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Operating in Two Worlds: Gynecologic Surgery for the Gravid Uterus 两个世界的手术:妊娠子宫的妇科手术
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-20 DOI: 10.1016/j.fertnstert.2026.02.024
Jose Carugno, Nash S. Moawad, Emad Mikhail
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引用次数: 0
Preimplantation genetic testing for BRCA-1 and risk-reducing surgery is more cost-effective at age 35 than age 40 植入前BRCA-1基因检测和降低风险的手术对35岁的人比40岁的人更具成本效益
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-20 DOI: 10.1016/j.fertnstert.2026.02.025
Kiley Hunkler, David Boedeker, Kelby Bulles, Joshua Combs, Jill Brown
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引用次数: 0
Development of children born from capacitation in vitro maturation vs. in vitro fertilization: 5-year follow-up of a randomized controlled trial. 能性IVM与体外受精出生儿童的发育:一项随机对照试验的5年随访。
IF 7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-19 DOI: 10.1016/j.fertnstert.2026.02.023
Lan N Vuong, Minh H N Nguyen, Toan D Pham, Nghia A Nguyen, Nam T Nguyen, Van T T Tran, Tuong M Ho
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引用次数: 0
Laparoscopic excision of a noncommunicating rudimentary horn containing an ongoing pregnancy with cardiac activity: a structured minimally invasive approach. 腹腔镜切除含有持续妊娠并伴有心脏活动的未连通的初级角:一种结构化的微创方法。
IF 7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-18 DOI: 10.1016/j.fertnstert.2026.02.019
Suzan Abd Elgani, Adi Dayan-Schwartz, Maya Muhlbauer Avni, David Danon, Liron Kogan
<p><strong>Objective: </strong>To describe the diagnostic process and a structured, stepwise laparoscopic excision of a noncommunicating rudimentary uterine horn containing an ongoing pregnancy with cardiac activity, demonstrating how expert transvaginal and 3-dimensional ultrasound can guide early diagnosis and safe minimally invasive surgical management.</p><p><strong>Design: </strong>Detailed case report with diagnostic imaging, stepwise operative video, and structured 5-step surgical technique.</p><p><strong>Subjects: </strong>A 31-year-old G2P1 woman with a history of a prior low-transverse cesarean delivery presented to the emergency department with suspected ectopic pregnancy. She was hemodynamically stable with no active vaginal bleeding or acute abdominal pain. Detailed history revealed asymptomatic presentation; routine first-trimester ultrasound performed for dating had raised suspicion of an ectopic pregnancy. On physical examination, the cervix was single and the os closed; bimanual examination revealed mild adnexal tenderness on the left but no peritoneal signs. TVUS performed by a radiologist with expertise in complex pelvic anomalies demonstrated a right unicornuate uterus with normal endometrial thickness and no intrauterine gestational sac. A separate, left-sided gestational sac measuring 20 mm was identified, surrounded by a thick myometrial mantle (approximately 15 mm), with no continuity to the endometrial cavity or main uterine cornu. The gestational sac contained a yolk sac and a fetal pole, with a crown-rump length consistent with approximately 7 weeks and 6 days of gestation, and demonstrated confirmed cardiac activity. Color and spectral Doppler demonstrated robust arterial flow surrounding the gestational sac, indicating a rich vascular supply to the rudimentary horn. Three-dimensional ultrasound reconstructions confirmed the uterine anatomy as unicornuate with a noncommunicating rudimentary horn. Given the early gestational age, hemodynamic stability, clear diagnostic features on expert transvaginal and 3D ultrasound (single cervix, noncommunicating sac, robust vascularity, known unicornuate anatomy), and the time-sensitive nature of the condition, same-day laparoscopic management was chosen. Preoperative magnetic resonance imaging (MRI) was not pursued because transvaginal ultrasound provided clear anatomic delineation, including characterization of the attachment between the rudimentary horn and the unicornuate uterus, assessment of vascular supply, and evaluation of surrounding pelvic anatomy for surgical planning. Medical management with methotrexate was considered inappropriate, as it was unlikely to provide definitive treatment and carried a risk of treatment prolongation and unexpected rupture. This management aligns with published case series where expert ultrasound diagnosis is confirmed intraoperatively, and MRI is reserved as an adjunct in cases of diagnostic uncertainty (1-3).</p><p><strong>Intervention: </
目的:描述诊断过程和有组织的、分阶段的腹腔镜切除含有持续妊娠和心脏活动的未连通的初步子宫角,展示专家经阴道和三维超声如何指导早期诊断和安全的微创手术处理。设计:详细的病例报告,诊断影像,分步手术视频,结构化的五步手术技术。研究对象:一名31岁G2P1女性,既往有低位横断面剖宫产史,因怀疑异位妊娠被送往急诊科。患者血流动力学稳定,无阴道活动性出血或急性腹痛。详细病史显示无症状表现;为了约会而进行的常规妊娠早期超声检查引起了宫外孕的怀疑。体格检查,子宫颈单侧,输卵管闭合;双手检查显示左侧附件有轻微压痛,但未见腹膜征。由具有复杂骨盆异常专业知识的放射科医生进行的TVUS显示右侧独角形子宫,子宫内膜厚度正常,无宫内妊娠囊。发现一个独立的左侧妊娠囊,直径20毫米,被一层厚的子宫内膜套膜(约15毫米)包围,与子宫内膜腔或主子宫角没有连续性。孕囊包含卵黄囊和胎极,冠臀长度与妊娠约7周6天一致,证实有心脏活动。彩色和光谱多普勒显示孕囊周围有强劲的动脉流动,表明初级角有丰富的血管供应。三维超声重建证实子宫解剖为独角状,有一个不能沟通的初级角。考虑到孕龄早,血流动力学稳定,经阴道和3D超声诊断特征明确(单宫颈,非连通囊,血管健全,已知独角状解剖),以及病情的时间敏感性,选择当日腹腔镜治疗。术前没有进行磁共振成像(MRI),因为经阴道超声提供了清晰的解剖描绘,包括初步角和独角形子宫之间附着的特征,血管供应的评估,以及手术计划中骨盆周围解剖的评估。甲氨蝶呤的医疗管理被认为是不合适的,因为它不太可能提供明确的治疗,并有延长治疗和意外破裂的风险。这种处理方法与已发表的病例系列一致,术中专家超声诊断得到确认,在诊断不确定的情况下,MRI保留作为辅助手段(1-3)。干预:第一步:暴露和解剖鉴定。子宫原位检查;右子宫呈独角状,左子宫角发育不全。初生角明显呈维管状,长约6厘米。左输卵管被确定为一个小的,独立的结构。两条输尿管清晰可见。仔细检查排除了腹膜积液或血液。第二步:子宫-卵巢韧带分离使妊娠角移位。左侧输尿管经腹膜在直接目视下被发现,因为它在骨盆底韧带下走行。使用Ligasure装置识别并分离左子宫卵巢韧带。左侧卵巢保留原位。第三步:打开阔韧带。左侧圆形韧带分开以增加暴露。将膀胱从子宫下段和子宫角的初步附着处轻轻剥离,以清晰地显示子宫角与子宫连接处的下边界。第四步:血管加压素辅助的角-子宫连接处断流和骨骼化。将稀释后叶加压素(2单位10毫升生理盐水)注射到原始角附着周围的肌层,以减少血管。在2-3分钟的等待期后,沿着角-子宫连接处的血管蒂被识别、分离并使用Ligasure设备仔细凝固。投资腹膜和子宫肌膜附着物逐渐骨化。步骤5:切除原始角,切除管,取标本,修复。一旦完全活动和断流,从与独角形子宫的连接处急剧切除初生角和同侧输卵管。将标本放入内窥镜取出袋中(以容纳妊娠内容物并减少腹腔内溢出)。左侧输尿管有清晰可见的蠕动,证实功能和解剖结构完好。 采用2-0可吸收倒刺穿线将子宫角与子宫交界处的子宫肌层缺损缝合成单层。标本通过脐带套管针取出。主要观察指标:专家经阴道超声和3D超声诊断的准确性,术中安全性和腹腔镜切除的可行性(估计出血量、手术时间、术中并发症),术后恢复情况(包括住院时间)。结果:术前专家经阴道及三维超声表现与术中解剖完全吻合。无术中并发症发生。估计手术失血量为30ml,总手术时间约为45分钟。患者术后第1天出院,病情稳定。6周随访期间无术后并发症发生。患者报告术后疼痛最小,早期恢复正常活动。结论:本病例表明,在高容量中心使用专家经阴道和3D超声可以实现早期,准确诊断早期角妊娠,避免诊断延误并实现当日微创治疗。在血流动力学稳定和清晰解剖描绘的背景下,采用结构化逐步入路的腹腔镜切除以最小的发病率获得了良好的结果。
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引用次数: 0
Responsible use of artificial intelligence in manuscript preparation: guidance from Fertility and Sterility. 在稿件准备中负责任地使用人工智能:来自生育和不育的指导。
IF 7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-18 DOI: 10.1016/j.fertnstert.2026.01.013
Allison Eubanks, Kurt T Barnhart
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引用次数: 0
Ethical considerations of in vitro gametogenesis: an Ethics Committee opinion 体外配子发生的伦理考虑:伦理委员会的意见
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-17 DOI: 10.1016/j.fertnstert.2026.01.006
ASRM Ethics Committee, Sigal Klipstein M.D., Sina Abhari M.D., Paula Amato M.D., Aishwarya Arjunan M.S. M.P.H., Tolulope Bakare M.D., Kim Bergman Ph.D., Michelle Bayefsky M.D., Zeki Beyhan Ph.D., Katherine Cameron M.D., Susan Crockin J.D., Jessica Goldstein R.N., Insoo Hyun Ph.D., Jennifer Kawwass M.D., Joshua Morris M.D., Jeanne O’Brien M.D., Torie Comeaux Plowden M.D. M.P.H., Gwendolyn Quinn Ph.D., Robert Rebar M.D., Jared Robins M.D. M.B.A., Chevis N. Shannon Dr.PH. M.P.H. M.B.A., Michael Thomas M.D., Sean Tipton M.A.
In vitro gametogenesis represents a potentially groundbreaking advancement in reproductive medicine, but one that faces major challenges before it can be implemented in humans. Scientific, ethical, and societal implications must be carefully considered before clinical application.
体外配子发生代表了生殖医学的一项潜在的突破性进展,但在将其应用于人类之前还面临着重大挑战。临床应用前必须仔细考虑科学、伦理和社会影响。
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引用次数: 0
Modified natural vs. natural cycle for endometrial preparation in frozen embryo transfer: a meta-analysis. 冷冻胚胎移植中子宫内膜制备的改良自然周期与自然周期:一项荟萃分析。
IF 7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-17 DOI: 10.1016/j.fertnstert.2026.02.021
Christos Venetis, Kokkoni Kiose, Maria Apostolidou, Evangelia Katsika, Julia Bosdou, George Lainas, Efstratios Kolibianakis
<p><strong>Importance: </strong>Frozen-thawed embryo transfer cycles have risen substantially. Synchronization between the embryo and endometrium is achieved via natural or artificial hormonal preparation. Emerging data associate artificial regimens with hypertensive disorders, potentially favoring natural cycles. Because of their limited scheduling flexibility, modified natural cycles (mNCs) have been proposed, although equivalence in live birth outcomes remains unconfirmed.</p><p><strong>Objective: </strong>To identify whether there is a difference in the probability of live birth between women undergoing frozen embryo transfer (FET) in the mNC and those in the natural cycle (NC).</p><p><strong>Data sources: </strong>A literature search was conducted until October 2024 in MEDLINE, Embase, Cochrane CENTRAL, Scopus, Web of Science and Clinicaltrials.gov to identify eligible randomized controlled trials (RCTs).</p><p><strong>Study selection and synthesis: </strong>Data were independently extracted by three reviewers. Quality and trustworthiness were assessed using the RoB2 tool and the Trustworthiness in RAndomised Controlled Trials (TRACT) checklist, respectively. Sensitivity analysis was performed by excluding studies with a high risk of bias. Meta-analysis was performed using the random or fixed effects model depending on the presence or absence of significant statistical (I<sup>2</sup>>50%) or clinical heterogeneity.</p><p><strong>Main outcomes: </strong>The primary outcome was live birth. Secondary outcomes included clinical and ongoing pregnancy, cycle cancellation, and miscarriage.</p><p><strong>Results: </strong>Six RCTs (n = 1,708) (published between 2010 and 2024) were identified. Three RCTs were deemed to have a high risk of bias. All studies were considered trustworthy for inclusion in the meta-analysis according to the TRACT checklist. No significant difference was observed in live birth rates (risk ratio [RR]: 0.93, 95% confidence interval [CI]: 0.74-1.17; I<sup>2</sup> = 0%, 4 studies, n = 1,280; [sensitivity analysis: RR: 0.90, 95% CI: 0.32-2.52; I<sup>2</sup> = 0%, 2 studies, n = 1,060]), ongoing pregnancy rates (RR: 0.74, 95% CI: 0.37-1.51; I<sup>2</sup> = 1%, 3 studies, n = 536), and clinical pregnancy rates (RR: 0.86, 95% CI: 0.67-1.10; I<sup>2</sup> = 0%, 4 studies, n = 648). Similarly, no significant difference was observed in cycle cancellation rates and miscarriage rates. The sensitivity analysis, performed by excluding the three studies deemed to be at high risk of bias, did not materially alter the results obtained for all the aforementioned outcomes.</p><p><strong>Conclusion and relevance: </strong>Clinicians and patients should be informed that, on the basis of the best available evidence, frozen-thawed embryo transfer in mNC results in comparable live birth rates with NC, making it a pragmatic option for scheduling or convenience.</p><p><strong>Trial registration: </strong>The protocol for the systematic review was reg
重要性:冻融胚胎移植周期已经大大增加。胚胎和子宫内膜之间的同步是通过自然或人工激素制备来实现的。新出现的数据将高血压疾病与人工治疗方案联系起来,可能有利于自然周期。由于其有限的调度灵活性,修改自然周期已提出,虽然等效的活产结果仍未得到证实。目的:探讨改良自然周期(mNC)冷冻胚胎移植妇女与自然周期(NC)冷冻胚胎移植妇女的活产概率是否存在差异。数据来源:在MEDLINE, Embase, Cochrane CENTRAL, Scopus, Web of Science and Clinicaltrials.gov中进行文献检索,直至2024年10月,以确定符合条件的随机对照试验。研究选择和综合:数据由三位评论者独立提取。分别使用RoB2工具和TRACT检查表评估质量和可信度。通过排除高偏倚风险的研究进行敏感性分析。采用随机效应或固定效应模型进行meta分析,这取决于是否存在显著的统计异质性(i2bb0 50%)或临床异质性。主要结局:主要结局为活产。次要结局包括临床和持续妊娠、周期取消和流产。结果:共纳入6项rct (n=1708),发表时间为2010-2024年。3项随机对照试验被认为具有高偏倚风险。所有的研究都被认为是可信的,可以根据TRACT检查表纳入meta分析。两组活产率无显著差异[RR: 0.93, 95% CI: 0.74-1.17;I2=0%, 4项研究,n=1280;(敏感性分析:RR: 0.90, 95% CI: 0.32-2.52; I2=0%, 2项研究,n=1060)]、持续妊娠率(RR: 0.74, 95% CI: 0.37-1.51; I2=1%, 3项研究,n=536)和临床妊娠率(RR: 0.86, 95% CI: 0.67-1.10; I2=0%, 4项研究,n=648)。同样,在周期取消率和流产率方面也没有观察到显著差异。敏感性分析排除了三个被认为具有高偏倚风险的研究,并没有实质性地改变上述所有结果的结果。结论和相关性:临床医生和患者应该被告知,根据现有的最佳证据,mNC冷冻解冻胚胎移植的活产率与NC相当,使其成为一种实用的选择,可以安排或方便。
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引用次数: 0
Rethinking do no harm. 反思不伤害。
IF 7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-14 DOI: 10.1016/j.fertnstert.2026.02.018
J Preston Parry, Stephanie Estes, Ted L Anderson
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引用次数: 0
In ART, does the quarterback really need a left tackle? 在ART比赛中,四分卫真的需要一个左截锋吗?
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-11 DOI: 10.1016/j.fertnstert.2026.01.035
David Boedeker, Michael J. Tucker, Kate Devine
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引用次数: 0
An intraoperative localization method and a stepwise surgical technique for hysteroscopic treatment of International Federation of Gynecology and Obstetrics type 3 fibroid 宫腔镜治疗国际妇产联合会3型肌瘤的术中定位方法及分步手术技术
IF 6.7 1区 医学 Q1 OBSTETRICS & GYNECOLOGY Pub Date : 2026-02-11 DOI: 10.1016/j.fertnstert.2026.02.004
Dongming Liu, Yaxing Guo, Ziyi Fan, Yang Wang
{"title":"An intraoperative localization method and a stepwise surgical technique for hysteroscopic treatment of International Federation of Gynecology and Obstetrics type 3 fibroid","authors":"Dongming Liu, Yaxing Guo, Ziyi Fan, Yang Wang","doi":"10.1016/j.fertnstert.2026.02.004","DOIUrl":"https://doi.org/10.1016/j.fertnstert.2026.02.004","url":null,"abstract":"","PeriodicalId":12275,"journal":{"name":"Fertility and sterility","volume":"60 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146153311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Fertility and sterility
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