{"title":"Extramammary Paget's disease in situ of the scrotum and penis with cervical lymph node metastasis of unknown origin.","authors":"Daiki Karube, Koji Kamiya, Soichiro Kado, Atsuko Sato, Mamitaro Ohtsuki, Mayumi Komine","doi":"10.1684/ejd.2025.4917","DOIUrl":"https://doi.org/10.1684/ejd.2025.4917","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 4","pages":"325-326"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro José Ezomo Gervilla, Francisco Javier De La Torre Gomar, Ricardo Ruiz-Villaverde
{"title":"sQUIZ your knowledge! Erythematous-violaceous plaques on the thigh progressing to ecchymosis.","authors":"Pedro José Ezomo Gervilla, Francisco Javier De La Torre Gomar, Ricardo Ruiz-Villaverde","doi":"10.1684/ejd.2025.4936","DOIUrl":"https://doi.org/10.1684/ejd.2025.4936","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 4","pages":"347-349"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"sQuiz your knowledge! Yellowish nodules on the knees and elbows: a warning sign of a potentially fatal disease.","authors":"Cherif Malek, Hammami Fatma, Turki Hamida","doi":"10.1684/ejd.2025.4938","DOIUrl":"https://doi.org/10.1684/ejd.2025.4938","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 4","pages":"351-353"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Zulaika-Lloret, Francisco Javier De La Torre-Gomar, Ricardo Ruiz-Villaverde
{"title":"sQUIZ your knowledge! Linear pinkish-orange papules on the forearms.","authors":"María Zulaika-Lloret, Francisco Javier De La Torre-Gomar, Ricardo Ruiz-Villaverde","doi":"10.1684/ejd.2025.4939","DOIUrl":"https://doi.org/10.1684/ejd.2025.4939","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 4","pages":"353-354"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
César Silva Ferreira, Belén Rodríguez Sánchez, Luis Jiménez-Briones, Simon Goller, Paloma Garcia Piqueras
{"title":"Journal club: Dupilumab and remibrutinib as treatment for chronic spontaneous urticaria: new pathways in disease control.","authors":"César Silva Ferreira, Belén Rodríguez Sánchez, Luis Jiménez-Briones, Simon Goller, Paloma Garcia Piqueras","doi":"10.1684/ejd.2025.4935","DOIUrl":"https://doi.org/10.1684/ejd.2025.4935","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 4","pages":"339-342"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheng Zhang, Wei He, Qiaoyu Cao, Hongsong Ge, Jie Yao, Jing Chu, Xinjie Lin, Ming Li, Wei Song
The GNAS gene gives rise to stimulatory G protein Gs-alpha (Gsα), a pivotal transducer of hormonal signalling pathways. Variants inherited maternally lead to reduced Gsα activity in certain tissues, resulting in resistance to multiple hormones and manifesting clinically as pseudohypoparathyroidism (PHP). In contrast, paternal transmission is linked to pseudopseudohypoparathyroidism (PPHP), which is characterized by extensive ectopic cutaneous ossification but lacks endocrine resistance. Thus, the phenotypic spectrum arising from GNAS gene variants is profoundly influenced by the parent-of-origin effect. Objectives: To analyse the clinical characteristics and GNAS gene variants of six patients with ectopic cutaneous ossification. We retrospectively analysed six patients with GNAS-related ectopic cutaneous ossification, with evaluation of clinical features, laboratory results, histopathology, and genetic testing data. Six patients presented with cutaneous ossification and Albright hereditary osteodystrophy (AHO) phenotype associated with GNAS gene variants. The identified variants comprised a splicing mutation (c.718+1G>A), two nonsense mutations (c.91C>T and c.103C>T), and three frameshift mutations (c.518_521del, c.565_568del, and c.522_523del). Notably, the frameshift variant c.522_523del has not been previously reported in the literature. Five patients were diagnosed with PHP, one with PPHP. This study expands the mutational spectrum of GNAS by identifying a novel variant and highlights the phenotypic heterogeneity of GNAS-associated disorders. Early molecular diagnosis, integrated with clinical evaluation, is essential for timely intervention, mitigating disease progression, and enhancing the overall quality of life in affected children.
{"title":"Six cases of ectopic cutaneous ossification associated with GNAS gene variants.","authors":"Cheng Zhang, Wei He, Qiaoyu Cao, Hongsong Ge, Jie Yao, Jing Chu, Xinjie Lin, Ming Li, Wei Song","doi":"10.1684/ejd.2025.4919","DOIUrl":"10.1684/ejd.2025.4919","url":null,"abstract":"<p><p>The GNAS gene gives rise to stimulatory G protein Gs-alpha (Gsα), a pivotal transducer of hormonal signalling pathways. Variants inherited maternally lead to reduced Gsα activity in certain tissues, resulting in resistance to multiple hormones and manifesting clinically as pseudohypoparathyroidism (PHP). In contrast, paternal transmission is linked to pseudopseudohypoparathyroidism (PPHP), which is characterized by extensive ectopic cutaneous ossification but lacks endocrine resistance. Thus, the phenotypic spectrum arising from GNAS gene variants is profoundly influenced by the parent-of-origin effect. Objectives: To analyse the clinical characteristics and GNAS gene variants of six patients with ectopic cutaneous ossification. We retrospectively analysed six patients with GNAS-related ectopic cutaneous ossification, with evaluation of clinical features, laboratory results, histopathology, and genetic testing data. Six patients presented with cutaneous ossification and Albright hereditary osteodystrophy (AHO) phenotype associated with GNAS gene variants. The identified variants comprised a splicing mutation (c.718+1G>A), two nonsense mutations (c.91C>T and c.103C>T), and three frameshift mutations (c.518_521del, c.565_568del, and c.522_523del). Notably, the frameshift variant c.522_523del has not been previously reported in the literature. Five patients were diagnosed with PHP, one with PPHP. This study expands the mutational spectrum of GNAS by identifying a novel variant and highlights the phenotypic heterogeneity of GNAS-associated disorders. Early molecular diagnosis, integrated with clinical evaluation, is essential for timely intervention, mitigating disease progression, and enhancing the overall quality of life in affected children.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 4","pages":"307-312"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Secukinumab is an IL-17A inhibitor that selectively binds to IL-17A and inhibits its interaction with IL-17 receptors, thereby reducing the production of pro-inflammatory cytokines, chemokines, and tissue-damaging mediators. Secukinumab has been proven to rapidly improve erythema and pustules in adult and paediatric generalized pustular psoriasis (GPP) patients. Here, we report a case study of erythema multiforme-like drug eruption induced by secukinumab and provide an overview of all cases reported so far. A systematic literature search of publications was conducted from inception to September 2024 via PubMed and Web of Science Core Collection, in order to identify all cases of drug hypersensitivity reactions associated with secukinumab. We conducted a search for retrospective and prospective studies, case series, case reports, and data from Phase II and III clinical trials related to immune-related (or potentially immune-related) adverse events associated with the use of secukinumab. In total, four cases of drug hypersensitivity reactions associated with secukinumab were identified. Drug hypersensitivity reactions associated with secukinumab are relatively rare. The recognition of potential rare adverse events by clinicians is important and may expand our understanding of immune-mediated diseases.
Secukinumab是一种IL-17A抑制剂，选择性结合IL-17A并抑制其与IL-17受体的相互作用，从而减少促炎细胞因子、趋化因子和组织损伤介质的产生。Secukinumab已被证明可以快速改善成人和儿童广泛性脓疱性银屑病（GPP）患者的红斑和脓疱。在这里，我们报告了一个由secukinumab引起的红斑多形性药疹的病例研究，并提供了迄今为止报道的所有病例的概述。通过PubMed和Web of Science Core Collection对从成立到2024年9月的出版物进行了系统的文献检索，以确定与secukinumab相关的所有药物超敏反应病例。我们检索了与使用secukinumab相关的免疫相关（或潜在免疫相关）不良事件相关的II期和III期临床试验的回顾性和前瞻性研究、病例系列、病例报告和数据。总共确定了4例与secukinumab相关的药物超敏反应。与secukinumab相关的药物超敏反应相对罕见。临床医生对潜在罕见不良事件的认识是重要的，并可能扩大我们对免疫介导疾病的理解。
{"title":"Secukinumab-induced erythema multiforme-like drug eruption in generalized pustular psoriasis: a case report and literature review.","authors":"Jing Sun, Zhaoyang Wang, Zigang Xu","doi":"10.1684/ejd.2025.4922","DOIUrl":"10.1684/ejd.2025.4922","url":null,"abstract":"<p><p>Secukinumab is an IL-17A inhibitor that selectively binds to IL-17A and inhibits its interaction with IL-17 receptors, thereby reducing the production of pro-inflammatory cytokines, chemokines, and tissue-damaging mediators. Secukinumab has been proven to rapidly improve erythema and pustules in adult and paediatric generalized pustular psoriasis (GPP) patients. Here, we report a case study of erythema multiforme-like drug eruption induced by secukinumab and provide an overview of all cases reported so far. A systematic literature search of publications was conducted from inception to September 2024 via PubMed and Web of Science Core Collection, in order to identify all cases of drug hypersensitivity reactions associated with secukinumab. We conducted a search for retrospective and prospective studies, case series, case reports, and data from Phase II and III clinical trials related to immune-related (or potentially immune-related) adverse events associated with the use of secukinumab. In total, four cases of drug hypersensitivity reactions associated with secukinumab were identified. Drug hypersensitivity reactions associated with secukinumab are relatively rare. The recognition of potential rare adverse events by clinicians is important and may expand our understanding of immune-mediated diseases.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 4","pages":"279-284"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of pemphigoid gestationis successfully treated with systemic corticosteroids combined with dupilumab.","authors":"Chen Sun, Yue-Ping Zeng","doi":"10.1684/ejd.2025.4912","DOIUrl":"https://doi.org/10.1684/ejd.2025.4912","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 4","pages":"320-321"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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