Pub Date : 2025-07-24DOI: 10.1038/s41430-025-01650-w
Tonghui Shen, Alice E. Thackray, Jack A. Sargeant, Thomas Yates, James A. King, Scott A. Willis, David J. Stensel
{"title":"Correction: The acute effects of moderate-intensity continuous or high-intensity interval exercise on appetite and appetite-related hormones in South Asian and white European adults with non-diabetic hyperglycaemia","authors":"Tonghui Shen, Alice E. Thackray, Jack A. Sargeant, Thomas Yates, James A. King, Scott A. Willis, David J. Stensel","doi":"10.1038/s41430-025-01650-w","DOIUrl":"10.1038/s41430-025-01650-w","url":null,"abstract":"","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 12","pages":"1245-1245"},"PeriodicalIF":3.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-025-01650-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-24DOI: 10.1038/s41430-025-01647-5
Daisy H. Coyle, Liping Huang, Monica Hu, Nadine Ghammachi, Simone Pettigrew, Jason H. Y. Wu
Most reformulation initiatives worldwide are implemented through voluntary measures. Despite the reliance on voluntary targets, there is limited evidence of their effectiveness. This study aimed to assess the impact of Australia’s voluntary sodium and saturated fat reformulation policy halfway through its four-year implementation period. The 2019 and 2022 FoodSwitch databases provided data on the nutritional composition of packaged foods sold by major Australian supermarket retailers. For the food categories targeted by the policy, we assessed changes between 2019 and 2022 in (i) the overall proportions of products that met the sodium and saturated fat targets and (ii) changes in the proportion of products meeting the targets across the top 10 leading food manufacturers. Between 2019 and 2022, there was a small increase in the proportion of products meeting the sodium targets (50.0% in 2019 versus 57.5% in 2022, p < 0.001). Across the top 10 manufacturers that sold products subject to a sodium target, seven made progress towards meeting the targets (ranging from +1.6% to +30.2%). For saturated fat, the proportion of products meeting the targets didn’t change (61.1% in 2019 versus 60.2% in 2022, p = 0.74) and nine of the 10 top manufacturers did not make any progress towards meeting the targets. Midway through the implementation period of Australia’s voluntary sodium and saturated fat targets, food manufacturers have made minimal progress towards meeting the targets, especially for saturated fat.
{"title":"Assessing the impact of voluntary food reformulation targets: Mid-point assessment of Australia’s voluntary sodium and saturated fat reduction policy","authors":"Daisy H. Coyle, Liping Huang, Monica Hu, Nadine Ghammachi, Simone Pettigrew, Jason H. Y. Wu","doi":"10.1038/s41430-025-01647-5","DOIUrl":"10.1038/s41430-025-01647-5","url":null,"abstract":"Most reformulation initiatives worldwide are implemented through voluntary measures. Despite the reliance on voluntary targets, there is limited evidence of their effectiveness. This study aimed to assess the impact of Australia’s voluntary sodium and saturated fat reformulation policy halfway through its four-year implementation period. The 2019 and 2022 FoodSwitch databases provided data on the nutritional composition of packaged foods sold by major Australian supermarket retailers. For the food categories targeted by the policy, we assessed changes between 2019 and 2022 in (i) the overall proportions of products that met the sodium and saturated fat targets and (ii) changes in the proportion of products meeting the targets across the top 10 leading food manufacturers. Between 2019 and 2022, there was a small increase in the proportion of products meeting the sodium targets (50.0% in 2019 versus 57.5% in 2022, p < 0.001). Across the top 10 manufacturers that sold products subject to a sodium target, seven made progress towards meeting the targets (ranging from +1.6% to +30.2%). For saturated fat, the proportion of products meeting the targets didn’t change (61.1% in 2019 versus 60.2% in 2022, p = 0.74) and nine of the 10 top manufacturers did not make any progress towards meeting the targets. Midway through the implementation period of Australia’s voluntary sodium and saturated fat targets, food manufacturers have made minimal progress towards meeting the targets, especially for saturated fat.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 10","pages":"1060-1065"},"PeriodicalIF":3.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-025-01647-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-24DOI: 10.1038/s41430-025-01644-8
Rohan Singh, Mathieu Théo Eric Verest, Marcel Salathé
Accurate dietary assessment is essential for understanding diet–health relationships, yet day-to-day variability in intake complicates the identification of individuals’ usual consumption. This study aimed to determine the minimum number of days required to obtain reliable estimates of dietary intake across various nutrients and food groups using data from a large digital cohort. We analyzed dietary data from 958 participants of the “Food & You” study in Switzerland, who tracked their meals for 2–4 weeks using the AI-assisted MyFoodRepo app. Over 315,000 meals were logged across 23,335 participant days. We assessed day-of-week intake patterns using linear mixed models and estimated minimum days for reliable measurement using two complementary methods: (1) the coefficient of variation (CV) method based on within- and between-subject variability, and (2) intraclass correlation coefficient (ICC) analysis across all possible day combinations. Our findings indicate that water, coffee, and total food quantity can be reliably estimated (r > 0.85) with just 1–2 days of data. Most macronutrients, including carbohydrates, protein, and fat, achieved good reliability (r = 0.8) within 2–3 days. Micronutrients and food groups like meat and vegetables generally required 3–4 days. Linear mixed models revealed significant day-of-week effects, with higher energy, carbohydrate, and alcohol intake on weekends—especially among younger participants and those with higher BMI. ICC analyses further showed that including both weekdays and weekends increased reliability, and specific day combinations outperformed others. Three to four days of dietary data collection, ideally non-consecutive and including at least one weekend day, are sufficient for reliable estimation of most nutrients. These results support and refine FAO recommendations, offering more nutrient-specific guidance for efficient and accurate dietary assessment in epidemiological research.
{"title":"Minimum days estimation for reliable dietary intake information: findings from a digital cohort","authors":"Rohan Singh, Mathieu Théo Eric Verest, Marcel Salathé","doi":"10.1038/s41430-025-01644-8","DOIUrl":"10.1038/s41430-025-01644-8","url":null,"abstract":"Accurate dietary assessment is essential for understanding diet–health relationships, yet day-to-day variability in intake complicates the identification of individuals’ usual consumption. This study aimed to determine the minimum number of days required to obtain reliable estimates of dietary intake across various nutrients and food groups using data from a large digital cohort. We analyzed dietary data from 958 participants of the “Food & You” study in Switzerland, who tracked their meals for 2–4 weeks using the AI-assisted MyFoodRepo app. Over 315,000 meals were logged across 23,335 participant days. We assessed day-of-week intake patterns using linear mixed models and estimated minimum days for reliable measurement using two complementary methods: (1) the coefficient of variation (CV) method based on within- and between-subject variability, and (2) intraclass correlation coefficient (ICC) analysis across all possible day combinations. Our findings indicate that water, coffee, and total food quantity can be reliably estimated (r > 0.85) with just 1–2 days of data. Most macronutrients, including carbohydrates, protein, and fat, achieved good reliability (r = 0.8) within 2–3 days. Micronutrients and food groups like meat and vegetables generally required 3–4 days. Linear mixed models revealed significant day-of-week effects, with higher energy, carbohydrate, and alcohol intake on weekends—especially among younger participants and those with higher BMI. ICC analyses further showed that including both weekdays and weekends increased reliability, and specific day combinations outperformed others. Three to four days of dietary data collection, ideally non-consecutive and including at least one weekend day, are sufficient for reliable estimation of most nutrients. These results support and refine FAO recommendations, offering more nutrient-specific guidance for efficient and accurate dietary assessment in epidemiological research.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 10","pages":"1007-1017"},"PeriodicalIF":3.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-025-01644-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-22DOI: 10.1038/s41430-025-01649-3
Anna Winkvist, Ciara Mangan, Ingegerd Johansson, Annemarie E. Bennett
High dietary diversity is recognized as a crucial element of diet quality because this ensures abundant nutrients. A diverse diet may also provide health benefits beyond nutritional adequacy. Few studies have evaluated associations with lipid profile. The aim of this study was to investigate the association between dietary diversity and metabolic health and common measures of diet quality in a large population-based sample. This was a cross-sectional analysis within the Västerbotten Intervention Programme (VIP). Participants filled out an extensive health questionnaire including a 66-item semi-quantitative food frequency questionnaire (FFQ). The FFQ was used to create dietary diversity scores (DDS) for 5 major and 13 minor food groups. Associations between DDS and concurrent fasting lipid profile and measured body mass index (BMI) were explored with multivariable linear regression. Correlation analyses were used to explore the relationship between DDS and diet quality. The mean age of participants was 51 ± 8.3 years, with females comprising 50.8% of the study population (n = 82,171). Higher DDS was associated with decreased total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides (all p < 0.01). DDS had no significant association with BMI. DDS had a positive correlation with the Relative Mediterranean Diet Score, the Healthy Nordic Food Index and the Healthy Diet Score, and a negative correlation with the Dietary Inflammatory Index (all p < 0.001). The results add to the body of research showing metabolic health benefits of dietary diversity. More consistent methods of measuring dietary diversity should be developed, with careful consideration given to the healthfulness of foods included in the definition.
{"title":"Dietary diversity and metabolic health among people in Västerbotten, Sweden","authors":"Anna Winkvist, Ciara Mangan, Ingegerd Johansson, Annemarie E. Bennett","doi":"10.1038/s41430-025-01649-3","DOIUrl":"10.1038/s41430-025-01649-3","url":null,"abstract":"High dietary diversity is recognized as a crucial element of diet quality because this ensures abundant nutrients. A diverse diet may also provide health benefits beyond nutritional adequacy. Few studies have evaluated associations with lipid profile. The aim of this study was to investigate the association between dietary diversity and metabolic health and common measures of diet quality in a large population-based sample. This was a cross-sectional analysis within the Västerbotten Intervention Programme (VIP). Participants filled out an extensive health questionnaire including a 66-item semi-quantitative food frequency questionnaire (FFQ). The FFQ was used to create dietary diversity scores (DDS) for 5 major and 13 minor food groups. Associations between DDS and concurrent fasting lipid profile and measured body mass index (BMI) were explored with multivariable linear regression. Correlation analyses were used to explore the relationship between DDS and diet quality. The mean age of participants was 51 ± 8.3 years, with females comprising 50.8% of the study population (n = 82,171). Higher DDS was associated with decreased total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides (all p < 0.01). DDS had no significant association with BMI. DDS had a positive correlation with the Relative Mediterranean Diet Score, the Healthy Nordic Food Index and the Healthy Diet Score, and a negative correlation with the Dietary Inflammatory Index (all p < 0.001). The results add to the body of research showing metabolic health benefits of dietary diversity. More consistent methods of measuring dietary diversity should be developed, with careful consideration given to the healthfulness of foods included in the definition.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 10","pages":"1046-1052"},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-025-01649-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-21DOI: 10.1038/s41430-025-01646-6
Mette Bohl, Søren Gregersen, Zhihang Li, Andreas Blennow, Kim H. Hebelstrup, Kjeld Hermansen
Genetically modified (GMO) high-amylose barley lowers postprandial glucose. Since certain EU countries do not allow GMO barley, we therefore assessed if high-amylose barley made from traditional breeding (Lean Baking Barley, LBB) lowers postprandial glucose compared to bread made from regular barley (RB) or wheat (WF) in individuals with or without type 2 diabetes (T2D). In a randomised crossover design, 38 participants (18 T2D and 20 non-T2D) consumed 160 g of bread made from 100% LBB, RB, or WF. Postprandial metabolic responses, appetite and bread perception were measured. A mixed model ANOVA was used for analysis. LBB bread reduced 4 h postprandial glucose measured as incremental area under the curve (iAUC) by 41% and 39% vs. WF and RB bread in T2D and by 28% and 32% in non-T2D (all, P < 0.05). In T2D, LBB reduced postprandial insulin (iAUC) by 52% and 38% vs. WF and RB, and by 60% vs. WF in non-T2D (all, P < 0.05). Postprandial GIP (iAUC) was lower after LBB in both groups vs. RB and WF (P < 0.05). GLP-1 (iAUC) and FFA (tAUC) were lower after LBB vs. WF in non-T2D (P < 0.05), but not in T2D. Appetite scores were similar for all breads. Overall liking was higher for WF but did not differ between barley types. LBB breads reduce postprandial glucose and insulin compared to RB and WF bread in individuals irrespective of T2D. LBB may have potential as a functional food in prevention and management of T2D. ClinicalTrails.gov registration: NCT04702672.
{"title":"High-amylose barley bread improves postprandial glycemia compared to regular barley and wheat bread in subjects with or without type 2 diabetes","authors":"Mette Bohl, Søren Gregersen, Zhihang Li, Andreas Blennow, Kim H. Hebelstrup, Kjeld Hermansen","doi":"10.1038/s41430-025-01646-6","DOIUrl":"10.1038/s41430-025-01646-6","url":null,"abstract":"Genetically modified (GMO) high-amylose barley lowers postprandial glucose. Since certain EU countries do not allow GMO barley, we therefore assessed if high-amylose barley made from traditional breeding (Lean Baking Barley, LBB) lowers postprandial glucose compared to bread made from regular barley (RB) or wheat (WF) in individuals with or without type 2 diabetes (T2D). In a randomised crossover design, 38 participants (18 T2D and 20 non-T2D) consumed 160 g of bread made from 100% LBB, RB, or WF. Postprandial metabolic responses, appetite and bread perception were measured. A mixed model ANOVA was used for analysis. LBB bread reduced 4 h postprandial glucose measured as incremental area under the curve (iAUC) by 41% and 39% vs. WF and RB bread in T2D and by 28% and 32% in non-T2D (all, P < 0.05). In T2D, LBB reduced postprandial insulin (iAUC) by 52% and 38% vs. WF and RB, and by 60% vs. WF in non-T2D (all, P < 0.05). Postprandial GIP (iAUC) was lower after LBB in both groups vs. RB and WF (P < 0.05). GLP-1 (iAUC) and FFA (tAUC) were lower after LBB vs. WF in non-T2D (P < 0.05), but not in T2D. Appetite scores were similar for all breads. Overall liking was higher for WF but did not differ between barley types. LBB breads reduce postprandial glucose and insulin compared to RB and WF bread in individuals irrespective of T2D. LBB may have potential as a functional food in prevention and management of T2D. ClinicalTrails.gov registration: NCT04702672.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 10","pages":"1000-1006"},"PeriodicalIF":3.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-025-01646-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-21DOI: 10.1038/s41430-025-01637-7
Tingwen Wang, Jiaqing Huang, Zhou Shang, Mai Deng, JiaDun Su, Xuanyu Duan, Derui Kong
The incidence of malnutrition in patients undergoing abdominal surgery exceeds 50%, and postoperative nutritional support is crucial for improving patient outcomes. While Enhanced Recovery After Surgery (ERAS) protocols highlight early nutrition support, their impact on different nutritional strategies remains unclear. This study assessed the effects and safety of enteral nutrition (EN), early-supplemental parenteral nutrition (E-SPN), late-supplemental parenteral nutrition (L-SPN), and total parenteral nutrition (TPN) through network meta-analysis. Three databases were searched to obtain randomized controlled trials involving four interventions for postoperative nutritional supportive therapy in abdominal surgical patients. We used The Cochrane Handbook tool (2.0) to assess the risk bias of included studies. The primary outcome was the occurrence of postoperative adverse events. Network meta-analysis was performed using STATA 14. A total of 48 studies involving 6277 patients were included. Network meta-analysis showed that compared with other nutritional therapy E-SPN was likely more effective than other modalities in terms of reduction of postoperative adverse events (OR = 3.02, 95% CI: 1.81–5.02), infectious adverse events (OR = 3.12, 95% CI: 1.59–6.15), non-infectious adverse events (OR = 2.47, 95% CI: 1.14–5.34), shortening the resumption of exhaust time (SMD = 0.98, 95% CI: 0.59–1.36), and improvement of serum albumin (SMD = −2.74, 95% CI: −4.98–0.50). The final surface under the cumulative ranking curve value indicated that E-SPN achieved the best effect in those outcomes. The obtained results support using E-SPN in patients undergoing abdominal surgery, which might reduce adverse events, shorten recovery time, and improve patient outcomes. However, since serum albumin is primarily an inflammatory marker rather than a direct indicator of nutritional status, its role in evaluating SPN benefits should be interpreted with caution. Further research is needed to assess SPN’s effectiveness in patients undergoing surgery according to an ERAS protocol.
{"title":"Efficacy and safety of nutrition therapy for patients undergoing abdominal surgery: a systematic review and network meta-analysis","authors":"Tingwen Wang, Jiaqing Huang, Zhou Shang, Mai Deng, JiaDun Su, Xuanyu Duan, Derui Kong","doi":"10.1038/s41430-025-01637-7","DOIUrl":"10.1038/s41430-025-01637-7","url":null,"abstract":"The incidence of malnutrition in patients undergoing abdominal surgery exceeds 50%, and postoperative nutritional support is crucial for improving patient outcomes. While Enhanced Recovery After Surgery (ERAS) protocols highlight early nutrition support, their impact on different nutritional strategies remains unclear. This study assessed the effects and safety of enteral nutrition (EN), early-supplemental parenteral nutrition (E-SPN), late-supplemental parenteral nutrition (L-SPN), and total parenteral nutrition (TPN) through network meta-analysis. Three databases were searched to obtain randomized controlled trials involving four interventions for postoperative nutritional supportive therapy in abdominal surgical patients. We used The Cochrane Handbook tool (2.0) to assess the risk bias of included studies. The primary outcome was the occurrence of postoperative adverse events. Network meta-analysis was performed using STATA 14. A total of 48 studies involving 6277 patients were included. Network meta-analysis showed that compared with other nutritional therapy E-SPN was likely more effective than other modalities in terms of reduction of postoperative adverse events (OR = 3.02, 95% CI: 1.81–5.02), infectious adverse events (OR = 3.12, 95% CI: 1.59–6.15), non-infectious adverse events (OR = 2.47, 95% CI: 1.14–5.34), shortening the resumption of exhaust time (SMD = 0.98, 95% CI: 0.59–1.36), and improvement of serum albumin (SMD = −2.74, 95% CI: −4.98–0.50). The final surface under the cumulative ranking curve value indicated that E-SPN achieved the best effect in those outcomes. The obtained results support using E-SPN in patients undergoing abdominal surgery, which might reduce adverse events, shorten recovery time, and improve patient outcomes. However, since serum albumin is primarily an inflammatory marker rather than a direct indicator of nutritional status, its role in evaluating SPN benefits should be interpreted with caution. Further research is needed to assess SPN’s effectiveness in patients undergoing surgery according to an ERAS protocol.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 11","pages":"1078-1086"},"PeriodicalIF":3.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-19DOI: 10.1038/s41430-025-01638-6
Maren Wolf, Mónica Mazariegos, Oscar Cordón, Karla Mesarina, Maria Elena D. Jefferds, O. Yaw Addo, Mireya Palmieri
This paper defines the double burden of malnutrition as occurring when over- and undernutrition coexist within a household. It is most common in countries undergoing the nutrition transition where cheap and accessible food is often of poor quality. This brief narrative review examines four cycles of reports from the Epidemiological Health and Nutrition Surveillance System (SIVESNU, Spanish acronym) in Guatemala between 2015–2018/19, examining the following indicators: overall double burden of stunting among children aged ≤59 months and overweight or obesity among women aged 15–49 years in the same household, and individual stunting, overweight, and obesity by indigenous/non-indigenous ethnicity. The review also incorporates double burden prevalence in Guatemala from the literature since 1995. In 1995, the double burden prevalence was 13.4%, and negligible change occurred from 2000 to 2018/19 (18.2% and 17.6%, respectively). Individual level prevalences for stunting, overweight, and obesity were notable, with large disparities in stunting prevalence by ethnicity.
{"title":"Double burden of malnutrition in Guatemala: co-existence of childhood stunting and overweight and obesity within the household","authors":"Maren Wolf, Mónica Mazariegos, Oscar Cordón, Karla Mesarina, Maria Elena D. Jefferds, O. Yaw Addo, Mireya Palmieri","doi":"10.1038/s41430-025-01638-6","DOIUrl":"10.1038/s41430-025-01638-6","url":null,"abstract":"This paper defines the double burden of malnutrition as occurring when over- and undernutrition coexist within a household. It is most common in countries undergoing the nutrition transition where cheap and accessible food is often of poor quality. This brief narrative review examines four cycles of reports from the Epidemiological Health and Nutrition Surveillance System (SIVESNU, Spanish acronym) in Guatemala between 2015–2018/19, examining the following indicators: overall double burden of stunting among children aged ≤59 months and overweight or obesity among women aged 15–49 years in the same household, and individual stunting, overweight, and obesity by indigenous/non-indigenous ethnicity. The review also incorporates double burden prevalence in Guatemala from the literature since 1995. In 1995, the double burden prevalence was 13.4%, and negligible change occurred from 2000 to 2018/19 (18.2% and 17.6%, respectively). Individual level prevalences for stunting, overweight, and obesity were notable, with large disparities in stunting prevalence by ethnicity.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 10","pages":"1066-1068"},"PeriodicalIF":3.3,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-11DOI: 10.1038/s41430-025-01640-y
Chanita Unhapipatpong, Katherine J. P. Schwenger, David Armstrong, Barbara Bielawska, Brian Jurewitsch, J. D. McHattie, Donald R. Duerksen, Yidan Lu, Dane Christina Daoud, Anabelle Cloutier, Matreyi Raman, Leah Gramlich, George Ou, Johane P. Allard
Home parenteral nutrition (HPN) is indicated for patients with intestinal failure, but its use in cancer patients requires careful consideration due to the unique challenges and complexities involved. This prospective cohort study analyzed data from cancer patients receiving HPN, recorded in the Canadian HPN Registry from 2003 to 2022. Patients were divided into two groups: those with gastrointestinal or gynecologic cancer and a propensity score-matched cohort of non-cancer patients. The objective was to assess survival rates by performance status and prescription decade in both groups. Secondary objectives were to compare complications between the groups. A total of 400 HPN patients were enrolled: 200 cancer patients (128 gastrointestinal, 72 gynecologic) and 200 matched non-cancer patients. Median age (interquartile range) was 58 (16) years for cancer and 56 (19) for non-cancer groups, with 71.5% and 66.5% female, respectively. Median survival was 1.71 years (95% confidence interval (CI), 0.81–2.61) for gastrointestinal cancer, 0.99 years (95% CI, 0.36–1.6) for gynecologic cancer, and 3.89 years (95% CI, 2.72–5.06) for non-cancer patients (p-value < 0.001). Survival showed no improvement over two decades. Patients with Karnofsky Performance Scale (KPS) ≤ 50 had shorter survival. Catheter complications and HPN-related hospitalizations were similar, but HPN-related liver disease was more common in non-cancer patients (16.5% vs. 9%, p-value = 0.025). Survival for patients with gastrointestinal and gynecologic cancer and co-existing intestinal failure has not improved over the past two decades, with poorer outcomes observed in those with low KPS. Complication rates were similar in both groups.
背景：家庭肠外营养（HPN）适用于肠衰竭患者，但由于其独特的挑战和复杂性，在癌症患者中的应用需要仔细考虑。方法：这项前瞻性队列研究分析了2003年至2022年加拿大HPN登记处记录的接受HPN治疗的癌症患者的数据。患者被分为两组：胃肠道或妇科癌症患者和倾向评分匹配的非癌症患者。目的是评估两组患者的表现状态和处方年限的生存率。次要目的是比较两组之间的并发症。结果：共纳入400例HPN患者：200例肿瘤患者（128例胃肠道患者，72例妇科患者）和200例匹配的非肿瘤患者。癌症组的中位年龄（四分位数范围）为58（16）岁，非癌症组为56（19）岁，分别为71.5%和66.5%的女性。胃肠道肿瘤患者的中位生存期为1.71年（95%可信区间（CI） 0.81-2.61），妇科肿瘤患者的中位生存期为0.99年（95% CI, 0.36-1.6），非癌症患者的中位生存期为3.89年（95% CI, 2.72-5.06） (p值结论：胃肠道和妇科肿瘤合并肠道衰竭患者的生存期在过去20年没有改善，低KPS患者的预后更差。两组的并发症发生率相似。图形摘要：在BioRender中创建。Unhapipatpong， C. (2025) https://BioRender.com/l25d998。
{"title":"Comparative clinical outcomes of home parenteral nutrition in adults with gastrointestinal or gynecologic cancers versus non-cancer patients: a prospective cohort study using propensity score matching from the Canadian HPN registry","authors":"Chanita Unhapipatpong, Katherine J. P. Schwenger, David Armstrong, Barbara Bielawska, Brian Jurewitsch, J. D. McHattie, Donald R. Duerksen, Yidan Lu, Dane Christina Daoud, Anabelle Cloutier, Matreyi Raman, Leah Gramlich, George Ou, Johane P. Allard","doi":"10.1038/s41430-025-01640-y","DOIUrl":"10.1038/s41430-025-01640-y","url":null,"abstract":"Home parenteral nutrition (HPN) is indicated for patients with intestinal failure, but its use in cancer patients requires careful consideration due to the unique challenges and complexities involved. This prospective cohort study analyzed data from cancer patients receiving HPN, recorded in the Canadian HPN Registry from 2003 to 2022. Patients were divided into two groups: those with gastrointestinal or gynecologic cancer and a propensity score-matched cohort of non-cancer patients. The objective was to assess survival rates by performance status and prescription decade in both groups. Secondary objectives were to compare complications between the groups. A total of 400 HPN patients were enrolled: 200 cancer patients (128 gastrointestinal, 72 gynecologic) and 200 matched non-cancer patients. Median age (interquartile range) was 58 (16) years for cancer and 56 (19) for non-cancer groups, with 71.5% and 66.5% female, respectively. Median survival was 1.71 years (95% confidence interval (CI), 0.81–2.61) for gastrointestinal cancer, 0.99 years (95% CI, 0.36–1.6) for gynecologic cancer, and 3.89 years (95% CI, 2.72–5.06) for non-cancer patients (p-value < 0.001). Survival showed no improvement over two decades. Patients with Karnofsky Performance Scale (KPS) ≤ 50 had shorter survival. Catheter complications and HPN-related hospitalizations were similar, but HPN-related liver disease was more common in non-cancer patients (16.5% vs. 9%, p-value = 0.025). Survival for patients with gastrointestinal and gynecologic cancer and co-existing intestinal failure has not improved over the past two decades, with poorer outcomes observed in those with low KPS. Complication rates were similar in both groups.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 10","pages":"1036-1045"},"PeriodicalIF":3.3,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Self-reported abdominal symptoms after consuming gluten-containing cereals in individuals without celiac disease (CeD) are common. The long-term outcomes of these individuals are unknown. Seventy-six adults experiencing symptoms from gluten-containing cereals underwent exclusion of CeD and wheat allergy in 1995–1997 and were thus advised to revert to a normal gluten-containing diet. These individuals were invited to a comprehensive health examination, including measurement of CeD antibodies and symptoms and assessment of quality of life using the Gastrointestinal Symptom Rating Scale (GSRS) and Psychological General Well-Being Index (PGWB). Healthy individuals (n = 160) and untreated CeD patients (n = 128) served as controls. Altogether, 28 individuals participated, half of whom were still avoiding gluten-containing cereals. None had acquired a diagnosis of any gastrointestinal disease, and all had negative CeD serology. The entire study group presented with significantly higher GSRS total (participants 2.8, 95% confidence interval 2.5–3.1 vs. controls 1.8, 1.7–1.9; p < 0.001) and other sub-scores than healthy controls, and higher total (vs. patients 2.5, 2.3–2.6; p = 0.041) and constipation scores than untreated CeD patients. Additionally, the group had worse PGWB total (participants 92.1, 84.9–99.4 vs. controls 105.3, 102.5–108.7; p = 0.002) and anxiety, self-control, general health, and vitality sub-cores than healthy controls, as well as self-control, general health, and vitality scores than untreated CeD patients. Twelve participants fulfilled the criteria for irritable bowel syndrome. None of the participants had developed CeD or been diagnosed with gastrointestinal disease for 25 years. They reported more gastrointestinal symptoms and a poorer quality of life, even when compared to untreated CeD patients.
{"title":"Long-term health outcomes of people without celiac disease avoiding gluten consumption: a 25-year prospective cohort study","authors":"Eeva Salmela, Kurppa Kalle, Katri Lindfors, Päivi Saavalainen, Heini Huhtala, Katri Kaukinen, Juha Taavela","doi":"10.1038/s41430-025-01641-x","DOIUrl":"10.1038/s41430-025-01641-x","url":null,"abstract":"Self-reported abdominal symptoms after consuming gluten-containing cereals in individuals without celiac disease (CeD) are common. The long-term outcomes of these individuals are unknown. Seventy-six adults experiencing symptoms from gluten-containing cereals underwent exclusion of CeD and wheat allergy in 1995–1997 and were thus advised to revert to a normal gluten-containing diet. These individuals were invited to a comprehensive health examination, including measurement of CeD antibodies and symptoms and assessment of quality of life using the Gastrointestinal Symptom Rating Scale (GSRS) and Psychological General Well-Being Index (PGWB). Healthy individuals (n = 160) and untreated CeD patients (n = 128) served as controls. Altogether, 28 individuals participated, half of whom were still avoiding gluten-containing cereals. None had acquired a diagnosis of any gastrointestinal disease, and all had negative CeD serology. The entire study group presented with significantly higher GSRS total (participants 2.8, 95% confidence interval 2.5–3.1 vs. controls 1.8, 1.7–1.9; p < 0.001) and other sub-scores than healthy controls, and higher total (vs. patients 2.5, 2.3–2.6; p = 0.041) and constipation scores than untreated CeD patients. Additionally, the group had worse PGWB total (participants 92.1, 84.9–99.4 vs. controls 105.3, 102.5–108.7; p = 0.002) and anxiety, self-control, general health, and vitality sub-cores than healthy controls, as well as self-control, general health, and vitality scores than untreated CeD patients. Twelve participants fulfilled the criteria for irritable bowel syndrome. None of the participants had developed CeD or been diagnosed with gastrointestinal disease for 25 years. They reported more gastrointestinal symptoms and a poorer quality of life, even when compared to untreated CeD patients.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 10","pages":"1053-1059"},"PeriodicalIF":3.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41430-025-01641-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The interplay between beverage consumption patterns and critical aspects of health, such as quality of life (QoL) and sleep disorders, has been increasingly recognized. This study is essential as it explores how the Healthy Beverage Index (HBI) and Healthy Beverage Score (HBS) relate to sleep disorders and QoL in a diverse adult population, highlighting their impact on various health aspects. A cross-sectional analysis was conducted using data from the Shiraz University of Medical Sciences Employees Health Cohort Study (SUMS EHCS), encompassing 3380 participants aged 20–65. Data collection included a 119-item Food Frequency Questionnaire (FFQ) and comprehensive anthropometric, lifestyle, and health-related assessments. HBI and HBS were computed to evaluate beverage consumption patterns, and their associations with sleep quality and QoL were analyzed using logistic regression models. Higher HBI scores were significantly associated with 16% improved QoL (OR: 1.16, 95% CI: 1.02–1.29, p = 0.034) and a 17% reduced risk of sleep disorders (OR = 0.83, 95% CI: 0.69–0.99, p = 0.039). However, HBS did not significantly correlate with QoL or sleep quality. As indicated by higher HBI scores, the findings emphasize that promoting healthier beverage choices could enhance sleep quality and overall life satisfaction.
背景/目的：饮料消费模式与健康的关键方面之间的相互作用，如生活质量（QoL）和睡眠障碍，已经越来越被认识到。这项研究是至关重要的，因为它探讨了健康饮料指数（HBI）和健康饮料评分（HBS）与不同成人人群中睡眠障碍和生活质量的关系，突出了它们对各个健康方面的影响。对象/方法：采用设拉子医科大学员工健康队列研究（sum EHCS）的数据进行横断面分析，包括3380名年龄在20-65岁之间的参与者。数据收集包括119项食物频率问卷（FFQ）和综合人体测量、生活方式和健康相关评估。计算HBI和HBS来评估饮料消费模式，并使用逻辑回归模型分析其与睡眠质量和生活质量的关系。结果：较高的HBI评分与16%的生活质量改善（OR: 1.16, 95% CI: 1.02-1.29, p = 0.034）和17%的睡眠障碍风险降低（OR = 0.83, 95% CI: 0.69-0.99, p = 0.039）显著相关。然而，HBS与生活质量或睡眠质量没有显著相关。结论：正如较高的HBI分数所表明的那样，研究结果强调了促进健康饮料的选择可以提高睡眠质量和整体生活满意度。
{"title":"Association between beverage quality with sleep disorders and quality of life: a cross-sectional study","authors":"Kimia Leilami, Seyedhassan Sadrian, Zahra Ghazimoradi, Zahra Rezaei, Atefeh Torabi Ardekani, Morteza Zare, Seyed Jalil Masoumi","doi":"10.1038/s41430-025-01624-y","DOIUrl":"10.1038/s41430-025-01624-y","url":null,"abstract":"The interplay between beverage consumption patterns and critical aspects of health, such as quality of life (QoL) and sleep disorders, has been increasingly recognized. This study is essential as it explores how the Healthy Beverage Index (HBI) and Healthy Beverage Score (HBS) relate to sleep disorders and QoL in a diverse adult population, highlighting their impact on various health aspects. A cross-sectional analysis was conducted using data from the Shiraz University of Medical Sciences Employees Health Cohort Study (SUMS EHCS), encompassing 3380 participants aged 20–65. Data collection included a 119-item Food Frequency Questionnaire (FFQ) and comprehensive anthropometric, lifestyle, and health-related assessments. HBI and HBS were computed to evaluate beverage consumption patterns, and their associations with sleep quality and QoL were analyzed using logistic regression models. Higher HBI scores were significantly associated with 16% improved QoL (OR: 1.16, 95% CI: 1.02–1.29, p = 0.034) and a 17% reduced risk of sleep disorders (OR = 0.83, 95% CI: 0.69–0.99, p = 0.039). However, HBS did not significantly correlate with QoL or sleep quality. As indicated by higher HBI scores, the findings emphasize that promoting healthier beverage choices could enhance sleep quality and overall life satisfaction.","PeriodicalId":11927,"journal":{"name":"European Journal of Clinical Nutrition","volume":"79 10","pages":"972-979"},"PeriodicalIF":3.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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