Pub Date : 1995-04-01DOI: 10.1097/00008469-199504000-00008
M. Filipe, D. Newell, B. Johnston, C. Caygill, P. I. Reed
The incidence of Helicobacter pylori was compared in high and low risk gastric cancer areas. Complete data were available on 116 age and sex matched sets of cases--patients with histologically proven intestinal metaplasia (IM)--and two control groups, one non-IM endoscoped controls (EC) and one non-endoscoped controls (NC) recruited from out-patient clinics. H. pylori status was determined by both serology and histology in individuals biopsied from three separate gastric sites. Our data show an increased incidence of H. pylori and intestinal metaplasia in areas at high risk for gastric cancer, good agreement on H. pylori status between histology and serology and a relationship between H. pylori status in individual biopsies and the degree of gastritis. With 116 matched sets of patients this is one of the largest series to date and supports the hypothesis that H. pylori infection may be involved in gastric carcinogenesis through chronic gastritis and intestinal metaplasia.
{"title":"Helicobacter pylori in patients with intestinal metaplasia and in controls: a serological and biopsy study in four UK centres. UK Sub-Group of the ECP-EURONUT-Intestinal Metaplasia Study Group.","authors":"M. Filipe, D. Newell, B. Johnston, C. Caygill, P. I. Reed","doi":"10.1097/00008469-199504000-00008","DOIUrl":"https://doi.org/10.1097/00008469-199504000-00008","url":null,"abstract":"The incidence of Helicobacter pylori was compared in high and low risk gastric cancer areas. Complete data were available on 116 age and sex matched sets of cases--patients with histologically proven intestinal metaplasia (IM)--and two control groups, one non-IM endoscoped controls (EC) and one non-endoscoped controls (NC) recruited from out-patient clinics. H. pylori status was determined by both serology and histology in individuals biopsied from three separate gastric sites. Our data show an increased incidence of H. pylori and intestinal metaplasia in areas at high risk for gastric cancer, good agreement on H. pylori status between histology and serology and a relationship between H. pylori status in individual biopsies and the degree of gastritis. With 116 matched sets of patients this is one of the largest series to date and supports the hypothesis that H. pylori infection may be involved in gastric carcinogenesis through chronic gastritis and intestinal metaplasia.","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"22 1","pages":"175-80"},"PeriodicalIF":0.0,"publicationDate":"1995-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73077416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1995-02-01DOI: 10.1097/00008469-199502000-00005
J. Wardle, A. Steptoe, H. Smith, E. Groll-knapp, M. Koller, D. Smith, A. Brodziak
Breast self examination (BSE) is recommended for the early detection of breast cancer in the European Code against Cancer. Evidence from North America suggests that there is reasonable public awareness of its importance, but compliance with regular BSE is reported by only a minority of young women. Attitudes to and practice of BSE has rarely been studied outside North America. In the present study, attitudes to BSE were evaluated by questionnaire in a sample of 16,486 students aged 17-30 from 20 European countries. Frequency of BSE practice was reported by the 9,181 women in the sample. Information on public recommendations concerning BSE was obtained from cancer organizations in each country. The data were collected as part of the European Health Behaviour Survey, an international study on health beliefs and health behaviour. The results showed that BSE was recommended in 16 countries and 'breast awareness' in two, while two countries did not recommend self-examination. 54% of women reported as never having practiced BSE. Regular practice (monthly) was reported by only 8% of the sample, with another 36% reporting occasional BSE. Significant differences emerged between centres in different countries ranging from 6% to 15% reporting regular BSE. Attitude towards BSE was a significant predictor of BSE practice within each centre and across all centres combined. Attitudes towards BSE were significantly less positive in the two centres from countries without BSE recommendations than in the others, but levels of practice were similar.(ABSTRACT TRUNCATED AT 250 WORDS)
{"title":"Breast self-examination: attitudes and practices among young women in Europe.","authors":"J. Wardle, A. Steptoe, H. Smith, E. Groll-knapp, M. Koller, D. Smith, A. Brodziak","doi":"10.1097/00008469-199502000-00005","DOIUrl":"https://doi.org/10.1097/00008469-199502000-00005","url":null,"abstract":"Breast self examination (BSE) is recommended for the early detection of breast cancer in the European Code against Cancer. Evidence from North America suggests that there is reasonable public awareness of its importance, but compliance with regular BSE is reported by only a minority of young women. Attitudes to and practice of BSE has rarely been studied outside North America. In the present study, attitudes to BSE were evaluated by questionnaire in a sample of 16,486 students aged 17-30 from 20 European countries. Frequency of BSE practice was reported by the 9,181 women in the sample. Information on public recommendations concerning BSE was obtained from cancer organizations in each country. The data were collected as part of the European Health Behaviour Survey, an international study on health beliefs and health behaviour. The results showed that BSE was recommended in 16 countries and 'breast awareness' in two, while two countries did not recommend self-examination. 54% of women reported as never having practiced BSE. Regular practice (monthly) was reported by only 8% of the sample, with another 36% reporting occasional BSE. Significant differences emerged between centres in different countries ranging from 6% to 15% reporting regular BSE. Attitude towards BSE was a significant predictor of BSE practice within each centre and across all centres combined. Attitudes towards BSE were significantly less positive in the two centres from countries without BSE recommendations than in the others, but levels of practice were similar.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"60 1","pages":"61-8"},"PeriodicalIF":0.0,"publicationDate":"1995-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80944751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1994-01-01DOI: 10.1097/00008469-199401000-00010
A. Sadowska, E. Pluygers, M. Narkiewicz, A. Pawełczak, B. Lata
It is well documented that environmental pollution from industrial activity, sewage farms, hazardous waste sites, incinerators, etc, contributes to the overall cancer risk and that this contribution can be considerable under certain circumstances. It is important, therefore, to identify the level of genotoxic activity in the environment and to relate it to biomarkers of cancer risk in humans. After reviewing a range of cytogenetic assays, we have selected the Tradescantia micronucleus assay (TRAD-MCN) developed by Ma et al to be used in indoor and field evaluations. The meiotic pollen mother cells of T clone 4430 are particularly sensitive to chemical pollutants; the buds are exposed for 6-8 h. We describe assays made down wind from a coal-fired power station and from the vicinity of two waste sites. Statistically significant results were obtained at 200 m and 600 m down wind from the power station; higher levels of micronucleus frequencies (MN) were found in foggy rather than dry conditions. Similarly, in the vicinity of two waste sites the MN frequencies were significantly increased in both dry and foggy conditions up to 1.5 km down wind; this was despite previous efforts to rehabilitate the sites. The TRAD-MCN assay is sensitive, reproducible, easy to perform, well standardized, inexpensive and undemanding in equipment. We propose that it be the primary test for genotoxicity evaluation and mapping followed, in suspicious areas, by human biomarker assays.
{"title":"Environmental genotoxicity and cancer risk in humans: a combined evaluation correlating the results of the Tradescantia micronucleus assay in the field and human biomarker assessments in serum. I. The TRAD-MCN assay.","authors":"A. Sadowska, E. Pluygers, M. Narkiewicz, A. Pawełczak, B. Lata","doi":"10.1097/00008469-199401000-00010","DOIUrl":"https://doi.org/10.1097/00008469-199401000-00010","url":null,"abstract":"It is well documented that environmental pollution from industrial activity, sewage farms, hazardous waste sites, incinerators, etc, contributes to the overall cancer risk and that this contribution can be considerable under certain circumstances. It is important, therefore, to identify the level of genotoxic activity in the environment and to relate it to biomarkers of cancer risk in humans. After reviewing a range of cytogenetic assays, we have selected the Tradescantia micronucleus assay (TRAD-MCN) developed by Ma et al to be used in indoor and field evaluations. The meiotic pollen mother cells of T clone 4430 are particularly sensitive to chemical pollutants; the buds are exposed for 6-8 h. We describe assays made down wind from a coal-fired power station and from the vicinity of two waste sites. Statistically significant results were obtained at 200 m and 600 m down wind from the power station; higher levels of micronucleus frequencies (MN) were found in foggy rather than dry conditions. Similarly, in the vicinity of two waste sites the MN frequencies were significantly increased in both dry and foggy conditions up to 1.5 km down wind; this was despite previous efforts to rehabilitate the sites. The TRAD-MCN assay is sensitive, reproducible, easy to perform, well standardized, inexpensive and undemanding in equipment. We propose that it be the primary test for genotoxicity evaluation and mapping followed, in suspicious areas, by human biomarker assays.","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"8 1","pages":"69-78"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78745352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00022
P. Neven
{"title":"Tamoxifen in premalignant and pre-invasive breast cancer.","authors":"P. Neven","doi":"10.1097/00008469-199311000-00022","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00022","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"51 1","pages":"147-51"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73981557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00011
R. Pauley, H. Soule, L. Tait, F. Miller, S. Wolman, P. Dawson, G. Heppner
{"title":"The MCF10 family of spontaneously immortalized human breast epithelial cell lines: models of neoplastic progression.","authors":"R. Pauley, H. Soule, L. Tait, F. Miller, S. Wolman, P. Dawson, G. Heppner","doi":"10.1097/00008469-199311000-00011","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00011","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"62 1","pages":"67-76"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84577713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00013
J. Russo, I. Russo
{"title":"Development pattern of human breast and susceptibility to carcinogenesis.","authors":"J. Russo, I. Russo","doi":"10.1097/00008469-199311000-00013","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00013","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"270 1","pages":"85-100"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82795269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00017
M. Stratton, N. Collins, S. Lakhani, J. Sloane
{"title":"Molecular analyses of in situ breast cancer.","authors":"M. Stratton, N. Collins, S. Lakhani, J. Sloane","doi":"10.1097/00008469-199311000-00017","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00017","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"32 1","pages":"123"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86269821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00021
J. Bonté
{"title":"Chemoprevention of breast cancer.","authors":"J. Bonté","doi":"10.1097/00008469-199311000-00021","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00021","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"12 1","pages":"141-5"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79515720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00018
D. Bishop
{"title":"The involvement of genetic factors in susceptibility to breast cancer.","authors":"D. Bishop","doi":"10.1097/00008469-199311000-00018","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00018","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"28 1","pages":"125-30"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85696893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00014
I. Russo, J. Russo
The relevance of this work lies in the possibility of extrapolating conclusions drawn here to the human situation, since we have assessed the validity of the rat model for the study of breast cancer in women through comparative studies in these two species (Russo and Russo, 1988). The novelty of our studies is the evidence that hCG protects the mammary gland against carcinogenic initiation and progression, mimicking the physiological process of pregnancy, without crippling other reproductive or endocrine functions (Russo et al, 1990d; Russo and Russo, 1992). The importance of both differentiation and cell proliferation in tumour initiation and progression, which we have stressed in previous publications (Russo and Russo, 1980, 1987, 1988; Russo et al, 1982) validates the use of these end-points for assessing the effect of hormones under the influence of hCG on the mammary gland initiated in the process of carcinogenesis. Collectively, our results provide solid bases for developing physiological means of breast cancer prevention and control.
这项工作的相关性在于有可能将这里得出的结论外推到人类的情况，因为我们已经通过对这两个物种的比较研究评估了大鼠模型在女性乳腺癌研究中的有效性(Russo和Russo, 1988)。我们研究的新颖之处在于，有证据表明，hCG可以保护乳腺免受致癌的发生和发展，模仿怀孕的生理过程，而不会损害其他生殖或内分泌功能(Russo等人，1990;Russo and Russo, 1992)。分化和细胞增殖在肿瘤发生和发展中的重要性，我们在以前的出版物中强调过(Russo和Russo, 1980,1987, 1988;Russo et al, 1982)验证了使用这些终点来评估激素在hCG影响下对癌变过程中启动的乳腺的影响。总之，我们的研究结果为发展乳腺癌的生理预防和控制手段提供了坚实的基础。
{"title":"Physiological bases of breast cancer prevention.","authors":"I. Russo, J. Russo","doi":"10.1097/00008469-199311000-00014","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00014","url":null,"abstract":"The relevance of this work lies in the possibility of extrapolating conclusions drawn here to the human situation, since we have assessed the validity of the rat model for the study of breast cancer in women through comparative studies in these two species (Russo and Russo, 1988). The novelty of our studies is the evidence that hCG protects the mammary gland against carcinogenic initiation and progression, mimicking the physiological process of pregnancy, without crippling other reproductive or endocrine functions (Russo et al, 1990d; Russo and Russo, 1992). The importance of both differentiation and cell proliferation in tumour initiation and progression, which we have stressed in previous publications (Russo and Russo, 1980, 1987, 1988; Russo et al, 1982) validates the use of these end-points for assessing the effect of hormones under the influence of hCG on the mammary gland initiated in the process of carcinogenesis. Collectively, our results provide solid bases for developing physiological means of breast cancer prevention and control.","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":"33 1","pages":"101-11"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85726744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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