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2009 14th National Biomedical Engineering Meeting最新文献

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Usage of statistical estimation method for the simultaneous mapping of inner and outer surfaces of the heart 利用统计估计法同时绘制心脏内外表面
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130288
U. Cunedioglu, Engin Baysoy, B. Yilmaz
To characterize the cardiac rhythm disturbances catheter-based cardiac mapping approaches have become a common practice due to their minimal invasiveness. A multielectrode basket-shaped contact catheter and the multielectrode intravenous catheter are two types of the used catheters. Catheter based approaches provide mapping of the one surface at a time. Therefore, there is a need for a method that can achieve mapping of the inner (endocard) and outer (epicard) surfaces of the heart in one heart beat. In this study, for simultaneous mapping of epi/endocardial surfaces multielectrode basket-shaped catheters and intravenous catheters we used statistical estimation method. In order to test this approach we used three dimensional simulations of the electrical activity of the heart. For this purpose, we created a simulation database using Aliev-Panfilov model. Our simulation database included 3880 maps formed by starting the simulations from endocardial, myocardial and epicardial sites. Half of these maps were used as training data and the rest were used as test data. We selected 64 points on left and 64 on right endocardial surfaces as multielectrode basket catheter measurement sites and 91 sites on epicardial surface as the intravenous catheter measurement sites. To test the performance of this approach we used criteria such as correlation coefficient (CC), root mean squared error (RMSE), relative error (RE) and localization error (LE). As a result, between the estimated and original maps CC is ∼0,98, RMSE is ∼2,7 ms, RE is ∼0,05 and LE is 5–6 mm.
为了表征心律失常,基于导管的心脏测绘方法由于其最小的侵入性而成为一种常见的做法。多电极篮状接触导管和多电极静脉导管是两种使用的导管。导管为基础的方法提供一次一个表面的映射。因此,需要一种方法能够在一次心跳中实现心脏的内(内)和外(外)表面的映射。在本研究中,我们采用统计估计的方法对多电极篮形导管和静脉导管同时进行外膜/心内膜表面的定位。为了测试这种方法,我们使用了心脏电活动的三维模拟。为此,我们使用Aliev-Panfilov模型创建了一个仿真数据库。我们的模拟数据库包括3880张由心内膜、心肌和心外膜部位开始模拟形成的地图。这些地图的一半用作训练数据,其余的用作测试数据。我们选择心内膜表面左侧64个点和右侧64个点作为多电极篮式导管测量点,心外膜表面91个点作为静脉导管测量点。为了测试该方法的性能,我们使用了相关系数(CC)、均方根误差(RMSE)、相对误差(RE)和定位误差(LE)等标准。结果,估计地图和原始地图之间的CC为~ 0,98,RMSE为~ 2,7 ms, RE为~ 0,05,LE为5-6 mm。
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引用次数: 0
Classification in frequency domain of EEG Signals of Motor Imagery for Brain Computer Interfaces 基于脑机接口的运动图像脑电信号频域分类
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130258
U. Halici
In this study the classification of the EEG Signals recorded during Motor Imagery for curser movement in Brain Computer Interfaces is examined, in which the feature vectors obtained in frequency domain is used and then the linear transformations are applied for reducing the size of the feature vectors.
本文研究了脑机接口中光标运动时脑电信号的分类问题,首先利用频域特征向量,然后利用线性变换减小特征向量的大小。
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引用次数: 1
To compare the different scaffolds according to porosity's properties 根据孔隙率的特性对不同支架进行比较
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130324
Berivan Çeçen, leyla didem kozaci, M. Yuksel, A. Pasinli, Ozge Oral, H. Havitcioglu
The main purpose of this study is to investigate the increase in osteoblast cells cultured on three different porosity scaffolds in vivo environment. Hence, Collagen + Poly-l-lactic acid (PLLA), Collagen +HA (30 C°), Collagen + HA (37 C°) were studied. During the operation, 20 ml bone marrow was taken for any of patient in sterile conditions. Mesenchymal stem cells were differentiated to osteoblast cells. After the ALP and morphological evaluations were assessed, osteoblast cells were planted on 3 different scaffolds and SEM observations were evaluated. At twenty-fifth day, konfleunt osteoblast cells were observed. Osteoblast cells were watched on Collagen + HA (30 C°) scaffold appropriately. According to our knowledge, in various bone defects, cell cultures on suitable scaffolds are contribute to clinical studies.
本研究的主要目的是研究三种不同孔隙度支架在体内环境下培养成骨细胞的增加情况。因此,我们研究了胶原+聚乳酸(PLLA)、胶原+HA(30℃)、胶原+HA(37℃)。术中,在无菌条件下取骨髓20 ml。间充质干细胞向成骨细胞分化。在进行ALP和形态学评估后,将成骨细胞植入3种不同的支架上,并进行扫描电镜观察。第25天,观察成骨细胞。将成骨细胞置于胶原+ HA(30℃)支架上观察。据我们所知,在各种骨缺损中,在合适的支架上进行细胞培养有助于临床研究。
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引用次数: 0
MR and X-Ray Angiography registration intensity based approach 基于MR和x线血管造影配准强度的方法
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130269
F. A. Durmaz, A. C. Yilmam, C. Ozturk
As we know during interventional studies X-Ray Angiography provides us a high resolution and refresh rate, but as a trade off it doesn't have soft tissue contrast. MR imaging provides us 3-D anatomic imaging, and soft tissue contrast. Our aim is to fuse 2-D X-ray images with 3-D MR volume (XFM). We are using an intensity based algorithm to find mutual information between two modalities.
在介入研究中,我们知道x射线血管造影为我们提供了高分辨率和刷新率,但作为交换,它没有软组织对比。磁共振成像为我们提供了三维解剖成像和软组织对比。我们的目标是融合二维x射线图像与三维MR体积(XFM)。我们使用基于强度的算法来查找两种模态之间的互信息。
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引用次数: 0
Analysis of catheter-based imaging devices for side-looking IVUS 侧视IVUS中导管成像装置的分析
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130312
A. Şişman, M. Karaman
We investigated a side-looking catheter structure employing rotating annular array with 8 concentric annuli.. This structure allows dynamic focusing with a simple front-end electronic. We tested the image quality of proposed structure using simulations and compared with the existing structures.
我们研究了一种具有8个同心环空的旋转环形阵列的侧视导管结构。这种结构允许动态聚焦与一个简单的前端电子。我们通过仿真测试了所提出结构的图像质量,并与现有结构进行了比较。
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引用次数: 1
Precision calibrator design and implementation for X-ray diagnostic devices x射线诊断设备精密校准器的设计与实现
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130263
Hakan Gemici, I. Karagoz, M. Ozden
In this study it is aimed to design and develop an instrumental device which is capable of measuring some key parameters of X-ray tubes employed in many medical imaging devices including conventional X-ray imaging, fluoroscopy, mammography and dental X-ray imaging and those measured parameters which is critical for both imaging quality and patient safety aspects are acquired and evaluated extremely precise and very reliable with the help of latest technological advancements. Furthermore the designed instrumental device is supplemented with a Bluetooth connection capability which allows both remote controlling of the device and data transmission between the device and PC. Also a graphical user interface which is capable of recording multiple exposure data acquired via Bluetooth module and plotting comparison graphs in demand of user is also programmed in .NET environment. Remote controlling of the device and data transmission via Bluetooth avoided possible risks of working close to high voltage transformer of X-ray tube, hence gives an extra protection to medical device technicians. Taken measurements can be used to make periodic calibrations of medical imaging devices and this also helps reducing possible risks may be caused by overdosing during imaging.
本研究旨在设计和开发一种仪器设备,能够测量许多医学成像设备中使用的x射线管的一些关键参数,包括常规x射线成像,透视,乳房x光检查和牙科x射线成像,这些测量参数对成像质量和患者安全至关重要,并在最新技术进步的帮助下获得和评估非常精确和可靠。此外,所设计的仪器设备还补充了蓝牙连接功能,允许设备的远程控制和设备与PC之间的数据传输。并在。net环境下编写了一个图形用户界面,该界面能够记录通过蓝牙模块采集到的多次曝光数据,并根据用户的需要绘制对比图。通过蓝牙对设备进行远程控制和数据传输,避免了在x射线管高压变压器附近工作可能存在的风险,为医疗器械技术人员提供了额外的保护。测量结果可用于定期校准医学成像设备,这也有助于减少成像期间过量使用可能造成的风险。
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引用次数: 0
Effects of depression on hippocampal memory: A computational model 抑郁症对海马记忆的影响:一个计算模型
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130384
Gokcen Yildiz
Animal studies have shown that chronic stress and depression produce irreversible atrophy of the apical dendrites of CA3 pyramidal neurons. Dysregulations caused by depression also disturbes molecular mechanisms of hippocampal long-term potentiation (LTP). The effect of stress on amygdala is just the opposite of the hippocampus; neuroimaging studies have found both increased baseline activity and a greater amygdala volume in depressed compared to nondepressed individuals. In our study, we have implemented a computational model of CA3 region of the hippocampus to simulate the auto-associative memory impairement caused by depression. In our model, the dendritic atrophy and disturbed synaptic plasticity, is represented by the increase in transmission delay and the increased amygdala activity, in turn, is represented by increased inhibitory input to CA3 region. Our auto-associative CA3 network incorporates 256 excitatory recurrent Hebb's synapses in a 16 × 16 array plus one interneuron representing the inhibition by amygdala. The network has been trained to recognize face patterns. We tested the auto-associative memory function with incomplete patterns and we expected our model to perform the pattern completion function. The pattern completion performance was negatively effected by the increase of the inhibition by amygdala. The increase in information delay due to dendritical atrophy had even more severe consequences on the memory performance. We observed a shutting off of the auto-associative memory for time delays longer than 10ms. In further studies, our dynamic model will be improved to include the molecular effects of stress on synaptic plasticity.
动物研究表明,慢性应激和抑郁可导致CA3锥体神经元顶端树突不可逆萎缩。抑郁症引起的失调也扰乱了海马长期增强(LTP)的分子机制。压力对杏仁核的影响正好与海马体相反;神经影像学研究发现,与非抑郁症患者相比,抑郁症患者的基线活动增加,杏仁核体积也更大。在我们的研究中,我们实现了海马CA3区域的计算模型来模拟抑郁症引起的自联想记忆障碍。在我们的模型中,树突萎缩和突触可塑性紊乱表现为传递延迟的增加,而杏仁核活动的增加则表现为对CA3区抑制性输入的增加。我们的自关联CA3网络包含256个16 × 16阵列的兴奋性复发Hebb突触和一个代表杏仁核抑制的中间神经元。该网络已经被训练来识别人脸模式。我们测试了不完整模式下的自动联想记忆功能,并期望我们的模型能够完成模式补全功能。杏仁核抑制的增加对图案完成性能有负向影响。由于树突萎缩导致的信息延迟增加对记忆性能的影响更为严重。我们观察到,当时间延迟超过10ms时,自动联想记忆会被关闭。在进一步的研究中,我们的动态模型将得到改进,以包括应力对突触可塑性的分子效应。
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引用次数: 0
The role of fibrin as a ligand for ICAM-1 and PMN in melanoma adhesion under different shear conditions. 纤维蛋白作为ICAM-1和PMN的配体在不同剪切条件下黑色素瘤粘附中的作用。
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130385
Tugba Ozdemir, C. Dong
One of the predominant cause of cancer patient death is the metastatic spread of tumor cells. The leading step in melanoma extravasation is the tumor cell adhesion to the endothelium of the capillaries. However, melanoma cells do not express the appropriate adhesion molecules to bind to an activated endothelium. Previous studies have found neutrophils facilitate melanoma cell adhesion under dynamic flow conditions throught the binding of ICAM-1 on melanoma cells and β2 integrins on PMNs. In addition, soluble fibrin (sFn) is a marker for propagated intravascular coagulation and have a dramatical increase in cancer patients' laboratory coagulation inspections . Soluble fibrin molecule has both receptors for Mac-1 on PMNs and ICAM-1 on tumor cell surface which may affect the tumor cell adherence to endothelial wall surface via PMN. The objective of this study is to investigate the role of soluble fibrin on PMN facilitated tumor cell adherence to endothelial wall and how different effects of hydrodynamic shear stress and shear rate affects the force of adhesion to vessel wall.
肿瘤细胞的转移扩散是癌症患者死亡的主要原因之一。黑色素瘤外渗的主要步骤是肿瘤细胞粘附到毛细血管内皮。然而,黑色素瘤细胞不表达适当的粘附分子来结合活化的内皮细胞。先前的研究发现,中性粒细胞通过ICAM-1结合黑色素瘤细胞和β2整合素结合PMNs,促进黑色素瘤细胞在动态流动条件下的粘附。此外,可溶性纤维蛋白(sFn)是血管内扩散性凝血的标志物,在癌症患者的实验室凝血检查中有显著增加。可溶性纤维蛋白分子在PMN上有Mac-1受体,在肿瘤细胞表面有ICAM-1受体,可能通过PMN影响肿瘤细胞对内皮壁的粘附。本研究的目的是探讨可溶性纤维蛋白在PMN促进肿瘤细胞粘附内皮壁中的作用,以及不同流体动力剪切应力和剪切速率对肿瘤细胞粘附血管壁力的影响。
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引用次数: 0
J-substitution and equipotential-projection based hybrid MREIT reconstruction algorithm 基于j置换和等势投影的混合MREIT重建算法
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130291
R. Boyacioglu, B. M. Eyuboglu
Magnetic Resonance Electrical Impedance Tomography is an imaging modality which reconstructs true conductivity images by using current density distribution and surface potential measurements. In this study, two current based algorithms, namely equipotential projection [1] and J-substitution image reconstruction [2] algorithms are compared. A novel reconstruction technique, J-substitution and equipotential-projection based hybrid reconstruction algorithm, is proposed. In this technique, the image which is reconstructed with equipotential projection algorithm is assigned as the starting conductivity distribution for J-substitution algorithm. Moreover, true conductivity values can be reconstructed with two surface potential measurements. Simulation results on a thorax phantom show that the proposed method has a better performance in some regions.
磁共振电阻抗断层成像是一种利用电流密度分布和表面电位测量重建真实电导率图像的成像方式。在本研究中,比较了两种现有的算法,即等势投影[1]和j替换图像重建[2]算法。提出了一种新的重建技术——基于j替换和等势投影的混合重建算法。在该技术中,将等势投影算法重构后的图像作为j -代换算法的起始电导率分布。此外,用两次表面电位测量可以重建真实的电导率值。仿真结果表明,该方法在某些区域具有较好的性能。
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引用次数: 4
Performing discrete fourier transform of the heart sounds on the pocket computer 在袖珍电脑上对心音进行离散傅立叶变换
Pub Date : 2009-05-20 DOI: 10.1109/BIYOMUT.2009.5130280
G. E. Guraksin, U. Ergun, Omer Deperlioglu
The heart is one of the two significant organs for human life. Today the most important method used by the medical doctors in diagnosing the disorders in connection with the heart is listening with the stethoscope. The sounds created by the flow of the blood entering the heart and movements of the valvular connected to the flow are listened and then the anormalities related to the heart are determined. On the other hand, the method of listening with the stethoscope has many constrains. In this study, from the heart sounds taken from the patient via electronic stethoscope digital data have been acquired, and with the discrete Fourier transform, which is one of the signal processing methods, frequency analysis has been performed, and both sound graphic and frequency spectrum have been displayed on the pocket computer. Thus, examining the frequency spectrum of the normal and anormal heart sounds, it is thought that the differences on the frequency axis of the normal and anormal sounds may be beneficial in diagnosing. Because unlike normal heart sounds, the diseased heart sounds taken from a patient who has any kind of heart disorder include higher frequency components. As the developed system can be operated in a mobile way, it is appropriate for the medical doctors to use it in clinical practically.
心脏是人类生命的两个重要器官之一。今天,医生在诊断与心脏有关的疾病时使用的最重要的方法是用听诊器听。聆听血液进入心脏时产生的声音以及与之相连的瓣膜的运动,然后确定与心脏有关的异常。另一方面,用听诊器听音的方法有很多限制。本研究通过电子听诊器采集患者心音的数字数据,利用信号处理方法之一的离散傅立叶变换进行频率分析,并在袖珍计算机上显示声图和频谱。因此,检查正常和异常心音的频谱,认为正常和异常心音的频率轴上的差异可能有助于诊断。因为与正常的心音不同,从患有任何心脏疾病的病人身上提取的患病心音包括更高的频率成分。由于所开发的系统可以移动操作,适合医生在临床实际中使用。
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引用次数: 6
期刊
2009 14th National Biomedical Engineering Meeting
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