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Parental Balanced Translocation Carriers do not have Decreased Usable Blastulation Rates or Live Birth Rates Compared to Infertile Controls. 与不育对照组相比,父母平衡易位携带者的可用胚胎率或活产率不会降低。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-12 DOI: 10.1016/j.fertnstert.2024.11.010
Kyle Nguyen Le, Marcy Maguire, Nicolás Garrido Puchalt, Laura Lidon, Alejandro Sánchez-Martínez, Jason Franasiak, Emily Osman

Objective: To determine if translocation carriers have a reduced number of usable blastocysts compared to infertile controls.

Design: Retrospective cohort study.

Subjects: All cycles of balanced translocation carriers undergoing IVF with preimplantation genetic testing (PGT-SR) for structural rearrangements at a single infertility center compared to an age-matched control cycles of infertile patients undergoing preimplantation genetic testing for aneuploidy (PGT-A) from January 2012-August 2022.

Exposure: Balanced translocation carriers.

Main outcome measures: Primary outcome measures were blastulation rate, usable blastulation rates and live birth rate. Secondary outcome measures were sustained implantation rate, fertilization rate, number of oocytes retrieved, number of metaphase II oocytes, total blastulation failure, number of 2 pronuclear embryos, and number of euploid embryos. Outcome measures were compared between male translocation carriers and controls, female translocation carriers and controls, and Robertsonian versus reciprocal translocation carriers.

Results: A total of 1,291 retrieval cycles from 993 patients were included, of which 255 patients were translocation carriers, while 738 were controls. Of those with translocations, 30 (11.5%) were Robertsonian and 231 (88.5%) were reciprocal carriers. There was a statistically significant difference in the blastulation rate between carriers and controls (59.5% versus 62.1%; p-value = 0.01). However, usable blastulation rates (47.2% versus 50.0%) were equivalent between groups. There were no differences in number of oocytes retrieved (18.5 versus 18.3), number of 2 pronuclear embryos (13.4 versus 12.5), sustained implantation rate (71.4% versus 75.1%) or live birth rate (63.0% versus 66.1%) between translocation carriers and controls. In both male and female translocation carriers versus controls, there were no differences in usable blastulation rates or live birth rates. When comparing Robertsonian with reciprocal translocation carriers, rates of blastulation, usable blastulation, sustained implantation, and live birth rate were equivalent.

Conclusion: Despite fewer euploid embryos, there were no differences in rates of usable blastulation or live birth rates in balanced translocation carriers, regardless of sex of affected partner or type of rearrangement, compared to controls. Routine karyotyping for blastulation failure may not be necessary based on these findings.

目的确定与不育对照组相比,易位携带者可用囊胚的数量是否会减少:设计:回顾性队列研究:2012年1月至2022年8月期间,在一家不孕不育中心接受植入前基因检测(PGT-SR)的平衡易位携带者与接受植入前基因检测(PGT-A)的非整倍体不孕患者的年龄匹配对照周期进行比较:主要结果指标:胚胎着床率、可用胚胎着床率和活产率。次要结果指标为持续植入率、受精率、取回的卵母细胞数、分裂期 II 卵母细胞数、胚胎移植失败总数、2 个无核胚胎数和优倍体胚胎数。对男性易位携带者与对照组、女性易位携带者与对照组、罗伯逊易位携带者与互易易位携带者的结果进行了比较:共纳入993名患者的1291个取卵周期,其中255名患者为易位携带者,738名患者为对照组。在易位携带者中,30 例(11.5%)为罗伯逊型,231 例(88.5%)为互易型。携带者和对照组之间的胚泡形成率差异有统计学意义(59.5% 对 62.1%;P 值 = 0.01)。不过,两组之间的可用胚泡率(47.2% 对 50.0%)相当。易位携带者和对照组在取卵数(18.5 对 18.3)、2 个无核胚胎数(13.4 对 12.5)、持续植入率(71.4% 对 75.1%)或活产率(63.0% 对 66.1%)方面没有差异。男性和女性易位携带者与对照组相比,可用胚泡率或活产率均无差异。在比较罗伯逊易位携带者和互易易位携带者时,胚胎着床率、可用胚胎着床率、持续着床率和活产率均相同:结论:尽管平衡易位携带者的优倍体胚胎较少,但与对照组相比,其可用胚泡形成率或活产率并无差异,与受影响伴侣的性别或重排类型无关。根据这些研究结果,可能没有必要对胚胎移植失败进行常规核型分析。
{"title":"Parental Balanced Translocation Carriers do not have Decreased Usable Blastulation Rates or Live Birth Rates Compared to Infertile Controls.","authors":"Kyle Nguyen Le, Marcy Maguire, Nicolás Garrido Puchalt, Laura Lidon, Alejandro Sánchez-Martínez, Jason Franasiak, Emily Osman","doi":"10.1016/j.fertnstert.2024.11.010","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2024.11.010","url":null,"abstract":"<p><strong>Objective: </strong>To determine if translocation carriers have a reduced number of usable blastocysts compared to infertile controls.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Subjects: </strong>All cycles of balanced translocation carriers undergoing IVF with preimplantation genetic testing (PGT-SR) for structural rearrangements at a single infertility center compared to an age-matched control cycles of infertile patients undergoing preimplantation genetic testing for aneuploidy (PGT-A) from January 2012-August 2022.</p><p><strong>Exposure: </strong>Balanced translocation carriers.</p><p><strong>Main outcome measures: </strong>Primary outcome measures were blastulation rate, usable blastulation rates and live birth rate. Secondary outcome measures were sustained implantation rate, fertilization rate, number of oocytes retrieved, number of metaphase II oocytes, total blastulation failure, number of 2 pronuclear embryos, and number of euploid embryos. Outcome measures were compared between male translocation carriers and controls, female translocation carriers and controls, and Robertsonian versus reciprocal translocation carriers.</p><p><strong>Results: </strong>A total of 1,291 retrieval cycles from 993 patients were included, of which 255 patients were translocation carriers, while 738 were controls. Of those with translocations, 30 (11.5%) were Robertsonian and 231 (88.5%) were reciprocal carriers. There was a statistically significant difference in the blastulation rate between carriers and controls (59.5% versus 62.1%; p-value = 0.01). However, usable blastulation rates (47.2% versus 50.0%) were equivalent between groups. There were no differences in number of oocytes retrieved (18.5 versus 18.3), number of 2 pronuclear embryos (13.4 versus 12.5), sustained implantation rate (71.4% versus 75.1%) or live birth rate (63.0% versus 66.1%) between translocation carriers and controls. In both male and female translocation carriers versus controls, there were no differences in usable blastulation rates or live birth rates. When comparing Robertsonian with reciprocal translocation carriers, rates of blastulation, usable blastulation, sustained implantation, and live birth rate were equivalent.</p><p><strong>Conclusion: </strong>Despite fewer euploid embryos, there were no differences in rates of usable blastulation or live birth rates in balanced translocation carriers, regardless of sex of affected partner or type of rearrangement, compared to controls. Routine karyotyping for blastulation failure may not be necessary based on these findings.</p>","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to: Enhancing Health Management in Patients with Primary Ovarian Insufficiency: An In-depth Exploration of Multimorbidity Associations. 回应:加强原发性卵巢功能不全患者的健康管理:多病关联的深入探讨。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-11 DOI: 10.1016/j.fertnstert.2024.11.009
Abirami Kirubarajan, Alison K Shea
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引用次数: 0
Luteinizing hormone's critical role in ovarian stimulation. 促黄体生成素(LH)在卵巢刺激(OS)中的关键作用。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-09 DOI: 10.1016/j.fertnstert.2024.11.005
James P Toner, Paul Pirtea
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引用次数: 0
Conceiving a new idea: fertile grounds for large-scale in vitro fertilization mergers. 孕育新理念:大规模试管婴儿合并的沃土。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-09 DOI: 10.1016/j.fertnstert.2024.11.006
Amanda Ferraro, M Blake Evans
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引用次数: 0
Why frozen embryo transfer results are lower with vaginal progesterone? Did we miss something? 为什么使用阴道黄体酮后冷冻胚胎移植结果较低?我们错过了什么吗?
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-08 DOI: 10.1016/j.fertnstert.2024.11.008
Dominique de Ziegler, Sean Soktean, Paul Pirtea
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引用次数: 0
Thank you to our reviewers 感谢我们的评论员
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-08 DOI: 10.1016/j.fertnstert.2024.11.004
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引用次数: 0
The ethics of egg sharing. 共享鸡蛋的伦理
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-08 DOI: 10.1016/j.fertnstert.2024.10.003
Meera Shah, Samuel Pang, Lydia Hughes, Katie Watson, Eve C Feinberg, Eric A Widra
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引用次数: 0
Characteristics and outcomes in endometrioma infections: a cohort of 94 cases. 子宫内膜瘤感染的特征和结果:94 个病例的队列。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-07 DOI: 10.1016/j.fertnstert.2024.11.002
Guillaume Parpex, Martin Belan, Asmaa Tazi, Laetitia Campin, Simon Ganancia, Etienne Canouï, Mathilde Bourdon, Charles Chapron, Louis Marcellin, Caroline Charlier
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引用次数: 0
Early embryo ontogeny and parental genetic legacy: from developmental mechanisms to diagnosis and treatment. 早期胚胎发育和父母遗传遗产:从发育机制到诊断和治疗。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-07 DOI: 10.1016/j.fertnstert.2024.10.043
Giovanni Coticchio, Danilo Cimadomo, Antonio Capalbo, Laura Rienzi
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引用次数: 0
Preeclampsia: More Than Just a Maternal Disease. 子痫前期:不仅仅是产妇疾病。
IF 6.6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2024-11-07 DOI: 10.1016/j.fertnstert.2024.10.047
Robert T Rydze, Stephanie J Gunderson, Jay Sandlow
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引用次数: 0
期刊
Fertility and sterility
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