Keratosis pilaris is a benign and prevalent dermatological condition, clinically characterized by erythematous and hyperpigmented papules with a rough texture. Its appearance on exposed areas, such as the extensor surfaces of upper arms, can lead to psychosocial distress. Despite the range of available topical and laser therapies, no standardized approach exists for selecting one treatment over another. This updated systematic review aims to provide innovative strategies for the therapeutic management of common keratosis pilaris. Twenty-seven articles published between 2011 and 2024 were included. The selected studies comprised monotherapies (topical or laser), comparative analyses, and combination treatments. Lactic and glycolic acids were the preferred topicals, demonstrating efficacy in the treatment of keratosis pilaris. The Nd:YAG laser yielded consistently favourable outcomes. Among ablative lasers, the CO2 laser showed efficacy, while the erbium:YAG appeared promising due to fewer adverse effects. The management of keratosis pilaris involves a multimodal strategy centred on patient education, topical treatments and laser therapies. To address the diverse clinical features of the condition, we propose a stepwise, stratified therapeutic approach.
{"title":"Keratosis pilaris: a systematic review of the literature and strategies for optimal treatment.","authors":"Anne Beyron","doi":"10.1684/ejd.2025.4951","DOIUrl":"10.1684/ejd.2025.4951","url":null,"abstract":"<p><p>Keratosis pilaris is a benign and prevalent dermatological condition, clinically characterized by erythematous and hyperpigmented papules with a rough texture. Its appearance on exposed areas, such as the extensor surfaces of upper arms, can lead to psychosocial distress. Despite the range of available topical and laser therapies, no standardized approach exists for selecting one treatment over another. This updated systematic review aims to provide innovative strategies for the therapeutic management of common keratosis pilaris. Twenty-seven articles published between 2011 and 2024 were included. The selected studies comprised monotherapies (topical or laser), comparative analyses, and combination treatments. Lactic and glycolic acids were the preferred topicals, demonstrating efficacy in the treatment of keratosis pilaris. The Nd:YAG laser yielded consistently favourable outcomes. Among ablative lasers, the CO2 laser showed efficacy, while the erbium:YAG appeared promising due to fewer adverse effects. The management of keratosis pilaris involves a multimodal strategy centred on patient education, topical treatments and laser therapies. To address the diverse clinical features of the condition, we propose a stepwise, stratified therapeutic approach.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 5","pages":"387-393"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Morgan Muncey-Buckley, Gillian Chin, Philip Brocklehurst, Colin Morton, Colin Fleming
{"title":"Identification and prioritisation of skin cancer-related use cases for dermatological artificial intelligence tools.","authors":"Morgan Muncey-Buckley, Gillian Chin, Philip Brocklehurst, Colin Morton, Colin Fleming","doi":"10.1684/ejd.2025.4952","DOIUrl":"https://doi.org/10.1684/ejd.2025.4952","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 5","pages":"413-415"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concurrent granulomatous skin and nasal lesions likely induced by adalimumab for ulcerative colitis: a unique case of localized drug-induced granulomatosis.","authors":"Tomoyuki Hioki, Hideki Kamiya, Ken Hayano, Bunya Kuze, Kengo Matsunaga, Tetsuya Yamada, Seiji Sugiyama, Yasuo Kitajima","doi":"10.1684/ejd.2025.4966","DOIUrl":"https://doi.org/10.1684/ejd.2025.4966","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 5","pages":"433-435"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristian Fernando Caballero-Linares, Mercè Grau-Pérez, Ana Collazo-Lorduy, Rita Cabeza-Martínez
{"title":"sQUIZ your knowledge! Persistent oral mucositis and neoplastic involvement of the thoracic cavity: the importance of starting over when the pieces don't fit.","authors":"Cristian Fernando Caballero-Linares, Mercè Grau-Pérez, Ana Collazo-Lorduy, Rita Cabeza-Martínez","doi":"10.1684/ejd.2025.4974","DOIUrl":"https://doi.org/10.1684/ejd.2025.4974","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 5","pages":"451-452"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomoki Murooka, Ken Okamura, Takanobu Kabasawa, Toru Saito, Ami Hemmi, Junnosuke Kawaguchi, Tamio Suzuki
{"title":"Complete response to nivolumab in a patient with HPV-associated squamous cell carcinoma of the anus: the predictive value of tumour-infiltrating CD8+PD-1+ T cells.","authors":"Tomoki Murooka, Ken Okamura, Takanobu Kabasawa, Toru Saito, Ami Hemmi, Junnosuke Kawaguchi, Tamio Suzuki","doi":"10.1684/ejd.2025.4944","DOIUrl":"https://doi.org/10.1684/ejd.2025.4944","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 5","pages":"408-409"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Absent expression of VISTA and LAG-3 in mycosis fungoides.","authors":"Miho Tanaka, Akihiro Horie, Kaori Nakajima, Takafumi Kadono, Tomomitsu Miyagaki","doi":"10.1684/ejd.2025.4948","DOIUrl":"https://doi.org/10.1684/ejd.2025.4948","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 5","pages":"419-420"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145585996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessia Primerano, Giovanna Floriddia, Emanuela De Domenico, Maria Chiara Collina, Enzo Palese, Biagio Didona, Giovanni Di Zenzo, Stefania Petrini, Angelo Giuseppe Condorelli, Teresa Odorisio, Daniele Castiglia
Dystrophic epidermolysis bullosa (DEB) is a clinically heterogeneous blistering disease caused by pathogenic variants in the COL7A1 gene. Phenotypes range from localized to generalized and are primarily determined by the variant type, though additional modifiers influence disease severity. To characterize the molecular basis of the disease phenotype in a diabetic patient presenting with localized skin blistering and nail dystrophy. Skin biopsies were taken from the index patient for immunofluorescence mapping and keratinocyte culture. Exome sequencing was used to screen for pathogenic variants and Sanger sequencing for variant segregation in family members. COL7A1 mRNA and protein studies were performed by reverse transcriptase-PCR analysis and western blot. Advanced glycation end products in skin were analysed by confocal immunofluorescence microscopy. Molecular analysis identified a heterozygous COL7A1 splice variant, c.5053-1G>C, which resulted in both an exonic deletion and an intronic insertion with decay of the mutant transcripts, leading to about half of the normal levels of mRNA and protein in the patient's keratinocytes. Although the diabetic proband was the only family member developing recurrent skin blisters, great toenail dystrophy segregated with the variant in the offspring. Functional COL7A1 haploinsufficiency is therefore the most likely mechanism for the segregation of this mild DEB trait in the family. Increased protein glycation was detected in the proband's skin. The effects of the mutation and increased protein glycation in the proband's skin suggest a concurrent effect of diabetic dermopathy and COL7A1 pathology on skin fragility.
{"title":"Localized dominant dystrophic epidermolysis bullosa worsened by diabetes.","authors":"Alessia Primerano, Giovanna Floriddia, Emanuela De Domenico, Maria Chiara Collina, Enzo Palese, Biagio Didona, Giovanni Di Zenzo, Stefania Petrini, Angelo Giuseppe Condorelli, Teresa Odorisio, Daniele Castiglia","doi":"10.1684/ejd.2025.4947","DOIUrl":"10.1684/ejd.2025.4947","url":null,"abstract":"<p><p>Dystrophic epidermolysis bullosa (DEB) is a clinically heterogeneous blistering disease caused by pathogenic variants in the COL7A1 gene. Phenotypes range from localized to generalized and are primarily determined by the variant type, though additional modifiers influence disease severity. To characterize the molecular basis of the disease phenotype in a diabetic patient presenting with localized skin blistering and nail dystrophy. Skin biopsies were taken from the index patient for immunofluorescence mapping and keratinocyte culture. Exome sequencing was used to screen for pathogenic variants and Sanger sequencing for variant segregation in family members. COL7A1 mRNA and protein studies were performed by reverse transcriptase-PCR analysis and western blot. Advanced glycation end products in skin were analysed by confocal immunofluorescence microscopy. Molecular analysis identified a heterozygous COL7A1 splice variant, c.5053-1G>C, which resulted in both an exonic deletion and an intronic insertion with decay of the mutant transcripts, leading to about half of the normal levels of mRNA and protein in the patient's keratinocytes. Although the diabetic proband was the only family member developing recurrent skin blisters, great toenail dystrophy segregated with the variant in the offspring. Functional COL7A1 haploinsufficiency is therefore the most likely mechanism for the segregation of this mild DEB trait in the family. Increased protein glycation was detected in the proband's skin. The effects of the mutation and increased protein glycation in the proband's skin suggest a concurrent effect of diabetic dermopathy and COL7A1 pathology on skin fragility.</p>","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 5","pages":"369-376"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A paediatric case of solitary cutaneous mastocytoma with progression to urticaria pigmentosa: phenotypic transition or dual phenotype?","authors":"Yoriko Muneishi, Noritaka Oyama, Minoru Hasegawa","doi":"10.1684/ejd.2025.4946","DOIUrl":"https://doi.org/10.1684/ejd.2025.4946","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 5","pages":"410-411"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145585993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Ferreirinha, Maria Cristina Fialho, Ana Luísa João
{"title":"sQUIZ your knowledge! Verrucous anogenital ulcers in AIDS.","authors":"Ana Ferreirinha, Maria Cristina Fialho, Ana Luísa João","doi":"10.1684/ejd.2025.4976","DOIUrl":"https://doi.org/10.1684/ejd.2025.4976","url":null,"abstract":"","PeriodicalId":11968,"journal":{"name":"European Journal of Dermatology","volume":"35 5","pages":"453-454"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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