{"title":"Oral roflumilast in a patient with psoriasis and prostate cancer.","authors":"Ana Maria Lé, Tiago Torres","doi":"10.1684/ejd.2024.4764","DOIUrl":"https://doi.org/10.1684/ejd.2024.4764","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"34 5","pages":"548-550"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of dermatomyositis with positivity to both anti-MDA5 and anti-ARS antibodies.","authors":"Sara Matsumoto, Yasuhito Hamaguchi, Tasuku Kitano, Kouhei Takehara, Kyouke Oishi, Shintaro Maeda, Takashi Matsushita","doi":"10.1684/ejd.2024.4742","DOIUrl":"10.1684/ejd.2024.4742","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"34 4","pages":"444-446"},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brigitte Dréno, Isabelle Benoit, Eric Perrier, Miroslav Radman
Skin aging is associated with a progressive decline in physiological functions, skin cancers and, ultimately, death. It may be categorized as intrinsic or extrinsic, whereby intrinsic aging is attributed to chronological and genetic factors. At the molecular level, skin aging involves changes in protein conformation and function. The skin proteome changes constantly, mainly through carbonylation; an irreversible phenomenon leading to protein accumulation as toxic aggregates that impair cellular physiology and accelerate skin aging. This review details the central role of proteostasis during skin aging and why proteome protection may be a promising approach in mitigating skin aging. A comprehensive literature review of 87 articles focusing on the proteome, proteostasis, proteotoxicity, protein carbonylation, and the impact of the damaged proteome on aging, and in particular skin aging, was conducted. Skin aging is associated with deficiencies in the repair mechanisms of DNA, transcriptional control, mitochondrial function, cell cycle control, apoptosis, cellular metabolism, changes in hormonal levels secondary to toxicity of damaged proteins, and cell-to-cell communication for tissue homeostasis, which are largely controlled by proteins. In this context, a damaged proteome that leads to the loss of proteostasis may be considered as the first step in tissue aging. There is growing evidence that a healthy proteome plays a central role in skin and in maintaining healthy tissues, thus slowing down the process of skin aging. Hence, protecting the proteome against oxidative or other damage may be an appropriate strategy to prevent and delay skin aging.
皮肤老化与生理功能逐渐衰退、皮肤癌以及最终死亡有关。皮肤老化可分为内在老化和外在老化，其中内在老化归因于时间和遗传因素。在分子水平上，皮肤老化涉及蛋白质构象和功能的变化。皮肤蛋白质组不断发生变化，主要是通过羰基化；羰基化是一种不可逆的现象，会导致蛋白质积聚成有毒的聚集体，损害细胞生理机能并加速皮肤衰老。这篇综述详细阐述了蛋白质稳态在皮肤老化过程中的核心作用，以及为什么保护蛋白质组可能是缓解皮肤老化的一种有前途的方法。我们对 87 篇文章进行了全面的文献综述，这些文章主要涉及蛋白质组、蛋白质稳态、蛋白质毒性、蛋白质羰基化以及受损的蛋白质组对衰老尤其是皮肤衰老的影响。皮肤衰老与 DNA 修复机制、转录控制、线粒体功能、细胞周期控制、细胞凋亡、细胞新陈代谢、受损蛋白质毒性导致的激素水平变化以及细胞间组织平衡交流等方面的缺陷有关，而这些方面主要由蛋白质控制。在这种情况下，蛋白质组受损导致蛋白质失去平衡可被视为组织衰老的第一步。越来越多的证据表明，健康的蛋白质组在皮肤和维持组织健康方面发挥着核心作用，从而延缓皮肤衰老的进程。因此，保护蛋白质组免受氧化或其他损伤可能是预防和延缓皮肤衰老的适当策略。
{"title":"Beyond the genome: protecting the proteome may be the key to preventing skin aging.","authors":"Brigitte Dréno, Isabelle Benoit, Eric Perrier, Miroslav Radman","doi":"10.1684/ejd.2024.4739","DOIUrl":"https://doi.org/10.1684/ejd.2024.4739","url":null,"abstract":"<p><p>Skin aging is associated with a progressive decline in physiological functions, skin cancers and, ultimately, death. It may be categorized as intrinsic or extrinsic, whereby intrinsic aging is attributed to chronological and genetic factors. At the molecular level, skin aging involves changes in protein conformation and function. The skin proteome changes constantly, mainly through carbonylation; an irreversible phenomenon leading to protein accumulation as toxic aggregates that impair cellular physiology and accelerate skin aging. This review details the central role of proteostasis during skin aging and why proteome protection may be a promising approach in mitigating skin aging. A comprehensive literature review of 87 articles focusing on the proteome, proteostasis, proteotoxicity, protein carbonylation, and the impact of the damaged proteome on aging, and in particular skin aging, was conducted. Skin aging is associated with deficiencies in the repair mechanisms of DNA, transcriptional control, mitochondrial function, cell cycle control, apoptosis, cellular metabolism, changes in hormonal levels secondary to toxicity of damaged proteins, and cell-to-cell communication for tissue homeostasis, which are largely controlled by proteins. In this context, a damaged proteome that leads to the loss of proteostasis may be considered as the first step in tissue aging. There is growing evidence that a healthy proteome plays a central role in skin and in maintaining healthy tissues, thus slowing down the process of skin aging. Hence, protecting the proteome against oxidative or other damage may be an appropriate strategy to prevent and delay skin aging.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"34 4","pages":"355-360"},"PeriodicalIF":2.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142079784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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