A total of 381 patients, aged 1 to 12 years, who presented one or more traumatized an terior teeth between September 2018 and August 2022, were included. Data on age, sex, mechanism of injury, type of trauma, dentition type, and number of affected teeth were collected. The World Health Organization classification system was used to classify the type of dental trauma. Results. Among the study population, there were 235 males (61.7%) and 146 females (38.3%), with a mean age of 7.67±3.87 years. Falls were the most common cause of trauma (52.2%). The maxillary central incisors were the most frequently affected teeth in both primary and permanent dentitions. Conclusion. Falls were the most common cause of trauma and the maxillary central incisors were the most commonly affected teeth in children.
{"title":"Patterns and characteristics of traumatic dental injuries in children – a retrospective study in a dental hospital in Kolkata, India","authors":"Suchetana Goswami","doi":"10.15584/ejcem.2024.1.25","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.25","url":null,"abstract":"Introduction and aim. Traumatic dental injuries (TDIs) in children can have aesthetic, functional, and psychological conse quences. This retrospective study aimed to investigate the epidemiology and patterns of TDIs in a hospital-based population. Material and methods. Patient records from the Department of pediatric and Preventive Dentistry in a dental college and hospital in Kolkata, India, were reviewed. A total of 381 patients, aged 1 to 12 years, who presented one or more traumatized an terior teeth between September 2018 and August 2022, were included. Data on age, sex, mechanism of injury, type of trauma, dentition type, and number of affected teeth were collected. The World Health Organization classification system was used to classify the type of dental trauma. Results. Among the study population, there were 235 males (61.7%) and 146 females (38.3%), with a mean age of 7.67±3.87 years. Falls were the most common cause of trauma (52.2%). The maxillary central incisors were the most frequently affected teeth in both primary and permanent dentitions. Conclusion. Falls were the most common cause of trauma and the maxillary central incisors were the most commonly affected teeth in children.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"12 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.15584/ejcem.2024.1.30
A. Fąfara, A. Krakowiak-Burdzy
Introduction and aim. Night nursing care ensures well-being, peace, and security allowing a patient to enter into the deep sleep phase. This study aims to analyze the relationship between an assessment of caring and therapeutic services and the opinion of in-patients on their experience and satisfaction with night nursing care. Material and methods. A questionnaire developed by the authors and the Newcastle Satisfaction with Nursing Scale were used in this study. This study was conducted in the eastern region of Poland in the Podkarpackie province. The study included 585 patients. Results. Tasks analyzed resulting from care and therapeutic functions, in the patient’s opinion, had a significant impact on the overall assessment of nursing care. Meeting the expectations regarding night rest (experience of nursing care) and satisfaction showed the strongest correlation. Tasks resulting from therapeutic functions showed an average correlation with the exception of planned medical care. Conclusion. The level of implemented health services by nurses at night significantly influences the overall assessment of the quality management system in health care.
{"title":"Caring and therapeutic services – a patient’s opinion on experience and satisfaction with night nursing care","authors":"A. Fąfara, A. Krakowiak-Burdzy","doi":"10.15584/ejcem.2024.1.30","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.30","url":null,"abstract":"Introduction and aim. Night nursing care ensures well-being, peace, and security allowing a patient to enter into the deep sleep phase. This study aims to analyze the relationship between an assessment of caring and therapeutic services and the opinion of in-patients on their experience and satisfaction with night nursing care. Material and methods. A questionnaire developed by the authors and the Newcastle Satisfaction with Nursing Scale were used in this study. This study was conducted in the eastern region of Poland in the Podkarpackie province. The study included 585 patients. Results. Tasks analyzed resulting from care and therapeutic functions, in the patient’s opinion, had a significant impact on the overall assessment of nursing care. Meeting the expectations regarding night rest (experience of nursing care) and satisfaction showed the strongest correlation. Tasks resulting from therapeutic functions showed an average correlation with the exception of planned medical care. Conclusion. The level of implemented health services by nurses at night significantly influences the overall assessment of the quality management system in health care.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"43 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.15584/ejcem.2024.1.18
Michał Szymoniuk, Leon Sakwa, Ł. Domagalski, J. Gałązka, Zofia Hoffman, Aleksandra Dryla, Wojciech Czyżewski, Dariusz Szczepanek, Kamil Torres, R. Rola
Introduction and aim. The foramen magnum is a rare location of meningioma development, accounting for 1.8 to 3.2% of all reported tumors of this type. Microsurgical resection, representing a gold standard in foramen magnum meningioma treat ment, may result in various neurological deficits or incomplete resection due to challenging anatomical conditions. Currently, even surgical resections of foramen magnum meningioma conducted by experienced neurosurgeons are burdened by a relatively high complication rate of 17.2% Description of the case. We report the case of a 25-year-old male who presented increasing headaches and decreasing activity for 5 months. In his medical history, the patient had been diagnosed with cerebral palsy, autism spectrum disorder, and suffered partial seizures. Magnetic resonance imaging revealed anterolateral foramen magnum meningioma. The tumor was resected via a far-lateral approach. After the surgery, the patient maintained a preoperative neurological state without additional neurological deficits. The post-operative magnetic resonance imaging demonstrated complete tumor removal. Histopatholog ical examination revealed transitional meningioma (WHO grade I). Conclusion. Our case demonstrates that the far-lateral approach can be efficient for the resection of anterolateral foramen magnum meningioma. In such cases, Simpson grade 1 can be achieved without complications, providing immediate relief of symptoms and minimizing the risk of recurrence.
{"title":"Total resection of foramen magnum meningioma via a far-lateral approach – a case report","authors":"Michał Szymoniuk, Leon Sakwa, Ł. Domagalski, J. Gałązka, Zofia Hoffman, Aleksandra Dryla, Wojciech Czyżewski, Dariusz Szczepanek, Kamil Torres, R. Rola","doi":"10.15584/ejcem.2024.1.18","DOIUrl":"https://doi.org/10.15584/ejcem.2024.1.18","url":null,"abstract":"Introduction and aim. The foramen magnum is a rare location of meningioma development, accounting for 1.8 to 3.2% of all reported tumors of this type. Microsurgical resection, representing a gold standard in foramen magnum meningioma treat ment, may result in various neurological deficits or incomplete resection due to challenging anatomical conditions. Currently, even surgical resections of foramen magnum meningioma conducted by experienced neurosurgeons are burdened by a relatively high complication rate of 17.2% Description of the case. We report the case of a 25-year-old male who presented increasing headaches and decreasing activity for 5 months. In his medical history, the patient had been diagnosed with cerebral palsy, autism spectrum disorder, and suffered partial seizures. Magnetic resonance imaging revealed anterolateral foramen magnum meningioma. The tumor was resected via a far-lateral approach. After the surgery, the patient maintained a preoperative neurological state without additional neurological deficits. The post-operative magnetic resonance imaging demonstrated complete tumor removal. Histopatholog ical examination revealed transitional meningioma (WHO grade I). Conclusion. Our case demonstrates that the far-lateral approach can be efficient for the resection of anterolateral foramen magnum meningioma. In such cases, Simpson grade 1 can be achieved without complications, providing immediate relief of symptoms and minimizing the risk of recurrence.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":"42 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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