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Korean Medicine for Carpal Tunnel Syndrome: a Systematic Review of Literature Published in Korea 腕管综合征的韩国医学:韩国发表文献的系统回顾
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.79
Jong Ho Lee
수근관증후군은 수부의 정중신경이 분포하는 지역에 저린감각, 통증, 이상감각 등의 증상과 무지구군의 약화를 주소로 하는 증후군 으로 상지에서 가장 흔한 빈도로 나타나는 압박신경병증으로 알려 져 있다1). 수근관증후군은 30~60세 사이에 주로 나타나며, 여성이 남성의 5배 정도로 많으며, 정확한 원인이나 유발인자는 명확하게 규명되지 않았으나 수근관의 공간을 감소시킬 수 있는 여러 가지 상황에 의 해 야기될 수 있다2). 수근관증후군에 대한 진단은 임상증상과 Phalen's test, Tinel's sign, 근력평가 등의 이학적 검사와 근전도 및 신경전도 검 사를 통하여 진단하지만, 확진을 위한 신경전도검사를 시행하기가 어려운 상황에서는 이학적 검사 및 임상증상을 고려하여 진단하는 경우가 많다2). 치료는 Non-steroidal anti-inflammatory drugs(NSAIDs)을 투여하거나 splinting을 이용한 운동제한법, 재활 운동요법 및 외과적 수술요법 등이 행해지고 있다3). 그러나 일반적으로 행하는 NSAIDs의 복용은 위장관 장애 등의 부작용을 일으키며 외과적 수술의 경우 영구적인 신경손상이 일어 날 수 있으며, 수술 후의 회복기간도 길다는 단점이 있다4). 한편 한의학에서 말하는 痺證은 風寒濕의 邪氣에 의해 肌肉과 筋骨, 關節의 痲木을 일으키며 浮腫, 疼痛, 屈伸不利를 유발하는 것 으로 수근관증후군의 증상과 상당히 유사하며2) 수근관증후군에 대 하여 한의학적 치료를 활용하여 의미있는 치료 효과를 나타낸 결과 들이 발표되어 있다5). 이에 본 저자는 현재까지 수근관 증후군에 대한 한의학적 치료에 대하여 연구된 국내 논문들을 고찰한 결과 일정한 지견을 얻었기에 보고하는 바이다.
手根管症候群是以手部正中神经分布地区麻、疼痛、异常感觉等症状和无虹口群减弱为主要症状的症候群,是上肢最常见的压迫神经病症。肌管症候群主要出现在30~60岁之间,女性是男性的5倍左右,虽然没有明确的原因或诱发因素,但可能是由于各种情况导致的,从而减少了肌管的空间2)。据以对冠症候群的诊断是임상증상和phalen ' s test, tinel ' s sign,肌肉力量等的物理检查和评价及肌心理战也通过检查诊断,确诊为精神检查实施艰难的情况下,考虑到物理检查及임상증상,诊断的情况很多2)。治疗包括使用Non-steroidal anti-inflammatory drugs(NSAIDs)、使用splinting的运动限制法、康复运动疗法及外科手术疗法3)。但是一般的NSAIDs服用会引起胃肠障碍等副作用,外科手术会引起永久性的神经损伤,手术后的恢复时间也长。另外,中医所说的痺两人家風濕的邪被气肌喂和筋,,一升節的痲木,浮腫,疼痛,不停伸不诱发背的须子冠症候群的症状和相当类似,对2)据以症候群,韩医学治疗运用表现出有意义的治疗效果,结果被发表出来,5)。对此,本作者到目前为止对研究对手根管症候群的韩医学治疗的国内论文进行了考察,结果得到了一定的见解,所以在此进行报告。
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引用次数: 2
Effects of Added Chongmyung-tang on Behavior and Molecular Factors in the Alzheimer's Disease Model 添加清明汤对阿尔茨海默病模型行为及分子因子的影响
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.39
K. Kim
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引用次数: 0
Protective Effect of Fermented Red Ginseng Extracts on Photoaging Skin of Induced by UVB in Hairless Mice 发酵红参提取物对UVB致无毛小鼠皮肤光老化的保护作用
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.58
Da-Young Lee, Chang-Hyun Lee, Mi-Jin Oh, Ha-Rim Kim, Min-Sun Kim, C. Oh, Jong-Suk Kim, Jong Min Kim
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引用次数: 2
Recovery From Chemotherapy Induced Neutropenia Treated with Samul-tanggagambang 三木汤加甘帮治疗化疗所致中性粒细胞减少症的康复
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.85
휘중 강, 소정 박, 종관 조, 연월 이, 화승 유
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引用次数: 4
Inhibitory Effect of Paeoniae Radix Alba Ethanol Extract on Osteoclast Differentiation and Formation 白芍乙醇提取物对破骨细胞分化和形成的抑制作用
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.51
Bora Park, G. Park, D. Gu, Wonmin Ko, Youn-Chul Kim, Seoung‐Hoon Lee
뼈대사(bone metabolism)와 뼈재형성(bone remodeling)은 뼈 기질(bone matrix)를 만드는 조골세포(osteoblasts)와 뼈를 흡수하 는 파골세포(osteoclasts) 사이의 조화로운 균형을 통해 이루어진다 1). 다핵 성체 파골세포(multinucleated mature osteoclasts)는 조 혈모세포(hematopoietic stem cells)로부터 증식(proliferation), 분 화(differentiation), 융합(fusion) 그리고 활성화(activation)를 포함 하는 일련의 과정을 통하여 생성된다. 조골세포에서 생산되는 macrophage colony-stimulating factor (M-CSF)와 receptor activator of nuclear factor kappa-B ligand (RANKL)은 조혈모 세포로부터 분화된 monocyte/macrophage 전구세포들을 파골세 포로 분화 생성시키는 역할을 하는 중요한 사이토카인이다1,2). 조골 세포에서 생성된 RANKL이 파골세포 전구세포의 표면에 있는 receptor activator of nuclear factor kappa-B (RANK)이라는 수용체에 결합을 하게 되면, 파골세포 분화, 활성 및 생성에 중요한 역할을 하는 세포내 신호전달 체계인 c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), p38 등의 mitogen-activated protein kinases (MAPKs), NF-κB 과 Akt의 활성화가 일어난다3). RANKL은 파골세포 분화 및 생성의 양성조절 자(positive modulator)로 작용하는 NF-κB, c-Fos, nuclear factor of activated T cells (NFAT) c1 등의 다양한 전사인자의 백작약 에탄올 추출물의 파골세포 분화 및 생성 억제 작용
骨骼死(bone metabolism)和骨再形成(bone remodeling)是通过制造骨基质(bone matrix)的造骨细胞(osteoblasts)和吸收骨的碎骨细胞(osteoclasts)之间的协调平衡形成的。由血母细胞(hematopoietic stem cells)通过一系列过程产生,包括增殖(proliferation)、分化(differentiation)、融合(fusion)和活性(activation)。在造骨细胞中生产的macrophage colony-stimulating factor (M-CSF)和receptor activator of nuclear factor kappa-B ligand (RANKL)是一种重要的细胞因子,可以将造血细胞分化的monocyte/macrophage细胞分化生成破骨细胞。由造骨细胞生成的RANKL与破骨细胞前导细胞表面的receptor activator of nuclear factor kappa-B (RANK)受体结合,细胞内信号传递系统c-Jun N-terminal kinase (JNK),对破骨细胞分化、活性及生成起重要作用。extracellular signal-regulated kinase (ERK), p38等的mitogen-activated protein kinases (MAPKs), NF-社团B和Akt的活性化3)。RANKL是一种抑制破骨细胞分化及生成阳性调节者(positive modulator) NF- B、c-Fos、nuclear factor of activated T cells (NFAT) c1等多种转录因子的白细胞弱乙醇提取物的破骨细胞分化及生成的作用
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引用次数: 7
Inhibitory Effects of Portulaca Oleracea Ethanol Extract and Glechoma Hederacea Ethanol Extract on the Periodontitis 马齿苋乙醇提取物和马齿苋乙醇提取物对牙周炎的抑制作用
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.46
박영미, Young-Rae Lee, 박상훈, 이봉근, 박연주, 오홍근, 문대인, 손민우, 강양규, O. Kim, Lee Seokryun, C-H Lee, Min Seuk Kim, 이학용
Both Portulaca oleracea (PO) and Glechoma hederacea (GH) have been used as traditional medicine due to the multiple pharmacological activities. However, the effects of PO and GH in the pathology of periodontitis is still elusive. In this study, we examined anti-microbial activity of PO ethanol extract (POEE) and GH ethanol extract (GHEE) in vitro, and physiological effects of POEE and GHEE on the cell inflammatory responses and the severity of periodontitis were determined using the rat periodontitis model. Our results indicate that POEE and GHEE had no effects on the proliferation of streptococcus mutans and on LPS-mediated inflammatory responses in gingival fibroblast cells. Notably, ingestion of POEE and GHEE resulted in attenuating the severity of periodontitis and population change of immune cells. These data suggests that PO and GH should be considered as candidates for relieving the severity of periondontitis.
马齿苋(porulaca oleracea, PO)和白头草(Glechoma hederacea, GH)均因其具有多种药理活性而被作为传统药物使用。然而,PO和GH在牙周炎病理中的作用尚不清楚。本研究通过对PO乙醇提取物(POEE)和GH乙醇提取物(GHEE)体外抑菌活性的研究,并采用大鼠牙周炎模型测定POEE和GHEE对牙周炎细胞炎症反应和牙周炎严重程度的生理影响。我们的研究结果表明,POEE和GHEE对变形链球菌的增殖和lps介导的牙龈成纤维细胞炎症反应没有影响。值得注意的是,摄入POEE和GHEE可以减轻牙周炎的严重程度和免疫细胞的数量变化。这些数据表明,应考虑PO和GH作为缓解牙周炎严重程度的候选药物。
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引用次数: 0
Inhibitory Effects of Black currant seed oil on 2,4-D initrochlorobenzene Induced Atopic Dermatitis in BALB/c Mice Model 黑加仑籽油对2,4- d硝基氯苯致BALB/c小鼠特应性皮炎的抑制作用
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.33
Yejin Lee, Kyo-Hyun Park, Bae-Hwan Kim
This study investigated the clinical parameters of atopic dermatitis and evaluated the inhibitory effects of Black currant seed oil for atopic dermatitis by using a Dinitrochlorobenzene(DNCB) induced BALB/c mice model. Five-week-old BALB/c mice were divided into four groups: normal group (N, non-treated), control group (C, atopic dermatitis-induced), positive control group (PC, Tacrolimus ointment-treated against induced atopic dermatitis, PC), experiment group (E, Black currant seed oil-treated against induced atopic dermatitis). After induction of atopic dermatitis by DNCB, the erythema, edema, eschar, and scratching were severely observed. The symptoms of atopic dermatitis were improved after 2 weeks, and almost disappeared after 4 weeks in PC and E group. The increased frequencies of scratching in C group were decreased in PC and E group. Transepidermal water loss, erythema index and serum IgE level were significantly decreased in E and PC compared to that in C after 4 weeks of the treatment. The results indicated that Black currant seed oil can relieve atopic dermatitis symptoms effectively, and may be possibly used as a functional material for suppression of atopic dermatitis.
本研究采用二硝基氯苯(DNCB)诱导的BALB/c小鼠模型,研究了黑加仑籽油对特应性皮炎的临床参数,并评价了黑加仑籽油对特应性皮炎的抑制作用。5周龄BALB/c小鼠分为4组:正常组(N,未处理)、对照组(c,诱发特应性皮炎)、阳性对照组(PC,他克莫司软膏治疗诱发特应性皮炎,PC)、实验组(E,黑加仑籽油治疗诱发特应性皮炎)。DNCB诱导特应性皮炎后,患者出现严重的红斑、水肿、结痂和抓痕。2周后异位性皮炎症状明显改善,4周后基本消失。C组大鼠抓挠次数增加,PC组和E组大鼠抓挠次数减少。治疗4周后,E组和PC组经皮失水、红斑指数及血清IgE水平均明显低于C组。结果表明,黑加仑籽油能有效缓解特应性皮炎症状,有可能作为抑制特应性皮炎的功能材料。
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引用次数: 0
Effect of Sympathy Module and Trust on Medical Service Quality, Medical Trust and Happiness 同情模块和信任对医疗服务质量、医疗信任和幸福感的影响
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.90
충식 조, 재익 김, 승규 남
전반적인 생활수준의 향상으로 인하여 과거와 달리 소비자들은 더욱더 다양하고 높은 질의 서비스를 요구하고 있다. 이것은 의료시 장에서도 예외는 아니며 이러한 사회적인 변화에 맞추어 최근의 의 료시장은 매우 급속도로 변화하고 있다. 따라서 이러한 변화에 빠르 게 대처하지 않으면 쉽게 도태되는 것이 최근 의료계의 현실이다. 2013년 의료자원 통계 핸드북1)에 따르면 2008년 11,316개였던 한 의원은 2012년 12,692개로 약 12% 증가하여 한의원 간의 경쟁이 점차 심화됨을 보이고 있다. 또한 2009-2013 건강보험 요양기관 개 ‧폐업 현황2)에 따르면 2009년 1,175개였던 신규한의원은 2013년 1,223개로 약 4%가 늘어난 반면, 같은 기간 폐업한 한의원은 2009 년 727개에서 2013년 828개로 약 13%가 늘어나 경쟁의 심화에 따 라 도태되는 한의원이 증가 추세임을 알 수 있다. 이러한 위기를 극복하기 위해서는 한의계와 관련된 인프라를 확충하는 등의 양적인 성장도 중요하지만, 환자 응대 및 진료 태도 와 같은 질적인 부분을 향상시키는 것의 중요성을 인식하고, 심리유 형별 진료도구를 이용하여 한방치료 만족도를 높이려는 시도3)와 한 방 의료 품질 향상을 위한 신뢰구현 의료시스템 구축을 통한 심리 특성별 맞춤 진료4) 등이 연구되었다. 의료서비스 품질은 1969년 Myers5)에 의해 처음 언급되었으며 Donabedian6), Vuori7), Bowers8), 남 등9)의 연구에서 이를 측정하기 위한 다양한 척도들이 개발되었다. 또한 조10)의 연구에 따르면 의료서비스 품질의 향상이 고객만족 및 재이용의도에 긍정적인 영향을 미치는 것으로 나타났 으며 정 등11)에 의하여 의료서비스 인식 및 품질지수에 관한 연구가 진행되었다. 한편 환자의 의료신뢰도 또한 한방 의료기관의 재이용 률을 높이는데 중요한 요소가 될 수 있는데, 김12)의 연구에 따르면 의료신뢰도가 높을수록 고객만족과 재이용의도가 높은 것으로 나타 공감모듈과 신뢰가 의료서비스 품질 및 의료 신뢰, 행복에 미치는 영향
由于整体生活水平的提高,与过去不同,消费者要求提供更加多样化和更高质量的服务。这在医疗市场也不例外,随着这种社会变化,最近的医疗市场变化非常迅速。因此,如果不迅速应对这种变化,就很容易被淘汰,这就是最近医疗界的现实。2013年医疗资源统计手册1),韩医院从2008年的11316家增加到2012年的12692家,约增加12%,韩医院间的竞争日趋激烈。也是2009 - 2013,健康保险疗养家,停业现状2)据2009年曾是1、175个新韩医院2013年1、223个,增加了约4%,而同期,停业的韩医院从2009年的727个2013年828个,约有13%增加竞争的深化而被淘汰的限度元根据增加的趋势就能知道。为了克服这样的危机,虽然扩充韩医界相关的基础设施等量的增长也很重要,但是认识到提高应对患者及诊疗态度等质的重要性。研究了利用心理类型诊疗工具提高韩医治疗满意度的尝试3)和为了提高韩医医疗质量的信赖体现医疗系统构筑的心理特性对症诊疗4)等。医疗服务质量在1969年由Myers5(英语:Myers5)首次被提及,Donabedian6)、Vuori7(英语:Vuori7)、Bowers8(英语:Bowers8)和nam(英语:nam) 9)的研究开发出了多种测量的尺度。另外,根据第10条的研究,医疗服务质量的提高对顾客的满足及再利用意图产生了积极的影响;根据郑等11条的研究,对医疗服务的认识及品质指数进行了研究。另外,患者的医疗信任度也韩医医疗机构提高재이용率,可以成为重要因素,据研究,医疗金12)的信任度越高,顾客满意和财富龙度较高的显示模块共识和信任医疗服务质量和医疗、对幸福的影响
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引用次数: 1
Study on Diseases Scope of Prescriptions Related with the Palpitation in 『Shanghanlun』 《上汉论》心悸方药病种范围研究
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.1
Misun Park, Y. Kim
*This article is a study on palpitation of which disease cause, disease mechanism and formulas were analyzed with reference to annotations on 『Shanghanlun』 and 『Jinkuiyaolue』. And the scope of modern diseases related with palpitation was drawn by research on clinical papers. The source books are 『Zhujieshanghanlun 』 and 『Jinkuiyaoluefanglun 』 and the clinical papers are searched in China Academic Journals(CAJ) of China National Knowledge Infrastructure(CNKI). 13 clauses in 『Shanghanlun』 and 9 clauses in 『Jinkuiyaolue』 and 12 formulas are related with palpitation. Disease mechanisms of palpitation were classified as yang deficiency, yin deficiency, qi deficiency, blood deficiency, retained fluid, cold, etc and these days, qi stagnation, phlegm turbidity, blood stasis and fire heat are also considered as disease mechanisms. Modern diseases related with palpitation are arrhythmia(extrasystole, atrial fibrillation, bradycardia, tachycardia, sick sinus syndrome, atrioventricular block), vascular diseases(arterial occlusion, phlebothrombosis, Buerger's disease, coronary artery disease, vasculitis), blood pressure disorder(hypertension, hypotension) and heart diseases such as heart failure, angina pectoris, myocardial infarction, myocarditis, cardiomyopathy, pericardial effusion. And diseases related with psychological change(cardiac neurosis, anxiety neurosis, neurosis, depression, hyperthyroidism, hypothyroidism), pyrexia, anemia, drug intoxication, etc are also related with palpitation. Zhen Wu Tang showing an efficacy in dilating blood vessels and strengthening cardiac function, Wuling Powder with diuretic effect and Fried Glycyrrhizae Decoction acting on the β receptor are applied to heart failure in different ways. Fried Glycyrrhizae Decoction(308 cases), Zhen Wu Tang(154), Wuling Powder(54), Xiao Chaihu Tang(34), Sini San(20) are reported to have been clinically applied to cardiovascular diseases and Zhen Wu Tang and Wuling Powder mainly applied to heart failure, Fried Glycyrrhizae Decoction, Lizhong Wan, Sini San and Zhen Wu Tang chiefly applied to arrhythmia related diseases. This study focuses on the general research and consideration on clinical applications and is a preliminary study to understand relations between Korean Medicine’s symptoms and categories of modern diseases.
*本文是对心悸的病因、发病机理和方剂进行分析,并参考《上汉论》和《金葵要略》的注释。通过对临床文献的研究,确定了与心悸相关的现代疾病范围。文献来源为《诸病商病论》和《金葵要论》,临床论文检索于中国知网(CNKI)中国学术期刊(CAJ)。《上寒论》中的13句、《金匮要略》中的9句以及12个方式与心悸有关。心悸的病机可分为阳虚、阴虚、气虚、血虚、瘀血、寒寒等,目前也认为气滞、痰浊、血瘀、火热等为病机。与心悸相关的现代疾病有心律失常(心律失常、心房颤动、心动过缓、心动过速、病窦综合征、房室传导阻滞)、血管疾病(动脉闭塞、静脉血栓形成、伯格氏病、冠状动脉疾病、血管炎)、血压紊乱(高血压、低血压)以及心衰、心绞痛、心肌梗死、心肌炎、心包积液等心脏疾病。而与心理变化有关的疾病(心脏神经症、焦虑神经症、神经症、抑郁症、甲状腺功能亢进、甲状腺功能减退)、发热、贫血、药物中毒等也与心悸有关。具有扩张血管、增强心功能作用的真武汤、利尿作用的五灵散、作用于β受体的炒甘草汤等均以不同方式应用于心力衰竭。据报道,临床上应用于心血管疾病的有炒甘草汤308例、真戊汤154例、五灵散54例、小柴胡汤34例、四思散20例,其中真戊汤、五灵散主要用于心力衰竭,炒甘草汤、立中丸、四思散、真戊汤主要用于心律失常相关疾病。本研究以总体研究和临床应用考虑为主,是了解韩医学症状与现代疾病分类关系的初步研究。
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引用次数: 0
Prioritization in the Policy of Integrated Medicine that Uses the Delphi Method and Analytic Hierarchy Process 基于德尔菲法和层次分析法的中西医结合政策的优先排序
Pub Date : 2015-02-28 DOI: 10.15188/KJOPP.2015.02.29.1.66
Y. Park, Chihyoung Son
The purpose of the study is to establish priorities in integrated medicine policy. Delphi method was used in conducting a survey on integrated medicine specialists regarding the policies of integrated medicine and actions. For specialists in integrated medicine, total 17 persons selected included scholars who performed minimum one study on integrated medicine, medical staff who performing integrated medical service at institutions that implemented integrated medical care or those who were involved in creating or implementing policies on integrated medicine. The first Delphi-method survey conducted from Apr. 14 through 18, while the second survey was carried out from Apr. 21 through 25. To prioritize the policies based on the results of the mini Delphi-method survey, Analytic Hierarchy Process(AHP) was performed for 15 persons answered to mini Delphi-method from May 2 through 16, 2014. From the Delphi-method survey, four policies and 16 actions were obtained. AHP showed the first priority placed on 'Building the Infrastructure of Industrialization in the Integrative medicine' of the 4 policies and 'Developing new diagnostic and treatment instruments' was given the highest priority of the 16 actions. For implementation of integrated medicine policy, the 4 policies and the 16 actions found in this research require government support and should be urgently implemented according to its priority.
本研究的目的是确定综合医学政策的优先事项。采用德尔菲法对中西医结合专科医师进行了关于中西医结合政策和行动的调查。在综合医学专家方面,共有17人入选,其中包括至少进行过一项综合医学研究的学者、在实施综合医疗保健的机构提供综合医疗服务的医务人员或参与制定或实施综合医学政策的人员。第一次德尔菲法调查于4月14日至18日进行,第二次调查于4月21日至25日进行。2014年5月2日至16日,为了根据迷你德尔菲法调查结果对政策进行优先排序,对15名回答迷你德尔菲法的人进行了层次分析法(AHP)。从德尔菲法调查中,得到4项政策和16项行动。AHP显示,在4项政策中,“建设中西医结合产业化基础设施”被列为第一优先事项,“开发新的诊断和治疗工具”在16项行动中被列为最高优先事项。对于整合医学政策的实施,本研究发现的4项政策和16项行动需要政府的支持,并应根据其优先顺序紧急实施。
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引用次数: 2
期刊
Korean Journal of Oriental Physiology & Pathology
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