European Journal of Cancer Prevention最新文献

Studies on the association between passive smoking and head and neck cancer (HNC) are controversial. This meta-analysis aimed to explore this association. A systematic search of the PubMed , Embase , Web of Science , and Cochrane Library databases was conducted up to July 2024 to identify relevant studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the DerSimonian-Laird random-effects model. Heterogeneity among studies was assessed, and the risk of bias was evaluated. A total of 1036 records were identified, of which 17 studies were included. Passive smoking was significantly associated with an increased risk of HNC overall (OR = 1.70, 95% CI: 1.27-2.28, P  < 0.001). The association was particularly strong for oral cancer (OR = 1.85, 95% CI: 1.07-3.17, P  = 0.026), oropharyngeal cancer (OR = 2.78, 95% CI: 1.29-5.98, P  = 0.009), laryngeal cancer (OR = 1.60, 95% CI: 1.24-2.06, P  < 0.001), and hypopharyngeal cancer (OR = 2.60, 95% CI: 1.45-4.66, P  = 0.001). No significant association was observed for nasopharyngeal carcinoma (OR = 1.14, 95% CI: 0.78-1.66, P  = 0.498). Geographically, the risk was elevated among both Asian and European populations. Passive smoking is associated with an increased risk of HNC, particularly for subtypes such as oral, oropharyngeal, laryngeal, and hypopharyngeal cancers. These findings underscore the importance of mitigating exposure to passive smoking as a public health measure.

Previous studies have shown that general and central obesity are each linked to adverse outcomes in gastrointestinal cancers. However, their combined effect on gastrointestinal cancers surgery outcomes were less understood. This study aims to integrate both general and central obesity to examine the outcomes of gastric cancer surgery in different obesity patterns. We retrospectively analyzed 248 patients who underwent gastric cancer surgery between 2021 and 2023 in a single institute. The Inbody720 body composition analyzer measured body composition. We evaluated the relationship between obesity patterns - combining BMI with central obesity measures (waist circumference, waist-to-hip ratio, visceral fat area) - and postoperative complications and 30-day readmission. Central-only obesity were more likely to induce fistula ( P  = 0.025), while non-obesity was more likely to develop postoperative abdominal effusion ( P  = 0.049) and bleeding ( P  = 0.042). Central-only obesity was significantly associated with severe postoperative complications after adjustment for hypertension, diabetes, abdominal surgery history, preoperative albumin levels, age, sex, and surgical types. This remains significant even after adjusting for muscle mass. However, we did not find the same results for significant complications. Regarding 30-day readmission, there are no differences between different patterns of obesity. Central-only obesity is an independent risk factor for severe postoperative complications in gastric cancer, while a high BMI appears to be associated with a lower risk compared to non-obese patients, but not significant postoperative complications. The likelihood of readmission within 30 days post-surgery may not be related to the patient's pattern of obesity.

The relationship between folate and the risk of cancer remains undetermined partially due to the dynamic changes in folate intakes at the population level caused by folic acid fortification implemented in the USA and other countries. To control for the interference from fortification, we assessed the relationship between folate and lung cancer death (LCD) risk among a national cohort established years before folic acid fortification. We followed up 14 528 adults aged 19 years or older who participated in the National Health and Nutrition Examination Survey (1988-1994) on average for 14 years. LCD's hazard ratios were estimated by the folate levels using Cox regressions. After 192 973 person-years (py) of follow-up, 233 LCDs were recorded. The LCD rates were 1.20/1000 py, 1.14/1000 py, and 1.38/1000 py for adults with low (1 st quarter), moderate (2 nd and 3 rd quarter), and high (4 th quarter) serum folate. In the first 10 years of follow-up, the adjusted hazard ratio was 2.87 (1.30-6.37) for adults with moderate, and 1.56 (0.58-4.23) for adults with high serum folate, compared to adults with low serum folate. For adults who survived longer than 10 years of follow-up, the hazard ratios were 0.45 (0.24-0.86) and 0.37 (0.16-0.87) respectively. No association was observed between LCD risk and red blood cell folate level. With minimized interference from folic acid fortification, we detected a time-dependent bidirectional association that supports the dual effects of folate on the carcinogenesis of lung cancer.

This systematic review focuses on the screening invitation process to identify the most effective methods for increasing participation in oncological cancer screening programs. The success of cancer screening programs heavily relies on the invitation process within a structured framework. This PRISMA-P compliant systematic review focuses on randomized controlled trials conducted worldwide between 2010 and 2021, with participation rates as the primary outcome. From the 7790 initially retrieved articles, 29 underwent quality assessment using the Cochrane Collaboration tool. The analysis revealed 13 studies with low risk, 11 with medium risk, and five with high risk of bias; the latter were excluded from further analysis. The review examined intervention types, control types, analysis approaches, and the effectiveness of various invitation methods. Different communication means, such as letters, text messages, phone calls, and face-to-face consultations, were evaluated along with the roles of various professionals. Specific invitation methods significantly increased participation rates, with multistep approaches using multiple communication channels proving more effective. Advanced notification techniques, interactive approaches such as phone calls and counseling sessions, and mailing fecal immunochemical test or fecal occult blood test kits directly with invitation letters demonstrated increased participation rates. In contrast, engaging general practitioners, attaching supplementary materials to invitation letters, sending reminders after the initial invitation, and applying behavioral theories showed limited impact on participation rates. The findings emphasize the importance of tailored, multistep invitation strategies incorporating various communication channels for optimal success in cancer screening programs.

Smoking is a prominent risk factor for laryngeal cancer (LC). Understanding the impacts of smoking on the burden of LC is crucial for its prevention. Data were obtained from the Global Burden of Disease study 2021. A systematic analysis was conducted, assessing mortality and disability-adjusted life years (DALYs) burden, disaggregated by age, sex, region, and the Social Development Index (SDI). From 1990 to 2021, global burden of LC attributable to smoking decreased, while the number of death cases and DALYs increased by 20.80 and 11.53%, respectively. The disease burden has shifted from high-middle SDI regions to middle-low SDI regions. The South Asian and Southeast Asian regions exhibited the largest scale and growth rate of death cases and DALYs, respectively, while the high-income Asia Pacific region demonstrated the most significant decrease in age-standardized death rate [EAPC: -3.99, 95% uncertainty interval (UI), -4.17 to -3.81] and age-standardized DALYs rate (EAPC: -4.19, 95% UI, -4.36 to -4.03). The burden is significantly greater in men than in women, undergoing substantial significant sex differences. The burden decreased in all the age groups, while increasing with age, peaking in the 90-94-year age group. In the next 15 years, the number of LC-related deaths attributable to smoking is expected to continue increasing. The global burden of LC attributable to smoking has decreased from 1990 to 2021; however, it continues to vary by SDI, region, country, age and sex. Further strengthening smoking control and healthcare system is crucial for reducing the burden of LC.

This study examined the characteristics of tumors, treatments, and survival outcomes, with a particular focus on the survival-related factors of second primary triple-negative breast cancer (TNBC) in comparison to first primary TNBC. The Surveillance, Epidemiology, and End Results database was utilized to identify and enroll patients diagnosed with TNBC between the years 2010 and 2015. The outcomes of this study were 3-year and 5-year breast cancer-specific survival (BCSS). The multivariate competing risk model was conducted to explore the association between the second primary cancer and BCSS and to estimate risk factors for BCSS of both first and second primary TNBC. The hazard ratio and 95% confidence interval (CI) were evaluation indices. Our study demonstrated that age, histological grade III/IV, high T stage, high N stage, and TNBC were associated with a decreased 3-year and 5-year BCSS in both first and second primary TNBC. Family income ≥$60 000 per year (hazard ratio: 0.68, 95% CI: 0.48-0.95, P  = 0.026) correlated with better 3-year BCSS in patients with second primary TNBC. Breast-conserving surgery, mastectomy, and the interval between two cancer diagnoses >3 years were associated with increased 3-year and 5-year BCSS in patients with second primary TNBC (all P  < 0.05). This paper reveals a worse survival of second primary TNBC. Great attention should be paid to the prognosis of patients with second primary TNBC.

Considering that carbohydrates play an important role in supplying the body with energy and exhibit diverse mechanisms that can either prevent or stimulate cancer, we hypothesize that the quality of carbohydrate intake may be associated with cancer risk, including lung cancer. This hospital-based case-control study was conducted on 135 newly diagnosed lung cancer patients, and 237 healthy age- and sex-matched hospitalized controls. We used a valid and reliable 148-item Food Frequency Questionnaire to collect the dietary intake of subjects. Multivariate logistic regression was used to estimate the association between carbohydrate quality indices and the odds of lung cancer. After adjustment for confounding variables, the high glycemic index appears to be an increased risk factor for lung cancer [odds ratio (OR) = 2.51, 95% confidence interval (CI): 1.28-4.91]. No statistically significant association was found between glycemic load and lung cancer (OR = 2.51, 95% CI: 0.98-6.43). In contrast, the carbohydrate quality index (OR = 0.23, 95% CI: 0.11-0.48) and low-carbohydrate diet score (OR = 0.17, 95% CI: 0.08-0.36), were associated with a decrease in the risk of lung cancer. In summary, our study showed that a high glycemic index is a risk factor for lung cancer, however carbohydrate quality index and low-carbohydrate diet score is a dietary approach to reduce the risk of lung cancer.

Colorectal cancer is the third most common malignancy in the USA and accounts for more than 1 million deaths worldwide with screening shown to reduce CRC mortality. This meta-analysis analyzed the use of stool DNA for screening average risk, asymptomatic subjects for colorectal cancer and advanced precancerous lesions and compared sDNA to FOBT tests (gFOBT and FIT). Eight studies were included from four different countries with a total of 39 665 subjects. Pooled sensitivity and specificity for sDNA for detecting CRC was 83.3% (95% CI: 60.8-94.2) and 92.4% (95% CI: 90.1-94.1), respectively, compared with FOBT, which had a lower sensitivity at 70.2% (95% CI: 45.5-86.9) but higher specificity 95.7% (95% CI: 95.1-96.2). Further analysis showed improved sensitivity of sDNA to 92.6% when only the studies employing sDNA tests that incorporate hemoglobin immunochemical test were used. Both sDNA and FOBT tests had low sensitivity for detecting advanced precancerous lesions. sDNA tests are sensitive and specific for the detection of CRC but show low sensitivity compared with colonoscopy for the detection of advanced precancerous lesions.

Despite significant advances in therapy, cancer remains the top cause of death in parts of the globe. For many types of cancer, the typical treatment is a combination of surgery, chemotherapy, and radiotherapy. However, this conventional treatment is not successful on its own. As a consequence, innovative approaches that improve treatment efficacy are urgently needed. The ketogenic diet is a high-fat, moderate protein, and low-carbohydrate diet that appears to sensitize most cancers to conventional therapies by exploiting cancer cells' altered metabolism, making it an effective adjuvant cancer treatment alternative. This diet could decrease glucose metabolism while enhancing lipid metabolism, interfering with the Warburg effect, and inhibiting tumor cell proliferation. The anticancer impact of ketogenic diet has been established in numerous animal trials and clinical investigations on a wide range of tumor types, including glioblastoma, pancreatic cancer, head and neck cancer, breast cancer, invasive rectal cancer, ovarian cancer, and endometrial cancer. In this review, we discussed the various types of ketogenic diets, the mechanism of action for ketogenic diet as a cancer therapy, and the data gathered from continuing preclinical and clinical studies, intending to establish a solid theoretical foundation for future research.

Human papillomavirus (HPV) coinfection remains common globally. However, its clinical significance compared to mono-infection remains controversial. Further, the epidemiology of HPV genotype combination in coinfection is not well studied in Kenya. . Between June and August 2023, a cross-sectional facility-based survey enrolled 434 women aged 16-68 years using purposive sampling strategy. Structured questionnaire was obtained from each woman regarding demographic and sexual behavior characteristics. Cervical specimen was collected from each participant and analyzed using RIATOL assay to determine HPV genotypes and viral load. Overall, HPV 52 was the most frequently detected HPV strain. The mean HPV viral load was elevated among coinfected women than those with mono-infection but there was no evidence to support differences in viral load in the two groups ( P  = 0.113). Mono-infection was common (58.52%). HPV 16 was noted to have a near equal presence both in mono-infection and coinfection (52.17% and 47. 83%), respectively. HPV 33 (alpha 9) and 45 (alpha 7) had the greatest preference for each other compared to all other HPV interactions. HPV 52 is the most prevalent HPV in the population supporting the need for the nonavalent HPV vaccine. Mono-infection with HPV 16 remains common corroborating the relevance of bivalent vaccine in resource limited setting where nonavalent vaccines may be unavailable. The frequent coinfection preference of HPV 33 and 45 (alpha 9 and alpha 7, respectively) pauses the need for further concurrent characterization. HPV vaccination and education on safe sexual behaviors is key in reducing HPV coinfection.