Experimental and clinical psychopharmacology最新文献

Ecological momentary assessment (EMA) is increasingly used to examine risk and protective factors associated with alcohol-involved sexual assault (SA). Whereas extant literature demonstrates limited reactivity (i.e., systematic behavior change) to repeated assessment of risk behaviors (e.g., drinking), we know little about the impact of EMA on protective behaviors (i.e., harm reduction strategies). The present study examined between- and within-person reactivity to EMA participation using data from a larger study of alcohol and SA protective behavioral strategy (PBS) use. First-year college women (N = 138) were randomized to a 14-day EMA or a reactivity control condition. Both conditions completed baseline/follow-up measures of drinking behavior, alcohol PBS, and SA PBS. The EMA condition reported alcohol and SA PBS use each morning after drinking. We used 2 × 2 analyses of variance to examine differences in PBS use by condition (EMA vs. control) over time (baseline vs. follow-up); within-person changes in PBS use were probed with multilevel models. We found Significant Condition × Time interactions for both alcohol PBS and SA PBS; the EMA condition increased PBS use relative to the control condition across the first semester of college. Across the 14-day EMA protocol, women marginally increased alcohol PBS use and significantly increased SA PBS use. Participation in a 14-day EMA protocol may lead to changes in PBS use among first-semester college women. Results encourage examination of and controlling for potential reactivity in etiology and intervention studies of PBS use and highlight the potential of momentary interventions to increase PBS use over time. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

A number of studies have been conducted to assess the efficacy of exercise-based interventions for substance-use disorders. Nicotine use has been overrepresented in prior meta-analytic and systematic reviews, potentially obscuring the effects of exercise on outcomes related to other drugs. The aim of this meta-analysis and systematic review was to offer an updated account of the impact of exercise on substance-use outcomes for drugs other than nicotine. Eligible studies included peer reviewed articles published before August 2023 describing randomized controlled trials or clinical trials involving adults in which exercise served as the primary treatment intervention and substance use and/or craving outcomes were assessed for drugs other than nicotine. In addition to omnibus effects, meta-regression models were conducted to assess study design (within vs. between), data collection (acute vs. long-term), and outcome measure (drug craving vs. drug use) as potential moderating variables. A total of 19 articles describing 17 unique studies were selected for analysis, including data from 1,363 individual participants. An omnibus robust variance estimation meta-analysis indicated a significant reduction in substance-use outcomes following exercise intervention. The moderator analysis additionally indicated a significant effect of design type such that between-subject designs displayed smaller magnitude reductions than within-subject designs. Other potential moderators were not significant. These findings indicate that a variety of exercise-based interventions produce moderate improvements in substance use and craving for people using nonmedical drugs and corroborate prior reports that exercise is effective as an adjunctive or standalone treatment for substance-use disorder. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

The operant demand cigarette purchase task conventionally prompts participants to report imagined purchases in units of single cigarettes. Although this purchasing modality diverges from the units deployed in real purchasing scenarios (i.e., packs of 20), no research has examined how simulated purchasing of the more ecologically valid unit of cigarette packs maps onto single cigarette purchasing metrics. A sample of 212 participants in this study reported hypothetical cigarette purchases across three iterations of the cigarette purchase task. Two of these collected responses in a binary format-would or would not purchase-at yoked unit prices, where tasks were distinguished as purchases of single cigarettes or packs of cigarettes. This binary framework permitted a simplified probabilistic description of purchasing that maintained a consistent timeframe. Participants also completed the standard cigarette purchase task, reporting the quantity of single cigarettes they would purchase and consume at each unit price. Purchasing breakpoint, or the highest price at which participants reported purchasing cigarettes, was broadly consistent across these tasks, weakly so when comparing purchases made on the binary tasks (r = .183). Tests of equivalence suggested that there were meaningful differences between breakpoint values reported on the single cigarette binary task and the per pack binary task, t(211) = -5.85, p < .001, and between breakpoint values reported on the standard purchase task and the per pack binary task, t(211) = 11.49, p < .001. Results suggest more research is needed to determine what environmental factors or imposed constraints are practically influencing reported cigarette valuation. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Alcohol-related consequences remain a major public health issue, especially for emerging adults. Additionally, experiences of discrimination can have a deleterious impact on an individuals' drinking habits and mental health, especially when an individual is discriminated against for multiple, intersecting aspects of their identity. For example, experiencing multiple forms of discrimination has been linked to anxiety, depression, and alcohol-related consequences. The purpose of this study was to investigate if experiences of multiple discrimination are associated with alcohol-related consequences and if a pathway exists between multiple discrimination, anxiety and depression coping motives, and alcohol-related consequences. Participants (N = 399; 54.9% female, 48.1% White) were emerging adults who completed a survey on Prolific Academic, including questionnaires on number of drinks per week, alcohol-related consequences, experiences of perceived discrimination, depression and anxiety, and substance use coping motives. Results supported a significant association between multiple forms of discrimination and alcohol consequences. Serial mediation analyses supported an indirect effect of multiple forms of discrimination on alcohol-related consequences through both depression and depression coping motives, and anxiety and anxiety coping motives. Overall, the results of this study build upon previous research on the association between coping motives and alcohol consequences, demonstrate the depth of the impact of experiencing discrimination, and highlight the need for research to consider discrimination from an intersectional lens. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Subjective responses to alcohol, which encompass the subjective feelings and experiences elicited by alcohol consumption, are important factors implicated in the etiology of alcohol use disorder. Previous human laboratory studies have investigated how subjective responses to priming doses of alcohol influence alcohol self-administration (SA) but have not accounted for responses throughout the task. The present study investigated how subjective responses to alcohol, measured at multiple time points during a progressive ratio SA task, impacted subsequent motivation to self-administer alcohol. Participants (n = 67; 36 male/31 female) who drank heavily completed a 120-min progressive ratio alcohol intravenous SA paradigm. Every 15 min, participants were breathalyzed and completed self-report questionnaires to measure alcohol-induced stimulation, sedation, alcohol wanting, alcohol liking, negative mood, and positive mood. Alcohol SA was indicated by an increase in breath alcohol concentration. Time-lagged subjective response outcomes were examined as predictors of subsequent SA using multilevel modeling. Sex and family history of alcohol-related problems were investigated as potential moderators of the impact of subjective response measures on SA. Higher levels of alcohol-induced stimulation, as well as wanting and liking alcohol, predicted increased SA of alcohol. An increase in time, as a proxy for task demand, predicted a decreased likelihood of subsequent SA and moderated the effect of liking on SA. Family history of alcohol-related problems moderated the impact of alcohol-induced wanting and negative mood on motivation to consume alcohol. Overall, these findings emphasize the significant role of subjective responses to alcohol, as well as their interactions with task demand and family history, in influencing alcohol consumption behaviors. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

We assessed heart rate variability (HRV) as a measure of autonomic nervous system function during an ongoing double blind, placebo-controlled, trial of adjunct gabapentin during a buprenorphine-assisted taper and transition to injection naltrexone to explore how adjunctive pharmacotherapy and time influence autonomic nervous system activity and whether HRV metrics are predictive of treatment outcomes. Individuals with opioid use disorder who began their participation in an ongoing trial of adjunct gabapentin during an outpatient 10-day buprenorphine-assisted transition to injection naltrexone underwent experimental sessions at Weeks 1, 2, and 3 of the parent trial. HRV metrics were assessed for 2 min each while standing, sitting, and sitting while performing paced breathing (PB) using the ProComp2 System with sensor belt and analysis suite. Multiple imputation was used to analyze the HRV metrics due to some participants lacking data at all three weekly timepoints. Among 28 participants, logistic regression analyses indicated significant effects for frequency distributions and heart rate during PB exercises. Trends in frequency distribution during PB suggested potential influences of gabapentin on autonomic balance, resulting in lower HRV. Predictor variables for outcomes indicated a significant effect with higher low frequency/high frequency ratio during PB decreasing the odds of completing supervised withdrawal. Higher respiration rate and low frequency values while sitting showed trends and significant effects, respectively, for decreasing the odds of receiving Week 4 injection naltrexone. Selected HRV metrics change during supervised opioid withdrawal and are associated with treatment outcomes during supervised opioid withdrawal procedures. The significance of HRV metrics during PB exercises underscores the impact of specific activities on autonomic function, highlighting the importance of considering such effects when recording HRV metrics. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Self-report is the most common way to measure substance use expectancies. Using such measures has led to insights regarding how, why, and for whom expectancies relate to use behavior. In fact, such insights have translated into interventions, such as expectancy challenges seeking to change one's expectancies. However, expectancy measures may be tricky for cannabis use, which has several product types and modalities that may impact the introspection of self-reported cannabis experiences. This study assessed whether a modern expectancies measure was invariant across cannabis use type/modality self-reported upon and whether cannabis type/modality moderated the influence of expectancies on use behavior. Young adults who recreationally used cannabis (N = 387) reported their cannabis use frequency and expectancies via the Anticipated Effects of Cannabis Scale. Participants also reported cannabis modality/type through which expectancies were self-reported upon. Each expectancy domain (high arousal negative, low arousal negative, positive) was invariant across cannabis type/modality. High arousal negative expectancies were higher when reporting vaping versus smoking, and positive expectancies were higher when reporting smoking versus vaping, but no other differences emerged. However, positive expectancies were associated with more frequent cannabis use when reporting on smoked (vs. vaporized) cannabis, and high arousal negative expectancies were associated with less frequent cannabis use when reporting on hash oil (vs. marijuana) and when reporting on vaporized (vs. smoked) cannabis. Cannabis type and modality may be important qualifiers in self-report research on cannabis expectancies. Future research should consider assessing modality- and type-specific cannabis constructs that are susceptible to such influences. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Induction of negative mood increases tobacco choice in dependent smokers; however, less is known about the mechanisms behind this. This study addressed this gap by applying a computational model of value-based decision making to tobacco and tobacco-unrelated choices following mood manipulation. Using a preregistered, within-subject design, 49 daily tobacco smokers (>10 daily cigarettes) watched two different videos which primed them to experience negative and positive mood (tobacco valuation and devaluation, respectively). Participants completed self-report measures of mood and craving to smoke before and after priming, followed by a two-alternative forced-choice task with (separate) blocks of tobacco-related and tobacco-unrelated (animal) images. On each block, participants selected the image that they previously rated higher. A drift-diffusion model was fitted to the reaction time and error data to estimate evidence accumulation processes and response thresholds during the different blocks. After watching videos intended to induce negative mood, happiness scores were lower (p < .001, d = 1.16), while sadness and craving to smoke scores were higher (both ps < .001, ds > .60) compared to after watching videos intended to induce positive mood. However, contrary to hypotheses, the experimental manipulation did not robustly affect evidence accumulation rates (F = 1.15, p = .29, η_p² = .02) or response thresholds (F = .07, p = .79, η_p² = .00) for either tobacco or tobacco-unrelated decisions. Manipulation of mood in daily smokers did not lead to alterations in the internal processes that precede value-based decisions made about tobacco and tobacco-unrelated cues. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Ketamine is increasingly used in community clinics as a long-term treatment for different psychiatric and pain conditions, including substance use disorders. Data are lacking, however, regarding the potential influence of ketamine on other substance use. In this secondary analysis, we aimed to explore the relationship between medical ketamine and other substance use among real-world patients by combining quantitative and qualitative data. In an online anonymous pilot survey (N = 201), patients rated change in other substance use since medical ketamine initiation and elaborated on their subjective experiences. Most patients self-reported positive/desirable change (54.7%) or no change in substance use (44.3%). Participants reporting past problematic substance use had significantly greater positive change compared with the groups of participants reporting present or no history of problematic substance use (ps < .020). Participants reported positive outcomes such as reduced substance use due to reduced need to self-medicate for coping, reduced craving, or enhanced motivation to quit use. Among participants with minimal or no substance use, ketamine did not appear to induce or increase drug-using behaviors. However, there were some reports of risky behaviors such as openness to using other psychedelics or ketamine used recreationally as a substitute for alcohol. Several implications for providers are discussed. More targeted quantitative and qualitative research is needed to fully characterize all patients but especially those at risk for potentially harmful nonmedical substance use. Such research could inform regulation efforts on safety, screening, monitoring, and patient and provider education, to maximize benefits and minimize risks related to medical ketamine. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Nicotine pouches (NPs) contain no tobacco leaf but instead are filled with nicotine powder, flavorants, and pH adjusters. There are very few independent (i.e., non-industry-funded/affiliated) studies regarding the effects of NPs. The purpose of this industry-independent study is to examine NP effects in people who use smokeless tobacco (SLT). Twenty-four participants completed four sessions that included three NP conditions (2, 4, and 8 mg labeled total nicotine content; "on!" brand, Altria, Richmond, Virginia) and participants' own brand (OB) SLT. Participants completed two 30-min administration periods per session, and outcomes included plasma nicotine concentration as well as subjective and behavioral economic measures. Results indicate that the 8 mg NP did not differ significantly from OB across physiological and subjective measures; the 4 mg NP differed from OB and 8 mg on some measures, and the 2 mg NP reliably delivered less nicotine and reduced abstinence symptoms less effectively when compared to OB and the 8 mg NP. Study results offer preliminary support for the notion that higher nicotine content NPs may substitute for SLT in people who use SLT regularly, while lower nicotine content NPs may not. Overall, labeled nicotine content influences the nicotine delivery and abstinence symptom suppression of "on!" brand NP, and nicotine content and delivery should be considered when assessing the individual and public health impact of NP regulations. (PsycInfo Database Record (c) 2025 APA, all rights reserved).