European Urology Open Science最新文献

{"title":"4 Percutaneous nephrolithotomy: Impact of intraoperative stone culture","authors":"Knoll T., Lieb S.","doi":"10.1016/S2666-1683(25)00035-7","DOIUrl":"10.1016/S2666-1683(25)00035-7","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S3"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"17 The risk of venous thromboembolism after cystectomy and prostatectomy with or without a pelvic lymph-node dissection","authors":"Akre O., Rautiola J., Björklund J., Zelic R., Pellegrino F., Vincent P.H., Aly M., Falconer H., Wiklund P.","doi":"10.1016/S2666-1683(25)00020-5","DOIUrl":"10.1016/S2666-1683(25)00020-5","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages S19-S20"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10 External validation of a digital pathology-based multimodal artificial intelligence prostatebiopsy biomarker in a prospective, real-world prostate cancer cohort treated with radicalprostatectomy","authors":"Bjartell A.S., Krzyzanowska A., Liu V., Thierney M., Joyce T., Sjöström M., Palominos-Rivera M.M., Chen E., Kraft A., Esteva A.E, Feng F.","doi":"10.1016/S2666-1683(25)00013-8","DOIUrl":"10.1016/S2666-1683(25)00013-8","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S11"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"27 Phoenix Study: An EAU Research Foundation prospective registry on penile prosthesis implantation in 1000 patients (EAU-RF 2018-01)","authors":"Moncada Iribarren I., Van Renterghem K., Deho F., Witjes W., EAU Research Foundation P.S.G.","doi":"10.1016/S2666-1683(25)00031-X","DOIUrl":"10.1016/S2666-1683(25)00031-X","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Page S31"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25 Novel biomaterials for stress urinary incontinence: development of a clinically relevant large animal model to mimic suburethral implantation","authors":"Osman N.I., Bullock A., Farr N., Workman V., MacNeil S., Chapple C.","doi":"10.1016/S2666-1683(25)00029-1","DOIUrl":"10.1016/S2666-1683(25)00029-1","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages S28-S29"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted Kidney Transplantation in Patients Undergoing Cystectomy with Urinary Diversion: First Cases Reported by the ERUS-RAKT Working Group","authors":"José Ignacio Pérez-Reggeti ,&nbsp;Begoña Etcheverry ,&nbsp;María Fiol ,&nbsp;Angelo Territo ,&nbsp;Luca Afferi ,&nbsp;Oscar Buisan ,&nbsp;Luis Riera ,&nbsp;José F. Suarez-Novo ,&nbsp;Alberto Breda ,&nbsp;Francesc Vigués ,&nbsp;European Association of Urology Robotic Urology Section (ERUS) Robot-assisted Kidney Transplantation (RAKT) Working Group","doi":"10.1016/j.euros.2024.12.002","DOIUrl":"10.1016/j.euros.2024.12.002","url":null,"abstract":"<div><div>The indication for kidney transplantation over a urinary diversion (UD) for patients with severe lower urinary tract dysfunction and end-stage renal disease is a controversial issue. Thanks to advances in robot-assisted kidney transplant (RAKT) programs, the boundaries are being pushed further. We present the first RAKT series reported for patients undergoing simple cystectomy and UD for benign bladder disease. The first case involved simultaneous robot-assisted simple cystectomy with intracorporeal UD and RAKT. The second case involved robot-assisted simple cystectomy with intracorporeal UD and bilateral nephrectomy in the first procedure, followed by RAKT 8 mo later. At 9 mo after surgery, both patients had experienced no complications and had stable renal function with no need for hemodialysis. This first experience of RAKT in patients with cystectomy and UD demonstrates the feasibility and safety of the procedure.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 144-147"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"7 Can we take a MEASURED (MRI-Enabled Active Surveillance Using Risk adaptEd decisions)approach to active surveillance for prostate cancer?","authors":"Moore C.,&nbsp;Adebusoye B.,&nbsp;Maffei D.,&nbsp;Englman C.,&nbsp;Giganti F.,&nbsp;Mallet S.","doi":"10.1016/S2666-1683(25)00038-2","DOIUrl":"10.1016/S2666-1683(25)00038-2","url":null,"abstract":"","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages S6-S7"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Surgical Margin Status and Tumor Volume on Mortality After Robotic Radical Prostatectomy","authors":"Zaki Zeidan ,&nbsp;Joshua Tran ,&nbsp;Yeagyeong Hwang ,&nbsp;Linda My Huynh ,&nbsp;Mai Xuan Nguyen ,&nbsp;Erica Huang ,&nbsp;Whitney Zhang ,&nbsp;Thomas Ahlering","doi":"10.1016/j.euros.2024.12.004","DOIUrl":"10.1016/j.euros.2024.12.004","url":null,"abstract":"<div><h3>Background and objective</h3><div>Positive surgical margins (PSMs) following radical prostatectomy (RP) have been seen as inherently unfavorable. However, a large international multi-institutional study recently revealed that unifocal PSMs (UPSMs) had no impact on prostate cancer–specific mortality (PCSM), whereas multifocal PSMs (MPSMs) did. Our aim was to assess the relative impact of PSMs versus percentage tumor volume (PTV) on PCSM.</div></div><div><h3>Methods</h3><div>We analyzed data for 1552 patients who underwent robot-assisted RP performed by a single surgeon between 2002 and 2018 at a tertiary referral center with up to 15-yr follow-up. Patients were divided into negative surgical margin (NSM), UPSM, and MPSM groups, with PTV stratification using a cutoff of 40%. The primary outcome was stepwise multivariate regression analysis of predictors of PCSM (pT stage, pathological Gleason grade group, PTV, UPSM, and MPSM). The secondary outcome was the risk of 15-yr PCSM via Kaplan-Meier analysis.</div></div><div><h3>Key findings and limitations</h3><div>The group with 40–100% PTV was older and presented with more advanced grade and stage. High PTV was significantly associated with greater risk of PSM, biochemical recurrence, PCSM, and overall mortality at 15 yr (<em>p</em> &lt; 0.001). In addition to high stage and grade, MPSM predicted PCSM in multivariate analysis, but lost predictive significance when PTV was included. Limitations of the study include the retrospective nature and the single-center setting.</div></div><div><h3>Conclusions and clinical implications</h3><div>Our study further challenges the belief that MPSMs inherently have an adverse impact on PCSM. Instead, MPSMs appear to signify more aggressive underlying disease that predominantly drives oncological outcomes. We recommend considering PTV as a more reliable predictor of PCSM. While avoidance of PSMs remains a critical surgical principle, this goal in prostate cancer needs to be weighed against urinary and sexual function outcomes.</div></div><div><h3>Patient summary</h3><div>After surgery to remove the prostate in men with prostate cancer, samples from the edge of the prostate that are positive for tumor cells are called positive surgical margins (PSMs). Results from our study show that a PSM on its own is not necessarily an adverse factor. However, PSMs may be a sign of higher severity of prostate cancer. We found that men with a high tumor volume have a higher risk of dying from their prostate cancer.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 187-192"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-sectional Survey of Physicians to Understand Biomarker Testing and Treatment Patterns in Patients with Prostate Cancer in the USA, EU5, Japan, and China","authors":"Christian Gratzke ,&nbsp;Himani Aggarwal ,&nbsp;Jeri Kim ,&nbsp;Holly Chaignaud ,&nbsp;Sabine Oskar","doi":"10.1016/j.euros.2024.07.113","DOIUrl":"10.1016/j.euros.2024.07.113","url":null,"abstract":"<div><h3>Background and objective</h3><div>Treatment landscape in advanced prostate cancer (PC) is evolving. There is limited understanding of the factors influencing decision-making for genetic/genomic testing and the barriers to recommending testing and treatment in international real-world clinical practice following the approval of poly-adenosine diphosphate-ribose polymerase inhibitors (PARPi) for metastatic castration-resistant PC (mCRPC). This work aims to assess genetic/genomic testing patterns and methods, including for homologous recombination repair mutation (HRRm), and treatment decisions among physicians caring for patients with PC across the USA, Europe, and Asia.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey of physicians treating patients with advanced PC was administered in the USA, France, Germany, Italy, Spain, UK, Japan, and China. Physicians were recruited (from August to December 2022) via clinical panels and provided informed consent. Survey questions covered factors influencing HRRm testing and treatment decision-making.</div></div><div><h3>Key findings and limitations</h3><div>Physicians reported that 50% of patients with mCRPC are recommended for HRRm testing, and among those recommended for testing, 60% are recommended for <em>BRCA1/2</em> mutation testing and 65% go on to receive HRRm testing. Overall proportions of patients recommended for testing increased following PARPi approval (from 20% to 50%) and following updated practice guidelines (from 25% to 50%). Perceived barriers to the use of genetic/genomic testing included patient refusal, lack of insurance/reimbursement, and lack of availability of adequate tissue for testing.</div></div><div><h3>Conclusions and clinical implications</h3><div>Overall, testing rates increased following PARPi approval and updated clinical practice guidelines; yet, there was a wide variation in the proportions of patients with mCRPC recommended for testing, and perceived barriers to testing remain, suggesting unmet needs for patients and physicians.</div></div><div><h3>Patient summary</h3><div>We surveyed physicians globally about their experience in treating patients with advanced prostate cancer and genetic testing. Physicians reported that half of patients are recommended for genetic testing, which varied across countries. We conclude that barriers to testing remain for patients and physicians.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 148-155"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Novel Clinical Classification for Radiation-induced Cystitis: The Portuguese Navy Radiation-induced Cystitis (PNRC) Scale","authors":"Tiago Ribeiro de Oliveira ,&nbsp;Carla D’Espiney Amaro ,&nbsp;Sérgio Henriques Pereira ,&nbsp;Afonso Sousa Castro ,&nbsp;Pedro Gomes Monteiro ,&nbsp;João Cardoso Felício ,&nbsp;Guilherme Bernardo ,&nbsp;João Chambino ,&nbsp;José Palma dos Reis ,&nbsp;Chandra Shekhar Biyani","doi":"10.1016/j.euros.2024.12.006","DOIUrl":"10.1016/j.euros.2024.12.006","url":null,"abstract":"<div><h3>Background and objective</h3><div>Radiation-induced cystitis (RIC) is an important consequence of pelvic radiotherapy that can cause high morbidity and, in extreme cases, mortality. The lack of a widely accepted classification system makes it difficult to compare treatment regimens. Our aim was to develop a new classification system covering the RIC spectrum to improve treatment comparisons and accurate incidence estimates for systematic use in clinical and research settings.</div></div><div><h3>Methods</h3><div>A three-phase project was planned. Phase 1 involved a literature review and development of the Portuguese Navy Radiation-induced Cystitis (PNRC) scale. In phase 2 the scale was applied to 20 clinical cases. Phase 3 involved assessment of the applicability, relevance, inter-rater reliability, and usability of the scale using numerical and graphical methods to achieve consensus among international experts.</div></div><div><h3>Key findings and limitations</h3><div>In phase 1, the panel analysed 13 existing classification systems and developed the PNRC scale, a comprehensive system encompassing five clinical domains: haematuria, other lower urinary tract symptoms, functional impairment, endoscopic findings, and therapeutic interventions. In phase 2, 114 experts from 30 countries completed the first validation round. Consensus was reached for 85% of cases. In phase 3, consensus was reached among 61 experts on the relevance and appropriateness of each domain, and on the exhaustiveness, hierarchy, clarity, mutual exclusivity, and clinical utility of the PNRC scale. Study limitations are the inclusion of only Medline-indexed manuscripts in the review and minor dispersion of responses, indicating subjectivity in the analysis of clinical case scenarios.</div></div><div><h3>Conclusions and clinical implications</h3><div>The PNRC scale showed reliability and face and construct validity in the stratification of RIC severity for clinical cases.</div></div><div><h3>Patient summary</h3><div>Radiation-induced cystitis is a debilitating complication of pelvic radiotherapy. A uniform classification system is needed to assess the incidence of this disease and to compare the results for different treatment options. We developed the Portuguese Navy Radiation-induced Cystitis (PNRC) scale, which was validated by an independent group of experts from 30 different countries.</div></div>","PeriodicalId":12254,"journal":{"name":"European Urology Open Science","volume":"71 ","pages":"Pages 193-199"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}