Pub Date : 2024-03-30DOI: 10.30574/gscarr.2024.18.3.0084
Vana Gkora
This paper explores the integration of autonomy-supportive practices and technological interventions in primary education for students with Attention-Deficit/Hyperactivity Disorder (ADHD). It underscores the significance of creating educational environments that promote autonomy, leveraging cutting-edge technology to tailor learning experiences to the unique needs of ADHD students. Through a systematic literature review, the study highlights the importance of parental involvement and interdisciplinary approaches in enhancing academic achievement, social integration, and emotional well-being of ADHD students. It presents a collaborative framework that combines autonomy, technology, and inclusive strategies, advocating for policy support, community engagement, and digital equity. The findings suggest that a holistic, adaptive educational model is essential for addressing the multifaceted challenges ADHD students face, offering insights for future research and practice.
{"title":"Advancing ADHD education: autonomy, technology, and inclusive strategies","authors":"Vana Gkora","doi":"10.30574/gscarr.2024.18.3.0084","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0084","url":null,"abstract":"This paper explores the integration of autonomy-supportive practices and technological interventions in primary education for students with Attention-Deficit/Hyperactivity Disorder (ADHD). It underscores the significance of creating educational environments that promote autonomy, leveraging cutting-edge technology to tailor learning experiences to the unique needs of ADHD students. Through a systematic literature review, the study highlights the importance of parental involvement and interdisciplinary approaches in enhancing academic achievement, social integration, and emotional well-being of ADHD students. It presents a collaborative framework that combines autonomy, technology, and inclusive strategies, advocating for policy support, community engagement, and digital equity. The findings suggest that a holistic, adaptive educational model is essential for addressing the multifaceted challenges ADHD students face, offering insights for future research and practice.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"45 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.30574/gscarr.2024.18.3.0089
Mustafa Ayobami Raji, H. B. Olodo, Timothy Tolulope Oke, Wilhelmina Afua Addy, Onyeka Chrisanctus Ofodile, A. Oyewole
Real-time data analytics has emerged as a pivotal tool in the retail sector, revolutionizing decision-making processes and operational strategies. This study delves into the extensive landscape of real-time data analytics in retail, offering a comprehensive review of practices both in the USA and on a global scale. In the United States, retail giants have harnessed real-time data analytics to gain unprecedented insights into consumer behavior, preferences, and market trends. From personalized marketing campaigns to dynamic pricing strategies, retailers leverage real-time analytics to optimize inventory management and enhance the overall customer experience. The integration of technologies like RFID, IoT devices, and advanced analytics platforms has facilitated the seamless flow of data, enabling retailers to respond swiftly to changing market dynamics. On a global scale, diverse retail markets have embraced real-time data analytics to stay competitive in an ever-evolving landscape. Cross-border e-commerce and the proliferation of online marketplaces have intensified the need for real-time insights into global consumer trends. Retailers worldwide are adopting predictive analytics to forecast demand, reduce stockouts, and streamline supply chain operations. Moreover, the integration of artificial intelligence and machine learning algorithms enhances the ability to analyze vast datasets, uncovering hidden patterns and predicting future market trends. Challenges such as data privacy concerns, integration complexities, and the need for skilled professionals are acknowledged in this review. Despite these challenges, the transformative impact of real-time data analytics on the retail sector is undeniable. As technology continues to advance, the synergy between real-time data analytics and retail practices is expected to deepen, fostering innovation and reshaping the industry's landscape. This study provides a glimpse into the dynamic and evolving realm of real-time data analytics in retail, offering insights into the strategies employed by both the USA and global players to thrive in an era of rapid technological change.
{"title":"Real-time data analytics in retail: A review of USA and global practices","authors":"Mustafa Ayobami Raji, H. B. Olodo, Timothy Tolulope Oke, Wilhelmina Afua Addy, Onyeka Chrisanctus Ofodile, A. Oyewole","doi":"10.30574/gscarr.2024.18.3.0089","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0089","url":null,"abstract":"Real-time data analytics has emerged as a pivotal tool in the retail sector, revolutionizing decision-making processes and operational strategies. This study delves into the extensive landscape of real-time data analytics in retail, offering a comprehensive review of practices both in the USA and on a global scale. In the United States, retail giants have harnessed real-time data analytics to gain unprecedented insights into consumer behavior, preferences, and market trends. From personalized marketing campaigns to dynamic pricing strategies, retailers leverage real-time analytics to optimize inventory management and enhance the overall customer experience. The integration of technologies like RFID, IoT devices, and advanced analytics platforms has facilitated the seamless flow of data, enabling retailers to respond swiftly to changing market dynamics. On a global scale, diverse retail markets have embraced real-time data analytics to stay competitive in an ever-evolving landscape. Cross-border e-commerce and the proliferation of online marketplaces have intensified the need for real-time insights into global consumer trends. Retailers worldwide are adopting predictive analytics to forecast demand, reduce stockouts, and streamline supply chain operations. Moreover, the integration of artificial intelligence and machine learning algorithms enhances the ability to analyze vast datasets, uncovering hidden patterns and predicting future market trends. Challenges such as data privacy concerns, integration complexities, and the need for skilled professionals are acknowledged in this review. Despite these challenges, the transformative impact of real-time data analytics on the retail sector is undeniable. As technology continues to advance, the synergy between real-time data analytics and retail practices is expected to deepen, fostering innovation and reshaping the industry's landscape. This study provides a glimpse into the dynamic and evolving realm of real-time data analytics in retail, offering insights into the strategies employed by both the USA and global players to thrive in an era of rapid technological change.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"7 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.30574/gscarr.2024.18.3.0097
Eric Almeida, Eric Almeida Xavier, Anelise Freitas, Isabela Canavezzi Matias
Circadian rhythms, are the basis of homeostasis of organisms like human and other mammals. Violation of circadian rhythms leads to the development of pathological conditions and severe course of preexisting pathologies. For example some work with B16-F1O cells (B16) has shown that molecules like opsins, Circadian Locomotor Output Cycles Kaput (CLOCK) and clock genes are changed after a white light pulse (WLP). Like this, melanopsin (OPN4) and rhodopsin (OPN2) through UVA irradiation induced B16 pigmentation. Thus, heat shock reduces secreted rhodopsin expression in normal Melan-a melanocytes, while the opposite effect is found in malignant B16 cells. In both cell lines UVA radiation increases the expression of melanopsin and melanin, interfering with several clock genes, and also increasing the DNA repair enzyme xeroderma pigmentosum, complementation group A (XPA). Furthermore, B16 are more responsive to UVA radiation when compared to normal cells. Thereby, opsins are involved in animal camouflage. And their functions in humans involve different wavelengths, for example in skin the keratinocyte differentiation by (410 nm) involved cone opsin (OPN1) and rhodopsin (OPN2), like this in epidermal keratinocytes irradiation by (447 nm) accelerates closure in wound-healing and violet light (415 nm) induced hyperpigmentation. Furthermore, in B16 cell culture certain wavelengths induce proliferation or inhibition like signs of apoptosis and necrosis. Finally understanding the response of opsins and clock genes to different wavelengths in the skin, we could attribute a therapeutic of photobiomodulation (PBM) to approach various dermatological conditions, such as psoriasis, atopic dermatitis, hair growth, wound healing and tissue regeneration.
{"title":"Human and animal cells under influence of different lighting and stimulus","authors":"Eric Almeida, Eric Almeida Xavier, Anelise Freitas, Isabela Canavezzi Matias","doi":"10.30574/gscarr.2024.18.3.0097","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0097","url":null,"abstract":"Circadian rhythms, are the basis of homeostasis of organisms like human and other mammals. Violation of circadian rhythms leads to the development of pathological conditions and severe course of preexisting pathologies. For example some work with B16-F1O cells (B16) has shown that molecules like opsins, Circadian Locomotor Output Cycles Kaput (CLOCK) and clock genes are changed after a white light pulse (WLP). Like this, melanopsin (OPN4) and rhodopsin (OPN2) through UVA irradiation induced B16 pigmentation. Thus, heat shock reduces secreted rhodopsin expression in normal Melan-a melanocytes, while the opposite effect is found in malignant B16 cells. In both cell lines UVA radiation increases the expression of melanopsin and melanin, interfering with several clock genes, and also increasing the DNA repair enzyme xeroderma pigmentosum, complementation group A (XPA). Furthermore, B16 are more responsive to UVA radiation when compared to normal cells. Thereby, opsins are involved in animal camouflage. And their functions in humans involve different wavelengths, for example in skin the keratinocyte differentiation by (410 nm) involved cone opsin (OPN1) and rhodopsin (OPN2), like this in epidermal keratinocytes irradiation by (447 nm) accelerates closure in wound-healing and violet light (415 nm) induced hyperpigmentation. Furthermore, in B16 cell culture certain wavelengths induce proliferation or inhibition like signs of apoptosis and necrosis. Finally understanding the response of opsins and clock genes to different wavelengths in the skin, we could attribute a therapeutic of photobiomodulation (PBM) to approach various dermatological conditions, such as psoriasis, atopic dermatitis, hair growth, wound healing and tissue regeneration.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"51 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This literature review critically evaluates the fairness of credit scoring models concerning mortgage accessibility for under-reserved populations. The review scrutinizes a diverse range of scholarly articles, reports, and empirical studies spanning various disciplines, including finance, economics, sociology, and public policy. It examines the methodologies, findings, and limitations of existing research to illuminate the multifaceted dimensions of credit scoring fairness and its implications for mortgage accessibility. Firstly, the review outlines the conceptual framework of credit scoring fairness, emphasizing the importance of equality, transparency, and accountability in credit assessment processes. It explores the evolution of credit scoring models and their impact on mortgage lending practices, particularly for historically marginalized communities such as racial minorities, low-income households, and individuals with limited credit histories. Secondly, the review analyzes the methodologies employed in evaluating the fairness of credit scoring models. It identifies key metrics and statistical techniques used to assess disparities in mortgage approval rates, interest rates, and loan terms across demographic groups. Thirdly, the review synthesizes empirical evidence on the extent and persistence of disparities in mortgage accessibility for under-reserved populations. It highlights systemic barriers, including discriminatory lending practices, redlining, and institutionalized biases embedded within credit scoring models. Fourthly, the review discusses the implications of credit scoring fairness for financial inclusion, social equity, and economic mobility. It underscores the need for innovative policy interventions, industry best practices, and consumer education initiatives to address systemic inequities in mortgage lending and promote inclusive homeownership opportunities for under-reserved, Finally, this literature review offers a comprehensive overview of the fairness of credit scoring models in the context of mortgage accessibility for under-reserved populations. By synthesizing empirical evidence, theoretical frameworks, and policy implications, it contributes to a deeper understanding of the challenges and opportunities in promoting equitable access to homeownership and financial security for all.
{"title":"Evaluating the fairness of credit scoring models: A literature review on mortgage accessibility for under-reserved populations","authors":"Taiwo Inumidun Adegoke, Onyeka Chrisanctus Ofodile, Nneka Adaobi Ochuba, Olatunji Akinrinola","doi":"10.30574/gscarr.2024.18.3.0104","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0104","url":null,"abstract":"This literature review critically evaluates the fairness of credit scoring models concerning mortgage accessibility for under-reserved populations. The review scrutinizes a diverse range of scholarly articles, reports, and empirical studies spanning various disciplines, including finance, economics, sociology, and public policy. It examines the methodologies, findings, and limitations of existing research to illuminate the multifaceted dimensions of credit scoring fairness and its implications for mortgage accessibility. Firstly, the review outlines the conceptual framework of credit scoring fairness, emphasizing the importance of equality, transparency, and accountability in credit assessment processes. It explores the evolution of credit scoring models and their impact on mortgage lending practices, particularly for historically marginalized communities such as racial minorities, low-income households, and individuals with limited credit histories. Secondly, the review analyzes the methodologies employed in evaluating the fairness of credit scoring models. It identifies key metrics and statistical techniques used to assess disparities in mortgage approval rates, interest rates, and loan terms across demographic groups. Thirdly, the review synthesizes empirical evidence on the extent and persistence of disparities in mortgage accessibility for under-reserved populations. It highlights systemic barriers, including discriminatory lending practices, redlining, and institutionalized biases embedded within credit scoring models. Fourthly, the review discusses the implications of credit scoring fairness for financial inclusion, social equity, and economic mobility. It underscores the need for innovative policy interventions, industry best practices, and consumer education initiatives to address systemic inequities in mortgage lending and promote inclusive homeownership opportunities for under-reserved, Finally, this literature review offers a comprehensive overview of the fairness of credit scoring models in the context of mortgage accessibility for under-reserved populations. By synthesizing empirical evidence, theoretical frameworks, and policy implications, it contributes to a deeper understanding of the challenges and opportunities in promoting equitable access to homeownership and financial security for all.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"46 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.30574/gscarr.2024.18.3.0094
Michael Alurame Eruaga, Esther Oleiye Itua, James Tabat Bature
The regulation of herbal medicine in Nigeria stands at the intersection of tradition and modernity, presenting a complex landscape shaped by historical practices, cultural beliefs, and contemporary healthcare standards. This paper delves into the intricate dynamics surrounding the regulation of herbal medicine in Nigeria, aiming to elucidate the challenges and opportunities inherent in balancing traditional practices with modern regulatory standards. Drawing from a multidisciplinary approach encompassing medical anthropology, public health, and legal studies, this research explores the historical roots of herbal medicine in Nigeria, tracing its evolution from indigenous healing practices to its current status within the broader healthcare system. It examines the cultural significance of traditional medicine, considering its role in local communities and its enduring relevance in addressing healthcare needs, particularly in underserved rural areas. However, alongside the rich tapestry of traditional healing, concerns regarding safety, efficacy, and standardization have prompted calls for regulatory reforms to align herbal medicine practices with modern healthcare standards. This paper scrutinizes the existing regulatory frameworks governing herbal medicine in Nigeria, analyzing the strengths, weaknesses, and gaps therein. It explores the tension between preserving traditional knowledge and ensuring consumer protection, highlighting the need for a nuanced approach that respects cultural heritage while safeguarding public health. Furthermore, this research assesses the implications of regulatory interventions on various stakeholders, including herbal practitioners, consumers, and policymakers. It considers strategies for enhancing collaboration between traditional healers and the formal healthcare sector, fostering mutual respect, and promoting evidence-based practices. Ultimately, this study underscores the imperative of striking a delicate balance between tradition and modernity in regulating herbal medicine in Nigeria, advocating for a harmonized approach that upholds both cultural integrity and healthcare quality.
{"title":"Exploring herbal medicine regulation in Nigeria: Balancing traditional practices with modern standards","authors":"Michael Alurame Eruaga, Esther Oleiye Itua, James Tabat Bature","doi":"10.30574/gscarr.2024.18.3.0094","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0094","url":null,"abstract":"The regulation of herbal medicine in Nigeria stands at the intersection of tradition and modernity, presenting a complex landscape shaped by historical practices, cultural beliefs, and contemporary healthcare standards. This paper delves into the intricate dynamics surrounding the regulation of herbal medicine in Nigeria, aiming to elucidate the challenges and opportunities inherent in balancing traditional practices with modern regulatory standards. Drawing from a multidisciplinary approach encompassing medical anthropology, public health, and legal studies, this research explores the historical roots of herbal medicine in Nigeria, tracing its evolution from indigenous healing practices to its current status within the broader healthcare system. It examines the cultural significance of traditional medicine, considering its role in local communities and its enduring relevance in addressing healthcare needs, particularly in underserved rural areas. However, alongside the rich tapestry of traditional healing, concerns regarding safety, efficacy, and standardization have prompted calls for regulatory reforms to align herbal medicine practices with modern healthcare standards. This paper scrutinizes the existing regulatory frameworks governing herbal medicine in Nigeria, analyzing the strengths, weaknesses, and gaps therein. It explores the tension between preserving traditional knowledge and ensuring consumer protection, highlighting the need for a nuanced approach that respects cultural heritage while safeguarding public health. Furthermore, this research assesses the implications of regulatory interventions on various stakeholders, including herbal practitioners, consumers, and policymakers. It considers strategies for enhancing collaboration between traditional healers and the formal healthcare sector, fostering mutual respect, and promoting evidence-based practices. Ultimately, this study underscores the imperative of striking a delicate balance between tradition and modernity in regulating herbal medicine in Nigeria, advocating for a harmonized approach that upholds both cultural integrity and healthcare quality.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"32 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Surgical site infections (SSIs) in orthopaedic surgeries pose a significant risk to outcomes. These infections ranging from superficial to periprosthetic joint complications result from various factors including patient-related conditions and environmental factors. Staphylococcus aureus, with increasing antibiotic resistance, is a predominant cause. Perioperative antibiotic prophylaxis recommended by the WHO is crucial. Establishing national surveillance considering local antibiotic resistance and continuous auditing are essential for formulating effective guidelines to prevent and manage SSIs. Methods: This is a retrospective study conducted at a tertiary care hospital from December 2022 to November 2023 at the orthopaedic unit. The study population was all the patients who had surgical site infections following clean orthopaedic surgeries during the study period. An institutional-level ethical clearance was obtained. Results: This retrospective study conducted at a tertiary orthopaedic unit in Jaffna, Sri Lanka, aimed to investigate surgical site infections (SSI) following clean orthopaedic surgeries. Analyzing data from 1676 surgeries over one year, the study identified 83 culture-proven SSIs, yielding an annual incidence of 4.95%. The majority of SSIs occurred in males (62.7%) and were associated predominantly with lower limb surgeries (83.1%). Contrary to global trends, Pseudomonas emerged as the most common causative organism (31.3%). Discussion: Notably, the study revealed significant variations in antibiotic sensitivity patterns among isolated organisms. While Pseudomonas exhibited sensitivity to a wide range of antibiotics, coliforms displayed resistance to several agents. This emphasizes regional and institutional differences in antibiotic resistance patterns. Conclusion: Continuous large-scale institutional audits are crucial for shaping effective antibiotic policies. The study underscores the dynamic nature of SSI aetiology, emphasizing the need for tailored preventive measures based on regional data.
{"title":"Prevalence of surgical site infections and antibiotic resistance pattern in a Tertiary care Orthopaedic unit","authors":"S. Gobinath, Thanabalasingam Satheeskumar, Sivarajah Ushjenthan, Thayasivam Gobyshanger, Aerampamoorthy Janithree, Paramanathan Shathana","doi":"10.30574/gscarr.2024.18.3.0100","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0100","url":null,"abstract":"Introduction: Surgical site infections (SSIs) in orthopaedic surgeries pose a significant risk to outcomes. These infections ranging from superficial to periprosthetic joint complications result from various factors including patient-related conditions and environmental factors. Staphylococcus aureus, with increasing antibiotic resistance, is a predominant cause. Perioperative antibiotic prophylaxis recommended by the WHO is crucial. Establishing national surveillance considering local antibiotic resistance and continuous auditing are essential for formulating effective guidelines to prevent and manage SSIs. Methods: This is a retrospective study conducted at a tertiary care hospital from December 2022 to November 2023 at the orthopaedic unit. The study population was all the patients who had surgical site infections following clean orthopaedic surgeries during the study period. An institutional-level ethical clearance was obtained. Results: This retrospective study conducted at a tertiary orthopaedic unit in Jaffna, Sri Lanka, aimed to investigate surgical site infections (SSI) following clean orthopaedic surgeries. Analyzing data from 1676 surgeries over one year, the study identified 83 culture-proven SSIs, yielding an annual incidence of 4.95%. The majority of SSIs occurred in males (62.7%) and were associated predominantly with lower limb surgeries (83.1%). Contrary to global trends, Pseudomonas emerged as the most common causative organism (31.3%). Discussion: Notably, the study revealed significant variations in antibiotic sensitivity patterns among isolated organisms. While Pseudomonas exhibited sensitivity to a wide range of antibiotics, coliforms displayed resistance to several agents. This emphasizes regional and institutional differences in antibiotic resistance patterns. Conclusion: Continuous large-scale institutional audits are crucial for shaping effective antibiotic policies. The study underscores the dynamic nature of SSI aetiology, emphasizing the need for tailored preventive measures based on regional data.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"44 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140361905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.30574/gscarr.2024.18.3.0083
Ashraf Alakkad, A. Chehal, Norbert W Dreier
Background: Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of cancer, characterized by its high propensity for metastasis. Patients who experience the development of brain metastases (BMs) and visceral metastasis face a challenging prognosis, as effective systemic treatment options for this specific condition are limited. Case presentation: This case report describes the journey of a 42-year-old female patient diagnosed with left-sided triple-negative breast cancer with metastasis to the lymph nodes, bone, and brain. The patient underwent a combination of chemotherapy, immunotherapy, and targeted therapy, showing an initial response but subsequent disease progression. Multiple treatment modalities, including surgery, radiotherapy, including stereotactic radiotherapy, were employed to manage the metastases. The patient experienced complications such as anemia and hypocalcemia and received supportive care. Serial imaging, including positron emission tomography and MRI, were utilized for monitoring treatment response and disease progression documented. Conclusion: The findings of this case report provide support for considering sacituzumab govitecan as a potential treatment option for recurrent and even BRCA-mutant triple-negative breast cancer (TNBC). Notably, sacituzumab govitecan demonstrated high activity in the presence of active bone and brain metastases.
{"title":"Stage IV Triple-negative breast cancer with brain and visceral metastasis has a complete response to sacituzumab govitecan: A Case Report","authors":"Ashraf Alakkad, A. Chehal, Norbert W Dreier","doi":"10.30574/gscarr.2024.18.3.0083","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0083","url":null,"abstract":"Background: Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of cancer, characterized by its high propensity for metastasis. Patients who experience the development of brain metastases (BMs) and visceral metastasis face a challenging prognosis, as effective systemic treatment options for this specific condition are limited. Case presentation: This case report describes the journey of a 42-year-old female patient diagnosed with left-sided triple-negative breast cancer with metastasis to the lymph nodes, bone, and brain. The patient underwent a combination of chemotherapy, immunotherapy, and targeted therapy, showing an initial response but subsequent disease progression. Multiple treatment modalities, including surgery, radiotherapy, including stereotactic radiotherapy, were employed to manage the metastases. The patient experienced complications such as anemia and hypocalcemia and received supportive care. Serial imaging, including positron emission tomography and MRI, were utilized for monitoring treatment response and disease progression documented. Conclusion: The findings of this case report provide support for considering sacituzumab govitecan as a potential treatment option for recurrent and even BRCA-mutant triple-negative breast cancer (TNBC). Notably, sacituzumab govitecan demonstrated high activity in the presence of active bone and brain metastases.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"56 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-30DOI: 10.30574/gscarr.2024.18.3.0087
Anthony Chigozie Anyanwu
This paper presents an open source platform aimed at revolutionizing healthcare delivery in the United States by significantly reducing the cost of virtual healthcare software. The proposed platform addresses the pressing challenges of accessibility and efficiency in the U.S. healthcare sector through cloud native backend solutions and mobile apps driven by modular design and IoT-enabled devices. By leveraging IoT technology, virtual healthcare platforms can provide real-time monitoring, remote consultations, and personalized care, thereby improving patient outcomes and reducing healthcare costs. The platform emphasizes nationwide scalability, inclusivity, and a transition towards a proactive, patient-centric healthcare model. By leveraging the opensource community, modular design and a plugin architecture, it aims to enable feature extensibility beyond what is foreseeable today, promote interoperability, ensure data privacy and security, and promote technology adoption among healthcare providers and patients. The proposal presented in this paper lays the foundation for the implementation aimed at harnessing the full potential of IoT and virtual healthcare to enhance accessibility and efficiency in the U.S. healthcare sector, ultimately advancing the quality of care and well-being of the population.
{"title":"Integrating IoT with Virtual Healthcare: A theoretical framework for enhancing accessibility and efficiency in the U.S. healthcare sector","authors":"Anthony Chigozie Anyanwu","doi":"10.30574/gscarr.2024.18.3.0087","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0087","url":null,"abstract":"This paper presents an open source platform aimed at revolutionizing healthcare delivery in the United States by significantly reducing the cost of virtual healthcare software. The proposed platform addresses the pressing challenges of accessibility and efficiency in the U.S. healthcare sector through cloud native backend solutions and mobile apps driven by modular design and IoT-enabled devices. By leveraging IoT technology, virtual healthcare platforms can provide real-time monitoring, remote consultations, and personalized care, thereby improving patient outcomes and reducing healthcare costs. The platform emphasizes nationwide scalability, inclusivity, and a transition towards a proactive, patient-centric healthcare model. By leveraging the opensource community, modular design and a plugin architecture, it aims to enable feature extensibility beyond what is foreseeable today, promote interoperability, ensure data privacy and security, and promote technology adoption among healthcare providers and patients. The proposal presented in this paper lays the foundation for the implementation aimed at harnessing the full potential of IoT and virtual healthcare to enhance accessibility and efficiency in the U.S. healthcare sector, ultimately advancing the quality of care and well-being of the population.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"45 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As artificial intelligence (AI) continues to permeate various aspects of our lives, the ethical challenges associated with its development become increasingly apparent. This paper navigates and reviews the ethical dilemmas in AI development, focusing on strategies to promote transparency, fairness, and accountability. The rapid growth of AI technology has given rise to concerns related to bias, lack of transparency, and the need for clear accountability mechanisms. In this exploration, we delve into the intricate ethical landscape of AI, examining issues such as bias and fairness, lack of transparency, and the challenges associated with accountability. To address these concerns, we propose strategies for transparency, including the implementation of Explainable AI (XAI), advocating for open data sharing, and embracing ethical AI frameworks. Furthermore, we explore strategies to promote fairness in AI algorithms, emphasizing the importance of fairness metrics, diverse training data, and continuous monitoring for iterative improvement. Additionally, the paper delves into strategies to ensure accountability in AI development, considering regulatory measures, ethical AI governance, and the incorporation of human-in-the-loop approaches. To provide practical insights, case studies and real-world examples are analyzed to distill lessons learned and best practices. The paper concludes with a comprehensive overview of the proposed strategies, emphasizing the importance of balancing innovation with ethical responsibility in the evolving landscape of AI development. This work contributes to the ongoing discourse on AI ethics, offering a roadmap for navigating the challenges and fostering responsible AI development practices.
{"title":"Navigating and reviewing ethical dilemmas in AI development: Strategies for transparency, fairness, and accountability","authors":"Olatunji Akinrinola, Chinwe Chinazo Okoye, Onyeka Chrisanctus Ofodile, Chinonye Esther Ugochukwu","doi":"10.30574/gscarr.2024.18.3.0088","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0088","url":null,"abstract":"As artificial intelligence (AI) continues to permeate various aspects of our lives, the ethical challenges associated with its development become increasingly apparent. This paper navigates and reviews the ethical dilemmas in AI development, focusing on strategies to promote transparency, fairness, and accountability. The rapid growth of AI technology has given rise to concerns related to bias, lack of transparency, and the need for clear accountability mechanisms. In this exploration, we delve into the intricate ethical landscape of AI, examining issues such as bias and fairness, lack of transparency, and the challenges associated with accountability. To address these concerns, we propose strategies for transparency, including the implementation of Explainable AI (XAI), advocating for open data sharing, and embracing ethical AI frameworks. Furthermore, we explore strategies to promote fairness in AI algorithms, emphasizing the importance of fairness metrics, diverse training data, and continuous monitoring for iterative improvement. Additionally, the paper delves into strategies to ensure accountability in AI development, considering regulatory measures, ethical AI governance, and the incorporation of human-in-the-loop approaches. To provide practical insights, case studies and real-world examples are analyzed to distill lessons learned and best practices. The paper concludes with a comprehensive overview of the proposed strategies, emphasizing the importance of balancing innovation with ethical responsibility in the evolving landscape of AI development. This work contributes to the ongoing discourse on AI ethics, offering a roadmap for navigating the challenges and fostering responsible AI development practices.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"40 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adolescence means "stepping into adult life." It is a prepubertal phase where the transmutation of childhood into adulthood occurs and the physical and psychosomatic growth of a child takes place. This study has focused on Normal & Over Weight in school going children aged between 10 and 19 years, and their status in skill related fitness. The minimum sample size for each group = 100. The subjects taken into the study were adolescent children with an age group of 10-19 years. For the study, all the students were taken from school who were studying between the 5th standard to 12th standards. After screening the children, the eligible students were randomly called to have their body composition assessed class and section-wise. The children were divided into two groups based on their Body Mass Index (BMI). The BMI was assessed with the weight in kgs divided by height in meters square of the child. The children were divided into two group and skill fitness outcome measures namely Broad Jump Test (BJT); Hand Grip Strength Test (HGS); Bent Arm Hang Test (BAH) were used. This study concluded that the physical fitness that includes skill fitness was decreased in Overweight than Normal weight adolescent boys and girls.
{"title":"Variations of skill-related fitness components in normal and overweight high school children","authors":"Ajeet Kumar, Preeti Sharma, A. Saharan, Manisha Saharan, Dharmita Yogeshwar, Maliram Sharma","doi":"10.30574/gscarr.2024.18.3.0079","DOIUrl":"https://doi.org/10.30574/gscarr.2024.18.3.0079","url":null,"abstract":"Adolescence means \"stepping into adult life.\" It is a prepubertal phase where the transmutation of childhood into adulthood occurs and the physical and psychosomatic growth of a child takes place. This study has focused on Normal & Over Weight in school going children aged between 10 and 19 years, and their status in skill related fitness. The minimum sample size for each group = 100. The subjects taken into the study were adolescent children with an age group of 10-19 years. For the study, all the students were taken from school who were studying between the 5th standard to 12th standards. After screening the children, the eligible students were randomly called to have their body composition assessed class and section-wise. The children were divided into two groups based on their Body Mass Index (BMI). The BMI was assessed with the weight in kgs divided by height in meters square of the child. The children were divided into two group and skill fitness outcome measures namely Broad Jump Test (BJT); Hand Grip Strength Test (HGS); Bent Arm Hang Test (BAH) were used. This study concluded that the physical fitness that includes skill fitness was decreased in Overweight than Normal weight adolescent boys and girls.","PeriodicalId":12791,"journal":{"name":"GSC Advanced Research and Reviews","volume":"43 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140364189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：