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A Study on the Fever of Unknown Origin Indicated by Janggam Disease 长骨病不明原因发热的临床研究
Pub Date : 2014-12-31 DOI: 10.15188/KJOPP.2014.12.28.6.683
Sang Jin Kim
發熱은 시상하부에 있는 체온조절중추의 변화로 정상수준 이상 으로 체온이 상승한 것을 말한다. 인체는 주위 환경이 변화됨에도 불구하고 체온조절중추에서 조직, 특히 근육, 간으로부터 열의 생산 과 소모를 조절할 수 있기 때문에 정상체온을 유지한다. 고체온증은 불충분한 열 소모로 인하여 시상하부에서 기준점 이상으로 체온이 상승한 것이다1). 불명열은 1961년 Petersdorf와 Beeson 등이 첫째, 수차례에 걸친 38.3°C 이상의 고열, 둘째, 3주 이상 지속되어져야 하고, 셋째 입원 후 일주일 이상의 검사에도 불구하고 發熱의 원인을 찾지 못 할 때로 정의하였다. 이상과 같은 정의가 내려진 이래, 어떤 질환들 이 이에 속하며, 어떻게 접근해야 할 것인지에 대한 많은 논의가 있 어 왔다2). 한의학에서는 發熱의 원인을 外感과 內傷으로 구분한다. 外感 의 경우는 외부에서 邪氣가 침범한 것으로 대개 風寒이나 溫熱邪氣 의 침범인 경우가 흔하며, 內傷의 경우는 贓腑經絡의 陰陽의 균형 이 어긋남으로써 發熱을 야기하게 된다3). 또 다른 관점으로, 『東醫 壽世保元』에서는 인체를 臟腑大小의 크기에 따라 4가지 체질로 분 류하고 각 체질 특성상 부족해지기 쉬운 기운을 保命之主라 명명하 여, 외부기운에 대한 保命之主의 반응에 따라 發熱이 나타난다고 보았고, 각 체질별로 保命之主가 다르기 때문에, 發熱양상 또한 다 르게 나타나는 것이라 하였다4). 그 중 太陰人은 肝大肺小한 특징으 로 呼散之氣가 부족하여 邪氣를 발산시키지 못하여 나타나는 發熱 과 肝熱이 肺로 올라가 肺燥하여 발생한 肝熱肺燥證의 일환으로 나 타나는 發熱이 나타난다. 呼散之氣의 부족으로 나타나는 發熱의 양 상 중에 『東醫壽世保元』 太陰人 胃脘受寒表寒病에서 언급된 長感 病이라는 것은 惡寒과 發熱, 汗出이 며칠씩 번갈아 가며 나타나는 것을 일컫는 질환으로 일반적인 外感에 비해 발병기간이 길어 長感 病이라 명명되었다5). 본 임상증례는 양방 병원에서 3주 간 각종 검사 및 약물 치료 를 받았으나, 원인이 파악되지 않고 發熱증상이 지속되는 불명열 환 자에 대해 사상체질 진단을 통해 太陰人으로 판단되었고, 發熱이 수차례에 걸쳐 간헐적으로 수 시간씩 나타나며 發熱이 3주 이상 지 속된다는 發熱양상을 통해 長感病으로 진단하여 치료한 결과 양호 한 치료효과를 거두었기에 보고하는 바이다.
发火是指由于下丘脑的体温调节中枢的变化,体温上升到正常水平以上。人体不顾周围环境的变化,在体温调节中枢中,组织,特别是肌肉,肝能够调节热量的生产和消耗,从而保持正常体温。固体温症是由于热量消耗不足,导致下丘脑体温上升到基准点以上1)。1961年,Petersdorf和Beeson等被定义为:第一,多次高烧38.3°C以上;第二,持续3周以上;第三,住院后虽然进行了一周以上的检查,但仍未找到起火原因。自从给出上述定义以来,关于哪些疾病属于这一类,以及应该如何治疗等问题已经有了很多讨论。韩医学将产生的原因分为外伤性和内分泌性。老外能感的情况从外部邪气侵犯的大多为風寒或热液温邪气的侵犯事件的情况很常见,內厌的情况贓腑经絡的陰默默地的均衡,违反发热液,将导致3)。另一个观点《东北,壽世保元》中,人体臟腑按照大小的大小4种体质分类,各体质特性,容易紧张的气息,它命名为保生命之主,外部对气息的按照保生命之主的反应产生的热液出现认为,各体质不同,所以多大保生命之主,并且产生的热局面。尔表现得是4)。其中,太阴人具有“气胸大”的特征,气胸不足,不能发散邪气而出现的“气胸”和“气胸”上升到“气胸”而发生的“气胸”的一环。呼散之气不足而出现的产生的热液的羊奖中,《东北委员会壽世保元》“太陰人胃脘人家受表寒病中提到的长白山区能感病是恶寒和产生的热,汗出几天轮流出现疾病,一般指的是外能感相比,发病时间长,长白山区是儿童病了5)命名。本临床病例在西医医院接受了3周的各种检查及药物治疗,但原因不明,通过四象体质诊断,判定为太阴人。发火多次间歇性地出现数小时,通过发火持续3周以上的发火现象诊断为长年性疾病,治疗结果取得了良好的治疗效果。
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引用次数: 0
Report on Two Cases of Gilbert's Syndrome Found in the Process of Administering Herbs 用药过程中发现吉尔伯特综合征2例报告
Pub Date : 2014-12-31 DOI: 10.15188/KJOPP.2014.12.28.6.657
Jong Deok Lee, D. W. Kim
길버트 증후군(Gilbert's syndrome)은 간질환이나 용혈의 증거 없이 간헐적인 비포합형 고빌리루빈 혈증을 보이는 양성 경과를 보 이는 증후군으로 흔히 건강검진이나 우연한 기회의 혈액 검사 중 발견된다1). 임상적으로 혈액화학 검사 결과에서 고빌리루빈 혈증이 발견되 면 간담도계의 다양한 질환을 감별하기 위한 간 기능 검사와 영상 의학 검사들을 시행해야 한다. 특히 한약을 비롯한 약물을 복용하고 있는 환자들은 약물 대사 로 인한 간 기능의 변화와 연관 가능성 때문에 투약에 주의하고 때 로는 일정기간 중지해야 하며 추가적인 검사를 시행해야 하는 경우 가 많다. 이들 중 혈중 AST (aspartate transaminase), ALT (alanine transaminase), ALP (alkaline phosphatate), GGT (gamma glutamyl transpeptidase)와 같은 간기능을 나타내는 효 소 수치의 증가 없이 단지 고빌리루빈 혈증을 보이는 경우 일반 적:으로 길버트 증후군을 가능성 있는 원인 질환 중의 하나로서 고려하게 된다. 길버트 증후군은 우리나라를 포함한 아시아 성인인구의 3-7% 에서 발견되고 서양인에서 약 16%에서 나타나는 발생 빈도가 높은 질환으로서 공복상태, 급격한 열량섭취의 제한, 임신 등은 이들 환 자에게서 황달을 유발하는 요인으로 알려져 있다1,2). 본 증후군에 관한 많은 연구와 임상 예들이 다수 발표되었고 최근 한방 의료기관에서 한의학적 치료 과정 중 우연히 발견된 혈 중 빌리루빈치의 상승 된 환자를 길버트 증후군으로 진단하고 임상 경과 관찰을 하였던 보고도 있다3). 본 증례는 大棗 煎湯液의 약물 역동학을 알아보기 위한 임상 시험 연구 도중 우연히 발견된 고빌리루빈 혈증 2예가 길버트 증후 군으로 진단되었다. 이에 임상적 경과를 관찰하여(원광대학교 광주 한방병원 IRB 승인: WKIRB 14-11)보고한다. 단미 한약 복용중 발견한 Gilbert's syndrome 2예 임상고찰
吉尔伯特综合症(Gilbert's syndrome)是一种没有肝病或溶血证据,呈间歇性非混合型高胆红素血症的阳性症状,通常在健康检查或偶然的血液检查中发现。从临床角度看,如果在血液化学检查结果中发现高胆红素血症,应进行肝功能检查和影像医学检查,以鉴别肝胆计的多种疾病。特别是,服用包括韩药在内的药物的患者可能会因药物代谢导致肝功能发生变化,因此要注意用药,有时要在一定时间内停止服用,而且还要进行追加检查。血液中的AST (aspartate transaminase), ALT (alanine transaminase), ALP (alkaline phosphatate)如果出现高胆红素血症(GGT, gamma glutamyl transpeptidase),肝功能功能的效素数值没有增加,通常会将吉伯特综合症视为可能的病因疾病之一。吉尔伯特症候群在包括韩国在内的亚洲成人人口中占3-7%,在西方人中约占16%,发病频率较高。空腹状态、热量摄取限制、怀孕等是诱发这些患者黄疸的因素。已经发表了很多有关本症候群的研究和临床例子,也有报告将最近在韩医医疗机关韩医学治疗过程中偶然发现的血液中比利·鲁·芬奇上升的患者诊断为吉伯特症候群,并对临床过程进行了观察。本症如大棗煎湯。冷藏的药物临床试验研究为了动态学途中偶然发现的高胆红素血症2例子吉尔伯特症状诊断为军了。对此进行临床观察(圆光大学光州韩方医院IRB批准:WKIRB 14-11)报告。Gilbert's syndrome 2例临床考察
{"title":"Report on Two Cases of Gilbert's Syndrome Found in the Process of Administering Herbs","authors":"Jong Deok Lee, D. W. Kim","doi":"10.15188/KJOPP.2014.12.28.6.657","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.12.28.6.657","url":null,"abstract":"길버트 증후군(Gilbert's syndrome)은 간질환이나 용혈의 증거 없이 간헐적인 비포합형 고빌리루빈 혈증을 보이는 양성 경과를 보 이는 증후군으로 흔히 건강검진이나 우연한 기회의 혈액 검사 중 발견된다1). 임상적으로 혈액화학 검사 결과에서 고빌리루빈 혈증이 발견되 면 간담도계의 다양한 질환을 감별하기 위한 간 기능 검사와 영상 의학 검사들을 시행해야 한다. 특히 한약을 비롯한 약물을 복용하고 있는 환자들은 약물 대사 로 인한 간 기능의 변화와 연관 가능성 때문에 투약에 주의하고 때 로는 일정기간 중지해야 하며 추가적인 검사를 시행해야 하는 경우 가 많다. 이들 중 혈중 AST (aspartate transaminase), ALT (alanine transaminase), ALP (alkaline phosphatate), GGT (gamma glutamyl transpeptidase)와 같은 간기능을 나타내는 효 소 수치의 증가 없이 단지 고빌리루빈 혈증을 보이는 경우 일반 적:으로 길버트 증후군을 가능성 있는 원인 질환 중의 하나로서 고려하게 된다. 길버트 증후군은 우리나라를 포함한 아시아 성인인구의 3-7% 에서 발견되고 서양인에서 약 16%에서 나타나는 발생 빈도가 높은 질환으로서 공복상태, 급격한 열량섭취의 제한, 임신 등은 이들 환 자에게서 황달을 유발하는 요인으로 알려져 있다1,2). 본 증후군에 관한 많은 연구와 임상 예들이 다수 발표되었고 최근 한방 의료기관에서 한의학적 치료 과정 중 우연히 발견된 혈 중 빌리루빈치의 상승 된 환자를 길버트 증후군으로 진단하고 임상 경과 관찰을 하였던 보고도 있다3). 본 증례는 大棗 煎湯液의 약물 역동학을 알아보기 위한 임상 시험 연구 도중 우연히 발견된 고빌리루빈 혈증 2예가 길버트 증후 군으로 진단되었다. 이에 임상적 경과를 관찰하여(원광대학교 광주 한방병원 IRB 승인: WKIRB 14-11)보고한다. 단미 한약 복용중 발견한 Gilbert's syndrome 2예 임상고찰","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126726206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-convulsant Effects of Methanol Extract of Gastrodia Elata on Kainic Acid-induced Epilepsy Mouse Model 天麻甲醇提取物对凯尼克酸致癫痫小鼠模型的抗惊厥作用
Pub Date : 2014-12-31 DOI: 10.15188/kjopp.2014.12.28.6.614
Jung-Hee Jang
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引用次数: 1
Anti-inflammatory Effect of Euphorbiae kansui Radix Extract in Lipopolysaccharide-stimulated M ouse Peritoneal Macrophages 宽水大戟提取物对脂多糖刺激小鼠腹腔巨噬细胞的抗炎作用
Pub Date : 2014-12-31 DOI: 10.15188/KJOPP.2014.12.28.6.593
Jeung-beum Kim, H. Kyung, H. Kang
This study is aimed to investigate the anti-inflammatory effect of Euphorbiae kansui radix methanol extract (ERE) in lipopolysaccharide(LPS)-stimulated mouse peritoneal macrophages. Peritoneal macrophages were obtained from thioglycollate-injected Balb/c mice. Cells were stimulated with LPS or LPS plus interferon-gamma (IFN-γ) in the presence of ERE and various inflammatory markers were assayed. Finally, LPS-induced signaling molecules were measured. ERE up to 400 ㎍/㎖, was not cytotoxic to ERE inhibited LPS/IFN-γ-induced nitric oxide (NO), inducible NO synthase. ERE also reduced the levels of cyclooxygenase-2 and the proinflammatory cytokines such as tumor necrosis factor-α, interleukin(IL)-6 and IL-12. The inhibitory effect of ERE on LPS-induced IκBα degradation was weak but phosphorylation of JNK, p38 and ERK1/2 was strongly suppressed. Our data indicated that the anti-inflammatory effect of ERE in LPS-stimulated macrophages was partly mediated by its inhibition of JNK, p38 and ERK1/2.
本研究旨在探讨大戟甲醇提取物(ERE)对脂多糖(LPS)刺激小鼠腹腔巨噬细胞的抗炎作用。从注射巯基乙酸酯的Balb/c小鼠中获得腹腔巨噬细胞。在ERE存在的情况下,用LPS或LPS加干扰素γ (IFN-γ)刺激细胞,并检测各种炎症标志物。最后,测量lps诱导的信号分子。ERE≤400毫升,对细胞无毒害,ERE抑制LPS/IFN-γ诱导的一氧化氮(NO)、诱导的NO合成酶。ERE还降低了环氧化酶-2和促炎细胞因子如肿瘤坏死因子-α、白细胞介素(IL)-6和IL-12的水平。ERE对lps诱导的i - κ b α降解的抑制作用较弱,但JNK、p38和ERK1/2的磷酸化被强烈抑制。我们的数据表明,在lps刺激的巨噬细胞中,ERE的抗炎作用部分是通过抑制JNK、p38和ERK1/2介导的。
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引用次数: 0
Acute Analgesic Effect of Electroacupuncture on a Cancer Pain in a Small Cell Lung Cancer Patient : a Case Report 电针对小细胞肺癌患者癌痛的急性镇痛作用:1例报告
Pub Date : 2014-12-31 DOI: 10.15188/KJOPP.2014.12.28.6.689
Minna Hong, J. H. Lee, Hye-lim Park, H. Lee, Min-kyoung Cho, Chang-woo Han, Seong-ha Park, So-Yeon Kim, J. Kwon, In Lee, Jin-woo Hong, Jun-Yong Choi
We report a female small cell lung cancer patient in the extensive stage(T3N3Mx). After 6 cycles of chemotherapy combined radiation therapy, she received inpatient Korean medical care including herbal medicine, acupuncture therapy and concurrent western oral medications of opioid analgesics and anti-anxiety agent. The chief complaint was right side thoracic wall pain which had started after chemotherapy and was not effectively controlled by analgesics. For this condition, we treated her with 2Hz of constant electrical stimulation on Jiaji (Ex-B2) points T5-T7 laterally (right) using three needles for 20 minutes once a day for 9 days. With every session of electrical acupuncture treatment, thoracic pain decreased acutely. Korean medicine treatments including Jiaji (Ex-B2) point stimulation might be tried for lung cancer patients with uncontrolled thoracic pain at least for the acute analgesic effect.
我们报告一例广泛期(T3N3Mx)女性小细胞肺癌患者。经6个周期的化疗联合放疗后,住院患者接受韩式医疗护理,包括中药、针灸治疗及同时口服阿片类镇痛药和抗焦虑药。主诉为化疗后开始的右侧胸壁疼痛,镇痛药无法有效控制。针对此病,我们采用3根针,以2Hz持续电刺激右侧夹脊(前b2) T5-T7穴,每次20分钟,每天1次,连用9天。随着每一疗程的电针治疗,胸痛明显减轻。对于胸痛不可控的肺癌患者,至少在急性镇痛效果上可尝试韩药治疗,包括甲集穴(Ex-B2)刺激。
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引用次数: 2
Two Cases Reports of Behcet's Disease with Arthritis Treated with Oriental Medical Treatment Including Cheongsimyeonja-tang and Cheonglijagam-tang on each 东方中药清心延子汤和清理加甘汤治疗白塞病伴关节炎2例报告
Pub Date : 2014-12-31 DOI: 10.15188/KJOPP.2014.12.28.6.643
T. Lim
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引用次数: 1
Case Report of Chemotherapy Induced Peripheral Neuropathy Treated with Korean Medicine 韩药治疗化疗所致周围神经病变1例
Pub Date : 2014-10-31 DOI: 10.15188/KJOPP.2014.10.28.5.565
이지혜, 박혜림, Hye-Yoon Lee, 조민경, Minna Hong, woo Chang-Han, Jun-Yong Choi, Seong-ha Park, J. Kwon, In Lee, Jin-woo Hong, Kim So-yeon
{"title":"Case Report of Chemotherapy Induced Peripheral Neuropathy Treated with Korean Medicine","authors":"이지혜, 박혜림, Hye-Yoon Lee, 조민경, Minna Hong, woo Chang-Han, Jun-Yong Choi, Seong-ha Park, J. Kwon, In Lee, Jin-woo Hong, Kim So-yeon","doi":"10.15188/KJOPP.2014.10.28.5.565","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.10.28.5.565","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"31 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120817998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Study on the Individual Characteristic Factor by the Inspection of Face Colour and Tongue & the Auscultation and Olfaction 面色、舌形及听闻特征的个体特征因子研究
Pub Date : 2014-10-31 DOI: 10.15188/KJOPP.2014.10.28.5.478
Jae Phil Kim, Gyeong-Cheol Kim, Jeong-Won Lee
In order to the excellent differentiation of syndromes, we study on the individual characteristic factor by the inspection of face colour and tongue & the auscultation and olfaction. To the subject of diagnosis special books and diagnostics textbook of korean medicine, we arrange the individual characteristic factor by the inspection of face colour and tongue & the auscultation and olfaction. The inspection on the individual characteristic factor was analyzed the face colour, inspection of tongue. The auscultation and olfaction on the individual characteristic factor was analyzed the 25 types by the five-voice (五音) in Huang Di Nei Jing (黃帝內經). As the results, the individual characteristic factor is very important item of the four methods of diagnosis and the differentiation of syndromes. And Therefore the process on four methods of diagnosis and differentiation of syndromesis is necessary to divide the signs of individual characteristic factor and the signs of disease. keywords : Individual characteristic factor, face colour, inspection of tongue
以面色、舌诊、听诊、嗅觉为依据,对个体特征因素进行研究,力求辨证论治。对韩国医学诊断专著和诊断教科书的主题,我们通过面色、舌色的检查和听诊、嗅觉来安排个体特征因素。对个体特征因素的检测进行了分析,包括面部颜色、舌头的检测。用《黄帝内经》中的五声对25种类型的个体特征因素进行了听诊和嗅觉分析。因此,个体特征因素是四证辨证的重要内容。因此,在四证辨证的过程中,有必要对个体特征因子的体征和疾病的体征进行划分。关键词:个体特征因素,面部颜色,舌检
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引用次数: 0
Clinical Reports of Patients with Singi-hwan Teatment of Male Climateric Syndrome with AMS Questionnaire 用AMS问卷分析Singi-hwan治疗男性气候综合征的临床报告
Pub Date : 2014-10-31 DOI: 10.15188/KJOPP.2014.10.28.5.558
신선미, Heung Ko, K. Tae, K. H. Hyun, Park, Sun-young
The purpose of this study was to investigate the clinical results of the 10 male climateric syndrome cases while treated with Singi-hwan. All patients were treated with Singi-hwan two times a days for 5 weeks. We checked testosterone, PSA in blood, HRV and AMS questionnaire score. The questionnaire score was improved after taking Singi-hwan. Stress resistance and autonomic nervous system activity is increased, but there was no statistical significance except for ApEn. Taking Singi-hwan did not affect the serum concentration of testosterone, PSA and blood biochemical tests. The next placebo-controlled studies about late onset hypogonadism treated with Singi-hwan are needed. keywords : Singi-hwan(腎氣丸), Male Climateric Syndrome, AMS(Ageing Males‘ Symptoms) questionnaire, HRV(Heart Rate Variability)
本研究旨在探讨星焕治疗10例男性气候症候群的临床效果。所有患者均给予Singi-hwan治疗,每天2次,连续5周。我们检查了血液中睾酮、PSA、HRV和AMS问卷评分。服用Singi-hwan后,问卷得分有所提高。抗逆性和自主神经系统活性均升高,但除ApEn外无统计学意义。服用Singi-hwan不影响血清睾酮浓度、PSA和血液生化测试。需要下一个关于Singi-hwan治疗晚发型性腺功能减退的安慰剂对照研究。关键词:Singi-hwan,男性气候综合征,AMS(老化男性症状)问卷,HRV(心率变异性)
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引用次数: 1
Study of Immunosuppressive Activity and Insulin Secretion by Treated Sanguisorba Officinalis 地榆免疫抑制活性及胰岛素分泌的研究
Pub Date : 2014-10-31 DOI: 10.15188/KJOPP.2014.10.28.5.499
Seock-Yeon Hwang
Immunosuppressors cyclosporine A(CsA) and tacrolimus(FK506), the primary cellular target of which is calcineurin/nuclear factor of activated T cells(NFAT) signalling pathways, decrease beta-cell insulin content and mRNA expression. The posttransplantation diabetes mellitus(PTDM) is a frequent complication in immunosuppressive therapy. The present study was to examine the effect of a crude water extracts of medicinal herbs such as Sanguisorba officinalis(SOE) on the immunosuppressive activity with lymphocyte and insulin secretion in insulinoma cell lines with RIN-5mF. It was found that SOE treatment had effect of immunosuppressor on lymphocytes and also significantly increased insulin secretion in RIN-5mF compared to other agents. we might suggest a mechanism on insulin secretion by HNF4a. Taken together, the present study suggested that SOE might serve as immunosuppressive drug in PTDM. keywords : Sanguisorba officinalis, immunosuppressor, insulin secretion, HNF-4α
免疫抑制剂环孢素A(CsA)和他克莫司(FK506),其主要细胞靶点是钙调神经磷酸酶/活化T细胞核因子(NFAT)信号通路,可降低β细胞胰岛素含量和mRNA表达。移植后糖尿病(PTDM)是免疫抑制治疗的常见并发症。本研究探讨了三地血(SOE)等中药粗提物对含RIN-5mF的胰岛素瘤细胞株淋巴细胞免疫抑制活性和胰岛素分泌的影响。结果发现SOE治疗对淋巴细胞具有免疫抑制作用,且与其他药物相比,显著增加了RIN-5mF的胰岛素分泌。我们可能会提出HNF4a影响胰岛素分泌的机制。综上所述,本研究提示SOE可能作为PTDM的免疫抑制药物。关键词:地榆,免疫抑制剂,胰岛素分泌,HNF-4α
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引用次数: 1
期刊
Korean Journal of Oriental Physiology & Pathology
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