The genus Mikania is the largest of its kind in the family Eupatorieae (Asteraceae), with more than 430 species concentrated mainly in the tropical regions, among which, Mikania glomerata is a most common herb generally employed in the treatment of respiratory disorders. The Milania glomerata plant leaf extracts were used for anticancer study against A549 human lung cancer cell line. The solid – liquid extraction method has been employed to prepare the ethanol extract of Mikania glomerata through soxhelt apparatus method. To check the anti-proliferative effect of this extract, the extract chosen was tested for cell viability on the lung cancer cells A549 in different concentrations. Cell viability was evaluated by MTT assay for 24 hour and 48 hours. The LD50 value was calculated for the level of cell death and its effectiveness. The dose-dependent manner plays an important role in the treatment of lung cancer cell lines. The present study suggests that Mikania glomerata may be used as an alternative anticancer agent and further research is needed to improve the effectiveness.
{"title":"Cytotoxicity effect of ethanolic extract of Mikania glomerata against A549 human lung cancer cell line","authors":"S. Sarojini, V. Ramesh, P. Senthilkumaar","doi":"10.7439/IJASR.V2I7.3512","DOIUrl":"https://doi.org/10.7439/IJASR.V2I7.3512","url":null,"abstract":"The genus Mikania is the largest of its kind in the family Eupatorieae (Asteraceae), with more than 430 species concentrated mainly in the tropical regions, among which, Mikania glomerata is a most common herb generally employed in the treatment of respiratory disorders. The Milania glomerata plant leaf extracts were used for anticancer study against A549 human lung cancer cell line. The solid – liquid extraction method has been employed to prepare the ethanol extract of Mikania glomerata through soxhelt apparatus method. To check the anti-proliferative effect of this extract, the extract chosen was tested for cell viability on the lung cancer cells A549 in different concentrations. Cell viability was evaluated by MTT assay for 24 hour and 48 hours. The LD50 value was calculated for the level of cell death and its effectiveness. The dose-dependent manner plays an important role in the treatment of lung cancer cell lines. The present study suggests that Mikania glomerata may be used as an alternative anticancer agent and further research is needed to improve the effectiveness.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116137103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Many mathematical physics models are contributed to give rise to of nonlinear integral equations. In this paper, we study the performance of two recently developed modifications of well known so called Adomian’s decomposition method applied using Laplace transform to nonlinear Volterra integral equations. Three nonlinear Volterra integral equations are solved analytically by implementing these modifications. From the obtained results, it may be concluded that that the modified techniques are reliable, efficient and easy to use through recursive relations that involve simple integrals. Moreover, these particular examples show the reliability and the performance of proposed modifications.
{"title":"A Comparative Study on Modifications of Decomposition Method","authors":"J. Ahmad, Madiha R. Tahir, L. Tahir, M. Naeem","doi":"10.7439/IJASR.V2I8.3484","DOIUrl":"https://doi.org/10.7439/IJASR.V2I8.3484","url":null,"abstract":"Many mathematical physics models are contributed to give rise to of nonlinear integral equations. In this paper, we study the performance of two recently developed modifications of well known so called Adomian’s decomposition method applied using Laplace transform to nonlinear Volterra integral equations. Three nonlinear Volterra integral equations are solved analytically by implementing these modifications. From the obtained results, it may be concluded that that the modified techniques are reliable, efficient and easy to use through recursive relations that involve simple integrals. Moreover, these particular examples show the reliability and the performance of proposed modifications.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"345 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124719450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present work investigates the synthesis of silver nanoparticles (AgNPs) by biological method using marine bacteria. The minimum inhibitory concentration (MIC) test was performed to find the inhibitory concentration of AgNO 3 against marine bacterial isolate. After MIC study, the biogenic AgNPs was prepared through marine bacterial isolate and characterized by using UV-visible spectroscopy, Scanning Electron Microscopy (SEM), X Ray Diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). From the UV-visible spectroscopy, the absorption peak was found at 420 nm. In SEM image, it is confirmed that the sample contains spherical shaped silver nanoparticles and most of the particles were below 100 nm in size. In XRD analysis, it was confirmed that the silver nanoparticles are crystalline in nature, which was confirmed by the FTIR peak at 518 cm -1 corresponding to the Ag vibration present in crystalline structure. The antimicrobial activity of silver nanoparticles was determined by disk diffusion method, and found that silver nanoparticles have significant antibacterial activity against most of the pathogens.
本文研究了利用海洋细菌生物合成纳米银的方法。通过最小抑菌浓度(MIC)试验确定agno3对海洋细菌分离物的抑菌浓度。通过MIC研究，利用海洋细菌分离物制备了生物源AgNPs，并利用紫外可见光谱、扫描电镜(SEM)、X射线衍射(XRD)和傅里叶变换红外光谱(FTIR)对其进行了表征。紫外可见光谱在420 nm处发现吸收峰。SEM图像证实，样品中含有球形的银纳米粒子，大部分粒径在100 nm以下。XRD分析证实了纳米银的结晶性，在518 cm -1处的FTIR峰与晶体结构中存在的Ag振动相对应。采用圆盘扩散法测定银纳米粒子的抑菌活性，发现银纳米粒子对大多数病原菌具有显著的抑菌活性。
{"title":"Biosynthesis and characterization of silver nanoparticles (AgNPs) using marine bacteria against certain human pathogens","authors":"J. Begam","doi":"10.7439/IJASR.V2I7.3514","DOIUrl":"https://doi.org/10.7439/IJASR.V2I7.3514","url":null,"abstract":"The present work investigates the synthesis of silver nanoparticles (AgNPs) by biological method using marine bacteria. The minimum inhibitory concentration (MIC) test was performed to find the inhibitory concentration of AgNO 3 against marine bacterial isolate. After MIC study, the biogenic AgNPs was prepared through marine bacterial isolate and characterized by using UV-visible spectroscopy, Scanning Electron Microscopy (SEM), X Ray Diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). From the UV-visible spectroscopy, the absorption peak was found at 420 nm. In SEM image, it is confirmed that the sample contains spherical shaped silver nanoparticles and most of the particles were below 100 nm in size. In XRD analysis, it was confirmed that the silver nanoparticles are crystalline in nature, which was confirmed by the FTIR peak at 518 cm -1 corresponding to the Ag vibration present in crystalline structure. The antimicrobial activity of silver nanoparticles was determined by disk diffusion method, and found that silver nanoparticles have significant antibacterial activity against most of the pathogens.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129714640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The levels of physiochemical, heavy metal and microbiological pollution in different oil contaminated regions of Tiruchirappalli city were reported in the study. The water and sediment samples from four different oil contaminated regions in Tiruchirappalli city were collected during monsoon 2015. The sampling regions were divided into two category such as heavy oil contaminated regions (oil shed / oil washed regions) and bus stand regions. In oil contaminated water sample, the ranges of pH, TDS, EC, DO, BOD, COD, TA, TH, Ca, Mg, Na, K, HCO3, CO3, Cl, SO4, N-NO2, O-PO4 and oil-grease were 7.4-8.4, 395.4-651.4 mg/L, 670.2-1104.1 μS/cm, 0-1, 3.4-6.4, 5.5-76.9, 14.2-17.4, 74.5-165.4, 24.4-159.9, 16.0-81.5, 8.4-78.4, 24.5-66.3, 21.5-48.9, 86.7-161.4, 0 - 0, 79.5-145.2, 48.5-115.6, 2.3-15.2, 6.2-14.4 and 7.9-15.4 mg/L, respectively. But in soil sample, the ranges of Cd, Cr, Cu, Fe, Ne Pb and Zn were 0.14-0.65, 0.11-0.22, 0.19-0.52, 0.91-3.46, 0.1-0.2, 0.12-0.22, 0.65-1.82 mg/kg, respectively. In oil contaminated water sample, counts of TVC, TC, TS, FC, FS, VC, SAC, SHC and PC were in the range of 21300-126000, 1620-13200, 240-1050, 250-1130, 100-250, 120-180, 80-160, 130-200 and 260-560 CFU/mL, respectively. In soil sample, the TVC, TC, TS, FC, FS, VLO, SC and PC ranges were 56000-218000, 3100-14800, 350-1260, 330-1420, 150-300, 110-240, 120-200, 160-260 and 410-1060 CFU/g, respectively. The results of this study indicated that oil shed regions gor higher pollutions tha bus stand regions. This study gave a special emphasis on the determination of the levels of pollution and also identified the vulnerable regions. Hence, throughout impoundment and continuous monitoring is needed.
{"title":"Assessment of physiochemical, heavy metal and indicator bacterial groups in water and soil samples of different oil contaminated regions, Tiruchirappalli city","authors":"C. Vinothini, R. Ravikumar","doi":"10.7439/IJASR.V2I7.3513","DOIUrl":"https://doi.org/10.7439/IJASR.V2I7.3513","url":null,"abstract":"The levels of physiochemical, heavy metal and microbiological pollution in different oil contaminated regions of Tiruchirappalli city were reported in the study. The water and sediment samples from four different oil contaminated regions in Tiruchirappalli city were collected during monsoon 2015. The sampling regions were divided into two category such as heavy oil contaminated regions (oil shed / oil washed regions) and bus stand regions. In oil contaminated water sample, the ranges of pH, TDS, EC, DO, BOD, COD, TA, TH, Ca, Mg, Na, K, HCO3, CO3, Cl, SO4, N-NO2, O-PO4 and oil-grease were 7.4-8.4, 395.4-651.4 mg/L, 670.2-1104.1 μS/cm, 0-1, 3.4-6.4, 5.5-76.9, 14.2-17.4, 74.5-165.4, 24.4-159.9, 16.0-81.5, 8.4-78.4, 24.5-66.3, 21.5-48.9, 86.7-161.4, 0 - 0, 79.5-145.2, 48.5-115.6, 2.3-15.2, 6.2-14.4 and 7.9-15.4 mg/L, respectively. But in soil sample, the ranges of Cd, Cr, Cu, Fe, Ne Pb and Zn were 0.14-0.65, 0.11-0.22, 0.19-0.52, 0.91-3.46, 0.1-0.2, 0.12-0.22, 0.65-1.82 mg/kg, respectively. In oil contaminated water sample, counts of TVC, TC, TS, FC, FS, VC, SAC, SHC and PC were in the range of 21300-126000, 1620-13200, 240-1050, 250-1130, 100-250, 120-180, 80-160, 130-200 and 260-560 CFU/mL, respectively. In soil sample, the TVC, TC, TS, FC, FS, VLO, SC and PC ranges were 56000-218000, 3100-14800, 350-1260, 330-1420, 150-300, 110-240, 120-200, 160-260 and 410-1060 CFU/g, respectively. The results of this study indicated that oil shed regions gor higher pollutions tha bus stand regions. This study gave a special emphasis on the determination of the levels of pollution and also identified the vulnerable regions. Hence, throughout impoundment and continuous monitoring is needed.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128472357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deepak Khobragde, A. Kotha, K. Ravalika, Richa Gupta, P. Kumar
Most of the ayurvedic medicines are in the form of powder. Being in powder form the administration of accurate dose with ease is a problem. They may have some kind of unacceptable bitter taste. Furthermore it needs water or honey for administration and chances of spoilage and waste are more. Oro-dispersible tablet which rapidly disintegrating in mouth will be the best remedy for efficient use of ayurvedic powders. The aim of this study was to formulate oro-dispersible tablets of ayurvedic polyherbal powder Talisadi. Talisadi is a traditional Ayurvedic powder preparation well known and effective in various disorders of respiratory and digestive system. Using various excipients like super-disintegrants and sweeteners, different formulation of polyherbal drug Talisadi were formulated by direct compression method. The acceptable formulation, among all the developed formulations of oro-dispersible tablet was having a disintegrating time of 1 min and 10 sec and acceptable taste. Thus the study concludes that formulation of oro-dispersible tablets of ayurvedic powder preparation can be a good option to enhance acceptability, efficiency and easy and accurate administration of powder ayurvedic preparations like Talisadi.
大多数阿育吠陀药物都是粉末状的。在粉末状的情况下，容易给药是一个问题。它们可能有某种令人难以接受的苦味。此外，它需要水或蜂蜜来管理，腐败和浪费的可能性更大。口服分散片在口腔中迅速崩解，是有效使用阿育吠陀粉末的最佳补救措施。本研究的目的是研制阿育吠陀多草药粉的口服分散片。Talisadi是一种传统的阿育吠陀粉末制剂，众所周知，对各种呼吸和消化系统疾病有效。采用超崩解剂、甜味剂等辅料，采用直接加压法制备了不同配方的复方药塔利沙帝。所研制的口腔分散片的可接受配方为崩解时间为1 min 10 s，口感可接受。因此，制备阿育吠陀粉末制剂的口服分散片是提高阿育吠陀粉末制剂的可接受性、效率和方便准确给药的一个很好的选择。
{"title":"Oro-dispersible tablets of ayurvedic powder for improving taste, compliance, ease and accuracy of administration","authors":"Deepak Khobragde, A. Kotha, K. Ravalika, Richa Gupta, P. Kumar","doi":"10.7439/IJASR.V2I6.3458","DOIUrl":"https://doi.org/10.7439/IJASR.V2I6.3458","url":null,"abstract":"Most of the ayurvedic medicines are in the form of powder. Being in powder form the administration of accurate dose with ease is a problem. They may have some kind of unacceptable bitter taste. Furthermore it needs water or honey for administration and chances of spoilage and waste are more. Oro-dispersible tablet which rapidly disintegrating in mouth will be the best remedy for efficient use of ayurvedic powders. The aim of this study was to formulate oro-dispersible tablets of ayurvedic polyherbal powder Talisadi. Talisadi is a traditional Ayurvedic powder preparation well known and effective in various disorders of respiratory and digestive system. Using various excipients like super-disintegrants and sweeteners, different formulation of polyherbal drug Talisadi were formulated by direct compression method. The acceptable formulation, among all the developed formulations of oro-dispersible tablet was having a disintegrating time of 1 min and 10 sec and acceptable taste. Thus the study concludes that formulation of oro-dispersible tablets of ayurvedic powder preparation can be a good option to enhance acceptability, efficiency and easy and accurate administration of powder ayurvedic preparations like Talisadi.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124847202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Model equation for predicting and analysing %Fe removed from a eutectic Al-Si alloy during Fe removal processing with Mn under controlled conditions has been derived and validated. The model derived; %Fe removed = +1.30700 + 0.095882* Al-Si + %Mn - 0.068512* Al-Si + %Mn^2 + 9.77000E-003* Al-Si+%Mn^3 , is found to predict the %Fe removed from Al-Si alloy as a cubic function of Mn content. With a standard deviation of 0.010. Analysed results obtained show that %Fe removal equation with Mn addition has been validly derived. The model " R-Squared" of 0.9814 is found to be in agreement with the "Adj R-Squared" of 0.9628; the difference being less than 0.2. The derived model equation gives a reasonable forecast of %Fe removed very close to the values obtained from the experiments. The close proximity of both model and experimental result values is attributed to the low standard error of the model coefficients. The processing parameters are process temperature, alloy contents and holding time.
{"title":"Model for Predicting and Analyzing the %Fe Removed as Deleterious Element from Al-Si alloys During Fe Removal Processing with Mn","authors":"F. Anene, N. E. Nwankwo","doi":"10.7439/IJASR.V2I6.3374","DOIUrl":"https://doi.org/10.7439/IJASR.V2I6.3374","url":null,"abstract":"Model equation for predicting and analysing %Fe removed from a eutectic Al-Si alloy during Fe removal processing with Mn under controlled conditions has been derived and validated. The model derived; %Fe removed = +1.30700 + 0.095882* Al-Si + %Mn - 0.068512* Al-Si + %Mn^2 + 9.77000E-003* Al-Si+%Mn^3 , is found to predict the %Fe removed from Al-Si alloy as a cubic function of Mn content. With a standard deviation of 0.010. Analysed results obtained show that %Fe removal equation with Mn addition has been validly derived. The model \" R-Squared\" of 0.9814 is found to be in agreement with the \"Adj R-Squared\" of 0.9628; the difference being less than 0.2. The derived model equation gives a reasonable forecast of %Fe removed very close to the values obtained from the experiments. The close proximity of both model and experimental result values is attributed to the low standard error of the model coefficients. The processing parameters are process temperature, alloy contents and holding time.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127622458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microorganisms are ubiquitous and their impact could be appreciated directly or indirectly. This study was aimed at determining the occurrence of pathogenic bacteria on the phylloplane of some medicinal plants commonly used to treat diseases by oral administration. Leaves samples were collected aseptically from Cassia fistula (Cassia) Mangifera indica (Mango) and Psidium guajavum (Guava) and their bacterial contents were assessed. Higher bacterial counts were observed in raw samples followed by those washed with sterile water. Samples washed with sterile warm water (blanched) were shown to have lower counts although without statistical significance (p ≤ 0.05). Guava leaves had higher counts (3.4×106 cfu/g) in the raw samples and cassia in blanched (6.4×105 cfu/g). However, mango leaves had the lowest (8.4×105 cfu/g and 2.0×105 cfu/g) in both the treatments respectively. Twenty bacterial species were isolated comprising Gram negative and Gram positive species. Bacterial identification revealed that Proteus mirabilis (35%), Proteus vulgaris (15%), Escherichia coli (15%), Klebsiella pneumoniae (5%), Morganella morganii (5%), Salmonella typhi (10%), Enterobacter sp. (5%), Staphylococcus aureus (5%) and Vibrio cholarae (5%) were the prevalent species. These organisms could be potential pathogens and proper washing with hot water may serve a better means of reducing the microbial contents and thus, it is recommended.
{"title":"Isolation of potential bacterial pathogens from the phylloplane of some selected medicinal plants","authors":"HY Ismail, H. Bello, I. Allamin, E. Danjuma","doi":"10.14419/IJSW.V4I2.6156","DOIUrl":"https://doi.org/10.14419/IJSW.V4I2.6156","url":null,"abstract":"Microorganisms are ubiquitous and their impact could be appreciated directly or indirectly. This study was aimed at determining the occurrence of pathogenic bacteria on the phylloplane of some medicinal plants commonly used to treat diseases by oral administration. Leaves samples were collected aseptically from Cassia fistula (Cassia) Mangifera indica (Mango) and Psidium guajavum (Guava) and their bacterial contents were assessed. Higher bacterial counts were observed in raw samples followed by those washed with sterile water. Samples washed with sterile warm water (blanched) were shown to have lower counts although without statistical significance (p ≤ 0.05). Guava leaves had higher counts (3.4×106 cfu/g) in the raw samples and cassia in blanched (6.4×105 cfu/g). However, mango leaves had the lowest (8.4×105 cfu/g and 2.0×105 cfu/g) in both the treatments respectively. Twenty bacterial species were isolated comprising Gram negative and Gram positive species. Bacterial identification revealed that Proteus mirabilis (35%), Proteus vulgaris (15%), Escherichia coli (15%), Klebsiella pneumoniae (5%), Morganella morganii (5%), Salmonella typhi (10%), Enterobacter sp. (5%), Staphylococcus aureus (5%) and Vibrio cholarae (5%) were the prevalent species. These organisms could be potential pathogens and proper washing with hot water may serve a better means of reducing the microbial contents and thus, it is recommended.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122451722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Victor, Bamikole Mathew, Oluyege Adekemi, A. Ayo, A. Odunayo
Pasteurella multocida is a poultry bacterial pathogen causing fowl cholera in chicken. The prevalence and antibiotic susceptibility of P. multocida isolates from freshly dead chicken were determined. Ninety seven (97) freshly dead chicken from 23 different farms were analyzed for the presence of P. multocida . Swabs of the trachea and the liver of the necropsied chicken were activated on buffered peptone water and later cultured on blood agar and MacConkey agar. Pure culture of organisms were subjected to cultural and biochemical characterization. In vitro susceptibility of the pure isolates of P. multocida against 12 antimicrobial agents was determined using disk diffusion method. Twelve isolates of P. multocida were recovered from the chicken, with a prevalence of 12.4%. Nine of the isolates were recovered from the trachea and three from the liver. All the 12 isolates recovered from the birds were multi-resistant to the antibiotics used in this research. The antibiogram showed that all the isolates resisted ampicillin, amoxicillin/clavulinate, doxycycline and tylosine. Nitrofuratoin and gentamycin had the best antimicrobial activity with 25% and 50% resistance respectively. The resistance of other antibiotics are: Ofloxacin 75%, Ciprofloxacin 83.3%, Enrofloxacin 75%, Furasol 66.7%, Ceftazidime 91.7% and Cefuroxime 66.7%. This result showed that there is an emergence of multi- resistance in P. multocida, therefore it is important to carry out sensitivity test before administration of antibiotics in order to control fowl cholera.
{"title":"Prevalence and antibiotic resistance of Pasteurella multocida isolated from chicken in Ado-Ekiti metropolis","authors":"A. Victor, Bamikole Mathew, Oluyege Adekemi, A. Ayo, A. Odunayo","doi":"10.14419/IJSW.V4I2.6273","DOIUrl":"https://doi.org/10.14419/IJSW.V4I2.6273","url":null,"abstract":"Pasteurella multocida is a poultry bacterial pathogen causing fowl cholera in chicken. The prevalence and antibiotic susceptibility of P. multocida isolates from freshly dead chicken were determined. Ninety seven (97) freshly dead chicken from 23 different farms were analyzed for the presence of P. multocida . Swabs of the trachea and the liver of the necropsied chicken were activated on buffered peptone water and later cultured on blood agar and MacConkey agar. Pure culture of organisms were subjected to cultural and biochemical characterization. In vitro susceptibility of the pure isolates of P. multocida against 12 antimicrobial agents was determined using disk diffusion method. Twelve isolates of P. multocida were recovered from the chicken, with a prevalence of 12.4%. Nine of the isolates were recovered from the trachea and three from the liver. All the 12 isolates recovered from the birds were multi-resistant to the antibiotics used in this research. The antibiogram showed that all the isolates resisted ampicillin, amoxicillin/clavulinate, doxycycline and tylosine. Nitrofuratoin and gentamycin had the best antimicrobial activity with 25% and 50% resistance respectively. The resistance of other antibiotics are: Ofloxacin 75%, Ciprofloxacin 83.3%, Enrofloxacin 75%, Furasol 66.7%, Ceftazidime 91.7% and Cefuroxime 66.7%. This result showed that there is an emergence of multi- resistance in P. multocida, therefore it is important to carry out sensitivity test before administration of antibiotics in order to control fowl cholera.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124061631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Present study is to evaluate the hepatoprotective potential of methanolic extract of the plant Dolichos biflorus Linn . against paracetamol and alcohol induced hepatotoxicity in rats. Oral administration of plant extract in two doses 200mg/kg and 400mg/kg body weight were subjected for the evaluation of hepatoprotective potential against alcohol (2ml/100g) and PCM (2g/kg) induced liver injury. Silymarin (25mg/kg) was used as a standard drug. The parameters like SGPT, SGO, ALP, TB and endogenous enzymes were estimated to assess the liver functions. In addition histopathological study was also carried out. Both the lower (200mg/kg) and higher dose (400mg/kg) of D.biflorus extract showed dose dependent significant decrease in SGPT, SGOT, ALP and TB levels when compared with toxic control. Both extracts showed decrease in LPO and increase in GSH, SOD and CAT levels. Hepatoprotective effect was also confirmed by histopathological analysis of liver which showed less damage in extract treated rats. The results obtained were comparable with that of the standard. The present study concluded that Dolichos biflorus Linn. plant were found to be effective against hepatotoxicity induced by Alcohol and Paracetamol.
{"title":"Evaluation of hepatoprotective potential of methanolic extract of the plant dolichos biflorus linn","authors":"B. Deepthi, M. AshokaShenoy, K. Hegde","doi":"10.7439/IJASR.V2I5.3300","DOIUrl":"https://doi.org/10.7439/IJASR.V2I5.3300","url":null,"abstract":"Present study is to evaluate the hepatoprotective potential of methanolic extract of the plant Dolichos biflorus Linn . against paracetamol and alcohol induced hepatotoxicity in rats. Oral administration of plant extract in two doses 200mg/kg and 400mg/kg body weight were subjected for the evaluation of hepatoprotective potential against alcohol (2ml/100g) and PCM (2g/kg) induced liver injury. Silymarin (25mg/kg) was used as a standard drug. The parameters like SGPT, SGO, ALP, TB and endogenous enzymes were estimated to assess the liver functions. In addition histopathological study was also carried out. Both the lower (200mg/kg) and higher dose (400mg/kg) of D.biflorus extract showed dose dependent significant decrease in SGPT, SGOT, ALP and TB levels when compared with toxic control. Both extracts showed decrease in LPO and increase in GSH, SOD and CAT levels. Hepatoprotective effect was also confirmed by histopathological analysis of liver which showed less damage in extract treated rats. The results obtained were comparable with that of the standard. The present study concluded that Dolichos biflorus Linn. plant were found to be effective against hepatotoxicity induced by Alcohol and Paracetamol.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"224 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130708903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study is to investigate knowledge management aspects on organizational performance of Sepah Bank in Ardebil Province. Research population includes all the employees, deputies and managers of Sepah Bank branches in Ardebil Province, which according to the table of Morgan, includes a total number of 169 subjects. Standard questionnaires were used for data collection. Research results showed that knowledge management aspects (knowledge storage, sharing and using) had a positive and significant effect on organizational performance variable and in general 80 percent of variance determines the organizational performance of Sepah Bank in Ardebil.
{"title":"An investigation of the effect of knowledge management aspects on organizational performance (case study: sepah bank in Ardebil province)","authors":"Daryoush Sahebnazar, Ebrahim Dadfar","doi":"10.14419/IJSW.V4I2.6244","DOIUrl":"https://doi.org/10.14419/IJSW.V4I2.6244","url":null,"abstract":"The purpose of this study is to investigate knowledge management aspects on organizational performance of Sepah Bank in Ardebil Province. Research population includes all the employees, deputies and managers of Sepah Bank branches in Ardebil Province, which according to the table of Morgan, includes a total number of 169 subjects. Standard questionnaires were used for data collection. Research results showed that knowledge management aspects (knowledge storage, sharing and using) had a positive and significant effect on organizational performance variable and in general 80 percent of variance determines the organizational performance of Sepah Bank in Ardebil.","PeriodicalId":119953,"journal":{"name":"International Journal of Advances in Scientific Research","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115217276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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