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The Analgesic and Anti-inflammatory Effects of Partially Purified Polysaccharide Fractions of Cell-free Medium and Biomass of Spirulina platensis PCST5. 部分纯化的无细胞培养基多糖馏分和 PCST5 螺旋藻生物质的镇痛和抗炎作用。
IF 1.6 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-07-19 eCollection Date: 2023-01-01 DOI: 10.5812/ijpr-136661
Mohammad Dehghanizadeh Baghdadabad, Nima Naderi, Vahideh Atabaki, Mohammad Ali Faramarzi, Maryam Tabarzad, Tahereh Hosseinabadi

Background: Spirulina is a cyanobacteria species containing various bioactive compounds. Spirulina is a known source of nutrients in some traditional diets. Different activities have been reported for various extracts of S. platensis.

Objectives: In this study, the polysaccharide content of culture media and biomass extract of one species of Spirulina was partially purified, and its analgesic and anti-inflammatory effects were evaluated.

Methods: Spirulina platensis PCST5 was cultured in a sterile Zarouk medium at 27°C and 16/8h of light/ dark exposure cycle for 25 days. Then, the polysaccharide content of biomass and cell-free culture medium samples (BPSs and CFPSs, respectively) was partially purified. The analgesic and anti-inflammatory effects were evaluated using animal models.

Results: 16S rRNA gene analysis confirmed that the organism was genetically similar to Spirulina platensis. The CFPSs (30 and 100 mg/kg) and BPSs (30 mg/kg) significantly reduced pain-related behaviors in rats. Similarly, all samples could significantly reduce carrageenan-induced paw inflammation volume compared with the control group. Our results suggest Spirulina's polysaccharide fractions (CFPSs and BPSs) had significant analgesic and anti-inflammatory effects.

Conclusions: Since Spirulina is a readily available source of bioactive compounds, finding such potent anti-inflammatory and anti-nociceptive compounds can provide promising leads for novel drug development.

背景:螺旋藻是一种蓝藻,含有多种生物活性化合物。螺旋藻是一些传统饮食中已知的营养来源。据报道,螺旋藻的各种提取物具有不同的活性:本研究部分纯化了一种螺旋藻的培养基和生物质提取物中的多糖含量,并评估了其镇痛和抗炎作用:方法:在无菌 Zarouk 培养基中培养 Platensis PCST5 螺旋藻,培养温度为 27°C,光照/黑暗周期为 16/8 小时,为期 25 天。然后,对生物质和无细胞培养基样品(分别为 BPSs 和 CFPSs)中的多糖含量进行了部分纯化。利用动物模型对其镇痛和抗炎作用进行了评估:结果:16S rRNA 基因分析证实,该生物在遗传学上与螺旋藻相似。CFPSs(30 毫克/千克和 100 毫克/千克)和 BPSs(30 毫克/千克)能显著减少大鼠与疼痛有关的行为。同样,与对照组相比,所有样品都能明显减少角叉菜胶诱发的爪炎症量。我们的研究结果表明,螺旋藻的多糖组分(CFPSs 和 BPSs)具有明显的镇痛和抗炎作用:结论:由于螺旋藻是生物活性化合物的现成来源,找到这种强效抗炎和抗痛觉化合物可为新型药物开发提供有希望的线索。
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引用次数: 0
Britain, Europe and the World 1850-1986 英国、欧洲和世界1850-1986
IF 7.5 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-07-07 DOI: 10.2307/20041778
F. Stern, B. Porter
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引用次数: 1
Fathers Work for Their Sons 父亲为儿子工作
IF 7.5 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-04-28 DOI: 10.2307/20042454
J. Whitaker, S. Berry
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引用次数: 59
The Collective and the Individual in Russia 俄罗斯的集体与个人
IF 7.5 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-04-28 DOI: 10.2307/20049500
Robert Legvold, Oleg Kharkhordin
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引用次数: 54
Historical-retrospective and legal analysis of the conditions, values and consequences of the Constitution of Pylyp Orlyk Pylyp Orlyk宪法形成的条件、价值和后果的历史回顾和法律分析
IF 7.5 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-03-02 DOI: 10.46493/2663-2675.33(1).2023.32-38
L. Spytska
The history of the Constitution of Pylyp Orlyk is sufficiently studied both in Ukrainian and foreign historiography, but the issue remains rather relevant for a full historical and legal review, so the interpretation and consideration of events of those times, and especially the legal study of the underlying document, is still important. The purpose of this article is to study the Constitution of Pylyp Orlyk, for the sake of interpretations of the events of 1710, to trace the processes and reasons that followed, to analyze the historical and legal role, the conditions and consequences of the adoption of the constitution, and consider the role of Pylyp Orlyk in its establishment. The study used various historical methods and approaches to analyze and select information relevant to the adoption of the Constitution of Pylyp Orlyk. Also, the article widely used methods of analysis and synthesis, general methods of scientific knowledge and methods of empirical research. Historical comparative, retrospective and abstract methods made it possible to reconstruct and model in greater detail the processes that were taking place before the adoption of the Constitution, as well as its consequences. It is argued that the Constitution was created based on democracy, which was the main factor in the creation of the historical goal, which was the development of state reforms. From the point of view of the law, a complete analysis of the new state system, which was referred to by the provisions of the Constitution, was carried out. In the process of research, the Constitution of Pylyp Orlyk was studied, as well as some factors that helped construct and reconstruct the conditions, values, and consequences that led to the adoption of the Constitution of 1710. It was determined that the specified Constitution depicts the improvement of relations in power, and can also be used as a regulator of the state tradition of the Ukrainian people. It has been investigated that the described and analyzed historical-political aspects fully describe the motive for the adoption of the Constitution of Pylyp Orlyk, caused by the completion of these events in the new time and the possibility of researching this issue as in domestic historiography
Pylyp Orlyk宪法的历史在乌克兰和外国史学中都得到了充分的研究,但这个问题仍然与全面的历史和法律审查相当相关,因此对那些时代事件的解释和考虑,特别是对基础文件的法律研究,仍然很重要。本文的目的是研究Pylyp Orlyk宪法,以解释1710年的事件,追溯随后的过程和原因,分析宪法的历史和法律作用,通过宪法的条件和后果,并考虑Pylyp Orlyk在其建立中的作用。本研究采用了多种历史方法和途径来分析和选择与通过Pylyp Orlyk宪法有关的信息。同时,本文广泛运用了分析综合方法、一般科学知识方法和实证研究方法。历史比较、回顾和抽象的方法使我们能够更详细地重建和模拟在《宪法》通过之前所发生的进程及其后果。认为宪法是在民主的基础上产生的,民主是产生国家改革发展这一历史目标的主要因素。从法律的角度,对《宪法》规定的新的国家制度进行了全面的分析。在研究过程中,研究了Pylyp Orlyk宪法,以及有助于构建和重建导致1710年宪法通过的条件,价值观和后果的一些因素。确定的是,具体的宪法描述了权力关系的改善,也可以用作乌克兰人民国家传统的调节器。通过对历史政治方面的描述和分析,充分地描述了《皮利普·奥尔利克宪法》通过的动机,以及这些事件在新时期的完成所导致的动机,以及国内史学研究这一问题的可能性
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引用次数: 0
China policy on Taiwan against the backdrop of the Russia-Ukraine War 俄乌战争背景下的中国对台湾政策
IF 7.5 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-03-02 DOI: 10.46493/2663-2675.33(1).2023.24-31
A. Hrubinko, Iryna Fedoriv
The relevance of the study is conditioned by the transformational trends in globalisation policy as a result of russia’s full-scale invasion of Ukraine, especially in the political relations of the People’s Republic of China with Taiwan, which is one of the most important aspects of international security. The purpose of the study is to identify the characteristic features of the Taiwan issue. The following methodological approaches were used: functional, dogmatic, logical analysis, synthesis, deduction, method of legal hermeneutics, etc. The study found that political relations between China and Taiwan are largely determined by the party affiliation of the latter’s leadership. Parallels were drawn between China-Taiwan and russia-Ukraine relations, which are associated with the asymmetry of relations between the two countries. It was found that the russia-Ukraine war serves as a factor that will have a further impact on the development and resolution of the conflict between Taiwan and China. The possibility of resolving the China-Taiwan war will depend on the results of the russia-Ukraine war and the reaction of the international community, especially the United States of America, which is Taiwan’s main ally. The study results showed that the factor that will help reduce the likelihood of China’s intervention against Taiwan is Ukraine’s victory in the russia-Ukraine war; another factor is the active role of the international community in countering russian aggression If the United States and Europe take a passive stance, this will act as a factor that will increase the tension between China and Taiwan The practical value of the findings allows for a causal analysis of the Taiwan issue and the identification of possible solutions to the conflict against the backdrop of the russia-Ukraine war
这项研究的相关性取决于俄罗斯全面入侵乌克兰所导致的全球化政策的转型趋势,特别是中华人民共和国与台湾的政治关系,这是国际安全最重要的方面之一。本研究的目的在于找出台湾问题的特征。运用了以下方法论:功能分析、教条分析、逻辑分析、综合分析、演绎分析、法律解释学方法等。研究发现,大陆和台湾的政治关系在很大程度上取决于台湾领导人所属的政党。有人将中国与台湾的关系与俄罗斯与乌克兰的关系相提并论,这与两国关系的不对称有关。研究发现,俄乌战争是影响台湾与中国冲突发展与解决的因素之一。解决中国-台湾战争的可能性将取决于俄罗斯-乌克兰战争的结果和国际社会的反应,特别是作为台湾主要盟友的美国。研究结果显示,降低中国干预台湾可能性的因素是乌克兰在俄乌战争中的胜利;另一个因素是国际社会在对抗俄罗斯侵略方面的积极作用,如果美国和欧洲采取被动立场,这将成为增加中国与台湾之间紧张关系的一个因素。研究结果的实用价值允许对台湾问题进行因果分析,并在俄乌战争的背景下确定冲突的可能解决方案
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引用次数: 0
Restoration of Ukraine’s foreign policy activities in the context of the founding of the United Nations 在联合国成立的背景下恢复乌克兰的外交政策活动
IF 7.5 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-03-02 DOI: 10.46493/2663-2675.33(1).2023.16-23
Ljupcho Sotiroski, Y. Kravtsov
The relevance of the subject matter is conditioned primarily by the desire to achieve the national interests of Ukraine and the need to fight russian military aggression for the right to pursue an independent foreign policy. In this regard, the purpose of the study is to reveal the issue of the restoration of Ukraine’s activities in the political sphere as a result of the establishment of the United Nations. The main methods of research of this problem are: analysis, induction, deduction, and synthesis, which allow describing and highlighting the most important aspects of the development of Ukraine’s foreign policy, as well as diagnostic, comparative, system and structural methods. The paper examines the process of resumption of Ukraine’s foreign policy after the establishment of the United Nations. The role of Ukraine in the founding of the United Nations is considered, and its activities in the organisation are evaluated. The prerequisites and historical traditions of Ukrainian diplomacy are revealed. The activities of the Ukrainian Soviet Socialist Republic and independent Ukraine in the United Nations bodies are investigated. The main modern achievements of Ukraine’s foreign policy are considered. It is determined that one of the main goals of Ukraine’s work in the UN Security Council was to inform council members and the international community about any attempts to escalate the situation in the temporarily occupied Crimea and Eastern Ukraine by russia. The main ways of the modern foreign policy of Ukraine were described, namely: preserving the supremacy of the state on its territory, independence in international relations, territorial integrity, and Euro-Atlantic integration. The materials of the study are of practical and theoretical value for political scientists, historians, other representatives of the scientific community, and researchers of the topic of restoring Ukraine’s foreign policy, who are interested in the features and aspects of this state activity, and study the role of Ukraine in the process of founding the United Nations
该主题的相关性主要取决于实现乌克兰国家利益的愿望,以及为追求独立外交政策的权利而对抗俄罗斯军事侵略的必要性。在这方面,研究的目的是揭示由于联合国的成立而恢复乌克兰在政治领域的活动的问题。研究这一问题的主要方法是:分析、归纳、推导和综合,可以描述和突出乌克兰外交政策发展的最重要方面,以及诊断、比较、系统和结构方法。本文考察了联合国成立后乌克兰恢复外交政策的过程。审议了乌克兰在联合国成立过程中的作用,并评估了乌克兰在该组织中的活动。揭示了乌克兰外交的先决条件和历史传统。调查乌克兰苏维埃社会主义共和国和独立的乌克兰在联合国机构中的活动。乌克兰外交政策的主要现代成就。乌克兰在联合国安理会工作的主要目标之一是向安理会成员和国际社会通报俄罗斯试图升级暂时占领的克里米亚和乌克兰东部局势的任何企图。阐述了乌克兰现代外交政策的主要方式,即:维护国家在其领土上的至高无上地位、国际关系中的独立、领土完整和欧洲-大西洋一体化。该研究的材料对政治学家、历史学家、科学界的其他代表以及恢复乌克兰外交政策主题的研究人员具有实际和理论价值,他们对这一国家活动的特点和方面感兴趣,并研究乌克兰在联合国成立过程中的作用
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引用次数: 1
Historical significance of Germany, France and Belgium in the creation of the European Union 德国、法国和比利时在创建欧盟中的历史意义
IF 7.5 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-03-02 DOI: 10.46493/2663-2675.33(1).2023.8-15
D. Pylypenko, Denis Spahija
The relevance of the study is conditioned by the need to analyse the positive experience of European countries for its use in Ukraine’s foreign policy when participating in international associations, in relations with the member states of the European Union. The purpose of the study is to investigate the role of the foreign policies of Germany, France, and Belgium in the development of the European Union, and to conduct a thorough assessment of the results of such policies. To achieve this goal, such methods as dialectical materialism, factor discourse analysis, deduction and induction, analysis and synthesis, system analysis, structural and functional analysis, and the comparative method were used. The paper examines the goals and objectives, the role and place of three states: Germany, France, and Belgium in the history of the creation of the European Union. The interests of each of the states are characterised, the specifics of their national policy and its impact on the deepening of European integration are determined. The approaches of countries to the organisation of the European Union, their common and distinctive features are analysed. The specifics of relations between Germany, France, and Belgium in the process of their cooperation are determined. It is stated that these countries have become the leading initiators of deepening integration in Europe. The study shows that relations between France and Germany in the late 20th century became an example of cooperation in European security issues. It is established that France is the author of successfully implemented projects and approved laws and regulations in the European Union. It is noted that despite the small territory, Belgium exerted significant political influence, and the Benelux Union became an example of economic unification in the process of creating the European Union. The conclusions obtained contribute to solving practical issues related to the development of Ukraine’s own integration processes and the protection of its own interests in building foreign policy. The material can serve as a basis for the educational process in the training of political scientists, international specialists, and in the work on scientific literature
这项研究的相关性取决于有必要分析欧洲国家的积极经验,以便在乌克兰参加国际组织和与欧洲联盟成员国的关系时,将其用于乌克兰的外交政策。本研究的目的是调查德国、法国和比利时的外交政策在欧盟发展中的作用,并对这些政策的结果进行彻底的评估。为达到这一目的,运用了辩证唯物主义、要素话语分析、演绎与归纳、分析与综合、系统分析、结构与功能分析、比较法等方法。本文考察了德国、法国和比利时这三个国家在欧盟创建历史上的目标、作用和地位。每个国家的利益都有自己的特点,它们的国家政策的具体内容及其对深化欧洲一体化的影响都是确定的。各国对欧盟组织的方法,他们的共同和独特的特点进行了分析。确定了德国、法国、比利时在合作过程中的具体关系。这些国家已成为欧洲深化一体化的主要发起者。研究表明,20世纪后期法国和德国的关系成为欧洲安全问题合作的典范。可以确定的是,法国是欧盟成功实施项目和批准法律法规的作者。值得注意的是,尽管国土面积小,比利时发挥了重大的政治影响,比荷卢经济联盟在创建欧洲联盟的过程中成为经济统一的一个例子。所获得的结论有助于解决与乌克兰自身一体化进程的发展和在制定外交政策时保护其自身利益有关的实际问题。这些材料可以作为培训政治科学家、国际专家和科学文献工作的教育过程的基础
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引用次数: 1
The InBIO barcoding initiative database: DNA barcodes of Iberian Trichoptera, documenting biodiversity for freshwater biomonitoring in a Mediterranean hotspot. InBIO 条形码倡议数据库:伊比利亚毛翅目鸟类的 DNA 条形码,记录地中海热点地区淡水生物监测的生物多样性。
IF 1.3 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-01-19 eCollection Date: 2023-01-01 DOI: 10.3897/BDJ.11.e97484
Joana Pauperio, Luis Martin Gonzalez, Jesus Martinez, Marcos A González, Filipa Ms Martins, Joana Veríssimo, Pamela Puppo, Joana Pinto, Cátia Chaves, Catarina J Pinho, José Manuel Grosso-Silva, Lorenzo Quaglietta, Teresa Luísa L Silva, Pedro Sousa, Paulo Celio Alves, Nuno Fonseca, Pedro Beja, Sónia Ferreira

Background: The Trichoptera are an important component of freshwater ecosystems. In the Iberian Peninsula, 380 taxa of caddisflies are known, with nearly 1/3 of the total species being endemic in the region. A reference collection of morphologically identified Trichoptera specimens, representing 142 Iberian taxa, was constructed. The InBIO Barcoding Initiative (IBI) Trichoptera 01 dataset contains records of 438 sequenced specimens. The species of this dataset correspond to about 37% of Iberian Trichoptera species diversity. Specimens were collected between 1975 and 2018 and are deposited in the IBI collection at the CIBIO (Research Center in Biodiversity and Genetic Resources, Portugal) or in the collection Marcos A. González at the University of Santiago de Compostela (Spain).

New information: Twenty-nine species, from nine different families, were new additions to the Barcode of Life Data System (BOLD). A success identification rate of over 80% was achieved when comparing morphological identifications and DNA barcodes for the species analysed. This encouraging step advances incorporation of informed Environmental DNA tools in biomonitoring schemes, given the shortcomings of morphological identifications of larvae and adult Caddisflies in such studies. DNA barcoding was not successful in identifying species in six Trichoptera genera: Hydropsyche (Hydropsychidae), Athripsodes (Leptoceridae), Wormaldia (Philopotamidae), Polycentropus (Polycentropodidae) Rhyacophila (Rhyacophilidae) and Sericostoma (Sericostomatidae). The high levels of intraspecific genetic variability found, combined with a lack of a barcode gap and a challenging morphological identification, rendered these species as needing additional studies to resolve their taxonomy.

背景:鞘翅目昆虫是淡水生态系统的重要组成部分。在伊比利亚半岛,已知的蝶类有 380 个类群,其中近三分之一是该地区特有的物种。伊比利亚半岛有 380 个蝶类类群,其中近 1/3 是该地区的特有物种。我们建立了一个经形态鉴定的毛翅目标本参考馆藏,代表了 142 个伊比利亚类群。InBIO Barcoding Initiative (IBI) Trichoptera 01 数据集包含 438 个测序标本的记录。该数据集中的物种约占伊比利亚毛翅目物种多样性的 37%。标本采集于 1975 年至 2018 年,保存在葡萄牙生物多样性与遗传资源研究中心(CIBIO)的 IBI 收藏馆或西班牙圣地亚哥德孔波斯特拉大学(University of Santiago de Compostela)的 Marcos A. González 收藏馆:新信息:生命条形码数据系统(BOLD)新增加了 29 个物种,分别来自 9 个不同的科。在对所分析物种的形态鉴定和 DNA 条形码进行比较时,成功鉴定率超过 80%。鉴于蝌蚪幼虫和成虫的形态鉴定在生物监测计划中的不足,这一令人鼓舞的进展推动了环境 DNA 工具在生物监测计划中的应用。DNA 条形码未能成功识别 6 个鞘翅目属中的物种:DNA条形码未能成功识别以下六个鞘翅目属中的物种:Hydropsyche(Hydropsychidae)、Athripsodes(Leptoceridae)、Wormaldia(Philopotamidae)、Polycentropus(Polycentropodidae)、Rhyacophila(Rhyacophilidae)和 Sericostoma(Sericostomatidae)。这些物种的种内遗传变异水平很高,加上缺乏条形码缺口和形态鉴定的挑战性,使得这些物种需要更多的研究来解决其分类问题。
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引用次数: 0
The return of historical monuments removed from the territory of Ukraine after 2014. Problems of archaeological research in times of war 2014年后从乌克兰领土上移走的历史古迹的归还。战争时期考古研究的问题
IF 7.5 2区 社会学 Q1 INTERNATIONAL RELATIONS Pub Date : 2023-01-01 DOI: 10.46493/2663-2675.33(3).2023.17-27
Kasa Arlind
The relevance of the research is conditioned upon the increase in the national consciousness of the Ukrainian nation, a new stage of the national revival of the Ukrainian state and consolidation of the Ukrainian people against the background of the full-scale invasion and occupation of Ukrainian territories. The purpose of this research is to explore the level of threat to the national historical and cultural heritage in Ukraine, including the temporarily occupied territories. The research methodology used in this work is a comprehensive combination of quantitative and qualitative analysis of archaeological and cultural monuments, and the following methods: ascent, synthesis, analysis, comparison, and the axiomatic method. As a result of the study, the main regions of historical and cultural monuments in the temporarily occupied territories and in the areas where hostilities are conducted were explored. The research examines the competent opinion of leading Ukrainian historians and archaeologists on the main problems of archaeological research and the restitution of the treasures of Ukrainian culture temporarily seized by the occupier. The legal foundations of such restitution are established in the context of the main provisions of national and international humanitarian law. These circumstances were the prerequisites for the cancellation of the decision of the District Court of Amsterdam in favour of the Ukrainian party. It is substantiated that the position of the authorities of the Kingdom of the Netherlands does not comply with the statute of legal identity and independence of the State and ignores the inviolability of property rights. Although, in turn, the country is based on the declaration of compliance with international law on the legal immunity of the state and its property, as established by the 2004 UN Convention. The conclusions presented based on them contain updated scientific knowledge on the areas of restoration of a fair legal status to the historical and cultural heritage of the Ukrainian nation and bring to science relevant scientific and practical recommendations for improving the current legislation of Ukraine in the field of museum and archaeological science
该研究的相关性取决于乌克兰民族民族意识的增强,乌克兰国家民族复兴的新阶段和乌克兰人民在全面入侵和占领乌克兰领土的背景下的巩固。本研究的目的是探讨对乌克兰国家历史和文化遗产的威胁程度,包括临时占领的领土。本工作采用的研究方法是对考古和文化古迹进行定量和定性分析的综合结合,采用上升法、综合法、分析法、比较法和公理法。研究的结果是,对临时被占领领土和发生敌对行动地区的主要历史和文化古迹区域进行了探索。这项研究考察了乌克兰主要历史学家和考古学家关于考古研究和归还被占领者暂时占领的乌克兰文化宝藏的主要问题的权威意见。这种恢复的法律基础是在国家和国际人道主义法的主要规定范围内确定的。这些情况是取消阿姆斯特丹地区法院对乌克兰一方有利的判决的先决条件。事实证明,荷兰王国当局的立场不符合关于国家的法律身份和独立性的规约,并且无视财产权的不可侵犯性。尽管反过来,该国的依据是声明遵守2004年《联合国公约》所确立的关于国家及其财产的法律豁免的国际法。在此基础上提出的结论载有关于恢复乌克兰民族历史和文化遗产的公平法律地位领域的最新科学知识,并为改进乌克兰在博物馆和考古科学领域的现行立法提出了有关的科学和实际建议
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引用次数: 2
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