Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36584
H-L Xia, C-J Li, X-F Hou, H Zhang, Z-H Wu, J Wang
The article "Interferon-γ affects leukemia cell apoptosis through regulating Fas/FasL signaling pathway" by H.-L. Xia, C.-J. Li, X.-F. Hou, H. Zhang, Z.-H. Wu, J. Wang, published in Eur Rev Med Pharmacol Sci 2017; 21 (9): 2244-2248 - PMID: 28537657 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/2F360E066992B4078059C72F8530B3), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. The journal's investigation revealed a duplicated area in Figure 1 between panels 100 U/mL and 1000 U/mL. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/12706.
H.-L. Xia、C.-J. Li、X.-F. Hou、H. Zhang、Z.-H. Zhang、Z.Hou、H. Zhang、Z.-H. Wu、J. Wang 的研究成果,发表于《细胞生物学》杂志。Wu, J. Wang, 发表于 Eur Rev Med Pharmacol Sci 2017; 21 (9):2244-2248 - PMID: 28537657 已被主编撤回。在PubPeer(链接:https://pubpeer.com/publications/2F360E066992B4078059C72F8530B3)上提出了一些问题后,主编已开始调查,以评估结果的有效性以及可能存在的数字操纵。本刊已向作者通报了调查情况,但作者一直没有回应,也没有提供研究的原始数据。期刊调查发现,图 1 中 100 U U/mL 和 1000 U U/mL 之间有重复区域。因此,主编对所提交的结果不信任,决定撤回该文章。本文已被撤稿。https://www.europeanreview.org/article/12706。
{"title":"Retraction Note: Interferon-γ affects leukemia cell apoptosis through regulating Fas/FasL signaling pathway.","authors":"H-L Xia, C-J Li, X-F Hou, H Zhang, Z-H Wu, J Wang","doi":"10.26355/eurrev_202407_36584","DOIUrl":"https://doi.org/10.26355/eurrev_202407_36584","url":null,"abstract":"<p><p>The article \"Interferon-γ affects leukemia cell apoptosis through regulating Fas/FasL signaling pathway\" by H.-L. Xia, C.-J. Li, X.-F. Hou, H. Zhang, Z.-H. Wu, J. Wang, published in Eur Rev Med Pharmacol Sci 2017; 21 (9): 2244-2248 - PMID: 28537657 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/2F360E066992B4078059C72F8530B3), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. The journal's investigation revealed a duplicated area in Figure 1 between panels 100 U/mL and 1000 U/mL. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/12706.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36582
Z-C Wang, J Qi, L-M Liu, J Li, H-Y Xu, B Liang, B Li
The article "Valsartan reduces AT1-AA-induced apoptosis through suppression oxidative stress mediated ER stress in endothelial progenitor cells" by Z.-C. Wang, J. Qi, L.-M. Liu, J. Li, H.-Y. Xu, B. Liang, B. Li, published in Eur Rev Med Pharmacol Sci 2017; 21 (5): 1159-1168 - PMID: 28338173 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/8FA8D4C63DE61DDB6C89537AD04B24), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. The journal's investigation revealed a Figure duplication in Figure 2C between panels AT1-AA (2.5 µM), AT1-AA (5 µM), AT1-AA (10 µM), and AT1-AA+Valsartan. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/12342.
文章 "缬沙坦通过抑制内皮祖细胞氧化应激介导的ER应激减少AT1-AA诱导的细胞凋亡 "的作者是Z.-C. Wang, J. Qi, L.-M.Wang, J. Qi, L.-M. Liu, J. Li, H.-M.Liu, J. Li, H.-Y. Xu, B. Liang, B.-Y.Xu, B. Liang, B. Li》,发表于《Eur Rev Med Pharmacol Sci 2017; 21 (5):1159-1168 - PMID: 28338173 已被主编撤回。在PubPeer(链接:https://pubpeer.com/publications/8FA8D4C63DE61DDB6C89537AD04B24)上提出了一些问题后,主编已开始调查,以评估结果的有效性以及可能存在的数字篡改。本刊已将调查情况告知作者,但作者一直没有回应,也没有提供研究的原始数据。期刊调查发现,图2C中的AT1-AA(2.5 µM)、AT1-AA(5 µM)、AT1-AA(10 µM)和AT1-AA+缬沙坦之间存在重复。因此,主编对所提供的结果不信任,决定撤回这篇文章。这篇文章已被撤回。出版商对由此造成的不便深表歉意。https://www.europeanreview.org/article/12342。
{"title":"Retraction Note: Valsartan reduces AT1-AA-induced apoptosis through suppression oxidative stress mediated ER stress in endothelial progenitor cells.","authors":"Z-C Wang, J Qi, L-M Liu, J Li, H-Y Xu, B Liang, B Li","doi":"10.26355/eurrev_202407_36582","DOIUrl":"https://doi.org/10.26355/eurrev_202407_36582","url":null,"abstract":"<p><p>The article \"Valsartan reduces AT1-AA-induced apoptosis through suppression oxidative stress mediated ER stress in endothelial progenitor cells\" by Z.-C. Wang, J. Qi, L.-M. Liu, J. Li, H.-Y. Xu, B. Liang, B. Li, published in Eur Rev Med Pharmacol Sci 2017; 21 (5): 1159-1168 - PMID: 28338173 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/8FA8D4C63DE61DDB6C89537AD04B24), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. The journal's investigation revealed a Figure duplication in Figure 2C between panels AT1-AA (2.5 µM), AT1-AA (5 µM), AT1-AA (10 µM), and AT1-AA+Valsartan. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/12342.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36580
Q Huang, G Wang, Y-L Hu, J-X Liu, J Yang, S Wang, H-B Zhang
The article "Study on the expression and mechanism of inflammatory factors in the brain of rats with cerebral vasospasm" by Q. Huang, G. Wang, Y.-L. Hu, J.-X. Liu, J. Yang, S. Wang, H.-B. Zhang, published in Eur Rev Med Pharmacol Sci 2017; 21 (12): 2887-2894 - PMID: 28682429 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/48E37B385D83F1B09741B2B06B39C3), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. The journal's investigation uncovered a duplication between Figure 2A and Figure 1D with a previously published article (https://doi.org/10.1371/journal.pone.0096212). Additionally, duplications were identified between panels b, c, d, f, g, and h of Figure 3A and Figure 6B, C, D, F, G, and H, respectively, of the same previously published article (https://doi.org/10.1371/journal.pone.0096212). Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/12948.
Q. Huang, G. Wang, Y.-L. Hu, J.-X. Liu, J. Yang, S. Wang, H.-B. Wong的文章 "脑血管痉挛大鼠脑内炎症因子的表达及机制研究"。Liu、J. Yang、S. Wang、H.-B. Zhang",发表于《Eur Rev Med》杂志。Zhang, 发表于 Eur Rev Med Pharmacol Sci 2017; 21 (12):2887-2894 - PMID: 28682429 已被主编撤回。在PubPeer(链接:https://pubpeer.com/publications/48E37B385D83F1B09741B2B06B39C3)上提出了一些问题后,主编已开始调查,以评估结果的有效性以及可能存在的数字篡改。本刊已向作者通报了调查情况,但作者仍未做出回应,也未提供研究的原始数据。期刊调查发现,图2A和图1D与之前发表的一篇文章(https://doi.org/10.1371/journal.pone.0096212)重复。此外,还发现图 3A 的 b、c、d、f、g 和 h 面板分别与之前发表的同一篇文章 (https://doi.org/10.1371/journal.pone.0096212) 的图 6B、C、D、F、G 和 H 之间存在重复。因此,主编不相信所提供的结果,决定撤回这篇文章。本文已被撤回。https://www.europeanreview.org/article/12948。
{"title":"Retraction Note: Study on the expression and mechanism of inflammatory factors in the brain of rats with cerebral vasospasm.","authors":"Q Huang, G Wang, Y-L Hu, J-X Liu, J Yang, S Wang, H-B Zhang","doi":"10.26355/eurrev_202407_36580","DOIUrl":"https://doi.org/10.26355/eurrev_202407_36580","url":null,"abstract":"<p><p>The article \"Study on the expression and mechanism of inflammatory factors in the brain of rats with cerebral vasospasm\" by Q. Huang, G. Wang, Y.-L. Hu, J.-X. Liu, J. Yang, S. Wang, H.-B. Zhang, published in Eur Rev Med Pharmacol Sci 2017; 21 (12): 2887-2894 - PMID: 28682429 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/48E37B385D83F1B09741B2B06B39C3), the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The authors have been informed about the journal's investigation but remained unresponsive and have not provided the study's raw data. The journal's investigation uncovered a duplication between Figure 2A and Figure 1D with a previously published article (https://doi.org/10.1371/journal.pone.0096212). Additionally, duplications were identified between panels b, c, d, f, g, and h of Figure 3A and Figure 6B, C, D, F, G, and H, respectively, of the same previously published article (https://doi.org/10.1371/journal.pone.0096212). Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/12948.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36523
A C Ozturk, B Dilbaz, R Ozelci, S Dilbaz
Objective: Assisted Reproductive Technologies (ART) are considered to be the most effective treatment option for unexplained infertility. This study aims to investigate the pregnancy outcomes of women who received in-vitro fertilization-embryo transfer (IVF-ET) treatment for unexplained infertility and the contributing factors affecting these outcomes.
Patients and methods: The present study included 789 consecutive women with unexplained infertility who were treated with IVF-ET at the ART Clinic of the Health Sciences University, Ankara Etlik Zübeyde Hanım Gynecology Training and Research Hospital between January 2007 and December 2019. The contributing factors affecting these outcomes, such as body mass index (BMI), basal follicle-stimulating hormone (FSH), and antimullerian hormone (AMH), were evaluated retrospectively.
Results: Clinical pregnancy per cycle was 19.8% among patients recruited. No statistically significant difference was detected in terms of age, infertility duration, and BMI of the patients who achieved pregnancy and who failed to get pregnant after IVF-ET treatment. The basal FSH level was found to be significantly lower (p=0.001), and the AMH level was significantly higher in patients who had clinical pregnancy (p=0.001). The basal AMH cut-off value was calculated to be 3.34 ng/mL, and the basal FSH cut-off value was calculated as 7.26 IU/L for the prediction of clinical pregnancy.
Conclusions: IVF-ET treatment can be applied as a successful treatment option in unexplained infertility cases. Although the basal FSH and AMH values are not the cut-off values that have high sensitivity and specificity, they are considered to be associated with pregnancy rates.
{"title":"Prestimulation parameters predicting the pregnancy outcomes after IVF-ET in patients with unexplained infertility.","authors":"A C Ozturk, B Dilbaz, R Ozelci, S Dilbaz","doi":"10.26355/eurrev_202407_36523","DOIUrl":"https://doi.org/10.26355/eurrev_202407_36523","url":null,"abstract":"<p><strong>Objective: </strong>Assisted Reproductive Technologies (ART) are considered to be the most effective treatment option for unexplained infertility. This study aims to investigate the pregnancy outcomes of women who received in-vitro fertilization-embryo transfer (IVF-ET) treatment for unexplained infertility and the contributing factors affecting these outcomes.</p><p><strong>Patients and methods: </strong>The present study included 789 consecutive women with unexplained infertility who were treated with IVF-ET at the ART Clinic of the Health Sciences University, Ankara Etlik Zübeyde Hanım Gynecology Training and Research Hospital between January 2007 and December 2019. The contributing factors affecting these outcomes, such as body mass index (BMI), basal follicle-stimulating hormone (FSH), and antimullerian hormone (AMH), were evaluated retrospectively.</p><p><strong>Results: </strong>Clinical pregnancy per cycle was 19.8% among patients recruited. No statistically significant difference was detected in terms of age, infertility duration, and BMI of the patients who achieved pregnancy and who failed to get pregnant after IVF-ET treatment. The basal FSH level was found to be significantly lower (p=0.001), and the AMH level was significantly higher in patients who had clinical pregnancy (p=0.001). The basal AMH cut-off value was calculated to be 3.34 ng/mL, and the basal FSH cut-off value was calculated as 7.26 IU/L for the prediction of clinical pregnancy.</p><p><strong>Conclusions: </strong>IVF-ET treatment can be applied as a successful treatment option in unexplained infertility cases. Although the basal FSH and AMH values are not the cut-off values that have high sensitivity and specificity, they are considered to be associated with pregnancy rates.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36455
X Zhang, L-F Huang, L Hua, H-K Feng, B Shen
The article "Resveratrol protects myocardial apoptosis induced by ischemia-reperfusion in rats with acute myocardial infarction via blocking P13K/Akt/e-NOS pathway", by X. Zhang, L.-F. Huang, L. Hua, H.-K. Feng, B. Shen, published in Eur Rev Med Pharmacol Sci 2019; 23 (4): 1789-1796-DOI: 10.26355/eurrev_201902_17142-PMID: 30840305 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/6A6E686494A160FBE7A1725E5CE30C) regarding figure duplication in Figures 1 and 2A, the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal investigation revealed a figure duplication between the panels AMI and AMI+RSV+LY of Figure 1. The authors were informed about the journal's investigation but remained unresponsive and did not provide the study's raw data. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/17142.
文章 "白藜芦醇通过阻断 P13K/Akt/e-NOS 通路保护急性心肌梗死大鼠缺血再灌注诱导的心肌凋亡",作者:X. Zhang, L.-F. Huang, L Hua, H.-K.Huang, L. Hua, H.-K.Feng, B. Shen, 发表于 Eur Rev Med Pharmacol Sci 2019; 23 (4):1789-1796-DOI: 10.26355/eurrev_201902_17142-PMID: 30840305 已被主编撤回。在PubPeer(链接:https://pubpeer.com/publications/6A6E686494A160FBE7A1725E5CE30C)上提出了一些关于图1和图2A中数字重复的问题后,主编已开始调查,以评估结果的有效性以及可能存在的数字篡改。期刊调查发现,图 1 的 AMI 和 AMI+RSV+LY 两幅图存在重复。作者被告知了期刊的调查,但一直没有回应,也没有提供研究的原始数据。因此,主编对所提交的结果不信任,决定撤回该文章。这篇文章已被撤回。出版商对此造成的不便深表歉意。https://www.europeanreview.org/article/17142。
{"title":"Retraction Note: Resveratrol protects myocardial apoptosis induced by ischemia-reperfusion in rats with acute myocardial infarction via blocking P13K/Akt/e-NOS pathway.","authors":"X Zhang, L-F Huang, L Hua, H-K Feng, B Shen","doi":"10.26355/eurrev_202407_36455","DOIUrl":"https://doi.org/10.26355/eurrev_202407_36455","url":null,"abstract":"<p><p>The article \"Resveratrol protects myocardial apoptosis induced by ischemia-reperfusion in rats with acute myocardial infarction via blocking P13K/Akt/e-NOS pathway\", by X. Zhang, L.-F. Huang, L. Hua, H.-K. Feng, B. Shen, published in Eur Rev Med Pharmacol Sci 2019; 23 (4): 1789-1796-DOI: 10.26355/eurrev_201902_17142-PMID: 30840305 has been retracted by the Editor in Chief. Following some concerns raised on PubPeer (link: https://pubpeer.com/publications/6A6E686494A160FBE7A1725E5CE30C) regarding figure duplication in Figures 1 and 2A, the Editor in Chief has started an investigation to assess the validity of the results as well as possible figure manipulation. The journal investigation revealed a figure duplication between the panels AMI and AMI+RSV+LY of Figure 1. The authors were informed about the journal's investigation but remained unresponsive and did not provide the study's raw data. Consequently, the Editor in Chief mistrusts the results presented and has decided to retract the article. This article has been retracted. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/17142.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36526
M Rubini, G Di Minno, E Ferrazzi
5-methyltetrahydrofolate (5-MTHF), or its synthetic precursor, folic acid, is traditionally used as a supplement for improving fertility and for the prevention of embryonal neural tube defects. However, in the last decade, starting from the effectiveness of this preventive treatment in the gynecological setting, the use of 5-MTHF was extended to other medical and pathological areas. Thus, there might be a rationale for the use of 5-MTHF for purposes other than the protection of the growing embryo linked to the possible effect of MTHFR variants in different pathological conditions. A narrative review was conducted to provide an overview of the available evidence on the use of 5-MTHF in the obstetric field and to critically discuss the available data regarding the use of 5-MTHF across other different therapeutic areas. Results showed that the use of 5-MTHF in pregnancy presents some advantages if compared with folic acid, such as immediate action, the non-necessity of metabolic activation, and the immediate bioavailability of the mother and fetus. Otherwise, the role of 5-MTHF in the management of cardiovascular risk is still debated due to the multiple confounding factors that characterize this patient setting. A link between folate deficiency in pregnancy and postpartum depression has been proposed, as well as between folate levels and the onset of depression. In conclusion, evidence from the literature supports the additional role of 5-MTHF as a pleiotropic drug with a transversal effect in different therapeutic contexts. With regard to the prevention of cardiovascular disorders, available evidence is not conclusive.
{"title":"Is there a multidisciplinary role for 5-methyltetrahydrofolate? The obstetric evidence in perspective.","authors":"M Rubini, G Di Minno, E Ferrazzi","doi":"10.26355/eurrev_202407_36526","DOIUrl":"https://doi.org/10.26355/eurrev_202407_36526","url":null,"abstract":"<p><p>5-methyltetrahydrofolate (5-MTHF), or its synthetic precursor, folic acid, is traditionally used as a supplement for improving fertility and for the prevention of embryonal neural tube defects. However, in the last decade, starting from the effectiveness of this preventive treatment in the gynecological setting, the use of 5-MTHF was extended to other medical and pathological areas. Thus, there might be a rationale for the use of 5-MTHF for purposes other than the protection of the growing embryo linked to the possible effect of MTHFR variants in different pathological conditions. A narrative review was conducted to provide an overview of the available evidence on the use of 5-MTHF in the obstetric field and to critically discuss the available data regarding the use of 5-MTHF across other different therapeutic areas. Results showed that the use of 5-MTHF in pregnancy presents some advantages if compared with folic acid, such as immediate action, the non-necessity of metabolic activation, and the immediate bioavailability of the mother and fetus. Otherwise, the role of 5-MTHF in the management of cardiovascular risk is still debated due to the multiple confounding factors that characterize this patient setting. A link between folate deficiency in pregnancy and postpartum depression has been proposed, as well as between folate levels and the onset of depression. In conclusion, evidence from the literature supports the additional role of 5-MTHF as a pleiotropic drug with a transversal effect in different therapeutic contexts. With regard to the prevention of cardiovascular disorders, available evidence is not conclusive.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36575
A Atlas, A Y Kaptan, E Büyükfırat, M Tercan, M A Karahan, N Altay
Objective: We aimed to investigate the effects of anesthesia methods and perioperative procedures on mortality in geriatric patients operated for hip fracture.
Patients and methods: This retrospective study included patients over 65 years of age who underwent hip fracture surgery. Demographic data, risk scores, perioperative and anesthesia management were analyzed in terms of mortality.
Results: Data from 451 patients who were eligible for the study were analyzed. It was determined that there was no difference in mortality between the anesthesia methods administered to the patients in hip fracture surgery (p>0.05). Being male increased the mortality risk by 4.568 times (95% CI: 1.215-17.168), and a one-unit increase in the number of erythrocyte suspensions given perioperatively increased the mortality risk by 2.801 times (95% CI: 1.509-5.197). Additionally, an American Society of Anesthesiologists (ASA) II score increased the mortality risk by 0.120 times (95% CI: 0.021-0.690), and a higher modified Charlson comorbidity index (mCCI) of 5-7 increased the mortality risk by 0.052 times (95% CI: 0.009-0.289).
Conclusions: Although high ASA and mCCI scores, male sex, and blood transfusion were associated with mortality in geriatric hip fracture surgery, we found that the method of anesthesia did not affect mortality.
{"title":"Effects of anesthesia and perioperative management on mortality in geriatric orthopedic surgery: a retrospective study of 451 patients.","authors":"A Atlas, A Y Kaptan, E Büyükfırat, M Tercan, M A Karahan, N Altay","doi":"10.26355/eurrev_202407_36575","DOIUrl":"https://doi.org/10.26355/eurrev_202407_36575","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the effects of anesthesia methods and perioperative procedures on mortality in geriatric patients operated for hip fracture.</p><p><strong>Patients and methods: </strong>This retrospective study included patients over 65 years of age who underwent hip fracture surgery. Demographic data, risk scores, perioperative and anesthesia management were analyzed in terms of mortality.</p><p><strong>Results: </strong>Data from 451 patients who were eligible for the study were analyzed. It was determined that there was no difference in mortality between the anesthesia methods administered to the patients in hip fracture surgery (p>0.05). Being male increased the mortality risk by 4.568 times (95% CI: 1.215-17.168), and a one-unit increase in the number of erythrocyte suspensions given perioperatively increased the mortality risk by 2.801 times (95% CI: 1.509-5.197). Additionally, an American Society of Anesthesiologists (ASA) II score increased the mortality risk by 0.120 times (95% CI: 0.021-0.690), and a higher modified Charlson comorbidity index (mCCI) of 5-7 increased the mortality risk by 0.052 times (95% CI: 0.009-0.289).</p><p><strong>Conclusions: </strong>Although high ASA and mCCI scores, male sex, and blood transfusion were associated with mortality in geriatric hip fracture surgery, we found that the method of anesthesia did not affect mortality.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36579
M G Tarsitano, G Dolcini, C Pandozzi, F Greco, C Iannuncelli, C Conte, E Giannetta, M Di Franco
Objective: Fibromyalgia (FM) is a multifactorial disease characterized principally by chronic, widespread pain impairing a patient's quality of life. The management of FM requires a multidisciplinary approach that combines pharmacological and non-pharmacological strategies. Growing evidence suggests a potential beneficial role of micronutrients such as minerals and vitamins. Overall, the role of these supplements remains controversial, but clinical trials on vitamin D, vitamin B12, magnesium, and iron supplementation seem to provide promising results. The aim of this study was to investigate their role in an Italian female sample.
Subjects and methods: An exploratory cross-sectional study was done to assess the association of selected micronutrients with symptoms of FM by using the Fibromyalgia Impact Questionnaire (FIQ) in twenty consecutive female patients with FM. A literature review was also conducted.
Results: FIQ results revealed that vitamin D and magnesium deficiency appear to play a role in FM symptoms, mainly in physical function and stiffness. From the literature review, only two studies investigating the role of micronutrients in FM were retrieved.
Conclusions: Screening for micronutrient deficiencies in FM patients and supplementing them when levels are low might help counteract FM symptoms.
目的:纤维肌痛(FM)是一种多因素疾病,主要表现为慢性、广泛性疼痛,影响患者的生活质量。纤维肌痛的治疗需要结合药物和非药物疗法的多学科方法。越来越多的证据表明,矿物质和维生素等微量营养素具有潜在的有益作用。总体而言,这些补充剂的作用仍存在争议,但关于维生素 D、维生素 B12、镁和铁补充剂的临床试验似乎提供了有希望的结果。本研究旨在调查意大利女性样本中这些补充剂的作用:本研究采用纤维肌痛影响问卷(Fibromyalgia Impact Questionnaire,FIQ)对连续20名女性纤维肌痛患者进行了一项探索性横断面研究,以评估特定微量营养素与纤维肌痛症状之间的关系。同时还进行了文献综述:FIQ结果显示,维生素D和镁的缺乏似乎对FM症状有影响,主要是身体功能和僵硬。在文献回顾中,仅检索到两项研究调查了微量营养素在 FM 中的作用:结论:对 FM 患者进行微量营养素缺乏筛查,并在微量营养素水平较低时补充微量营养素,可能有助于缓解 FM 症状。
{"title":"Role of micronutrients in the symptoms of fibromyalgia: a review of the literature and analysis of an Italian female sample.","authors":"M G Tarsitano, G Dolcini, C Pandozzi, F Greco, C Iannuncelli, C Conte, E Giannetta, M Di Franco","doi":"10.26355/eurrev_202407_36579","DOIUrl":"https://doi.org/10.26355/eurrev_202407_36579","url":null,"abstract":"<p><strong>Objective: </strong>Fibromyalgia (FM) is a multifactorial disease characterized principally by chronic, widespread pain impairing a patient's quality of life. The management of FM requires a multidisciplinary approach that combines pharmacological and non-pharmacological strategies. Growing evidence suggests a potential beneficial role of micronutrients such as minerals and vitamins. Overall, the role of these supplements remains controversial, but clinical trials on vitamin D, vitamin B12, magnesium, and iron supplementation seem to provide promising results. The aim of this study was to investigate their role in an Italian female sample.</p><p><strong>Subjects and methods: </strong>An exploratory cross-sectional study was done to assess the association of selected micronutrients with symptoms of FM by using the Fibromyalgia Impact Questionnaire (FIQ) in twenty consecutive female patients with FM. A literature review was also conducted.</p><p><strong>Results: </strong>FIQ results revealed that vitamin D and magnesium deficiency appear to play a role in FM symptoms, mainly in physical function and stiffness. From the literature review, only two studies investigating the role of micronutrients in FM were retrieved.</p><p><strong>Conclusions: </strong>Screening for micronutrient deficiencies in FM patients and supplementing them when levels are low might help counteract FM symptoms.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36578
J-B Wu, L Chen, X Yang, Y Liu, K-Y Chen, L-W Chen
Objective: Low cardiac output syndrome (LCOS) is a dangerous postoperative complication in patients with acute type A aortic dissection (ATAAD). This study aims to develop and evaluate a nomogram model that can reliably identify risk variables for postoperative LCOS in elderly patients suffering from ATAAD.
Patients and methods: In this retrospective study, a total of 310 elderly patients with ATAAD admitted to Fujian Medical University Union Hospital were included and categorized into the LCOS and non-LCOS groups. Stepwise logistic regression was used to analyze independent predictors of LCOS, and a nomogram was constructed. The best clinical decision points were found using decision analysis and a clinical impact curve.
Results: Postoperative LCOS occurred in 22 (7.1%) of elderly patients with ATAAD. Independent risk factors for postoperative LCOS were age, smoking history, aortic cross-clamp (ACC), coronary heart disease (CHD), and preoperative shock. The nomogram constructed based on the identified risk factors showed good performance.
Conclusions: Our results suggest that preventive treatment can be administered when needed when the risk of LCOS in older patients with ATAAD after surgery is >60%. This study contributes to developing a methodology that may improve therapeutic decision-making in older patients and provides insights for assessing the risk of LCOS.
{"title":"A nomogram for predicting low cardiac output syndrome in older patients undergoing acute type A aortic dissection surgery.","authors":"J-B Wu, L Chen, X Yang, Y Liu, K-Y Chen, L-W Chen","doi":"10.26355/eurrev_202407_36578","DOIUrl":"https://doi.org/10.26355/eurrev_202407_36578","url":null,"abstract":"<p><strong>Objective: </strong>Low cardiac output syndrome (LCOS) is a dangerous postoperative complication in patients with acute type A aortic dissection (ATAAD). This study aims to develop and evaluate a nomogram model that can reliably identify risk variables for postoperative LCOS in elderly patients suffering from ATAAD.</p><p><strong>Patients and methods: </strong>In this retrospective study, a total of 310 elderly patients with ATAAD admitted to Fujian Medical University Union Hospital were included and categorized into the LCOS and non-LCOS groups. Stepwise logistic regression was used to analyze independent predictors of LCOS, and a nomogram was constructed. The best clinical decision points were found using decision analysis and a clinical impact curve.</p><p><strong>Results: </strong>Postoperative LCOS occurred in 22 (7.1%) of elderly patients with ATAAD. Independent risk factors for postoperative LCOS were age, smoking history, aortic cross-clamp (ACC), coronary heart disease (CHD), and preoperative shock. The nomogram constructed based on the identified risk factors showed good performance.</p><p><strong>Conclusions: </strong>Our results suggest that preventive treatment can be administered when needed when the risk of LCOS in older patients with ATAAD after surgery is >60%. This study contributes to developing a methodology that may improve therapeutic decision-making in older patients and provides insights for assessing the risk of LCOS.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.26355/eurrev_202407_36522
H Zhao, X-L Ma, K Yu, F-H Zhang, S-Q Liu
Background: Madelung's disease is a rare disorder characterized by massive deposits of excess subcutaneous fat around the neck, shoulders, arms, and other parts of the body. It has a high prevalence among middle-aged alcoholic men in Mediterranean countries and a low incidence in Asian populations. Although patients with Madelung's disease are often associated with a variety of alcohol-induced metabolic disorders, the comorbidity of alcoholic cardiomyopathy is rarely reported, probably because of its low incidence or neglect by clinicians.
Case report: A 67-year-old man with a 10-year history of soft fat masses in the neck developed chest tightness and shortness of breath on exertion for the past 2 years. Laboratory tests revealed elevated γ-glutamyl transferase, glucose intolerance, hyperuricemia, hyperlipidemia, and anemia. Computed tomography of the neck showed symmetric nonencapsulated fat deposits, mainly in the anterior cervical regions. Echocardiography showed left heart enlargement and severe global left ventricular systolic dysfunction with an ejection fraction of 31%. Coronary angiography revealed 40-50% stenoses of the left anterior descending and right coronary arteries. After the exclusion of other causes of dilated cardiomyopathy, the patient was finally diagnosed with type I Madelung's disease and alcoholic cardiomyopathy. He underwent lifestyle changes, including reducing his alcohol intake, and received full pharmacological treatment for heart failure. One and a half years later, his cardiac function was partially restored, and all metabolic abnormalities improved except for elevated liver enzymes.
Conclusions: Alcohol use disorder should be assessed in patients with newly diagnosed Madelung's disease. Screening for alcoholic cardiomyopathy in alcoholic patients with Madelung's disease is necessary for early detection of cardiac abnormalities and intervention to improve the prognosis of this group of patients.
背景:马德龙病是一种罕见的疾病,其特征是颈部、肩部、手臂和身体其他部位有大量多余的皮下脂肪沉积。这种疾病在地中海国家的中年酗酒男性中发病率较高,而在亚洲人群中发病率较低。虽然马德龙氏病患者通常伴有多种酒精引起的代谢紊乱,但很少有报道称其合并酒精性心肌病,这可能是因为其发病率低或被临床医生忽视:病例报告:一名 67 岁的男性,颈部软脂肪肿块病史长达 10 年,过去两年来出现胸闷和用力时气短。实验室检查显示γ-谷氨酰转移酶升高、葡萄糖不耐受、高尿酸血症、高脂血症和贫血。颈部计算机断层扫描显示,对称性非包裹性脂肪沉积,主要位于颈椎前部。超声心动图显示左心增大,左心室整体收缩功能严重障碍,射血分数为31%。冠状动脉造影显示,左前降支冠状动脉和右冠状动脉有40%至50%的狭窄。在排除了扩张型心肌病的其他病因后,患者最终被诊断为 I 型马德隆氏病和酒精性心肌病。他改变了生活方式,包括减少酒精摄入量,并接受了针对心力衰竭的全面药物治疗。一年半后,他的心功能得到部分恢复,除了肝酶升高外,所有代谢异常均得到改善:结论:对于新确诊的马德隆氏病患者,应评估酒精使用障碍。结论:应评估新确诊的马德龙病患者的饮酒障碍,有必要对马德龙病患者进行酒精性心肌病筛查,以便及早发现心脏异常,并采取干预措施改善这类患者的预后。
{"title":"A Chinese patient with Madelung's disease and alcoholic cardiomyopathy: a case report and literature review.","authors":"H Zhao, X-L Ma, K Yu, F-H Zhang, S-Q Liu","doi":"10.26355/eurrev_202407_36522","DOIUrl":"10.26355/eurrev_202407_36522","url":null,"abstract":"<p><strong>Background: </strong>Madelung's disease is a rare disorder characterized by massive deposits of excess subcutaneous fat around the neck, shoulders, arms, and other parts of the body. It has a high prevalence among middle-aged alcoholic men in Mediterranean countries and a low incidence in Asian populations. Although patients with Madelung's disease are often associated with a variety of alcohol-induced metabolic disorders, the comorbidity of alcoholic cardiomyopathy is rarely reported, probably because of its low incidence or neglect by clinicians.</p><p><strong>Case report: </strong>A 67-year-old man with a 10-year history of soft fat masses in the neck developed chest tightness and shortness of breath on exertion for the past 2 years. Laboratory tests revealed elevated γ-glutamyl transferase, glucose intolerance, hyperuricemia, hyperlipidemia, and anemia. Computed tomography of the neck showed symmetric nonencapsulated fat deposits, mainly in the anterior cervical regions. Echocardiography showed left heart enlargement and severe global left ventricular systolic dysfunction with an ejection fraction of 31%. Coronary angiography revealed 40-50% stenoses of the left anterior descending and right coronary arteries. After the exclusion of other causes of dilated cardiomyopathy, the patient was finally diagnosed with type I Madelung's disease and alcoholic cardiomyopathy. He underwent lifestyle changes, including reducing his alcohol intake, and received full pharmacological treatment for heart failure. One and a half years later, his cardiac function was partially restored, and all metabolic abnormalities improved except for elevated liver enzymes.</p><p><strong>Conclusions: </strong>Alcohol use disorder should be assessed in patients with newly diagnosed Madelung's disease. Screening for alcoholic cardiomyopathy in alcoholic patients with Madelung's disease is necessary for early detection of cardiac abnormalities and intervention to improve the prognosis of this group of patients.</p>","PeriodicalId":12152,"journal":{"name":"European review for medical and pharmacological sciences","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}