{"title":"Seroprevalence of Hepatitis A virus according to age groups in Northern Anatolia of Turkey","authors":"T. Düzenli","doi":"10.17941/agd.1055281","DOIUrl":"https://doi.org/10.17941/agd.1055281","url":null,"abstract":"","PeriodicalId":118745,"journal":{"name":"Akademik Gastroenteroloji Dergisi","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115205350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuğçe Çağlar, Azar Abi̇yev, Özlem Erdem, Murat Kekilli, Ibrahim Dogan
their use is limited due to toxicity concerns. We present an human immmuno-deficiency virus-negative case who received azathioprine treatment for autoimmune hepatitis and subsequently developed Kaposi sarcoma.
{"title":"Otoimmün hepatit tanılı hastada azatioprin tedavisi sonrası gelişen Kaposi sarkomu","authors":"Tuğçe Çağlar, Azar Abi̇yev, Özlem Erdem, Murat Kekilli, Ibrahim Dogan","doi":"10.17941/agd.978336","DOIUrl":"https://doi.org/10.17941/agd.978336","url":null,"abstract":"their use is limited due to toxicity concerns. We present an human immmuno-deficiency virus-negative case who received azathioprine treatment for autoimmune hepatitis and subsequently developed Kaposi sarcoma.","PeriodicalId":118745,"journal":{"name":"Akademik Gastroenteroloji Dergisi","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132357873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Özgün, V. Oter, Erol Pişkin, M. Çolakoğlu, O. Aydın, B. Bostancı
Background and Aims: This study aims to determine the early and late postoperative effects of distal pancreatectomy plus splenectomy in patients who underwent cytoreductive surgery and hyperthermic intra- peritoneal chemotherapy and achieved CC0 resection due to peritoneal carcinomatosis. Materials and Method: All patients who underwent a cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedure due to peritoneal carcinomatosis of various tumors in our clinic between 2014 and 2020 were included in the study. Data from all patients who underwent additional distal pancreatectomy plus splenec- tomy were analyzed retrospectively. Results: The cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedure with CC/0 resection was performed on 85 of 136 patients diagnosed with peritoneal carcinomatosis. Of these patients, 13 (15.3%) had undergone distal pancreatectomy plus splenectomy together with the main procedure. The mean hospital stay was 15 (range, 5–50) days in patients who underwent distal pancreatectomy plus splenectomy, whereas it was 13 (range, 4–109) days in those who did not, and the difference was statistically insignificant. The most common major complications seen in the distal pancreatectomy plus splenectomy group were an anastomotic leak, enterocutaneous fistula, and intraabdominal abscess. The 30-day mortality was two (15.38%) and one (1.38%) in the group with and the group without distal pancreatectomy plus splenectomy, respectively. When the groups were evaluated, the median survival time was 19 months in the cytoreductive surgery and hyperthermic intraperitoneal chemotherapy group and 18 months in the cytoreductive surgery and hyperthermic intraperitoneal chemotherapy + distal pancreatectomy plus splenectomy group. This difference was statistically insignificant (p = 0.382). Conclusion: The addition of distal pancreatectomy plus splenectomy increased major postoperative complications in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy but did not affect overall survival. We think distal pancreatectomy plus splenectomy can be performed for a complete cytoreduction if necessary. However, it increases major postoperative complications, and patient follow-up should be done accordingly.
{"title":"Effects of distal pancreatectomy and splenectomy on outcomes in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with CC/0 resection","authors":"Y. Özgün, V. Oter, Erol Pişkin, M. Çolakoğlu, O. Aydın, B. Bostancı","doi":"10.17941/agd.978955","DOIUrl":"https://doi.org/10.17941/agd.978955","url":null,"abstract":"Background and Aims: This study aims to determine the early and late postoperative effects of distal pancreatectomy plus splenectomy in patients who underwent cytoreductive surgery and hyperthermic intra- peritoneal chemotherapy and achieved CC0 resection due to peritoneal carcinomatosis. Materials and Method: All patients who underwent a cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedure due to peritoneal carcinomatosis of various tumors in our clinic between 2014 and 2020 were included in the study. Data from all patients who underwent additional distal pancreatectomy plus splenec- tomy were analyzed retrospectively. Results: The cytoreductive surgery and hyperthermic intraperitoneal chemotherapy procedure with CC/0 resection was performed on 85 of 136 patients diagnosed with peritoneal carcinomatosis. Of these patients, 13 (15.3%) had undergone distal pancreatectomy plus splenectomy together with the main procedure. The mean hospital stay was 15 (range, 5–50) days in patients who underwent distal pancreatectomy plus splenectomy, whereas it was 13 (range, 4–109) days in those who did not, and the difference was statistically insignificant. The most common major complications seen in the distal pancreatectomy plus splenectomy group were an anastomotic leak, enterocutaneous fistula, and intraabdominal abscess. The 30-day mortality was two (15.38%) and one (1.38%) in the group with and the group without distal pancreatectomy plus splenectomy, respectively. When the groups were evaluated, the median survival time was 19 months in the cytoreductive surgery and hyperthermic intraperitoneal chemotherapy group and 18 months in the cytoreductive surgery and hyperthermic intraperitoneal chemotherapy + distal pancreatectomy plus splenectomy group. This difference was statistically insignificant (p = 0.382). Conclusion: The addition of distal pancreatectomy plus splenectomy increased major postoperative complications in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy but did not affect overall survival. We think distal pancreatectomy plus splenectomy can be performed for a complete cytoreduction if necessary. However, it increases major postoperative complications, and patient follow-up should be done accordingly.","PeriodicalId":118745,"journal":{"name":"Akademik Gastroenteroloji Dergisi","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122755192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The inlet patch (IP) is an island of heterotopic gastric mucosa and was first described by Schumidt in the cervical esophagus, but it’s pathogenesis has not been elucidated yet (1,2). Globus sensation, laryngopharengeal reflux and dysphagia are commonly reported symptoms of esophageal IP (3,4). Globus is a nonpainful sensation of a lump or foreign body in the throat which frequently improves with eating and swallowing (5). Globus diagnosis requires the absence of structural lesions as esophageal IP, gastroesophageal reflux disease (GERD) or motor disorders. For this reason, the exclusion of IPs in the diBackground and Aims: An esophageal inlet patch is crucial in swallowing difficulty, laryngopharyngeal reflux symptoms, and rarely in the etiology of proximal esophagus adenocarcinoma. We aimed to evaluate the endoscopic and demographic features of patients with esophageal inlet patch during endoscopic evaluation and compare them with those of the literature. Materials and Method: Between January 2017 and January 2021, we evaluated the age, gender ratio, inlet patch size, and number along with the other endoscopic findings in patients with proximal esophageal inlet patch. Results: Overall, 53 patients (women, 36 (68%); mean age, 46.3 ± 15.8 years; range, 19–83 years) were included the study. Only 13 patients (24.5%) had specific symptoms of esophageal inlet patch. The median esophageal inlet patch size was 7.0 mm in women (range, 4–30), while it was 8 mm (range, 5–20) in men. The median inlet patch number was 1 in both sexes (range, 1–3 in women, 1–2 in men). Forceps biopsy was possible in 30 (56.6%) patients. We found no additional esophageal pathology in 45 (84.9%) patients, normal lower esophageal sphincter in 39 (73.5%), incompetent lower esophageal sphincter in 14 (26.4%), hiatal diaphragmatic hernia in 1 (1.8%), and endoscopic antral gastritis in 29 (55.7%) patients. Twelve (54.5%) of 22 endoscopic biopsies were positive for Helicobacter pylori. We detected esophageal inlet patch in the distal esophagus in 2 (3.7%) patients. Conclusion: Esophageal inlet patch was more common in women, unrelated to gastroesophageal reflux disease, and most patients were asymptomatic, with a median size of 8 mm (range, 4–30), with no gender difference. Moreover, inlet patch size was not associated with presence of symptoms. Evidence of malignancy in the biopsied inlet patches was not observed.
{"title":"Esophageal inlet patch: Demographic and endoscopic characteristics of patients and review of the literature","authors":"I. Köker, N. Şahin","doi":"10.17941/agd.982255","DOIUrl":"https://doi.org/10.17941/agd.982255","url":null,"abstract":"The inlet patch (IP) is an island of heterotopic gastric mucosa and was first described by Schumidt in the cervical esophagus, but it’s pathogenesis has not been elucidated yet (1,2). Globus sensation, laryngopharengeal reflux and dysphagia are commonly reported symptoms of esophageal IP (3,4). Globus is a nonpainful sensation of a lump or foreign body in the throat which frequently improves with eating and swallowing (5). Globus diagnosis requires the absence of structural lesions as esophageal IP, gastroesophageal reflux disease (GERD) or motor disorders. For this reason, the exclusion of IPs in the diBackground and Aims: An esophageal inlet patch is crucial in swallowing difficulty, laryngopharyngeal reflux symptoms, and rarely in the etiology of proximal esophagus adenocarcinoma. We aimed to evaluate the endoscopic and demographic features of patients with esophageal inlet patch during endoscopic evaluation and compare them with those of the literature. Materials and Method: Between January 2017 and January 2021, we evaluated the age, gender ratio, inlet patch size, and number along with the other endoscopic findings in patients with proximal esophageal inlet patch. Results: Overall, 53 patients (women, 36 (68%); mean age, 46.3 ± 15.8 years; range, 19–83 years) were included the study. Only 13 patients (24.5%) had specific symptoms of esophageal inlet patch. The median esophageal inlet patch size was 7.0 mm in women (range, 4–30), while it was 8 mm (range, 5–20) in men. The median inlet patch number was 1 in both sexes (range, 1–3 in women, 1–2 in men). Forceps biopsy was possible in 30 (56.6%) patients. We found no additional esophageal pathology in 45 (84.9%) patients, normal lower esophageal sphincter in 39 (73.5%), incompetent lower esophageal sphincter in 14 (26.4%), hiatal diaphragmatic hernia in 1 (1.8%), and endoscopic antral gastritis in 29 (55.7%) patients. Twelve (54.5%) of 22 endoscopic biopsies were positive for Helicobacter pylori. We detected esophageal inlet patch in the distal esophagus in 2 (3.7%) patients. Conclusion: Esophageal inlet patch was more common in women, unrelated to gastroesophageal reflux disease, and most patients were asymptomatic, with a median size of 8 mm (range, 4–30), with no gender difference. Moreover, inlet patch size was not associated with presence of symptoms. Evidence of malignancy in the biopsied inlet patches was not observed.","PeriodicalId":118745,"journal":{"name":"Akademik Gastroenteroloji Dergisi","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121378321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harun Erdal, Ayfer Bakir, Ümit Savaşçi, Tunahan Ayaz, Hilal İşi̇kan, Mine Filiz, Yakup Arslan, Gonca Fidan, Umut Yener Kara, Gulden Yilmaz, D. Doğan, B. Başgöz, Gürhan Taşkın, Serkan Şenkal, Cantürk Taşçi, Levent Yamanel, Ahmet Uygun, M. Gülşen
Background and Aims: The primary mechanism of liver damage in coronavirus disease-2019 is the binding of severe acute respiratory syn-drome coronavirus-2 to the angiotensin-converting enzyme 2 receptors, which is highly expressed in the bile duct cells. This study aimed to inves-tigate comorbid liver diseases in patients hospitalized with coronavirus disease-2019 and assess the relationship between the rates of abnormal liver function biochemical test results on the day of hospitalization and the clinical course and prognosis of the disease. Materials and Methods: Data of patients over the age of 18 years who were hospi- talized due to coronavirus disease-2019 were retrospectively assessed. This included data analysis of the relationship between aspartate aminotransferase, alanine transaminase, alkaline phosphatase, gamma-glu-tamyl transferase, total bilirubin levels of patients and length of hospital stay, admission to the intensive care unit, and mortality. Results: Out of 795 patients who were confirmed as infected with coronavirus dis-ease-2019 by the reverse transcription-polymerase chain reaction test, 113 (14.2%) had a high prevalence of liver enzyme (alanine transami- nase and/or aspartate aminotransferase), whereas the high prevalence of alanine transaminase was 11.1% and aspartate aminotransferase was 9.6%. The rate of high alanine transaminase levels was greatest in the 71-and-above age group (17.4%), and high aspartate aminotrans- ferase levels were more common in the 51–57 age group (14.8%). No significant difference was found between patients with and without high alanine transaminase and/or aspartate aminotransferase in terms of the clinical course of coronavirus disease-2019, length of hospital stay, intensive care admission, and mortality. In addition, aspartate aminotransferase and alanine transaminase elevations were found to not make a significant difference in the survival time. Conclusions: Abnormal liver function can be detected in patients with coronavirus disease-2019. However, to develop sufficient knowledge of its causes and effects on patient prognosis, further prospective studies based on larger populations are needed.
{"title":"COVID 19 hastalarında karaciğer fonksiyon bozukluğu ve prognoz ile ilişkisi","authors":"Harun Erdal, Ayfer Bakir, Ümit Savaşçi, Tunahan Ayaz, Hilal İşi̇kan, Mine Filiz, Yakup Arslan, Gonca Fidan, Umut Yener Kara, Gulden Yilmaz, D. Doğan, B. Başgöz, Gürhan Taşkın, Serkan Şenkal, Cantürk Taşçi, Levent Yamanel, Ahmet Uygun, M. Gülşen","doi":"10.17941/agd.980896","DOIUrl":"https://doi.org/10.17941/agd.980896","url":null,"abstract":"Background and Aims: The primary mechanism of liver damage in coronavirus disease-2019 is the binding of severe acute respiratory syn-drome coronavirus-2 to the angiotensin-converting enzyme 2 receptors, which is highly expressed in the bile duct cells. This study aimed to inves-tigate comorbid liver diseases in patients hospitalized with coronavirus disease-2019 and assess the relationship between the rates of abnormal liver function biochemical test results on the day of hospitalization and the clinical course and prognosis of the disease. Materials and Methods: Data of patients over the age of 18 years who were hospi- talized due to coronavirus disease-2019 were retrospectively assessed. This included data analysis of the relationship between aspartate aminotransferase, alanine transaminase, alkaline phosphatase, gamma-glu-tamyl transferase, total bilirubin levels of patients and length of hospital stay, admission to the intensive care unit, and mortality. Results: Out of 795 patients who were confirmed as infected with coronavirus dis-ease-2019 by the reverse transcription-polymerase chain reaction test, 113 (14.2%) had a high prevalence of liver enzyme (alanine transami- nase and/or aspartate aminotransferase), whereas the high prevalence of alanine transaminase was 11.1% and aspartate aminotransferase was 9.6%. The rate of high alanine transaminase levels was greatest in the 71-and-above age group (17.4%), and high aspartate aminotrans- ferase levels were more common in the 51–57 age group (14.8%). No significant difference was found between patients with and without high alanine transaminase and/or aspartate aminotransferase in terms of the clinical course of coronavirus disease-2019, length of hospital stay, intensive care admission, and mortality. In addition, aspartate aminotransferase and alanine transaminase elevations were found to not make a significant difference in the survival time. Conclusions: Abnormal liver function can be detected in patients with coronavirus disease-2019. However, to develop sufficient knowledge of its causes and effects on patient prognosis, further prospective studies based on larger populations are needed.","PeriodicalId":118745,"journal":{"name":"Akademik Gastroenteroloji Dergisi","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127405643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ferit Çelik, Alper Uysal, Ali Şenkaya, N. Ünal, İlkçe Kurtulmuş, F. Teki̇n, A. Özütemiz
{"title":"Yaşlılarda kandida özofajiti: Tek merkez deneyimi","authors":"Ferit Çelik, Alper Uysal, Ali Şenkaya, N. Ünal, İlkçe Kurtulmuş, F. Teki̇n, A. Özütemiz","doi":"10.17941/agd.978470","DOIUrl":"https://doi.org/10.17941/agd.978470","url":null,"abstract":"","PeriodicalId":118745,"journal":{"name":"Akademik Gastroenteroloji Dergisi","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126454070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ak ad em ik g as tr o en te ro lo ji d er g is i 2 02 1; 2 0( 2) : 6 569 Background and Aims: It has been suggested that chronic Helicobacter pylori infection plays a protective role against inflammatory bowel disease by inducing systemic immune tolerance and suppressing inflammatory responses. The primary aim of the study was to determine the frequency of Helicobacter pylori in inflammatory bowel disease patients. A secondary aim was to investigate the relationship between inflammatory bowel disease and Helicobacter pylori infection. Materials and Methods: Patients over 18 years of age who were in follow-up with a diagnosis of inflammatory bowel disease and who underwent upper gastrointestinal system endoscopy for dyspepsia were included in the study and their data retrospectively analyzed. The control group consisted of patients who were not diagnosed with inflammatory bowel disease and had upper gastrointestinal system endoscopy for dyspepsia. For all patients, age; gender; and the presence of Helicobacter pylori, atrophic gastritis, and intestinal metaplasia as a result of pathological evaluation of biopsy samples taken by upper gastrointestinal system endoscopy were recorded. Both groups were compared in terms of Helicobacter pylori frequency and histopathological findings (presence of intestinal metaplasia and atrophic gastritis). Results: A total of 220 cases, including 160 inflammatory bowel disease and 60 controls, were included in the study. In all, 53.8% (n = 86) of inflammatory bowel disease patients were diagnosed with ulcerative colitis and 46.2% (n = 74) with Crohn’s disease. The rate of Helicobacter pylori was found to be significantly lower in the inflammatory bowel disease group compared with the control group (52.5% versus 73.3% and p = 0.005). The rate of atrophic gastritis was significantly lower in the inflammatory bowel disease group compared with the control group (3.1% vs 15% and p = 0.001). The intestinal metaplasia rate was significantly lower in the inflammatory bowel disease group compared with the control group (1.9% vs 11.7% and p = 0.002). Conclusion: Helicobacter pylori positivity was found at a significantly lower rate in the inflammatory bowel disease group. The presence of atrophic gastritis and intestinal metaplasia was found to be lower in the inflammatory bowel disease group. We believe that antibiotics used in the routine treatment of inflammatory bowel disease patients decrease the frequency of Helicobacter pylori and lead to less frequent development of atrophic gastritis and intestinal metaplasia.
阿克·阿克·阿克看起来就像一个小男孩，他在2001年被杀了。[20](2): 6 569背景与目的:研究表明，慢性幽门螺杆菌感染通过诱导全身免疫耐受和抑制炎症反应，对炎症性肠病具有保护作用。该研究的主要目的是确定炎症性肠病患者幽门螺杆菌的频率。第二个目的是调查炎症性肠病和幽门螺杆菌感染之间的关系。材料和方法:18岁以上诊断为炎症性肠病并因消化不良接受上消化道内镜检查的随访患者纳入研究，并对其数据进行回顾性分析。对照组由未被诊断为炎症性肠病且因消化不良而接受上消化道内镜检查的患者组成。对于所有患者，年龄;性别;记录上消化道内窥镜活检标本病理评估结果中幽门螺杆菌、萎缩性胃炎和肠化生的存在。比较两组幽门螺杆菌的频率和组织病理学结果(肠化生和萎缩性胃炎的存在)。结果:共纳入220例，其中炎性肠病患者160例，对照组60例。总体而言，53.8% (n = 86)的炎症性肠病患者被诊断为溃疡性结肠炎，46.2% (n = 74)被诊断为克罗恩病。与对照组相比，炎症性肠病组幽门螺杆菌的感染率明显降低(52.5%对73.3%，p = 0.005)。与对照组相比，炎症性肠病组萎缩性胃炎的发生率显著降低(3.1% vs 15%， p = 0.001)。炎症性肠病组的肠化生率明显低于对照组(1.9% vs 11.7%， p = 0.002)。结论:炎症性肠病组幽门螺杆菌阳性率明显低于对照组。在炎症性肠病组中，萎缩性胃炎和肠化生的发生率较低。我们认为，在炎性肠病患者的常规治疗中使用抗生素可降低幽门螺杆菌的发病率，减少萎缩性胃炎和肠化生的发生。
{"title":"Helicobacter pylori ve inflamatuvar bağırsak hastalığı arasındaki ilişki","authors":"Emre Gerçeker, Serkan Cerrah, A. Baykan","doi":"10.17941/agd.975765","DOIUrl":"https://doi.org/10.17941/agd.975765","url":null,"abstract":"ak ad em ik g as tr o en te ro lo ji d er g is i 2 02 1; 2 0( 2) : 6 569 Background and Aims: It has been suggested that chronic Helicobacter pylori infection plays a protective role against inflammatory bowel disease by inducing systemic immune tolerance and suppressing inflammatory responses. The primary aim of the study was to determine the frequency of Helicobacter pylori in inflammatory bowel disease patients. A secondary aim was to investigate the relationship between inflammatory bowel disease and Helicobacter pylori infection. Materials and Methods: Patients over 18 years of age who were in follow-up with a diagnosis of inflammatory bowel disease and who underwent upper gastrointestinal system endoscopy for dyspepsia were included in the study and their data retrospectively analyzed. The control group consisted of patients who were not diagnosed with inflammatory bowel disease and had upper gastrointestinal system endoscopy for dyspepsia. For all patients, age; gender; and the presence of Helicobacter pylori, atrophic gastritis, and intestinal metaplasia as a result of pathological evaluation of biopsy samples taken by upper gastrointestinal system endoscopy were recorded. Both groups were compared in terms of Helicobacter pylori frequency and histopathological findings (presence of intestinal metaplasia and atrophic gastritis). Results: A total of 220 cases, including 160 inflammatory bowel disease and 60 controls, were included in the study. In all, 53.8% (n = 86) of inflammatory bowel disease patients were diagnosed with ulcerative colitis and 46.2% (n = 74) with Crohn’s disease. The rate of Helicobacter pylori was found to be significantly lower in the inflammatory bowel disease group compared with the control group (52.5% versus 73.3% and p = 0.005). The rate of atrophic gastritis was significantly lower in the inflammatory bowel disease group compared with the control group (3.1% vs 15% and p = 0.001). The intestinal metaplasia rate was significantly lower in the inflammatory bowel disease group compared with the control group (1.9% vs 11.7% and p = 0.002). Conclusion: Helicobacter pylori positivity was found at a significantly lower rate in the inflammatory bowel disease group. The presence of atrophic gastritis and intestinal metaplasia was found to be lower in the inflammatory bowel disease group. We believe that antibiotics used in the routine treatment of inflammatory bowel disease patients decrease the frequency of Helicobacter pylori and lead to less frequent development of atrophic gastritis and intestinal metaplasia.","PeriodicalId":118745,"journal":{"name":"Akademik Gastroenteroloji Dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128653546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kaplan, I. Ateş, M. Akdoğan, S. Kaçar, V. Gökbulut, O. Coşkun
additi-Background and Aims: In this study, we investigated the usefulness of the ascites sodium level for prognostic purposes and its association with 2-year mortality, spontaneous bacterial peritonitis, hepatic encephalopa- thy, and hepatorenal syndrome. Material and Methods: This study was performed between July and October 2018 in patients with liver cirrhosis in whom the ascites sodium level was studied. Patients with severe heart failure, nephrotic syndrome, or electrolyte disturbance; patients who had spontaneous bacterial peritonitis, hepatic encephalopathy or hepatorenal syndrome at admission; and patients who used diuretics for another reason were excluded from the study. Results: The study population consisted of 72 cirrhotic patients [32 females (44.4%) and 40 males (55.6%)]. The patients were followed up for 2 years, and mortality developed in 33 patients (45.8%). During follow-up, hepatic encephalopathy developed in 13 patients (18.1%), hepatorenal syndrome in 13 patients (18.1%), and spontaneous bacterial peritonitis in 32 patients (44.4%). Hepatic encephalopathy, hepatorenal syndrome, and the spon- taneous bacterial peritonitis ratio were higher in the deep hyponatremia group compared with other hyponatremia groups (p < 0.05). The mean Child-Pugh and Model for End-Stage Liver Disease-Na scores were similar in the moderate and deep hyponatremia groups, and they were higher than in the other groups (p < 0.05). The mortality rate was found to be higher in the deep hyponatremia group than in the other hyponatremia groups (p < 0.05). Hyponatremia in ascites was found to be an independent predictor of mortality, and patients in the deep hyponatremia group had a 29.55-fold increased risk of mortality compared with those patients without hyponatremia. Conclusion: In this study, it was shown that deep hyponatremia less than 125 mEq/L in ascites was associated with increased cirrhotic complications and mortality.
{"title":"The prognostic utility of ascites sodium level in cirrhotic patients","authors":"M. Kaplan, I. Ateş, M. Akdoğan, S. Kaçar, V. Gökbulut, O. Coşkun","doi":"10.17941/agd.977865","DOIUrl":"https://doi.org/10.17941/agd.977865","url":null,"abstract":"additi-Background and Aims: In this study, we investigated the usefulness of the ascites sodium level for prognostic purposes and its association with 2-year mortality, spontaneous bacterial peritonitis, hepatic encephalopa- thy, and hepatorenal syndrome. Material and Methods: This study was performed between July and October 2018 in patients with liver cirrhosis in whom the ascites sodium level was studied. Patients with severe heart failure, nephrotic syndrome, or electrolyte disturbance; patients who had spontaneous bacterial peritonitis, hepatic encephalopathy or hepatorenal syndrome at admission; and patients who used diuretics for another reason were excluded from the study. Results: The study population consisted of 72 cirrhotic patients [32 females (44.4%) and 40 males (55.6%)]. The patients were followed up for 2 years, and mortality developed in 33 patients (45.8%). During follow-up, hepatic encephalopathy developed in 13 patients (18.1%), hepatorenal syndrome in 13 patients (18.1%), and spontaneous bacterial peritonitis in 32 patients (44.4%). Hepatic encephalopathy, hepatorenal syndrome, and the spon- taneous bacterial peritonitis ratio were higher in the deep hyponatremia group compared with other hyponatremia groups (p < 0.05). The mean Child-Pugh and Model for End-Stage Liver Disease-Na scores were similar in the moderate and deep hyponatremia groups, and they were higher than in the other groups (p < 0.05). The mortality rate was found to be higher in the deep hyponatremia group than in the other hyponatremia groups (p < 0.05). Hyponatremia in ascites was found to be an independent predictor of mortality, and patients in the deep hyponatremia group had a 29.55-fold increased risk of mortality compared with those patients without hyponatremia. Conclusion: In this study, it was shown that deep hyponatremia less than 125 mEq/L in ascites was associated with increased cirrhotic complications and mortality.","PeriodicalId":118745,"journal":{"name":"Akademik Gastroenteroloji Dergisi","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125811402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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