Pub Date : 2014-12-31DOI: 10.15188/KJOPP.2014.12.28.6.577
Okha Lee, Yun Im Jung, G. Bae, Kyu Kwon
The purpose of this study was to examine how the term Yin-Yang and Sasang categorized in the book 『Huangdineijing』. In order to investigate how the terms are used, we reviewed the text including the terms expressed in the manner of [(Yin/Yang) within (Yin/Yang)] and [Sasang]. We found three forms of expressions; [(Yin/Yang) within (Yin/Yang)], [Sasang], [(Sasang) within (Yin/Yang)]. Two paragraphs of [(Yin/Yang) within (Yin/Yang)] was found in one chapter, two paragraphs of [(Sasang)] was found in two chapters, and three paragraphs of [(Sasang) within (Yin/Yang)] was found in three chapters. We found five types of relation between [(Yin/Yang) within (Yin/Yang)], [Sasang], and five phases in 『Huangdi neijing』 as follows; ① Yang within Yin, lesser Yang, and wood ② Yang within Yang, greater Yang, and fire ③ ( ), ( ), and extreme Yin ④ Yin within Yang, lesser Yin, and metal, and ⑤ Yin within Yin, greater Yin, and water. And, as for the [(Yin/Yang) within (Yin/Yang)] and [(Sasang) within (Yin/Yang)], the classification criteria for Yin-Yang were brightness, abdomen/back or lumbar. The order of Sasang with the description form of [Sasang] or [(Sasang) within (Yin/Yang)] in 「Siqi Tiaoshen Dalun」 and 「Liu Jie ZangXiang Theory」 was lesser Yang, greater Yang, greater Yin, and lesser Yin, which is based on the meridian system or a plant-shaped change order. We discussed the results and its implication for the analysis of medical classics with the consideration of previous studies on Yin-Yang theories in 『Huangdi neijing』.
{"title":"Study on the M eaning of Yin-Yang and Sasang in the \"Huangdineijing \"","authors":"Okha Lee, Yun Im Jung, G. Bae, Kyu Kwon","doi":"10.15188/KJOPP.2014.12.28.6.577","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.12.28.6.577","url":null,"abstract":"The purpose of this study was to examine how the term Yin-Yang and Sasang categorized in the book 『Huangdineijing』. In order to investigate how the terms are used, we reviewed the text including the terms expressed in the manner of [(Yin/Yang) within (Yin/Yang)] and [Sasang]. We found three forms of expressions; [(Yin/Yang) within (Yin/Yang)], [Sasang], [(Sasang) within (Yin/Yang)]. Two paragraphs of [(Yin/Yang) within (Yin/Yang)] was found in one chapter, two paragraphs of [(Sasang)] was found in two chapters, and three paragraphs of [(Sasang) within (Yin/Yang)] was found in three chapters. We found five types of relation between [(Yin/Yang) within (Yin/Yang)], [Sasang], and five phases in 『Huangdi neijing』 as follows; ① Yang within Yin, lesser Yang, and wood ② Yang within Yang, greater Yang, and fire ③ ( ), ( ), and extreme Yin ④ Yin within Yang, lesser Yin, and metal, and ⑤ Yin within Yin, greater Yin, and water. And, as for the [(Yin/Yang) within (Yin/Yang)] and [(Sasang) within (Yin/Yang)], the classification criteria for Yin-Yang were brightness, abdomen/back or lumbar. The order of Sasang with the description form of [Sasang] or [(Sasang) within (Yin/Yang)] in 「Siqi Tiaoshen Dalun」 and 「Liu Jie ZangXiang Theory」 was lesser Yang, greater Yang, greater Yin, and lesser Yin, which is based on the meridian system or a plant-shaped change order. We discussed the results and its implication for the analysis of medical classics with the consideration of previous studies on Yin-Yang theories in 『Huangdi neijing』.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131317131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-31DOI: 10.15188/KJOPP.2014.12.28.6.601
H. Jeong
{"title":"Effects of Acupuncture at the Wijung(BL40) and Chok-Samni(ST36) on the Cerebral Blood Flow and Blood Pressure","authors":"H. Jeong","doi":"10.15188/KJOPP.2014.12.28.6.601","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.12.28.6.601","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123558400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-31DOI: 10.17208/KJOPP.2014.12.28.6.650
Y. Moon, J. Oh, Seon Jong Kim
The purpose of this study is to investigate the effect of 2 Kobangs. Daecheongryong-tang and Samhwangsasim-tang on to two psoriasis patients each. The improvement of the skin condition was observed by Psoriasis Area and Severity Index (PASI) score. The patient treated with Daecheongryong-tang showed significant improvement after the patient's state of sweating improved and the PASI score of the patient reduced from 17.6 to 1.8 after five months of treatment. The patient treated with Samhwangsasim-tang showed gradual improvement after the patient's defecation was improved and the PASI score of the patient reduced from 27.3 to 3.6 after three months of treatment. According to the results, we obtained clinically positive effects from 2 Kobangs applied on 2 psoriasis cases respectively. Although there were few reports on psoriasis treated with Kobang, we can suggest effective treatment on psoriasis.
{"title":"Two different Cases of Psoriasis Patients Treated with 2 different Kobangs","authors":"Y. Moon, J. Oh, Seon Jong Kim","doi":"10.17208/KJOPP.2014.12.28.6.650","DOIUrl":"https://doi.org/10.17208/KJOPP.2014.12.28.6.650","url":null,"abstract":"The purpose of this study is to investigate the effect of 2 Kobangs. Daecheongryong-tang and Samhwangsasim-tang on to two psoriasis patients each. The improvement of the skin condition was observed by Psoriasis Area and Severity Index (PASI) score. The patient treated with Daecheongryong-tang showed significant improvement after the patient's state of sweating improved and the PASI score of the patient reduced from 17.6 to 1.8 after five months of treatment. The patient treated with Samhwangsasim-tang showed gradual improvement after the patient's defecation was improved and the PASI score of the patient reduced from 27.3 to 3.6 after three months of treatment. According to the results, we obtained clinically positive effects from 2 Kobangs applied on 2 psoriasis cases respectively. Although there were few reports on psoriasis treated with Kobang, we can suggest effective treatment on psoriasis.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128679450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-31DOI: 10.15188/KJOPP.2014.12.28.6.585
Jong-min Kim, Hyung-joon Jeon, Seungyoo Kim, C. Cho, Chul Jung, Hwa-Seung Yoo
This study is to develop a standard tool for pattern identifications in Korean Medicine for Lung Cancer. The advisor committee for this study was organized by 12 Korean Medicine professors from the Korean Association of Traditional Oncology. The item and structure of instrument were based on review of published literature. We took the consultation twice from the advisor committee and additional advices by e-mail correspondences. We divided the symptoms and signs of lung cancer into 6 pattern identifications. - lung spleen both deficiency (肺脾兩虛), lung kidney both deficiency (肺腎兩虛), dampness phlegm obstructing the lung (濕痰蘊肺), qi stagnation blood stasis (氣滯血瘀), yin deficiency toxin heat (陰虛毒熱), and heat toxin accumulation (熱毒蘊結). We obtained the mean weights which reflected the standard deviations from each symptoms of the 6 pattern identifications which were scored on a 5-point scale by 12 experts. We designed the Korean medicine pattern identification tool for lung cancer. It was composed of 57 questions in the question-and-answer format. Though there are some limits that this study is not proved about validity and reliability, the instrument is meaningful and expected to be applied to the subsequent research.
{"title":"Preliminary Study to Develop the Instrument on Pattern Identification for Lung Cancer","authors":"Jong-min Kim, Hyung-joon Jeon, Seungyoo Kim, C. Cho, Chul Jung, Hwa-Seung Yoo","doi":"10.15188/KJOPP.2014.12.28.6.585","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.12.28.6.585","url":null,"abstract":"This study is to develop a standard tool for pattern identifications in Korean Medicine for Lung Cancer. The advisor committee for this study was organized by 12 Korean Medicine professors from the Korean Association of Traditional Oncology. The item and structure of instrument were based on review of published literature. We took the consultation twice from the advisor committee and additional advices by e-mail correspondences. We divided the symptoms and signs of lung cancer into 6 pattern identifications. - lung spleen both deficiency (肺脾兩虛), lung kidney both deficiency (肺腎兩虛), dampness phlegm obstructing the lung (濕痰蘊肺), qi stagnation blood stasis (氣滯血瘀), yin deficiency toxin heat (陰虛毒熱), and heat toxin accumulation (熱毒蘊結). We obtained the mean weights which reflected the standard deviations from each symptoms of the 6 pattern identifications which were scored on a 5-point scale by 12 experts. We designed the Korean medicine pattern identification tool for lung cancer. It was composed of 57 questions in the question-and-answer format. Though there are some limits that this study is not proved about validity and reliability, the instrument is meaningful and expected to be applied to the subsequent research.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123751348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-31DOI: 10.15188/KJOPP.2014.12.28.6.674
M. Song, C. Choi
{"title":"A Study on Reliability and Applicability of Oriental M edical M usic Therapy Using","authors":"M. Song, C. Choi","doi":"10.15188/KJOPP.2014.12.28.6.674","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.12.28.6.674","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130304362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-31DOI: 10.15188/KJOPP.2014.12.28.6.630
N. Hong, Tae Seok Ahn, H. Park, H. Chae, Y. Kwon, B. Kim
{"title":"Inhibitory Effects of Naeso-san on Pacemaker Potentials in Interstitial Cells of Cajal of Murine Small Intestine","authors":"N. Hong, Tae Seok Ahn, H. Park, H. Chae, Y. Kwon, B. Kim","doi":"10.15188/KJOPP.2014.12.28.6.630","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.12.28.6.630","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"590 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123132284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-31DOI: 10.15188/KJOPP.2014.12.28.6.662
Jihye Kim, Han-li Yu, Boncho Ku, Hyunho Kim, Jong-Yeol Kim, Y. Jeon
寸口脈診은 望聞問切의 四診 중 切診의 하나로, 환자의 손목부 분 요골동맥 맥상파를 측정함으로써 건강 또는 질병에 대한 정보를 얻어 생리, 병리적 상태를 진단하는 방법이다1). 한의사는 손가락 감 각을 이용하여 경맥의 박동상태를 관찰함으로써 환자의 氣血盛衰와 병의 順逆 및 進退를 판별할 수 있으며1), 五臟六腑와 經絡의 상태 를 진단할 수 있다2). 이는 병의 치료근거를 파악하는 과정에서 한의 학이 가지는 고유한 특성인 辨證施治에 있어 매우 중요한 수단이다. 맥상파에 영향을 주는 인자로는 季節의 外因 외에도, 인체의 體質 적인 특성, 性別, 年齡, 정신적·육체적 虛勞, 飮食攝食, 七情, 여성 의 月經 등이 거론되고 있다. 맥진은 측정이 용이한 비침습적 진단방법이라는 점에서 강점을 가지나 이를 측정하는 측정자의 감각에 의존하기 때문에 주관적인 견해가 개입될 요소가 많다는 한계점도 존재한다. 이러한 한계점을 해결하고자 전통적 맥진의 객관화와 정량화를 위한 방안으로 다양 한 방식의 맥진기가 개발되고 있으며, 현재까지 국내외에서 많은 연 구가 진행되어 왔다. 국내 한의학계에서 이루어진 맥진 연구들은 맥 측정기기의 정 밀도와 재현성을 높이는 연구와 맥진에 대한 문헌조사3) 및 식사에 따른 맥상파 변화 연구4-6), 당뇨병 및 사상체질과 맥상파 변화 연구 7-9), 중풍환자의 맥진 지표 연구10), 성별 및 연령에 따른 맥상파 차 이 연구11-13), 심혈관 노화에 따른 맥상파 변화 연구14,15), 맥진기 개 발 수요조사16,17), 맥진기술동향 조사18) 등에 대한 연구가 이루어졌 음을 확인할 수 있었다. 그 동안의 연구를 살펴보면 맥상파와 병인 변증에 대한 연구는 주로 실험 논문과 문헌 고찰이 대부분을 차지 하고 있고, 그 중 임상연구는 전체 연구에서 2%를 약간 상회하는 정도로 거의 진행된 바가 없었다. 따라서 맥상파와 병인변증 간의 연관성을 검증하는 임상시험의 필요성을 확인한 바 예비 임상시험을 진행하고자 한다. 본 논문은 병인변증과 요골동맥 맥상파의 특성 파악을 위한 탐색적 관찰 연구 :
{"title":"Development of Clinical Protocol on the Correlation Between Disease Cause Pattern I dentification and Pulse Wave Variables","authors":"Jihye Kim, Han-li Yu, Boncho Ku, Hyunho Kim, Jong-Yeol Kim, Y. Jeon","doi":"10.15188/KJOPP.2014.12.28.6.662","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.12.28.6.662","url":null,"abstract":"寸口脈診은 望聞問切의 四診 중 切診의 하나로, 환자의 손목부 분 요골동맥 맥상파를 측정함으로써 건강 또는 질병에 대한 정보를 얻어 생리, 병리적 상태를 진단하는 방법이다1). 한의사는 손가락 감 각을 이용하여 경맥의 박동상태를 관찰함으로써 환자의 氣血盛衰와 병의 順逆 및 進退를 판별할 수 있으며1), 五臟六腑와 經絡의 상태 를 진단할 수 있다2). 이는 병의 치료근거를 파악하는 과정에서 한의 학이 가지는 고유한 특성인 辨證施治에 있어 매우 중요한 수단이다. 맥상파에 영향을 주는 인자로는 季節의 外因 외에도, 인체의 體質 적인 특성, 性別, 年齡, 정신적·육체적 虛勞, 飮食攝食, 七情, 여성 의 月經 등이 거론되고 있다. 맥진은 측정이 용이한 비침습적 진단방법이라는 점에서 강점을 가지나 이를 측정하는 측정자의 감각에 의존하기 때문에 주관적인 견해가 개입될 요소가 많다는 한계점도 존재한다. 이러한 한계점을 해결하고자 전통적 맥진의 객관화와 정량화를 위한 방안으로 다양 한 방식의 맥진기가 개발되고 있으며, 현재까지 국내외에서 많은 연 구가 진행되어 왔다. 국내 한의학계에서 이루어진 맥진 연구들은 맥 측정기기의 정 밀도와 재현성을 높이는 연구와 맥진에 대한 문헌조사3) 및 식사에 따른 맥상파 변화 연구4-6), 당뇨병 및 사상체질과 맥상파 변화 연구 7-9), 중풍환자의 맥진 지표 연구10), 성별 및 연령에 따른 맥상파 차 이 연구11-13), 심혈관 노화에 따른 맥상파 변화 연구14,15), 맥진기 개 발 수요조사16,17), 맥진기술동향 조사18) 등에 대한 연구가 이루어졌 음을 확인할 수 있었다. 그 동안의 연구를 살펴보면 맥상파와 병인 변증에 대한 연구는 주로 실험 논문과 문헌 고찰이 대부분을 차지 하고 있고, 그 중 임상연구는 전체 연구에서 2%를 약간 상회하는 정도로 거의 진행된 바가 없었다. 따라서 맥상파와 병인변증 간의 연관성을 검증하는 임상시험의 필요성을 확인한 바 예비 임상시험을 진행하고자 한다. 본 논문은 병인변증과 요골동맥 맥상파의 특성 파악을 위한 탐색적 관찰 연구 :","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133979083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-31DOI: 10.15188/KJOPP.2014.12.28.6.668
Jang-Han Bae, Y. Jeon, Hyunho Kim, Jaeuk U. Kim
Cold and Heat pattern identification(CHPI) in traditional East Asian medicine(TEAM) is one of the major indicator to distinguish characteristics of disease and to determine treatment method. Basic parameters to determine CHPI include the pulse rate, respiration rate, and pulse power. Studies to associate physiological responses of human body by cold stress(CS) with CHPI in TEAM were rarely done so far. This study aims to explore the effects of cold stress on pulse signal via a feasibility study for three subjects and investigate some indices which can reflect autonomic nerve reaction(ANR). We measured radial pulse signals and respiration signal of the investigated subjects before the CS, during the CS which continues for 5 minutes, and immediately after the CS, respectively. Finally, we analyzed the pulse rate (P), respiration rate (R), pulse power, pulse depth, and pulse rate per respiration (P/R ratio). As a result, the P/R ratio showed a consistently decreasing tendency through the CS stimulation process, while other parameters behaved more complex and in subject-specific ways. It implies that, among candidate parameters, the P/R ratio is a simple but the most probable parameter that can be used as the ANR indicator. This result is also consistent with the theory in TEAM scripts, in which the P/R ratio is predicted to be a direct indicator for the CHPI. This pilot study shows that P/R ratio can be more appropriately associated with the ANR than heart rate or respiration rate alone. Extensive studies will be necessary to verify or confirm the P/R ratio as an appropriate and well defined parameter for ANR.
{"title":"A Feasibility Study of Pulse Rate Per Respiration as an Indicator for the Reaction to Cold Stress","authors":"Jang-Han Bae, Y. Jeon, Hyunho Kim, Jaeuk U. Kim","doi":"10.15188/KJOPP.2014.12.28.6.668","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.12.28.6.668","url":null,"abstract":"Cold and Heat pattern identification(CHPI) in traditional East Asian medicine(TEAM) is one of the major indicator to distinguish characteristics of disease and to determine treatment method. Basic parameters to determine CHPI include the pulse rate, respiration rate, and pulse power. Studies to associate physiological responses of human body by cold stress(CS) with CHPI in TEAM were rarely done so far. This study aims to explore the effects of cold stress on pulse signal via a feasibility study for three subjects and investigate some indices which can reflect autonomic nerve reaction(ANR). We measured radial pulse signals and respiration signal of the investigated subjects before the CS, during the CS which continues for 5 minutes, and immediately after the CS, respectively. Finally, we analyzed the pulse rate (P), respiration rate (R), pulse power, pulse depth, and pulse rate per respiration (P/R ratio). As a result, the P/R ratio showed a consistently decreasing tendency through the CS stimulation process, while other parameters behaved more complex and in subject-specific ways. It implies that, among candidate parameters, the P/R ratio is a simple but the most probable parameter that can be used as the ANR indicator. This result is also consistent with the theory in TEAM scripts, in which the P/R ratio is predicted to be a direct indicator for the CHPI. This pilot study shows that P/R ratio can be more appropriately associated with the ANR than heart rate or respiration rate alone. Extensive studies will be necessary to verify or confirm the P/R ratio as an appropriate and well defined parameter for ANR.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130143043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-31DOI: 10.15188/KJOPP.2014.12.28.6.621
Chulkyu Lee, Jong-Min Han, Mi Young Lee, I. Jung, M. Jin, S. Kim, Yang-Chun Park
This study aimed to evaluate the genotoxicity of GST (Gamisasangja-tang). For examining genotoxicity, we carried out bacterial reverse mutation assay, chromosome aberration assay, micronucleus induction test according to OECD guidelines. Bacterial reverse mutation assay: In GST treating group, regardless of existence S9 mix, revertant colonies counts appeared to be less than twice of negative control group and dose dependent increase. In positive control group, revertant colonies counts were shown to be more than twice of negative control croup. Chromosome aberration assay: All cell line showed repetition rate of abnormal chromosome aberration less than 5%, regardless of treating time, existence of S9 mix, and no significant change (p0.05) compared with negative control group. Micronucleus induction test: Micronucleated polychromatic erythrocytes (MNPCE) repetition rate of Polychromatic erythrocytes (PCE) showed no significant changes compared with negative control group (p0.05). PCE portion of total erythrocytes also showed no significant changes (p0.05). Our results showed that GST didn’t induce any genotoxicity.
{"title":"Genotoxicity Study of GST Extract","authors":"Chulkyu Lee, Jong-Min Han, Mi Young Lee, I. Jung, M. Jin, S. Kim, Yang-Chun Park","doi":"10.15188/KJOPP.2014.12.28.6.621","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.12.28.6.621","url":null,"abstract":"This study aimed to evaluate the genotoxicity of GST (Gamisasangja-tang). For examining genotoxicity, we carried out bacterial reverse mutation assay, chromosome aberration assay, micronucleus induction test according to OECD guidelines. Bacterial reverse mutation assay: In GST treating group, regardless of existence S9 mix, revertant colonies counts appeared to be less than twice of negative control group and dose dependent increase. In positive control group, revertant colonies counts were shown to be more than twice of negative control croup. Chromosome aberration assay: All cell line showed repetition rate of abnormal chromosome aberration less than 5%, regardless of treating time, existence of S9 mix, and no significant change (p0.05) compared with negative control group. Micronucleus induction test: Micronucleated polychromatic erythrocytes (MNPCE) repetition rate of Polychromatic erythrocytes (PCE) showed no significant changes compared with negative control group (p0.05). PCE portion of total erythrocytes also showed no significant changes (p0.05). Our results showed that GST didn’t induce any genotoxicity.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129736670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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