Pub Date : 2011-07-02DOI: 10.1109/biyomut.2009.5130330
Ebru Unlu, H. Bolay, A. Akın
The aim of this study was to investigate the differences in the hemodynamic response caused by the mental arithmetic task between migraineurs and healthy subjects by using functional near infrared spectroscopy. 16 healthy subjects and 16 migraine patients participated in the study. Subjects were asked to perform mental subtraction and answer verbally to 3 sets of questions with increasing complexity. Performance, work load, Functional Near Infrared Spectroscopy (FNIRS) data and laterality index were analyzed. The difference in the oksihemoglobin levels across different complexity levels were calculated. As the MA task got harder, work load increased, performance decreased and the change in [HbO2] increased for both groups but showing a lower incremental in oxy-Hb concentration in migraine patients for varying complexity levels. Control group showed a right dominant PFC activity, whereas migraine patients showed a left dominant PFC actvity. Our results support the hypothesis that migraine is a neurovascular coupling dysfunction causing unregulated activation in PFC than controls.
{"title":"Hemodynamic correlates of mental arithmetic task in migraine","authors":"Ebru Unlu, H. Bolay, A. Akın","doi":"10.1109/biyomut.2009.5130330","DOIUrl":"https://doi.org/10.1109/biyomut.2009.5130330","url":null,"abstract":"The aim of this study was to investigate the differences in the hemodynamic response caused by the mental arithmetic task between migraineurs and healthy subjects by using functional near infrared spectroscopy. 16 healthy subjects and 16 migraine patients participated in the study. Subjects were asked to perform mental subtraction and answer verbally to 3 sets of questions with increasing complexity. Performance, work load, Functional Near Infrared Spectroscopy (FNIRS) data and laterality index were analyzed. The difference in the oksihemoglobin levels across different complexity levels were calculated. As the MA task got harder, work load increased, performance decreased and the change in [HbO2] increased for both groups but showing a lower incremental in oxy-Hb concentration in migraine patients for varying complexity levels. Control group showed a right dominant PFC activity, whereas migraine patients showed a left dominant PFC actvity. Our results support the hypothesis that migraine is a neurovascular coupling dysfunction causing unregulated activation in PFC than controls.","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115043116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-20DOI: 10.1109/BIYOMUT.2009.5130387
H. Tarman
Numerical simulation of flow through stenotic artery is performed using spectral element method in an axisymmetric geometry.This method, under suitable conditions, provides high accuracy. The use of the weak form of the governing model equations, brings flexibility in treating solution domains with nonstandard geometry. The solenoidal character of the flow is preserved by the treatment of the pressure in a natural way in the numerical formulation. The use of Legendre-Lobatto grid points with its denser distribution near the boundaries increases the ability of the grid to resolve the flow boundary layer. This study is aimed as the first step in the development of the technique.
{"title":"Numerical simulation of flow through stenotic artery","authors":"H. Tarman","doi":"10.1109/BIYOMUT.2009.5130387","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2009.5130387","url":null,"abstract":"Numerical simulation of flow through stenotic artery is performed using spectral element method in an axisymmetric geometry.This method, under suitable conditions, provides high accuracy. The use of the weak form of the governing model equations, brings flexibility in treating solution domains with nonstandard geometry. The solenoidal character of the flow is preserved by the treatment of the pressure in a natural way in the numerical formulation. The use of Legendre-Lobatto grid points with its denser distribution near the boundaries increases the ability of the grid to resolve the flow boundary layer. This study is aimed as the first step in the development of the technique.","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123151925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-20DOI: 10.1109/BIYOMUT.2009.5130381
A. Oniz, B. Aydin, Cagdas Guducu, M. Ozgoren
The aim of this study was to investigate the delta oscillatory responses to non-painful tactile stimuli for the blind subjects. The measurements were performed with thirteen blind subjects (15.07 age ±1.65, 10 male) and thirteen healthy subjects (15.92 age ± 2.90, 8 male). One type of tactile stimuli, were applied to middle finger and index finger of the right hand. The electroencephalogram (EEG) was recorded from 64 channels, 3 of which (CZ, C3, C4) were primarily analyzed. Peak-to-peak maximum amplitudes and durations of delta (0.5–3.5 Hz) were measured in 1000 ms following stimuli. For the statistical analysis Wilcoxon test was used. In this present study, increases in delta (0.5–3.5 Hz) responses for non-painful tactile stimuli in blind subjects were compared with the control group. In each electrode area (CZ, C3, C4) the amplitude measurements of the blind group found higher than the control group and the difference found statistically significant in C4 electrode area (p≪0.05).The durations in each electrode area (CZ, C3, C4) for the blind group found statistically longer than the control group ( for each one p≪0.05).
{"title":"Delta oscillatory responses to somatosensory stimuli in blind humans","authors":"A. Oniz, B. Aydin, Cagdas Guducu, M. Ozgoren","doi":"10.1109/BIYOMUT.2009.5130381","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2009.5130381","url":null,"abstract":"The aim of this study was to investigate the delta oscillatory responses to non-painful tactile stimuli for the blind subjects. The measurements were performed with thirteen blind subjects (15.07 age ±1.65, 10 male) and thirteen healthy subjects (15.92 age ± 2.90, 8 male). One type of tactile stimuli, were applied to middle finger and index finger of the right hand. The electroencephalogram (EEG) was recorded from 64 channels, 3 of which (C<inf>Z</inf>, C<inf>3</inf>, C<inf>4</inf>) were primarily analyzed. Peak-to-peak maximum amplitudes and durations of delta (0.5–3.5 Hz) were measured in 1000 ms following stimuli. For the statistical analysis Wilcoxon test was used. In this present study, increases in delta (0.5–3.5 Hz) responses for non-painful tactile stimuli in blind subjects were compared with the control group. In each electrode area (C<inf>Z</inf>, C<inf>3</inf>, C<inf>4</inf>) the amplitude measurements of the blind group found higher than the control group and the difference found statistically significant in C4 electrode area (p≪0.05).The durations in each electrode area (C<inf>Z</inf>, C<inf>3</inf>, C<inf>4</inf>) for the blind group found statistically longer than the control group ( for each one p≪0.05).","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124277742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-20DOI: 10.1109/BIYOMUT.2009.5130306
Pinar Kanlikilicer, Nilay Budeyri, B. S. Akbulut, A. Hortaçsu, Elif Ozkirimli Olmez
β-lactam antibiotics are the most commonly used antibiotics which cause bacterial cell lysis by inhibiting the enzyme responsible for the cell wall synthesis. Production of β-lactamase enzyme, which catalyzes the hydrolysis of β-lactam ring of β-lactam antibiotics is the most common mechanism of bacterial resistance. β-Lactamase Inhibitory Protein (BLIP), is an effective inhibitor of class A β-lactamases such as TEM-1 and SHV-1. TEM-1 and SHV-1 are the most commonly found β-lactamases and they are responsible for the resistance to β-lactam antibiotics of various pathogenic bacteria. In an effort to elucidate the mechanism of β-lactamase inhibiton by BLIP and to make predictions of binding affinity between these molecules, Molecular Dynamics (MD) simulations were performed on TEM-1 and SHV-1 bound to BLIP and BLIP based peptides. Asp49 residue which is known to play a critical role on binding on BLIP was mutated to Alanine to determine the contribution of this residue to binding. Binding free energy of the TEM-1 and SHV-1 bound BLIP, mutant BLIP (D49A) complexes were estimated by the molecular mechanics Poisson Boltzmann Surface Area method (MM-PBSA). Free energy of binding calculations show that the mutation on D49 causes a decrease in binding affinity for both TEM-1 and SHV-1 β-lactamase.
{"title":"Dynamic analysis of ß lactamase ligand interaction","authors":"Pinar Kanlikilicer, Nilay Budeyri, B. S. Akbulut, A. Hortaçsu, Elif Ozkirimli Olmez","doi":"10.1109/BIYOMUT.2009.5130306","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2009.5130306","url":null,"abstract":"β-lactam antibiotics are the most commonly used antibiotics which cause bacterial cell lysis by inhibiting the enzyme responsible for the cell wall synthesis. Production of β-lactamase enzyme, which catalyzes the hydrolysis of β-lactam ring of β-lactam antibiotics is the most common mechanism of bacterial resistance. β-Lactamase Inhibitory Protein (BLIP), is an effective inhibitor of class A β-lactamases such as TEM-1 and SHV-1. TEM-1 and SHV-1 are the most commonly found β-lactamases and they are responsible for the resistance to β-lactam antibiotics of various pathogenic bacteria. In an effort to elucidate the mechanism of β-lactamase inhibiton by BLIP and to make predictions of binding affinity between these molecules, Molecular Dynamics (MD) simulations were performed on TEM-1 and SHV-1 bound to BLIP and BLIP based peptides. Asp49 residue which is known to play a critical role on binding on BLIP was mutated to Alanine to determine the contribution of this residue to binding. Binding free energy of the TEM-1 and SHV-1 bound BLIP, mutant BLIP (D49A) complexes were estimated by the molecular mechanics Poisson Boltzmann Surface Area method (MM-PBSA). Free energy of binding calculations show that the mutation on D49 causes a decrease in binding affinity for both TEM-1 and SHV-1 β-lactamase.","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116867318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-20DOI: 10.1109/BIYOMUT.2009.5130249
M. Ceylan, Y. Ozbay
In this study, a new structure formed by complex wavelet transform (CWT) with different levels and complex-valued artificial neural network (CVANN) is proposed for classification of ECG arryhytmias. In this structure, features of ECG data are extracted using CWT and data size is reduced. After then, four statistical features (maximum value, minimum value, mean value and standard deviation) are obtained from extracted features. These new statistical features are presented to CVANN as inputs. Data set used in this study, including five different arrhytmias (normal sinus rhythm, right bundle branch block, left bundle branch block, atrial fibrilation and atrial flutter), are selected from MITBIH ECG database. Number of samples in training and test sets for each pattern is reduced from 200 real-valued samples to 100, 50 and 25 complex-valued samples using first level CWT, second level CWT and third level CWT, respectively. Classificaton results shown that arrhytmias are classified with 100 % accuracy rate using CWT with third level. Classification process was done in 32.62 second.
{"title":"Effects of complex wavelet transform with different levels in classification of ECG arrhytmias using complex-valued ANN","authors":"M. Ceylan, Y. Ozbay","doi":"10.1109/BIYOMUT.2009.5130249","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2009.5130249","url":null,"abstract":"In this study, a new structure formed by complex wavelet transform (CWT) with different levels and complex-valued artificial neural network (CVANN) is proposed for classification of ECG arryhytmias. In this structure, features of ECG data are extracted using CWT and data size is reduced. After then, four statistical features (maximum value, minimum value, mean value and standard deviation) are obtained from extracted features. These new statistical features are presented to CVANN as inputs. Data set used in this study, including five different arrhytmias (normal sinus rhythm, right bundle branch block, left bundle branch block, atrial fibrilation and atrial flutter), are selected from MITBIH ECG database. Number of samples in training and test sets for each pattern is reduced from 200 real-valued samples to 100, 50 and 25 complex-valued samples using first level CWT, second level CWT and third level CWT, respectively. Classificaton results shown that arrhytmias are classified with 100 % accuracy rate using CWT with third level. Classification process was done in 32.62 second.","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125908534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-20DOI: 10.1109/BIYOMUT.2009.5130304
C. Kandemir-Cavas, E. Nasibov
Hierarchical clustering algorithms are frequently used in constructing phylogenetic trees of protein sequences. Hierarchical clustering is the recursive clustering of data points. Similarity is computed by measuring the distance between elements. Relationship between data is visually denoted by dendrogram. Single linkage, average linkage, complete linkage and Ward's linkage are some of frequently used hierarchical clustering algorithms. In this study, an alternative solution based on Ordered Weighted Average (OWA) aggregation operator is proposed in solving distance between clusters in hierarchical clustering of proteins.
{"title":"Alternative hierarchical clustering approach in construction of phylogenetic trees","authors":"C. Kandemir-Cavas, E. Nasibov","doi":"10.1109/BIYOMUT.2009.5130304","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2009.5130304","url":null,"abstract":"Hierarchical clustering algorithms are frequently used in constructing phylogenetic trees of protein sequences. Hierarchical clustering is the recursive clustering of data points. Similarity is computed by measuring the distance between elements. Relationship between data is visually denoted by dendrogram. Single linkage, average linkage, complete linkage and Ward's linkage are some of frequently used hierarchical clustering algorithms. In this study, an alternative solution based on Ordered Weighted Average (OWA) aggregation operator is proposed in solving distance between clusters in hierarchical clustering of proteins.","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123291213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-20DOI: 10.1109/BIYOMUT.2009.5130266
Ferit Volkan Suer, Dilek Cokeliler, I. Kocum
Improving new diagnosis kit or increasing the performance of existing systems plays an important role in an application at the biomedical engineering. In this study, the production of the probe based on amperometric measurement have been achieved under the laboratory conditions. By this way some background on the main components of sensors which form the diagnostic systems will be gathered. In this study it is also aimed that this sensor will be applied as analytical device the probe with an appropriate recognation layer.
{"title":"The construction of biosensors with amperometric tranducers in biomedical engineering","authors":"Ferit Volkan Suer, Dilek Cokeliler, I. Kocum","doi":"10.1109/BIYOMUT.2009.5130266","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2009.5130266","url":null,"abstract":"Improving new diagnosis kit or increasing the performance of existing systems plays an important role in an application at the biomedical engineering. In this study, the production of the probe based on amperometric measurement have been achieved under the laboratory conditions. By this way some background on the main components of sensors which form the diagnostic systems will be gathered. In this study it is also aimed that this sensor will be applied as analytical device the probe with an appropriate recognation layer.","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129904653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-20DOI: 10.1109/BIYOMUT.2009.5130297
F. Ates, P. Huijing, C. Yucesoy
History effects are the changes in isometric forces of muscles previously activated at high length. The aim of our study was to investigate determinants of history effects in the context of epimuscular myofascial force transmission. Isometric forces of maximally active extensor digitorum longus (EDL) muscle, as well as tibialis anterior and extensor hallicus longus muscle complex (TA+EHL) of the rat were measured simultaneously. (i) length-force (l-f) data were collected and (ii) control measurements were performed at EDL optimum (higher) length and ii) at reference (lower) length. Between consecutive contractions muscles were allowed to recover for 2 min. History effects were quantified as Fl-f-Fcontrol for the indicated lengths. 4 conditions were studied: (1) in the intact condition, during extensor digitorum longus (EDL) lengthening, at low length of EDL, history effects were 45.49%. However, no significant effects were shown for the forces at high length of EDL and restrained TA+EHL. (2) Second control measurements taken 15 minutes after first ones showed that extra time increased the history effects (i.e. EDL proximal force decrease increased from 41.53% to 55.69%). (3) After simultaneous lengthening of EDL and TA+EHL history effects decreased by 42.12% (4) History effects decreased to %34.92 after blunt dissection and 29.56% after fasciotomy. Our study showed that history effect is a fundamental phenomenon determined by intrinsic muscle properties and epimuscular connections may change this effect.
{"title":"In epimuscularly connected muscle previous activity at high length yields sizable history effects causing decreased muscle force at low lengths","authors":"F. Ates, P. Huijing, C. Yucesoy","doi":"10.1109/BIYOMUT.2009.5130297","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2009.5130297","url":null,"abstract":"History effects are the changes in isometric forces of muscles previously activated at high length. The aim of our study was to investigate determinants of history effects in the context of epimuscular myofascial force transmission. Isometric forces of maximally active extensor digitorum longus (EDL) muscle, as well as tibialis anterior and extensor hallicus longus muscle complex (TA+EHL) of the rat were measured simultaneously. (i) length-force (l-f) data were collected and (ii) control measurements were performed at EDL optimum (higher) length and ii) at reference (lower) length. Between consecutive contractions muscles were allowed to recover for 2 min. History effects were quantified as Fl-f-Fcontrol for the indicated lengths. 4 conditions were studied: (1) in the intact condition, during extensor digitorum longus (EDL) lengthening, at low length of EDL, history effects were 45.49%. However, no significant effects were shown for the forces at high length of EDL and restrained TA+EHL. (2) Second control measurements taken 15 minutes after first ones showed that extra time increased the history effects (i.e. EDL proximal force decrease increased from 41.53% to 55.69%). (3) After simultaneous lengthening of EDL and TA+EHL history effects decreased by 42.12% (4) History effects decreased to %34.92 after blunt dissection and 29.56% after fasciotomy. Our study showed that history effect is a fundamental phenomenon determined by intrinsic muscle properties and epimuscular connections may change this effect.","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120831730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-20DOI: 10.1109/BIYOMUT.2009.5130259
Balkar Erdoğan, N. G. Gencer
Spelling Paradigm first introduced by Farwell and Donchin, is one of the Brain Computer Interface (BCI) applications that enables paralyzed people to communicate with their environment. In such a problem, user needs to focus on the characters which are randomly flashed row or column-wise on the computer screen in a small period of time. The accuracy in spelling words is the main problem in this scheme and the duration of the correct prediction is quite important. The purpose of this work is twofold: to analyze a user specific response to a spelling paradigm system considering the optimal frequency bands for P300 detection, and secondly to investigate the classification performance for the perception of row and columnwise flashings in the spelling system. The preprocessing is performed with Wiener Deconvolution Model (WDM) and optimal filters for user specific system is constructed. The proposed algorithm is applied to dataset IIb of BCI competition 2003 and the words for training and testing sets are predicted with 100% accuracy after first 4 trials, as compared to other winning algorithms (100% accuracy in 5 repetitions) of the competition. Furthermore, our classification results show that perception to row and column flashings may differ considerably.
{"title":"Application of Wiener Deconvolution Model in P300 Spelling Paradigm","authors":"Balkar Erdoğan, N. G. Gencer","doi":"10.1109/BIYOMUT.2009.5130259","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2009.5130259","url":null,"abstract":"Spelling Paradigm first introduced by Farwell and Donchin, is one of the Brain Computer Interface (BCI) applications that enables paralyzed people to communicate with their environment. In such a problem, user needs to focus on the characters which are randomly flashed row or column-wise on the computer screen in a small period of time. The accuracy in spelling words is the main problem in this scheme and the duration of the correct prediction is quite important. The purpose of this work is twofold: to analyze a user specific response to a spelling paradigm system considering the optimal frequency bands for P300 detection, and secondly to investigate the classification performance for the perception of row and columnwise flashings in the spelling system. The preprocessing is performed with Wiener Deconvolution Model (WDM) and optimal filters for user specific system is constructed. The proposed algorithm is applied to dataset IIb of BCI competition 2003 and the words for training and testing sets are predicted with 100% accuracy after first 4 trials, as compared to other winning algorithms (100% accuracy in 5 repetitions) of the competition. Furthermore, our classification results show that perception to row and column flashings may differ considerably.","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124377935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-05-20DOI: 10.1109/BIYOMUT.2009.5130348
Y. Isler, M. Kuntalp, Gokhan Gonel
In this paper, new microcontroller based hardware for simulation of neurons is introduced. Excitable membranes with voltage-gated ionic channels can be modeled by using the hardware and current-clamp experiments can be simulated. The hardware allows user to supply the analog current to be injected to the model. First-order differential equations used to define dynamics of the gate and membrane potential are solved using forward Euler method of integration. Output of the simulation can be seen as analog values both on the computer screen via serial port and on the LCD display or expansion port of the designed board.
{"title":"Microcontroller based Hodgkin-Huxley model neuron simulation","authors":"Y. Isler, M. Kuntalp, Gokhan Gonel","doi":"10.1109/BIYOMUT.2009.5130348","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2009.5130348","url":null,"abstract":"In this paper, new microcontroller based hardware for simulation of neurons is introduced. Excitable membranes with voltage-gated ionic channels can be modeled by using the hardware and current-clamp experiments can be simulated. The hardware allows user to supply the analog current to be injected to the model. First-order differential equations used to define dynamics of the gate and membrane potential are solved using forward Euler method of integration. Output of the simulation can be seen as analog values both on the computer screen via serial port and on the LCD display or expansion port of the designed board.","PeriodicalId":119026,"journal":{"name":"2009 14th National Biomedical Engineering Meeting","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127726794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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