European Urology Open Science最新文献

{"title":"The Importance of Antimicrobial Strategies Associated with Clinical Cure and Increased Microbiological Eradication in Patients with Complicated Urinary Tract Infections and High Risk of Relapse","authors":"José Medina Polo ,&nbsp;Jose Luis Alfonso Sánchez ,&nbsp;Jorge Arca-Suárez ,&nbsp;Ángel Estella ,&nbsp;Pablo González ,&nbsp;Martí Blasco ,&nbsp;Alicia Gil ,&nbsp;Leonor del Mar Periañez Párraga ,&nbsp;Francisco Javier Membrillo de Novales","doi":"10.1016/j.euros.2024.12.001","DOIUrl":"10.1016/j.euros.2024.12.001","url":null,"abstract":"<div><h3>Background and objective</h3><div>Complicated urinary tract infections (cUTIs) are serious, potentially life-threatening infections that occur in patients with an increased disease progression risk. Antimicrobial resistance represents an important health issue worldwide, contributing to relapses, which can generate further resistances. It is necessary to clarify the role of microbiological eradication as an additional objective in the management of cUTIs. Some publications suggest that relapses relate to insufficient bacterial suppression in the urinary tract. This study focuses on generating a consensus on how patients with cUTIs would benefit from effective antimicrobial agents associated with higher rates of bacterial eradication.</div></div><div><h3>Methods</h3><div>The nominal group technique was followed: systematic literature review, development of a questionnaire, expert panel meeting to discuss results, individual review of draft consensus document, and expert panel meeting to discuss final views and finalise the consensus document.</div></div><div><h3>Key findings and limitations</h3><div>Experts identified risk factors for cUTIs (patients with a higher risk of relapse, physiological obstruction of urinary tract, immune suppression, and previous relapse), and patients who would benefit most from a therapeutic strategy combining clinical cure and aim for microbiological eradication. While experts agreed that the scientific evidence discourages repetition of urine cultures after treatment, they proposed recommendations to prioritise antibiotics with higher evidence of microbiological eradication and close follow-up in patients with a higher risk of relapse, considering any symptoms appearing following clinical cure of the cUTI.</div></div><div><h3>Conclusions and clinical implications</h3><div>Selection of active antimicrobial agents associated with increased microbiological eradication should be prioritised in patients with cUTIs and a high risk of relapse.</div></div><div><h3>Patient summary</h3><div>Complicated urinary tract infections (cUTIs) occur in patients with an increased risk of disease progression or are caused by multidrug-resistant uropathogens. Antimicrobial resistance is of concern as it can result in relapses. Antimicrobial therapeutic strategies associated with increased microbiological eradication in cUTI patients with a high risk of relapse are crucial to prevent relapses and development of antibiotic resistance.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 165-171"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4 Percutaneous nephrolithotomy: Impact of intraoperative stone culture","authors":"Knoll T.,&nbsp;Lieb S.","doi":"10.1016/S2666-1683(25)00035-7","DOIUrl":"10.1016/S2666-1683(25)00035-7","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"17 The risk of venous thromboembolism after cystectomy and prostatectomy with or without a pelvic lymph-node dissection","authors":"Akre O.,&nbsp;Rautiola J.,&nbsp;Björklund J.,&nbsp;Zelic R.,&nbsp;Pellegrino F.,&nbsp;Vincent P.H.,&nbsp;Aly M.,&nbsp;Falconer H.,&nbsp;Wiklund P.","doi":"10.1016/S2666-1683(25)00020-5","DOIUrl":"10.1016/S2666-1683(25)00020-5","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages S19-S20"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10 External validation of a digital pathology-based multimodal artificial intelligence prostatebiopsy biomarker in a prospective, real-world prostate cancer cohort treated with radicalprostatectomy","authors":"Bjartell A.S.,&nbsp;Krzyzanowska A.,&nbsp;Liu V.,&nbsp;Thierney M.,&nbsp;Joyce T.,&nbsp;Sjöström M.,&nbsp;Palominos-Rivera M.M.,&nbsp;Chen E.,&nbsp;Kraft A.,&nbsp;Esteva A.E, Feng F.","doi":"10.1016/S2666-1683(25)00013-8","DOIUrl":"10.1016/S2666-1683(25)00013-8","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S11"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"27 Phoenix Study: An EAU Research Foundation prospective registry on penile prosthesis implantation in 1000 patients (EAU-RF 2018-01)","authors":"Moncada Iribarren I.,&nbsp;Van Renterghem K.,&nbsp;Deho F.,&nbsp;Witjes W.,&nbsp;EAU Research Foundation P.S.G.","doi":"10.1016/S2666-1683(25)00031-X","DOIUrl":"10.1016/S2666-1683(25)00031-X","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S31"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25 Novel biomaterials for stress urinary incontinence: development of a clinically relevant large animal model to mimic suburethral implantation","authors":"Osman N.I.,&nbsp;Bullock A.,&nbsp;Farr N.,&nbsp;Workman V.,&nbsp;MacNeil S.,&nbsp;Chapple C.","doi":"10.1016/S2666-1683(25)00029-1","DOIUrl":"10.1016/S2666-1683(25)00029-1","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages S28-S29"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted Kidney Transplantation in Patients Undergoing Cystectomy with Urinary Diversion: First Cases Reported by the ERUS-RAKT Working Group","authors":"José Ignacio Pérez-Reggeti ,&nbsp;Begoña Etcheverry ,&nbsp;María Fiol ,&nbsp;Angelo Territo ,&nbsp;Luca Afferi ,&nbsp;Oscar Buisan ,&nbsp;Luis Riera ,&nbsp;José F. Suarez-Novo ,&nbsp;Alberto Breda ,&nbsp;Francesc Vigués ,&nbsp;European Association of Urology Robotic Urology Section (ERUS) Robot-assisted Kidney Transplantation (RAKT) Working Group","doi":"10.1016/j.euros.2024.12.002","DOIUrl":"10.1016/j.euros.2024.12.002","url":null,"abstract":"<div><div>The indication for kidney transplantation over a urinary diversion (UD) for patients with severe lower urinary tract dysfunction and end-stage renal disease is a controversial issue. Thanks to advances in robot-assisted kidney transplant (RAKT) programs, the boundaries are being pushed further. We present the first RAKT series reported for patients undergoing simple cystectomy and UD for benign bladder disease. The first case involved simultaneous robot-assisted simple cystectomy with intracorporeal UD and RAKT. The second case involved robot-assisted simple cystectomy with intracorporeal UD and bilateral nephrectomy in the first procedure, followed by RAKT 8 mo later. At 9 mo after surgery, both patients had experienced no complications and had stable renal function with no need for hemodialysis. This first experience of RAKT in patients with cystectomy and UD demonstrates the feasibility and safety of the procedure.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 144-147"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"7 Can we take a MEASURED (MRI-Enabled Active Surveillance Using Risk adaptEd decisions)approach to active surveillance for prostate cancer?","authors":"Moore C.,&nbsp;Adebusoye B.,&nbsp;Maffei D.,&nbsp;Englman C.,&nbsp;Giganti F.,&nbsp;Mallet S.","doi":"10.1016/S2666-1683(25)00038-2","DOIUrl":"10.1016/S2666-1683(25)00038-2","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages S6-S7"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"28 Efficacy vs. cost effectiveness, a timely discussion in onco-urology","authors":"Malavaud B.","doi":"10.1016/S2666-1683(25)00032-1","DOIUrl":"10.1016/S2666-1683(25)00032-1","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S32"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Surgical Margin Status and Tumor Volume on Mortality After Robotic Radical Prostatectomy","authors":"Zaki Zeidan ,&nbsp;Joshua Tran ,&nbsp;Yeagyeong Hwang ,&nbsp;Linda My Huynh ,&nbsp;Mai Xuan Nguyen ,&nbsp;Erica Huang ,&nbsp;Whitney Zhang ,&nbsp;Thomas Ahlering","doi":"10.1016/j.euros.2024.12.004","DOIUrl":"10.1016/j.euros.2024.12.004","url":null,"abstract":"<div><h3>Background and objective</h3><div>Positive surgical margins (PSMs) following radical prostatectomy (RP) have been seen as inherently unfavorable. However, a large international multi-institutional study recently revealed that unifocal PSMs (UPSMs) had no impact on prostate cancer–specific mortality (PCSM), whereas multifocal PSMs (MPSMs) did. Our aim was to assess the relative impact of PSMs versus percentage tumor volume (PTV) on PCSM.</div></div><div><h3>Methods</h3><div>We analyzed data for 1552 patients who underwent robot-assisted RP performed by a single surgeon between 2002 and 2018 at a tertiary referral center with up to 15-yr follow-up. Patients were divided into negative surgical margin (NSM), UPSM, and MPSM groups, with PTV stratification using a cutoff of 40%. The primary outcome was stepwise multivariate regression analysis of predictors of PCSM (pT stage, pathological Gleason grade group, PTV, UPSM, and MPSM). The secondary outcome was the risk of 15-yr PCSM via Kaplan-Meier analysis.</div></div><div><h3>Key findings and limitations</h3><div>The group with 40–100% PTV was older and presented with more advanced grade and stage. High PTV was significantly associated with greater risk of PSM, biochemical recurrence, PCSM, and overall mortality at 15 yr (<em>p</em> &lt; 0.001). In addition to high stage and grade, MPSM predicted PCSM in multivariate analysis, but lost predictive significance when PTV was included. Limitations of the study include the retrospective nature and the single-center setting.</div></div><div><h3>Conclusions and clinical implications</h3><div>Our study further challenges the belief that MPSMs inherently have an adverse impact on PCSM. Instead, MPSMs appear to signify more aggressive underlying disease that predominantly drives oncological outcomes. We recommend considering PTV as a more reliable predictor of PCSM. While avoidance of PSMs remains a critical surgical principle, this goal in prostate cancer needs to be weighed against urinary and sexual function outcomes.</div></div><div><h3>Patient summary</h3><div>After surgery to remove the prostate in men with prostate cancer, samples from the edge of the prostate that are positive for tumor cells are called positive surgical margins (PSMs). Results from our study show that a PSM on its own is not necessarily an adverse factor. However, PSMs may be a sign of higher severity of prostate cancer. We found that men with a high tumor volume have a higher risk of dying from their prostate cancer.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 187-192"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}