Pub Date : 2023-03-01DOI: 10.12968/s0261-2097(23)60461-7
A partnership using a range of software tools has created a purpose-designed integrated handling solution for its new TQ-Lab modular plastics packaging testing station.
{"title":"Festo Delivers Complete Package","authors":"","doi":"10.12968/s0261-2097(23)60461-7","DOIUrl":"https://doi.org/10.12968/s0261-2097(23)60461-7","url":null,"abstract":"A partnership using a range of software tools has created a purpose-designed integrated handling solution for its new TQ-Lab modular plastics packaging testing station.","PeriodicalId":11962,"journal":{"name":"EUREKA: Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80645805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.12968/s0261-2097(23)60464-2
On 23rd March at the British Motor Museum, Gaydon, Engineering Solutions Live will once again open its doors. Featuring FAST Live, Engineering Materials Live and PCB Design all under one roof in a one-day, one-stop shop format, the event promises once again to deliver for design engineers.
{"title":"<b>Engineering Solutions</b> Live","authors":"","doi":"10.12968/s0261-2097(23)60464-2","DOIUrl":"https://doi.org/10.12968/s0261-2097(23)60464-2","url":null,"abstract":"On 23rd March at the British Motor Museum, Gaydon, Engineering Solutions Live will once again open its doors. Featuring FAST Live, Engineering Materials Live and PCB Design all under one roof in a one-day, one-stop shop format, the event promises once again to deliver for design engineers.","PeriodicalId":11962,"journal":{"name":"EUREKA: Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.12968/s0261-2097(23)60460-5
New torque sensor technologies could offer significant benefits in a range of new and traditional areas.
新的扭矩传感器技术可以在一系列新的和传统的领域提供显着的好处。
{"title":"Talking the <b>Torque</b>","authors":"","doi":"10.12968/s0261-2097(23)60460-5","DOIUrl":"https://doi.org/10.12968/s0261-2097(23)60460-5","url":null,"abstract":"New torque sensor technologies could offer significant benefits in a range of new and traditional areas.","PeriodicalId":11962,"journal":{"name":"EUREKA: Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.12968/s0261-2097(23)60467-8
{"title":"Thermal Interface Gel for Automotive","authors":"","doi":"10.12968/s0261-2097(23)60467-8","DOIUrl":"https://doi.org/10.12968/s0261-2097(23)60467-8","url":null,"abstract":"","PeriodicalId":11962,"journal":{"name":"EUREKA: Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87766694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.12968/s0261-2097(23)60457-5
How simulation software can save time, materials and instils confidence in additive are absolutely key reasons to invest in it, says Doug Kenik, Director, SW Product Management at Markforged
{"title":"Engineering Confidence","authors":"","doi":"10.12968/s0261-2097(23)60457-5","DOIUrl":"https://doi.org/10.12968/s0261-2097(23)60457-5","url":null,"abstract":"How simulation software can save time, materials and instils confidence in additive are absolutely key reasons to invest in it, says Doug Kenik, Director, SW Product Management at Markforged","PeriodicalId":11962,"journal":{"name":"EUREKA: Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73922559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.12968/s0261-2097(23)60462-9
Ralph Oertli, Design Project Manager at Burckhardt Compression, looks at the importance of expert knowledge and how it can enhance efficiency, reliability and running costs.
{"title":"Material Benefits for Gas Compression","authors":"","doi":"10.12968/s0261-2097(23)60462-9","DOIUrl":"https://doi.org/10.12968/s0261-2097(23)60462-9","url":null,"abstract":"Ralph Oertli, Design Project Manager at Burckhardt Compression, looks at the importance of expert knowledge and how it can enhance efficiency, reliability and running costs.","PeriodicalId":11962,"journal":{"name":"EUREKA: Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85701877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Casali, L. Pescio, Dylan E. Sendyk, Luciana Erjavec, Emanuel Morel Gómez, Leandro Parra, M. Fernández-Tomé
AIMS Calcium oxalate (Oxa), constituent of most common kidney stones, damages renal tubular epithelial cells leading to kidney disease. Most in vitro studies designed to evaluate how Oxa exerts its harmful effects were performed in proliferative or confluent non-differentiated renal epithelial cultures; none of them considered physiological hyperosmolarity of renal medullary interstitium. Cyclooxygenase 2 (COX2) has been associated to Oxa deleterious actions; however, up to now, it is not clear how COX2 acts. In this work, we proposed an in vitro experimental system resembling renal differentiated-epithelial cells that compose medullary tubular structures which were grown and maintained in a physiological hyperosmolar environment and evaluated whether COX2 → PGE2 axis (COX2 considered a cytoprotective protein for renal cells) induces Oxa damage or epithelial restitution. MAIN METHODS MDCK cells were differentiated with NaCl hyperosmolar medium for 72 h where cells acquired the typical apical and basolateral membrane domains and a primary cilium. Then, cultures were treated with 1.5 mM Oxa for 24, 48, and 72 h to evaluate epithelial monolayer restitution dynamics and COX2-PGE2 effect. KEY FINDINGS Oxa completely turned the differentiated phenotype into mesenchymal one (epithelial-mesenchymal transition). Such effect was partially and totally reverted after 48 and 72 h, respectively. Oxa damage was even deeper when COX2 was blocked by NS398. PGE2 addition restituted the differentiated-epithelial phenotype in a time and concentration dependence. SIGNIFICANCE This work presents an experimental system that approaches in vitro to in vivo renal epithelial studies and, more important, warns about NSAIDS use in patients suffering from kidney stones.
{"title":"Dynamics of differentiated-renal epithelial cell monolayer after calcium oxalate injury: The role of cyclooxygenase-2.","authors":"C. Casali, L. Pescio, Dylan E. Sendyk, Luciana Erjavec, Emanuel Morel Gómez, Leandro Parra, M. Fernández-Tomé","doi":"10.2139/ssrn.4327447","DOIUrl":"https://doi.org/10.2139/ssrn.4327447","url":null,"abstract":"AIMS\u0000Calcium oxalate (Oxa), constituent of most common kidney stones, damages renal tubular epithelial cells leading to kidney disease. Most in vitro studies designed to evaluate how Oxa exerts its harmful effects were performed in proliferative or confluent non-differentiated renal epithelial cultures; none of them considered physiological hyperosmolarity of renal medullary interstitium. Cyclooxygenase 2 (COX2) has been associated to Oxa deleterious actions; however, up to now, it is not clear how COX2 acts. In this work, we proposed an in vitro experimental system resembling renal differentiated-epithelial cells that compose medullary tubular structures which were grown and maintained in a physiological hyperosmolar environment and evaluated whether COX2 → PGE2 axis (COX2 considered a cytoprotective protein for renal cells) induces Oxa damage or epithelial restitution.\u0000\u0000\u0000MAIN METHODS\u0000MDCK cells were differentiated with NaCl hyperosmolar medium for 72 h where cells acquired the typical apical and basolateral membrane domains and a primary cilium. Then, cultures were treated with 1.5 mM Oxa for 24, 48, and 72 h to evaluate epithelial monolayer restitution dynamics and COX2-PGE2 effect.\u0000\u0000\u0000KEY FINDINGS\u0000Oxa completely turned the differentiated phenotype into mesenchymal one (epithelial-mesenchymal transition). Such effect was partially and totally reverted after 48 and 72 h, respectively. Oxa damage was even deeper when COX2 was blocked by NS398. PGE2 addition restituted the differentiated-epithelial phenotype in a time and concentration dependence.\u0000\u0000\u0000SIGNIFICANCE\u0000This work presents an experimental system that approaches in vitro to in vivo renal epithelial studies and, more important, warns about NSAIDS use in patients suffering from kidney stones.","PeriodicalId":11962,"journal":{"name":"EUREKA: Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90197888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.12968/s0261-2097(23)60459-9
As we face escalating environmental challenges, with power consumption an increasingly critical cost factor, electrically-driven systems must become more energy efficient.
随着我们面临日益严峻的环境挑战，电力消耗成为越来越重要的成本因素，电力驱动系统必须变得更加节能。
{"title":"A Breath of <b>Fresh Air</b>","authors":"","doi":"10.12968/s0261-2097(23)60459-9","DOIUrl":"https://doi.org/10.12968/s0261-2097(23)60459-9","url":null,"abstract":"As we face escalating environmental challenges, with power consumption an increasingly critical cost factor, electrically-driven systems must become more energy efficient.","PeriodicalId":11962,"journal":{"name":"EUREKA: Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.12968/s0261-2097(23)60470-8
{"title":"Waste Not","authors":"","doi":"10.12968/s0261-2097(23)60470-8","DOIUrl":"https://doi.org/10.12968/s0261-2097(23)60470-8","url":null,"abstract":"","PeriodicalId":11962,"journal":{"name":"EUREKA: Life Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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