Khezia Asamoah, Freda Yang, Ian M. Adcock, Dragana Vuckovic, Mohib Uddin, Kian Fan Chung, Marc Chadeau‐Hyam
{"title":"Trajectory‐Based Clustering to Identify Asthma Subgroups Responsive to the Selective CXCR2 Antagonist, AZD5069","authors":"Khezia Asamoah, Freda Yang, Ian M. Adcock, Dragana Vuckovic, Mohib Uddin, Kian Fan Chung, Marc Chadeau‐Hyam","doi":"10.1111/all.70140","DOIUrl":"https://doi.org/10.1111/all.70140","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"22 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145427412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mi Jeong Kim,Seung Hwa Lee,Su Jung Kim,Ha Eun Song,Hyoyeong Lee,Mi Jin Kang,Song-I Yang,Hyo-Bin Kim,So Yeon Lee,Jeong-Hyun Kim,Hosub Im,Hoon Je Seong,Yong Joo Park,Jeonghun Yeom,Ji-Hye Oh,Eom Ji Choi,Dong In Suh,Kyung Won Kim,Kangmo Ahn,Youn Ho Shin,Soo-Jong Hong,Hyun Ju Yoo
{"title":"Association Between Di-(2-Ethylhexyl) Phthalate and Childhood Asthma Through Plasma Metabolome Alterations.","authors":"Mi Jeong Kim,Seung Hwa Lee,Su Jung Kim,Ha Eun Song,Hyoyeong Lee,Mi Jin Kang,Song-I Yang,Hyo-Bin Kim,So Yeon Lee,Jeong-Hyun Kim,Hosub Im,Hoon Je Seong,Yong Joo Park,Jeonghun Yeom,Ji-Hye Oh,Eom Ji Choi,Dong In Suh,Kyung Won Kim,Kangmo Ahn,Youn Ho Shin,Soo-Jong Hong,Hyun Ju Yoo","doi":"10.1111/all.70143","DOIUrl":"https://doi.org/10.1111/all.70143","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"45 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stéphanie Wanin, Rola Abou Taam, Lisa Giovannini Chami, Christophe Marguet, Jocelyne Just, Christele Da Silva, Jérôme Msihid, Olivier Ledanois, Rebecca Gall, Harry J. Sacks, Juby A. Jacob‐Nara, Capucine Daridon, Antoine Deschildre
{"title":"Characteristics of Adolescents With Uncontrolled Severe Asthma Starting Dupilumab: The PEDIASTHMA Registry","authors":"Stéphanie Wanin, Rola Abou Taam, Lisa Giovannini Chami, Christophe Marguet, Jocelyne Just, Christele Da Silva, Jérôme Msihid, Olivier Ledanois, Rebecca Gall, Harry J. Sacks, Juby A. Jacob‐Nara, Capucine Daridon, Antoine Deschildre","doi":"10.1111/all.70119","DOIUrl":"https://doi.org/10.1111/all.70119","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"84 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145396864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asthma is a complex airway disorder driven by diverse immunological pathways. While type 2 (T2)-mediated inflammation is well characterized, the mechanisms underlying T2-low (also referred to as mixed inflammatory phenotype) or non-T2-mediated asthma, often associated with Th1/Th17-driven immune responses and high pulmonary neutrophilic inflammation, remain poorly understood. This study investigates airway remodeling in acute and chronic experimental asthma models induced by house dust mite extract to elucidate inflammatory and structural changes. Two acute T2-low models demonstrated pronounced airway inflammation characterized by goblet cell hyperplasia, collagen deposition, and significant upregulation of extracellular matrix remodeling and fibroblast activation. In contrast, the chronic Th17-mediated model exhibited reduced ECM deposition, increased matrix metalloproteinase (MMP) activity, and a distinct molecular signature dominated by IL-17A-driven pathways, indicative of ECM degradation and structural instability. Furthermore, the acute models showed immune cell apoptosis as the predominant cell death mechanism. In contrast, the chronic inflammation model was marked by necroptosis localized to structural lung cells, contributing to persistent inflammation and remodeling. Our findings provide new insights into the distinct immunopathological mechanisms underlying airway remodeling and fibrosis in T2-low and Th17-mediated asthma phenotypes. The study emphasizes the need for advanced preclinical models and targeted therapeutic strategies to address ECM dysregulation and chronic inflammation to progress in airway remodeling treatment in asthma.
{"title":"Dynamic Regulation of Collagens, Proteases, Their Inhibitors, and Cell Death in Experimental Asthma in Mice.","authors":"Marlena Tynecka,Agnieszka Tarasik,Bartosz Hanczaruk,Adrian Janucik,Krystian Czolpinski,Alicja Walewska,Arkadiusz Zbikowski,Anna Zeller,Agnieszka Kulczynska-Przybik,Magdalena Niemira,Joanna Reszec-Gielazyn,Barbara Mroczko,Adam Kretowski,Cezmi A Akdis,Milena Sokolowska,Marcin Moniuszko,Cagatay Karaaslan,Andrzej Eljaszewicz","doi":"10.1111/all.70126","DOIUrl":"https://doi.org/10.1111/all.70126","url":null,"abstract":"Asthma is a complex airway disorder driven by diverse immunological pathways. While type 2 (T2)-mediated inflammation is well characterized, the mechanisms underlying T2-low (also referred to as mixed inflammatory phenotype) or non-T2-mediated asthma, often associated with Th1/Th17-driven immune responses and high pulmonary neutrophilic inflammation, remain poorly understood. This study investigates airway remodeling in acute and chronic experimental asthma models induced by house dust mite extract to elucidate inflammatory and structural changes. Two acute T2-low models demonstrated pronounced airway inflammation characterized by goblet cell hyperplasia, collagen deposition, and significant upregulation of extracellular matrix remodeling and fibroblast activation. In contrast, the chronic Th17-mediated model exhibited reduced ECM deposition, increased matrix metalloproteinase (MMP) activity, and a distinct molecular signature dominated by IL-17A-driven pathways, indicative of ECM degradation and structural instability. Furthermore, the acute models showed immune cell apoptosis as the predominant cell death mechanism. In contrast, the chronic inflammation model was marked by necroptosis localized to structural lung cells, contributing to persistent inflammation and remodeling. Our findings provide new insights into the distinct immunopathological mechanisms underlying airway remodeling and fibrosis in T2-low and Th17-mediated asthma phenotypes. The study emphasizes the need for advanced preclinical models and targeted therapeutic strategies to address ECM dysregulation and chronic inflammation to progress in airway remodeling treatment in asthma.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"109 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDIgG4-related chronic rhinosinusitis (IgG4-CRS) is a new clinical entity characterized by nasal lesions; however, its pathogenesis remains unclear. This study aimed to reveal single-cell transcriptomic changes in patients with IgG4-CRS via single-cell RNA sequencing (scRNA-seq) and illustrate its pathogenesis at the single-cell level.METHODSNasal mucosal tissues from five patients with IgG4-CRS were used for unbiased scRNA-seq. Bioinformatic analysis was performed using these five samples and three published control samples. Immunohistochemical and multicolor immunofluorescence analyses were performed to validate the sequencing results.RESULTSA total of 49,063 cells and 11 sub-clusters were identified. CXCL12 secretion increased in endothelial cells and fibroblasts, and CXCR4 was upregulated in the immune cells of IgG4-CRS. Enhanced chemotaxis mediated by the CXCL12-CXCR4 axis recruits excess immune cells and overactivation. Compared with those in the control group, the immunocompetence of CD4+ T cells and cytotoxicity of CD8+ T cells were enhanced in the IgG4-CRS group, and B cells were more differentiated to secrete IgG-type plasma cells.CONCLUSIONSChemotaxis of the CXCL12-CXCR4 axis plays a role in the pathogenesis of IgG4-CRS by influencing both the immune and nonimmune cells of IgG4-CRS.
{"title":"The CXCL12-CXCR4 Axis Mediates Lymphocyte Immune Overactivation in IgG4-Related Chronic Rhinosinusitis.","authors":"Jing Ding,Li Cui,Chengshuo Wang,Ming Wei,Yuan Zhang,Luo Zhang,Yingshi Piao","doi":"10.1111/all.70124","DOIUrl":"https://doi.org/10.1111/all.70124","url":null,"abstract":"BACKGROUNDIgG4-related chronic rhinosinusitis (IgG4-CRS) is a new clinical entity characterized by nasal lesions; however, its pathogenesis remains unclear. This study aimed to reveal single-cell transcriptomic changes in patients with IgG4-CRS via single-cell RNA sequencing (scRNA-seq) and illustrate its pathogenesis at the single-cell level.METHODSNasal mucosal tissues from five patients with IgG4-CRS were used for unbiased scRNA-seq. Bioinformatic analysis was performed using these five samples and three published control samples. Immunohistochemical and multicolor immunofluorescence analyses were performed to validate the sequencing results.RESULTSA total of 49,063 cells and 11 sub-clusters were identified. CXCL12 secretion increased in endothelial cells and fibroblasts, and CXCR4 was upregulated in the immune cells of IgG4-CRS. Enhanced chemotaxis mediated by the CXCL12-CXCR4 axis recruits excess immune cells and overactivation. Compared with those in the control group, the immunocompetence of CD4+ T cells and cytotoxicity of CD8+ T cells were enhanced in the IgG4-CRS group, and B cells were more differentiated to secrete IgG-type plasma cells.CONCLUSIONSChemotaxis of the CXCL12-CXCR4 axis plays a role in the pathogenesis of IgG4-CRS by influencing both the immune and nonimmune cells of IgG4-CRS.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"2 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDSeborrheic dermatitis (SD) is a common skin disease characterized by epithelial barrier breakdown. The epithelial barrier theory (EBT) implicates epithelial barrier disruption in the development of epithelial barrier diseases (EBDs). We hypothesized that SD is associated with an increased risk of EBDs and investigated the bidirectional association between SD and EBDs.METHODSRetrospective cohort study of 5,083,689 patients using a large US administrative claims database from January 1, 2016, to June 30, 2022. The mean (standard deviation) follow-up was 3.25 (1.75) years with a total follow-up of over 16 million person-years. The outcomes were a diagnosis of (i) SD after an EBD and (ii) EBD after SD, analyzed using a multivariable Cox proportional hazards model (hazard ratio [95% confidence interval]).RESULTSThe risk of SD was increased after EBD diagnosis for multiple diseases, including atopic dermatitis [2.46 (2.40, 2.53)], alopecia areata [3.47 (3.24, 3.71)], contact dermatitis [1.92 (1.88, 1.96)], psoriasis [2.62 (2.54, 2.69)], rosacea [2.84 (2.78, 2.90)], hidradenitis suppurativa [1.79 (1.63, 1.97)], rhinosinusitis [1.34 (1.32, 1.35)], food allergy [1.47 (1.42, 1.54)], celiac disease [1.55 (1.43, 1.68)], ocular allergy [1.55 (1.49, 1.61)], and dry eye [1.54 (1.52, 1.56)]. The risk of EBD after SD diagnosis followed similar trends, with the largest effect estimates being psoriasis [3.52 (3.42, 3.61)], rosacea [2.85 (2.79, 2.92)], and alopecia areata [2.81 (2.61, 3.03)].CONCLUSIONSOur results support the EBT as a shared driver of EBD pathogenesis at not only local (e.g., skin) barriers but also at non-local sites, including the respiratory, gastrointestinal, and ocular epithelial barriers.
{"title":"Bidirectional Associations Between Seborrheic Dermatitis and Epithelial Barrier Diseases: A Retrospective Cohort Study.","authors":"Sabrina Meng,Ronald Berna,Junko Takeshita,Ole Hoffstad,Daniel Shin,Nandita Mitra,David J Margolis","doi":"10.1111/all.70112","DOIUrl":"https://doi.org/10.1111/all.70112","url":null,"abstract":"BACKGROUNDSeborrheic dermatitis (SD) is a common skin disease characterized by epithelial barrier breakdown. The epithelial barrier theory (EBT) implicates epithelial barrier disruption in the development of epithelial barrier diseases (EBDs). We hypothesized that SD is associated with an increased risk of EBDs and investigated the bidirectional association between SD and EBDs.METHODSRetrospective cohort study of 5,083,689 patients using a large US administrative claims database from January 1, 2016, to June 30, 2022. The mean (standard deviation) follow-up was 3.25 (1.75) years with a total follow-up of over 16 million person-years. The outcomes were a diagnosis of (i) SD after an EBD and (ii) EBD after SD, analyzed using a multivariable Cox proportional hazards model (hazard ratio [95% confidence interval]).RESULTSThe risk of SD was increased after EBD diagnosis for multiple diseases, including atopic dermatitis [2.46 (2.40, 2.53)], alopecia areata [3.47 (3.24, 3.71)], contact dermatitis [1.92 (1.88, 1.96)], psoriasis [2.62 (2.54, 2.69)], rosacea [2.84 (2.78, 2.90)], hidradenitis suppurativa [1.79 (1.63, 1.97)], rhinosinusitis [1.34 (1.32, 1.35)], food allergy [1.47 (1.42, 1.54)], celiac disease [1.55 (1.43, 1.68)], ocular allergy [1.55 (1.49, 1.61)], and dry eye [1.54 (1.52, 1.56)]. The risk of EBD after SD diagnosis followed similar trends, with the largest effect estimates being psoriasis [3.52 (3.42, 3.61)], rosacea [2.85 (2.79, 2.92)], and alopecia areata [2.81 (2.61, 3.03)].CONCLUSIONSOur results support the EBT as a shared driver of EBD pathogenesis at not only local (e.g., skin) barriers but also at non-local sites, including the respiratory, gastrointestinal, and ocular epithelial barriers.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"20 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Inflammasome in IgE-Mediated Anaphylaxis.","authors":"S Fernandez-Bravo,R Fernandez-Santamaria","doi":"10.1111/all.70123","DOIUrl":"https://doi.org/10.1111/all.70123","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"110 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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