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Expression of Concern ‘Effect of cell-phone assisted postpartum counseling on the use of long-acting reversible contraceptives: a randomized controlled trial’ [Fertil Steril 2019; 112: e9] “手机辅助产后咨询对长效可逆避孕药使用的影响:一项随机对照试验”[Fertil Steril 2019;112年:e9]
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-03 DOI: 10.1016/j.fertnstert.2026.02.008
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引用次数: 0
Expression of concern ‘Induction of ovulation using clomiphene citrate plus N-Acetyl cysteine versus letrozole in infertile patients with polycystic ovarian disease: a randomized clinical trial’ [Fertil Steril 2018; 110: e102] “克罗米芬加n -乙酰半胱氨酸与来曲唑对多囊卵巢不孕症患者的诱导排卵:一项随机临床试验”[Fertil Steril 2018;110年:e102]
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-03 DOI: 10.1016/j.fertnstert.2026.02.012
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引用次数: 0
Expression of concern ‘A randomized controlled trial of oral diclofenac potassium for analgesic control during office hysteroscopy’ [Fertil Steril 2017; 108: e15] “口服双氯芬酸钾用于办公室宫腔镜镇痛控制的随机对照试验”[Fertil Steril 2017;108年:e15]
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-03 DOI: 10.1016/j.fertnstert.2026.02.009
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引用次数: 0
Expression of concern ‘Effect of cervical glyceryl trinitrate cream on pain perception during copper T 380A intrauterine device insertion among parous women’ [Fertil Steril 2017; 108: e68] 关注表达“宫颈三硝酸甘油乳膏对产妇铜t380a宫内节育器置入过程中疼痛感知的影响”[Fertil Steril 2017;108年:e68]
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-02 DOI: 10.1016/j.fertnstert.2026.02.010
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引用次数: 0
Too Fast, Too Frozen: Rethinking Sperm Cryopreservation. 太快,太冷冻:重新思考精子冷冻保存。
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-02 DOI: 10.1016/j.fertnstert.2026.02.031
Seifeldin Sadek,Amr S El Haraki
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引用次数: 0
Expression of concern ‘Effect of dehydroepiandrosterone (DHEA) supplementation on intracytoplasmic sperm injection outcome in infertile women with anticipated normo-ovarian response’ [Fertil Steril 2019; 112: e30] “补充脱氢表雄酮(DHEA)对预期卵巢正常反应的不孕症女性胞浆内单精子注射结果的影响”[Fertil Steril 2019;112年:e30]
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-02 DOI: 10.1016/j.fertnstert.2026.02.011
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引用次数: 0
Expression of Concern ‘A randomized clinical trial between ultrasound-guided and uterine sound-sparing approach for copper intrauterine device insertion’ [Fertil Steril 2019; 112: e9] “超声引导和子宫保声入路在铜宫内节育器置入中的随机临床试验”[Fertil Steril 2019;112年:e9]
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-02 DOI: 10.1016/j.fertnstert.2026.02.007
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引用次数: 0
Do not measure antimüllerian hormone to predict women’s fecundity 不要通过测量抗微生物激素来预测女性的生育能力。
IF 7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-01 Epub Date: 2025-07-22 DOI: 10.1016/j.fertnstert.2025.07.025
Dominique de Ziegler M.D., Ph.D. , Sokteang Sean M.D. , Paul Pirtea M.D.
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引用次数: 0
Comparative outcomes of in vitro fertilization and frozen embryo transfer cycles in patients with nonmajor thalassemia spectrum and nonthalassemia: a propensity score-matched cohort study 非重度地中海贫血和非地中海贫血患者体外受精和冷冻胚胎移植周期的比较结果:一项倾向评分匹配的队列研究。
IF 7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-01 Epub Date: 2025-09-09 DOI: 10.1016/j.fertnstert.2025.09.005
Wenjie Huang M.S. , Xiaohua Wei M.S. , Liuyan Wei M.S. , Ni Tang M.S. , Zhetao Li M.S. , Wugao Li M.S. , Liuying Nong Ph.D. , Jingjing Li Ph.D. , Li Fan Ph.D.
<div><h3>Objective</h3><div>To assess whether oocyte yield, embryo development, and pregnancy rates differ between patients with nonmajor thalassemia spectrum (NMTS) and nonthalassemia (NT) undergoing in vitro fertilization (IVF) or frozen embryo transfer (FET) cycles.</div></div><div><h3>Design</h3><div>A propensity score-matched retrospective cohort study.</div></div><div><h3>Subjects</h3><div>A total of 41,804 patients who underwent IVF (18,215 cycles) or FET (23,589 cycles) between January 2013 and December 2022 were included in the study. Patients were matched 1:2 for the NT (n = 5,816 IVF, n = 8,004 FET) and NMTS (n = 2,908 IVF, n = 4,002 FET) groups. Within the NMTS group, thalassemia carriers accounted for 80.7% of IVF cases and 74.9% of FET cases, whereas patients with nontransfusion-dependent thalassemia represented 19.3% and 25.1%, respectively.</div></div><div><h3>Exposure</h3><div>Standard ovarian stimulation protocols (gonadotropin-releasing hormone agonist, gonadotropin-releasing hormone antagonist, and minimal stimulation) were used for all patients. Clinical outcomes, including embryo development, clinical pregnancy, live birth, and miscarriage rates, were compared between the groups.</div></div><div><h3>Main Outcome Measures</h3><div>The IVF cycle outcome (e.g., oocyte retrieval rate, fertilization rate, and blastocyst formation rate) and pregnancy outcomes (e.g., clinical pregnancy rate, live birth rate, and miscarriage rate).</div></div><div><h3>Results</h3><div>After matching, the baseline characteristics, including age and body mass index, were comparable between the NT and NMTS groups. No significant differences were observed in oocyte yield and embryo development, including blastocyst formation (NT: 0.54 vs. NMTS: 0.56). In IVF cycles, the clinical pregnancy rate (adjusted relative risk [aRR] = 1.03, 95% confidence interval [CI] = 0.96–1.09), live birth rate (aRR = 1.02, 95% CI = 0.95–1.09), and miscarriage rate (aRR = 1.07, 95% CI = 0.92–1.25) were similar. In FET cycles, the clinical pregnancy rate (aRR = 1.01, 95% CI = 0.96–1.07), live birth rate (aRR = 1.03, 95% CI = 0.97–1.10), and miscarriage rate (aRR = 0.92, 95% CI = 0.81–1.04) were comparable. Interaction analysis showed that baseline hormonal levels and ovarian stimulation protocols significantly influenced embryo development but did not affect pregnancy outcomes.</div></div><div><h3>Conclusion</h3><div>No significant differences in embryo development or pregnancy outcomes were found between patients with NMTS and NT undergoing IVF or FET cycles. These findings suggest that patients with NMTS do not face additional reproductive challenges in assisted reproductive technology. This study may help reduce reproductive anxiety in patients with NMTS and has important public health relevance in resource-limited and high-prevalence regions, where it can support clinical decisions and inform equitable assisted reproductive technology care delivery.</div></div><div><div>Re
目的评价非重度地中海贫血(NMTS)和非重度地中海贫血(NT)患者在体外受精(IVF)或冷冻胚胎移植(FET)周期中卵母细胞产量、胚胎发育和妊娠率是否存在差异。设计倾向评分匹配的回顾性队列研究。在2013年1月至2022年12月期间,共有41804名接受试管婴儿(18215个周期)或FET(23589个周期)的患者被纳入该研究。NT组(n = 5,816例IVF, n = 8,004例FET)和NMTS组(n = 2,908例IVF, n = 4,002例FET)患者按1:2匹配。在NMTS组中,地中海贫血携带者(TC)占IVF病例的80.7%和FET病例的74.9%,而非输血依赖型地中海贫血(NTDT)患者分别占19.3%和25.1%。所有患者均采用标准卵巢刺激方案(GnRH激动剂、GnRH拮抗剂和最小刺激)。比较两组的临床结果,包括胚胎发育、临床妊娠、活产和流产率。主要观察指标:周期结局(如卵母细胞回收率、受精率、囊胚形成率)和妊娠结局(如临床妊娠率、活产率、流产率)。结果匹配后,NT组和NMTS组的基线特征(包括年龄和体重指数)具有可比性。两组在卵母细胞数量和胚胎发育(包括囊胚形成)方面无显著差异(NT: 0.54 vs. NMTS: 0.56)。在IVF周期中,临床妊娠率(调整相对危险度[aRR] = 1.03, 95%可信区间[CI] = 0.96-1.09)、活产率(aRR = 1.02, 95% CI = 0.95-1.09)、流产率(aRR = 1.07, 95% CI = 0.92-1.25)相似。在FET周期中,临床妊娠率(aRR = 1.01, 95% CI = 0.96-1.07)、活产率(aRR = 1.03, 95% CI = 0.97-1.10)和流产率(aRR = 0.92, 95% CI = 0.81-1.04)具有可比性。相互作用分析表明,基线激素水平和卵巢刺激方案显著影响胚胎发育,但不影响妊娠结局。结论NMTS和NT患者接受IVF或FET周期的胚胎发育和妊娠结局无显著差异。这些发现表明NMTS患者在辅助生殖技术中不会面临额外的生殖挑战。这项研究可能有助于减少NMTS患者的生殖焦虑,并在资源有限和高流行地区具有重要的公共卫生相关性,在那里它可以支持临床决策并为公平的抗逆转录病毒治疗提供信息。
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引用次数: 0
Balance matters more than sample size in assisted reproductive technology research 在ART研究中平衡比样本量更重要
IF 7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-03-01 Epub Date: 2026-01-02 DOI: 10.1016/j.fertnstert.2025.12.024
Allison A. Eubanks M.D. , Mae Healy M.D.
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引用次数: 0
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Fertility and sterility
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