European review for medical and pharmacological sciences最新文献

The article "MiR-411-5p acts as a tumor suppressor in non-small cell lung cancer through targeting PUM1" by L.-H. Xia, Q.-H. Yan, Q.-D. Sun, Y.-P. Gao published in Eur Rev Med Pharmacol Sci 2018; 22 (17): 5546-5553-DOI: 10.26355/eurrev_201809_15816-PMID: 30229827 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer, the Journal has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation confirmed several instances of Figure duplication with previously published articles, specifically in Figures 3 and 4. The authors were contacted, informed of the ongoing investigation, and requested to provide the original data supporting the manuscript, but they remained unresponsive. As a result, the Journal has decided to retract this article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/15816.

Multiple sclerosis (MS) is a chronic, autoimmune and neurodegenerative disease characterized by inflammation, lesions, demyelination, and axonal damage. Approximately 2.8 million people globally have MS. Many pharmacological agents can reduce relapsing-remitting episodes, but are ineffective on secondary progressive MS, causing symptoms to worsen over time. MS patients have significant impairment in neurophysiological factors such as demyelination and the balance between inhibitory and excitatory synaptic interactions. These impairments disrupt normal communication between neurons in the cerebral cortex, which contributes to the symptoms and disease progression. Transcranial Magnetic Stimulation (TMS) can identify and measure such neurophysiological parameters, including cortical excitability, linked with progression and the severity of disease. Thus, TMS could serve as a potential surrogate marker to monitor MS activity and severity. The review highlights the potential of TMS in managing MS, including enhanced cognitive functions, reduced fatigue, and improved spasticity, balance, and gait. In addition, TMS contributes to reducing neuroinflammation and oxidative stress while promoting neuronal repair and remyelination. However, further research is required for a better understanding of the stimulation- and site-specific effects of TMS in MS.

Graphical abstract: https://www.europeanreview.org/wp/wp-content/uploads/graphical-abstract-25.jpg.

The article "Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation" by R. Sferra, A. Vetuschi, V. Catitti, S. Ammanniti, S. Pompili, D. Melideo, G. Frieri, E. Gaudio, G. Latella published in Eur Rev Med Pharmacol Sci 2012; 16 (11): 1484-1498-PMID: 23111960 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer, the Journal has started an investigation to assess the validity of the results as well as possible figure and data manipulation. The authors were contacted and informed of the ongoing investigation. The authors stated that "due to an inadvertent error that occurred during the preparation of the manuscript, some images and data were mistakenly selected from an incorrect file, resulting in the inclusion of material previously published in Liver International (2009)". The article has been, therefore, retracted according to COPE guidelines. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/1806.

OBJECTIVE: Timely response and identification of risk factors are critical components of suicide prevention, enabling appropriate intervention. By applying machine learning to clinical data analysis, predictive models can be developed to classify patients into high- and low-risk groups, which can help prevent loss of life. This study aims to develop a machine learning model to categorize patients based on their risk of suicide attempts. MATERIALS AND METHODS: We analyzed data from 301 respondents hospitalized at the Clinic of Psychiatry for either suicidal behavior or non-suicidal reasons. They were divided into two groups according to the presence of suicidal behavior. By using machine learning methods, we analyzed the influence of 18 observed features on the development of suicidal behavior. A predictive model was developed to classify individuals into two risk categories - high and low - for the observed population. The k-Nearest Neighbors (kNN) algorithm was used to train the model. RESULTS: The kNN-based model achieved a classification accuracy of 87%, with sensitivity at 87%, precision at 90% and an F-score of 85% for the tested sample. CONCLUSIONS: Early identification of risk factors for suicidal behavior remains the most effective strategy for prevention. Classification models may serve as valuable clinical tools for assessing suicide risk, potentially contributing to a reduction in suicide rates in Vojvodina. Expanding the database could improve the functions of the obtained classifier and enable its introduction into medical practice.

Graphical abstract: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-27.jpg.

The article "Long non-coding RNA BANCR indicates poor prognosis for breast cancer and promotes cell proliferation and invasion" by K.-X. Lou, Z.-H. Li, P. Wang, Z. Liu, Y. Chen, X.-L. Wang, H.-X. Cui published in Eur Rev Med Pharmacol Sci 2018; 22 (5): 1358-1365-DOI: 10.26355/eurrev_201803_14479-PMID: 29565494 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer and whistleblowers, the Journal has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation identified several instances of figure duplication, specifically in Figure 2 (panels B and D), with previously published articles. The authors were contacted, informed of the ongoing investigation, and requested to provide the original data supporting the manuscript, but they remained unresponsive. As a result, the Journal has decided to retract this article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/14479.

The article "Long non-coding RNA MEG3 represses cholangiocarcinoma by regulating miR-361-5p/TRAF3 axis" by W.-X. Lu published in Eur Rev Med Pharmacol Sci 2019; 23 (17): 7356-7368-DOI: 10.26355/eurrev_201909_18842-PMID: 31539122 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer (https://pubpeer.com/publications/1CE3437CE3D1F5CA10D8494E9EFEE2), the Journal has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation identified multiple instances of figure duplication, specifically in panel C of Figure 9, with previously published articles. Additionally, a duplication was also found in the Western Blots of Figure 8 with a previously published article. The author was contacted and informed of the ongoing investigation, and was requested to provide the original data supporting the manuscript, but remained unresponsive. As a result, the Journal has decided to retract this article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/18842.

OBJECTIVE: Status epilepticus (SE) is a life-threatening neurological emergency. However, studies on the prognostic factors of adult patients with SE in the Middle East remain lacking. Therefore, the present study aimed to analyze the clinical presentation, causes, and complications of SE and determine predictors of poor outcomes in patients treated in a tertiary care university hospital in Saudi Arabia. MATERIALS AND METHODS: This retrospective cohort study was conducted in the Department of Medicine, Neurology Division, College of Medicine, King Saud University, Riyadh, Saudi Arabia. This study recruited 38 patients aged 14 years or older who met the diagnostic criteria for SE. The median age was 30, and males accounted for 60.5% of cases. The outcomes were assessed using the Glasgow Outcome Scale (GOS). RESULTS: A history of epilepsy was present among 78.9% of patients; generalized seizures were observed in 89.5%, and focal seizures were observed in 10.59%. The primary complications included respiratory problems (36.89%) and acute kidney injury (23.7%). Antiepileptic drug reduction or withdrawal was the most common etiology in patients with preexisting epilepsy. Systemic infection (42.1%) was the most common cause in the general population, followed by withdrawal or reduction of anti-epileptic drugs (39.5%) and cerebrovascular disease (23.7%). Overall, 36.8% of patients experienced poor outcomes. CONCLUSIONS: It was concluded that, overall, one-third of patients experienced poor outcomes. The mortality rate was 18.4%. The refractory SE, caused by cerebrovascular disease and respiratory/renal complications, was identified as a significant predictor of poor outcomes. This study highlights poor medication adherence and systemic infections as the primary causes of SE in Saudi Arabia. Refractory SE, respiratory complications, acute kidney injury, and SE due to cerebrovascular disease emerged as key predictors of poor outcomes, emphasizing the importance of addressing the underlying causes and the early recognition and management of complications.

Graphical abstract: https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-24.jpg.

The article "miR-564 inhibited metastasis and proliferation of prostate cancer by targeting MLLT3" by F.-J. Meng, F.-M. Meng, H.-X. Wu, X.-F. Cao published in Eur Rev Med Pharmacol Sci 2017; 21 (21): 4828-4834-PMID: 29164580 has been retracted in accordance with the authors, the Publisher, and the Editor in Chief. The authors initially informed the journal of their intention to retract the article due to data inaccuracies and a lack of clarity in some figures. The journal's investigation additionally identified image duplications within the cell migration and invasion assay panels (panels G and H of Figure 3), as well as among the Western blot images (panels E and F of Figure 3). This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/13723.

The article "MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17" by W.-Z. Su, L.-F. Ren published in Eur Rev Med Pharmacol Sci 2019; 23 (8): 3390-3400-DOI: 10.26355/eurrev_201904_17703-PMID: 31081094 has been retracted in accordance with the Publisher and the Editor in Chief. Following some concerns raised on PubPeer (https://pubpeer.com/publications/2E8256B0FA92987A3510C854E633DA), the Journal has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal's investigation identified multiple instances of figure duplication, specifically in panel E of Figure 2 and in the Western blots of Figure 4, which appear to overlap with images from previously published articles. In addition, a duplication was detected within panel C of Figure 5. The authors were contacted and informed of the ongoing investigation, and were requested to provide the original data supporting the manuscript. The authors responded that, due to their relocation and lack of access to the original computer files, the underlying data could not be retrieved. As a result, the Journal has decided to retract this article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/17703.

Eur Rev Med Pharmacol Sci 2023; 27 (1): 378-383-DOI: 10.26355/eurrev_202301_30891-PMID: 36647886, published online on January 13, 2023. This erratum addresses errors in the reference list of the published PDF version. Due to an internal error during layout finalization, incorrect references from another article were inadvertently inserted into the final PDF. The error was not detected by the authors prior to publication, and the PDF file was approved for publication. The corrected list of references is provided below: 1.         Chen J, Jiang Q, Xia X, Liu K, Yu Z, Tao W, Gong W, Han JJ. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell 2020; 19: e13168. 2.         Atlas SA. The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition. J Manag Care Pharm 2007; 13: 9-20. 3.         Stanley KE, Thomas E, Leaver M, Wells D. Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues. Fertil Steril 2020; 114: 33-43. 4.         Younis JS, Abassi Z, Skorecki K. Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection. Am J Physiol Endocrinol Metab 2020; 318: E878-E880. 5.         Reis AB, Araújo FC, Pereira VM, Dos Reis AM, Santos RA, Reis FM. Angiotensin (1-7) and its receptor Mas are expressed in the human testis: implications for male infertility. J Mol Histol 2010; 41: 75-80. 6.         Tiwari S, Kc N, Thapa S, Ghimire A, Bijukchhe S, Sah GS, Isnuwardana R. Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis. Middle East Fertil Soc J 2021; 26: 44-53. 7.         Boitrelle F, Shah R, Saleh R, Henkel R, Kandil H, Chung E, Vogiatzi P, Zini A, Arafa M, Agarwal A. The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis. Life (Basel) 2021; 11: 1368. 8.         Cocuzza M, Agarwal A. Nonsurgical treatment of male infertility: spesific and empiric therapy. Biologics 2007; 1: 259-269. 9.         Twigg JP, Irvine DS, Aitken RJ. Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod 1998; 13: 1864-1871. 10.          Tremellen K. Oxidative stress and male infertility-a clinical perspective. Hum Reprod Update 2008; 14: 243-258. 11.          Wang Z, Xu X. scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in Spermatogonia, Leydig and sertoli Cells. Cells 2020; 9: 920. 12.          Dejucq N, Jégou B. Viruses in the mammalian male genital tract and their effects on the reproductive system. Microbiol Mol Biol Rev 2001; 65: 208-231. 13.          Heller CG, Clermont Y. Spermatogenesis in man: an estimate of its duration. Science 1963; 140: 184-186. 14.          Pan F, Xiao X, Guo J, Song Y, Li H, Patel DP, Spivak AM, Alukal JP, Zhang X, Xiong C, Li PS, Hotaling JM. No evidence of severe acute r