Pub Date : 2016-02-29DOI: 10.15188/kjopp.2016.02.30.1.20
M. Jang, H. Seo, Sang Chan Kim, Young Woo Kim
{"title":"Effect of Prunellae Spica on Oxidative Stress and Mitochondrial Dysfunction in the Hepatocyte","authors":"M. Jang, H. Seo, Sang Chan Kim, Young Woo Kim","doi":"10.15188/kjopp.2016.02.30.1.20","DOIUrl":"https://doi.org/10.15188/kjopp.2016.02.30.1.20","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124762401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-29DOI: 10.15188/KJOPP.2016.02.30.1.27
K. Kim, B. Park, J. Min, Mingi Chae, Jaesung Lim, H. Son, Gi Hoon Lee, S. An, B. Jeon, Na-Young Choi, Y. You
Streptococcus mutans plays a virtal role in trigering dental caries establishment due to its ability to synthesize two significant factors. The two factors are organic acids and glucans. The former demineralized dental enamel and the latter mediates the attachment of bacteria to tooth surface. It is believed that demineralization of dental enamel and attachment of bacteria are the crucial events that indicate and develop dental caries. For this reason, we studied the effect of the ethanol extracts of Radix Pulsatillae on the growth and acid production of S. mutans. Ethanol extracts of the Radix Pulsatillae showed concentration dependent inhibitory activity against the growth and acid production of S. mutans, and produced significant inhibition compared to the control groups (p<0.05). The extracts inhibited S. mutans adherence to hydroxyapatite treated with saliva, and cell adherence was repressed by Radix Pulsatillae. the ethanol extract of Radix Pulsatillae showed remarkable inhibition of glucosyltransferase, which synthesizes water insoluble glucan form sucrose. Phytochemical analysis showed Radix Pulsatillae contained major components such as phenolic compounds, glycosides, steroids, terpenoid, and saponin. These results suggest that Radix Pulsatillae may have anti-cariogenic properties, which may be related with major components such as phenolic compounds, glycosides, steroids, terpenoid, and saponin.
{"title":"Inhibitory Effects of Radix Pulsatillae Extract on Insoluble Glucan Synthesis and Adhesion of Streptococcus mutans","authors":"K. Kim, B. Park, J. Min, Mingi Chae, Jaesung Lim, H. Son, Gi Hoon Lee, S. An, B. Jeon, Na-Young Choi, Y. You","doi":"10.15188/KJOPP.2016.02.30.1.27","DOIUrl":"https://doi.org/10.15188/KJOPP.2016.02.30.1.27","url":null,"abstract":"Streptococcus mutans plays a virtal role in trigering dental caries establishment due to its ability to synthesize two significant factors. The two factors are organic acids and glucans. The former demineralized dental enamel and the latter mediates the attachment of bacteria to tooth surface. It is believed that demineralization of dental enamel and attachment of bacteria are the crucial events that indicate and develop dental caries. For this reason, we studied the effect of the ethanol extracts of Radix Pulsatillae on the growth and acid production of S. mutans. Ethanol extracts of the Radix Pulsatillae showed concentration dependent inhibitory activity against the growth and acid production of S. mutans, and produced significant inhibition compared to the control groups (p<0.05). The extracts inhibited S. mutans adherence to hydroxyapatite treated with saliva, and cell adherence was repressed by Radix Pulsatillae. the ethanol extract of Radix Pulsatillae showed remarkable inhibition of glucosyltransferase, which synthesizes water insoluble glucan form sucrose. Phytochemical analysis showed Radix Pulsatillae contained major components such as phenolic compounds, glycosides, steroids, terpenoid, and saponin. These results suggest that Radix Pulsatillae may have anti-cariogenic properties, which may be related with major components such as phenolic compounds, glycosides, steroids, terpenoid, and saponin.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124712640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-29DOI: 10.15188/KJOPP.2016.02.30.1.66
E. Lee, J. Choi, Eunsu Jang, Yang-Chun Park, I. Jung
{"title":"Effects of Shinchubogun-tang and Common Korean Medicine Treatment on Symptom Reduction in Patients with Intervertebral Lumbar Disc Herniation : A Retrospective Observational Study","authors":"E. Lee, J. Choi, Eunsu Jang, Yang-Chun Park, I. Jung","doi":"10.15188/KJOPP.2016.02.30.1.66","DOIUrl":"https://doi.org/10.15188/KJOPP.2016.02.30.1.66","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131825540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-30DOI: 10.15188/kjopp.2015.06.29.3.223
최형욱, 인명희, 문연자, 임규상, 우원홍
In this study, we investigated the effect of ethanol extracts from Gentianae scabrae bunge (GSB) on the activities of antioxidant, whitening and anti-inflammation. Viability of cells was measured by neutral red (NR) assay, and inhibitory effects of GSB on melanin synthesis was determined the melanin production in B16F10 cells. The expression level of matrix metalloproteinase-1 (MMP-1) in media was analyzed by ELISA kit, and nitric oxide (NO) production in RAW264.7 cells was monitored by measuring the nitrite content in culture medium. GSB showed highly efficacy in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and significantly reduced melanin synthesis in B16F10 cells. MMP-1 production in UVB-stimulated human dermal fibroblast (HDF) cells was inhibited by GSB treatments. NO production was suppressed by the treatment of GSB in LPS-stimulated RAW264.7 cells. From this results, it was indicated that GSB could be utilized as anti-aging and whitening cosmetic ingredients.
{"title":"용담초 추출물의 화장품 소재로서 약리활성에 관한 연구","authors":"최형욱, 인명희, 문연자, 임규상, 우원홍","doi":"10.15188/kjopp.2015.06.29.3.223","DOIUrl":"https://doi.org/10.15188/kjopp.2015.06.29.3.223","url":null,"abstract":"In this study, we investigated the effect of ethanol extracts from Gentianae scabrae bunge (GSB) on the activities of antioxidant, whitening and anti-inflammation. Viability of cells was measured by neutral red (NR) assay, and inhibitory effects of GSB on melanin synthesis was determined the melanin production in B16F10 cells. The expression level of matrix metalloproteinase-1 (MMP-1) in media was analyzed by ELISA kit, and nitric oxide (NO) production in RAW264.7 cells was monitored by measuring the nitrite content in culture medium. GSB showed highly efficacy in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and significantly reduced melanin synthesis in B16F10 cells. MMP-1 production in UVB-stimulated human dermal fibroblast (HDF) cells was inhibited by GSB treatments. NO production was suppressed by the treatment of GSB in LPS-stimulated RAW264.7 cells. From this results, it was indicated that GSB could be utilized as anti-aging and whitening cosmetic ingredients.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131572465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-30DOI: 10.15188/KJOPP.2015.06.29.3.230
S. Jung, Hee-soo Hur, H. Jeong, K. Kim, Young-kyun Kim
{"title":"Clinical Study on Relationship between Pattern Identifications for Stroke and the Second Derivative of Photoplethysmogram Waveform from Stroke Preventive Examination","authors":"S. Jung, Hee-soo Hur, H. Jeong, K. Kim, Young-kyun Kim","doi":"10.15188/KJOPP.2015.06.29.3.230","DOIUrl":"https://doi.org/10.15188/KJOPP.2015.06.29.3.230","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"68 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114014807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-30DOI: 10.15188/KJOPP.2015.06.29.3.240
C. H. Hwang, M. Kim, B. Kim
{"title":"Study of Discussion for Pulse Diagnosis of Meridian System seen by Research Assignment of the Small and Large Intestine in Wrist Pulse-taking Method","authors":"C. H. Hwang, M. Kim, B. Kim","doi":"10.15188/KJOPP.2015.06.29.3.240","DOIUrl":"https://doi.org/10.15188/KJOPP.2015.06.29.3.240","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129303840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-30DOI: 10.15188/KJOPP.2015.06.29.3.203
Sin Seo Kim, M. Kim
Scolpendra subspinipes (centipede) is pungent in flavor, activates the channels to stop pain, and, removes toxins and resolves masses. So it has been used as a folk remedy. We researched folk remedies which used centipede as a single medicine and results of its prior clinical and experimental study, and figured out that centipedes are effective on ulcerative disease, herpes zoster, clavus, insect bite, inflammatory disease, furunculus, pain disease by external therapy, and oral administration is effective on anti-cancer such as hepatoma and uterine cancer, cerebrovascular disease, inhibition of atherosclerosis, sedation of central nervous system, antipyretic action, and anti-inflammation, and centipede Herb-Acupuncture is effective on inflammatory disease and pain disease. Centipede preparation materials for external therapy were sesame oil, perilla oil, vinegar, salt, and, burnt alum. Fumigation of centipede treated paronychia, pertussis, and hemorrhoids. For the external therapy, the way of centipede powder mixing with other materials has been used. It is needed that we use dusted powder to make skin absorb its ingredients more easily, and we study intensely minor ingredients to make centipede components absorbed more effectively and do pharmacological action. Also, fumigation, a kind of another external therapy, is considered to be effective treatment of upper respiratory infection like pertussis, so it needs an in-depth study on centipede fumigation.
{"title":"Study of Developmet of External Medicine Based on the Result of Prior Study and Folk Remedy Using Scolopendra subspinipes mutilans as a Single Medicine in Korea and China","authors":"Sin Seo Kim, M. Kim","doi":"10.15188/KJOPP.2015.06.29.3.203","DOIUrl":"https://doi.org/10.15188/KJOPP.2015.06.29.3.203","url":null,"abstract":"Scolpendra subspinipes (centipede) is pungent in flavor, activates the channels to stop pain, and, removes toxins and resolves masses. So it has been used as a folk remedy. We researched folk remedies which used centipede as a single medicine and results of its prior clinical and experimental study, and figured out that centipedes are effective on ulcerative disease, herpes zoster, clavus, insect bite, inflammatory disease, furunculus, pain disease by external therapy, and oral administration is effective on anti-cancer such as hepatoma and uterine cancer, cerebrovascular disease, inhibition of atherosclerosis, sedation of central nervous system, antipyretic action, and anti-inflammation, and centipede Herb-Acupuncture is effective on inflammatory disease and pain disease. Centipede preparation materials for external therapy were sesame oil, perilla oil, vinegar, salt, and, burnt alum. Fumigation of centipede treated paronychia, pertussis, and hemorrhoids. For the external therapy, the way of centipede powder mixing with other materials has been used. It is needed that we use dusted powder to make skin absorb its ingredients more easily, and we study intensely minor ingredients to make centipede components absorbed more effectively and do pharmacological action. Also, fumigation, a kind of another external therapy, is considered to be effective treatment of upper respiratory infection like pertussis, so it needs an in-depth study on centipede fumigation.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121041856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-06-30DOI: 10.15188/KJOPP.2015.06.29.3.246
M. Yeo, S. Dong, Young Seop Lee, Eun-su Jang
{"title":"Review on Reliability and Validity of Questionnaire of Pattern Identification in Traditional Chinese Medicine -Using China National Knowledge Infrastructure-","authors":"M. Yeo, S. Dong, Young Seop Lee, Eun-su Jang","doi":"10.15188/KJOPP.2015.06.29.3.246","DOIUrl":"https://doi.org/10.15188/KJOPP.2015.06.29.3.246","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116607905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-30DOI: 10.15188/KJOPP.2015.04.29.2.195
J. Shim, Soojin Lee, Huijin Gim, H. Park, B. Kim
The aim of the study is to investigate the anti-cancer effects of Scutellaria barbata in AGS human gastric adenocarcinoma cells. MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay and caspase 3 or 9 activity assay were carried out to examine cell death with Scutellaria barbata. To elucidate the inhibitory effects of Scutellaria barbata, cell cycle (sub-G1) analysis and mitochondrial membrane potential were performed in AGS cells after 24 h incubation with Scutellaria barbata. Scutellaria barbata induced apoptosis in AGS cells by using the MTT assay, the sub-G1 analysis and mitochondrial membrane potential assay. The stronger inhibition effects of AGS cell growth was observed by application of Scutellaria barbata combined with several anti-cancer drugs (paclitaxel, 5-fluorouracil, cisplatin, ectoposide, doxorubicin and docetaxel) in comparison to the application of Scutellaria barbata or anti-cancer drugs. Our findings provide insight into unraveling the effects of Scutellaria barbata in human gastric cancer cells and developing therapeutic agents against gastric cancer.
{"title":"Anti-cancer Effects of Scutellaria barbata in AGS Human Gastric Adenocarcinoma Cells","authors":"J. Shim, Soojin Lee, Huijin Gim, H. Park, B. Kim","doi":"10.15188/KJOPP.2015.04.29.2.195","DOIUrl":"https://doi.org/10.15188/KJOPP.2015.04.29.2.195","url":null,"abstract":"The aim of the study is to investigate the anti-cancer effects of Scutellaria barbata in AGS human gastric adenocarcinoma cells. MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay and caspase 3 or 9 activity assay were carried out to examine cell death with Scutellaria barbata. To elucidate the inhibitory effects of Scutellaria barbata, cell cycle (sub-G1) analysis and mitochondrial membrane potential were performed in AGS cells after 24 h incubation with Scutellaria barbata. Scutellaria barbata induced apoptosis in AGS cells by using the MTT assay, the sub-G1 analysis and mitochondrial membrane potential assay. The stronger inhibition effects of AGS cell growth was observed by application of Scutellaria barbata combined with several anti-cancer drugs (paclitaxel, 5-fluorouracil, cisplatin, ectoposide, doxorubicin and docetaxel) in comparison to the application of Scutellaria barbata or anti-cancer drugs. Our findings provide insight into unraveling the effects of Scutellaria barbata in human gastric cancer cells and developing therapeutic agents against gastric cancer.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130453872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-30DOI: 10.15188/KJOPP.2015.04.29.2.189
B. Park, W. Jung, S. J. You, C. Lee, J. S. Kim, S. An, B. Jeon, Y. You, K. Kim
현대사회가 발전하면서 구강건강 문제가 중요하게 대두되고 있 다 치아우식증은 치면세균막내 세균의 당 대사를 통해 생성되는 산 . 에 의해 치질이 탈회되는 과정으로 이루어지는 세균성 치아경조직 질환이다1) 이를 방치하게 되면 치수염을 일으켜 심한 통증을 느끼 . 게 되고 이로 인해서 치아를 상실할 수도 있다 치아우식증을 유발 , . 하는데 관련된 요인으로는 크게 미생물요인2) 숙주요인 및 식이요인 , 3) 등이 있는데 이 중에서 미생물요인은 치아우식증의 원인균들과 , 관련된 중요한 인자이다 치아우식증에 관련된 여러 세균 중에서 그 . 람양성 세균인 Streptococcus mutans는 외부로부터 섭취한 음식 물에 포함되어 있는 설탕 이나 포도당 등을 분해하여 치아 (sucrose) 우식증을 유발하는 중요한 원인로 지적되어왔다4) 또한 . , S. mutans 가 생산하는 는 자당을 기질로 하여 점착성의 비수용성 글 GTFase Galla Chinensis Streptococcus mutans
随着现代社会的发展，口腔健康问题正在成为重要的问题。牙齿蚀症是通过牙免税菌最小的细菌的糖代谢产生的酸。1 .如果放任这种疾病，就会引起治水炎，感到严重的疼痛。因此可能会失去牙齿，引发牙齿蚀症。与此相关的主要因素有微生物因素2)宿主因素及食物因素3)等，其中微生物因素是引起牙齿蚀症的细菌和相关的重要因素。Streptococcus mutans是一种蓝阳性细菌，它分解从外部摄取的食物中的糖和葡萄糖，被认为是引发牙齿(sucrose)蚀症的重要原因4)。， S. mutans生产的以蔗糖为基质的黏性非水溶性GTFase Galla Chinensis Streptococcus mutans
{"title":"Inhibitory Effects of Galla Chinensis Extract on Cariogenic Properties of Streptococcus mutans","authors":"B. Park, W. Jung, S. J. You, C. Lee, J. S. Kim, S. An, B. Jeon, Y. You, K. Kim","doi":"10.15188/KJOPP.2015.04.29.2.189","DOIUrl":"https://doi.org/10.15188/KJOPP.2015.04.29.2.189","url":null,"abstract":"현대사회가 발전하면서 구강건강 문제가 중요하게 대두되고 있 다 치아우식증은 치면세균막내 세균의 당 대사를 통해 생성되는 산 . 에 의해 치질이 탈회되는 과정으로 이루어지는 세균성 치아경조직 질환이다1) 이를 방치하게 되면 치수염을 일으켜 심한 통증을 느끼 . 게 되고 이로 인해서 치아를 상실할 수도 있다 치아우식증을 유발 , . 하는데 관련된 요인으로는 크게 미생물요인2) 숙주요인 및 식이요인 , 3) 등이 있는데 이 중에서 미생물요인은 치아우식증의 원인균들과 , 관련된 중요한 인자이다 치아우식증에 관련된 여러 세균 중에서 그 . 람양성 세균인 Streptococcus mutans는 외부로부터 섭취한 음식 물에 포함되어 있는 설탕 이나 포도당 등을 분해하여 치아 (sucrose) 우식증을 유발하는 중요한 원인로 지적되어왔다4) 또한 . , S. mutans 가 생산하는 는 자당을 기질로 하여 점착성의 비수용성 글 GTFase Galla Chinensis Streptococcus mutans","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115339886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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