{"title":"sQUIZ your knowledge! Chronic indurated plaques in a 42-year-old woman.","authors":"Leria Pietri, Rodolphe Dupuis, Sophie Leducq","doi":"10.1684/ejd.2025.5014","DOIUrl":"https://doi.org/10.1684/ejd.2025.5014","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 6","pages":"579-580"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alopecia areata can be accompanied by atopic dermatitis. Alopecia areata accompanied by atopic dermatitis shows more severe symptoms and responds limitedly to dupilumab monotherapy. Topical immunotherapy often fails due to atopic dermatitis flares. To report the usefulness of dupilumab combined with topical immunotherapy in alopecia areata patients with atopic dermatitis. Eleven cases of alopecia areata with atopic dermatitis, all with Severity of Alopecia Tool (SALT) scores ≥70 and Eczema Area and Severity Index (EASI) scores ≥16, received dupilumab for atopic dermatitis and topical immunotherapy for alopecia areata. A representative treatment began with sensitization using squaric acid dibutyl ester or diphenylcyclopropenone, followed by dupilumab monotherapy to control atopic dermatitis. After topical immunotherapy titration, concurrent dupilumab and topical immunotherapy were administered. SALT scores were evaluated at week 28. All patients completed the combination therapy without atopic dermatitis flares. At week 28, 64% achieved SALT ≤20, including those with alopecia areata duration ≤seven years. Patients with IgE ≥200 IU/mL tended towards higher efficacy. No serious adverse events were reported, including in paediatric or oncology cases. Notably, 75% of patients who had previously failed topical immunotherapy tolerated concentrations up to 100-fold higher. Dupilumab combined with topical immunotherapy demonstrated favourable effects in alopecia areata patients with atopic dermatitis, offering a safer and effective option, especially for paediatric or oncology cases.
{"title":"Clinical outcome of alopecia areata in patients with atopic dermatitis treated with dupilumab combined with topical immunotherapy: a case series.","authors":"Takayoshi Komatsu-Fujii, Ryang Cho, Tomoko Nomiyama, Yosuke Yamamoto, Toshiaki Kogame, Kenji Kabashima","doi":"10.1684/ejd.2025.5003","DOIUrl":"https://doi.org/10.1684/ejd.2025.5003","url":null,"abstract":"<p><p>Alopecia areata can be accompanied by atopic dermatitis. Alopecia areata accompanied by atopic dermatitis shows more severe symptoms and responds limitedly to dupilumab monotherapy. Topical immunotherapy often fails due to atopic dermatitis flares. To report the usefulness of dupilumab combined with topical immunotherapy in alopecia areata patients with atopic dermatitis. Eleven cases of alopecia areata with atopic dermatitis, all with Severity of Alopecia Tool (SALT) scores ≥70 and Eczema Area and Severity Index (EASI) scores ≥16, received dupilumab for atopic dermatitis and topical immunotherapy for alopecia areata. A representative treatment began with sensitization using squaric acid dibutyl ester or diphenylcyclopropenone, followed by dupilumab monotherapy to control atopic dermatitis. After topical immunotherapy titration, concurrent dupilumab and topical immunotherapy were administered. SALT scores were evaluated at week 28. All patients completed the combination therapy without atopic dermatitis flares. At week 28, 64% achieved SALT ≤20, including those with alopecia areata duration ≤seven years. Patients with IgE ≥200 IU/mL tended towards higher efficacy. No serious adverse events were reported, including in paediatric or oncology cases. Notably, 75% of patients who had previously failed topical immunotherapy tolerated concentrations up to 100-fold higher. Dupilumab combined with topical immunotherapy demonstrated favourable effects in alopecia areata patients with atopic dermatitis, offering a safer and effective option, especially for paediatric or oncology cases.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 6","pages":"519-526"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A rare case of peristomal pemphigus foliaceus: possible involvement of the Koebner phenomenon.","authors":"Mizuki Yamamoto-Murata, Atsuna Nishino, Tsukasa Ugajin","doi":"10.1684/ejd.2025.4994","DOIUrl":"https://doi.org/10.1684/ejd.2025.4994","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 6","pages":"543-545"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gustavo Almeida-Silva, Joana Antunes, Paulo Filipe
{"title":"sQUIZ your knowledge! Asymptomatic purplish papules on the limbs of a 16-year-old female.","authors":"Gustavo Almeida-Silva, Joana Antunes, Paulo Filipe","doi":"10.1684/ejd.2025.5011","DOIUrl":"https://doi.org/10.1684/ejd.2025.5011","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 6","pages":"574-575"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful treatment with upadacitinib for tumour necrosis factor-alpha inhibitor-induced palmoplantar pustulosis following infliximab therapy for ulcerative colitis.","authors":"Brandon Ce Hu, Francis Yx Lai, Senhong Lee","doi":"10.1684/ejd.2025.5001","DOIUrl":"https://doi.org/10.1684/ejd.2025.5001","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 6","pages":"554-556"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinyue Pang, Jin Shao, Yuan Liu, Yan Li, Suju Luo, Huiping Wang, Jingyue Ma
{"title":"Sweet syndrome presenting with pustular lesions and pulmonary involvement: a case report.","authors":"Xinyue Pang, Jin Shao, Yuan Liu, Yan Li, Suju Luo, Huiping Wang, Jingyue Ma","doi":"10.1684/ejd.2025.4978","DOIUrl":"https://doi.org/10.1684/ejd.2025.4978","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 6","pages":"537-539"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146085239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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