Pub Date : 2014-08-31DOI: 10.15188/KJOPP.2014.08.28.4.411
In-Jun Yang, C. Tettey, H. Shin
Simple formulas (單方) of muscle section in Donguibogam (東醫寶鑑) have long been prescribed for strengthening muscle and/or prevention of age-related muscle loss. However, biological activity and mechanisms by which they influence myoblast differentiation have not been studied. Therefore, in this study, we evaluated the effects of 14 simple formulas on myoblast differentiation in C2C12 myoblast cells under non-cytotoxic (0.5 ㎎/㎖) conditions. C2C12 cells were treated with water extracts of simple formulas for 72 h, and RT-PCR was performed to determine the gene expression levels of myogenic regulatory factors (MRFs), including myoD, myogenin, MRF4, myf5, and insulin like growth factor-1 (IGF-1). Treatment with Colocasiae Rhizoma (CR), Pini Semen (PS), and Sesami Semen (SS) resulted in a significant increase in expression of myogenin in C2C12 cells. Treatment with Allii Macrostemi Bulbus (AM), Colocasiae Rhizoma (CR), and Pini Semen (PS) also resulted in increased expression of MRF4 in C2C12 cells. In addition, enhanced expression of IGF-1 was observed in treatment with Eucommiae cortex (EC), Dioscoreae Rhizoma (DR), Colocasiae Rhizoma (CR), Pini Semen (PS), and Sesami Semen (SS) in C2C12 cells. These results indicate that simple formulas of muscle section in Donguibogam could potentially enhance myoblast differentiation at least in part via increasing expression of myogenin, and/or MRF4 and/or IGF-1.
{"title":"Effect of Simple Formulas of Muscle Section in Donguibogam on Myogenic Regulatory Factors and IGF-1 Expression in C2C12 Cells","authors":"In-Jun Yang, C. Tettey, H. Shin","doi":"10.15188/KJOPP.2014.08.28.4.411","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.08.28.4.411","url":null,"abstract":"Simple formulas (單方) of muscle section in Donguibogam (東醫寶鑑) have long been prescribed for strengthening muscle and/or prevention of age-related muscle loss. However, biological activity and mechanisms by which they influence myoblast differentiation have not been studied. Therefore, in this study, we evaluated the effects of 14 simple formulas on myoblast differentiation in C2C12 myoblast cells under non-cytotoxic (0.5 ㎎/㎖) conditions. C2C12 cells were treated with water extracts of simple formulas for 72 h, and RT-PCR was performed to determine the gene expression levels of myogenic regulatory factors (MRFs), including myoD, myogenin, MRF4, myf5, and insulin like growth factor-1 (IGF-1). Treatment with Colocasiae Rhizoma (CR), Pini Semen (PS), and Sesami Semen (SS) resulted in a significant increase in expression of myogenin in C2C12 cells. Treatment with Allii Macrostemi Bulbus (AM), Colocasiae Rhizoma (CR), and Pini Semen (PS) also resulted in increased expression of MRF4 in C2C12 cells. In addition, enhanced expression of IGF-1 was observed in treatment with Eucommiae cortex (EC), Dioscoreae Rhizoma (DR), Colocasiae Rhizoma (CR), Pini Semen (PS), and Sesami Semen (SS) in C2C12 cells. These results indicate that simple formulas of muscle section in Donguibogam could potentially enhance myoblast differentiation at least in part via increasing expression of myogenin, and/or MRF4 and/or IGF-1.","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128107975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-08-31DOI: 10.15188/KJOPP.2014.08.28.4.425
민선정, 김진희, 김민수, Seung-ryong Yeom, Young-dal Kwon
The purpose of this study is to suggest a possibility of the Korean medical treatment in patient with anterior interoseous nerve entrapment syndrome. The patient treated with acupunture, herbal medicine and Needle-embedding Therapy from April 19th to May 15th. We measured Visual Analotgue Scale(VAS), and Observed the change in body tempreture using Digital Infrared Thermal Imaging(DITI). After received Korean medical treatment, the patient showed improvement in muscle strength, sensation, VAS, temperature differential. Therefore we can consider Korean medical treatment before operation in interosseous nerve syndrome.
The purpose of this study is to suggest a possibility of the Korean medical treatment in patient with anterior interoseous nerve entrapment syndrome. The patient treated with acupunture, herbal medicine and Needle-embedding Therapy from April 19th to May 15th. We measured Visual Analotgue Scale(VAS), and Observed the change in body tempreture using Digital Infrared Thermal Imaging(DITI). After received Korean medical treatment, the patient showed improvement in muscle strength, sensation, VAS, temperature differential. Therefore we can consider Korean medical treatment before operation in interosseous nerve syndrome.
{"title":"Clinical Case of the Korean Medical Treatment for the Patient with Anterior Interosseous Nerve Syndrome","authors":"민선정, 김진희, 김민수, Seung-ryong Yeom, Young-dal Kwon","doi":"10.15188/KJOPP.2014.08.28.4.425","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.08.28.4.425","url":null,"abstract":"The purpose of this study is to suggest a possibility of the Korean medical treatment in patient with anterior interoseous nerve entrapment syndrome. The patient treated with acupunture, herbal medicine and Needle-embedding Therapy from April 19th to May 15th. We measured Visual Analotgue Scale(VAS), and Observed the change in body tempreture using Digital Infrared Thermal Imaging(DITI). After received Korean medical treatment, the patient showed improvement in muscle strength, sensation, VAS, temperature differential. Therefore we can consider Korean medical treatment before operation in interosseous nerve syndrome. ","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"33 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117350373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-08-31DOI: 10.15188/KJOPP.2014.08.28.4.440
Jeong Won Lee
{"title":"Study on the Selection Factors of Korean and Western Medical Institutions","authors":"Jeong Won Lee","doi":"10.15188/KJOPP.2014.08.28.4.440","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.08.28.4.440","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129607852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-08-31DOI: 10.15188/KJOPP.2014.08.28.4.384
W. Park
The purpose of this study is to investigate the modulatory effect of oroxylin A on hydrogen peroxide production in TM4 mouse testis sertoli cells induced by the synthetic analog of double-stranded RNA [polyinosinic-polycytidylic acid]. Hydrogen peroxide production was measured by dihydrorhodamine 123 (DHR) assay. Oroxylin A significantly inhibited the polyinosinic-polycytidylic acid (PIC)-induced production of hydrogen peroxide for 0.5, 2, 12, 18, and 24 hr incubation at the concentrations of 5, 10, 25, and 50 μM in TM4 (P < 0.05) in dose dependent manner. These results suggest that oroxylin A has a protective effect against PIC-induced cellular toxicity with its inhibition of hydrogen peroxide production in PIC-induced sertoli cells.
The purpose of this study is to investigate the modulatory effect of oroxylin A on hydrogen peroxide production in TM4 mouse testis sertoli cells induced by the synthetic analog of double-stranded RNA [polyinosinic-polycytidylic acid]. Hydrogen peroxide production was measured by dihydrorhodamine 123 (DHR) assay. Oroxylin A significantly inhibited the polyinosinic-polycytidylic acid (PIC)-induced production of hydrogen peroxide for 0.5, 2, 12, 18, and 24 hr incubation at the concentrations of 5, 10, 25, and 50 μM in TM4 (P < 0.05) in dose dependent manner. These results suggest that oroxylin A has a protective effect against PIC-induced cellular toxicity with its inhibition of hydrogen peroxide production in PIC-induced sertoli cells.
{"title":"Effect of Oroxylin A on Hydrogen Peroxide Production in Polyinosinic-Polycytidylic acid-induced TM4 Mouse Testis Sertoli Cells","authors":"W. Park","doi":"10.15188/KJOPP.2014.08.28.4.384","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.08.28.4.384","url":null,"abstract":"The purpose of this study is to investigate the modulatory effect of oroxylin A on hydrogen peroxide production in TM4 mouse testis sertoli cells induced by the synthetic analog of double-stranded RNA [polyinosinic-polycytidylic acid]. Hydrogen peroxide production was measured by dihydrorhodamine 123 (DHR) assay. Oroxylin A significantly inhibited the polyinosinic-polycytidylic acid (PIC)-induced production of hydrogen peroxide for 0.5, 2, 12, 18, and 24 hr incubation at the concentrations of 5, 10, 25, and 50 μM in TM4 (P < 0.05) in dose dependent manner. These results suggest that oroxylin A has a protective effect against PIC-induced cellular toxicity with its inhibition of hydrogen peroxide production in PIC-induced sertoli cells. ","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133916453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-08-31DOI: 10.15188/KJOPP.2014.08.28.4.430
Ji Hye Kim
{"title":"Survey of Traditional Korean Medical Device : Number of devices, Problems, Solution Plan","authors":"Ji Hye Kim","doi":"10.15188/KJOPP.2014.08.28.4.430","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.08.28.4.430","url":null,"abstract":"","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122374366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-06-30DOI: 10.15188/KJOPP.2014.06.28.3.280
성범 변, 주희 유, 아지 문, 봉우 박, 선엽 이, 종민 윤, 병순 문
The aim of this study was to collect and analyze clinical studies on electro-acupuncture therapies of post-stroke dysphagia to suggest the methods of the study about electro-acupuncture therapy. In this study, electronic searches were performed with searching sites. Searched words such as ‘중풍’, ‘뇌졸중’, ‘연하장애’, ‘전침’, ‘stroke’, ‘dysphagia’, ‘deglutition disorders’, ‘electro-acupuncture’ were used as a single keyword or in combinations. Through searching, 27 studies were selected and analyzed. In comparison of results before and after electro-acupuncture treatment, there were statistically significant improvement in 26 studies by using assessment such as video fluoroscopy swallowing study, swallowing water function test. The study of electro-acupuncture treatment for post-stroke dysphagia needs to be standardized and high-quality study models should be introduced.
The aim of this study was to collect and analyze clinical studies on electro-acupuncture therapies of post-stroke dysphagia to suggest the methods of the study about electro-acupuncture therapy. In this study, electronic searches were performed with searching sites. Searched words such as ‘중풍’, ‘뇌졸중’, ‘연하장애’, ‘전침’, ‘stroke’, ‘dysphagia’, ‘deglutition disorders’, ‘electro-acupuncture’ were used as a single keyword or in combinations. Through searching, 27 studies were selected and analyzed. In comparison of results before and after electro-acupuncture treatment, there were statistically significant improvement in 26 studies by using assessment such as video fluoroscopy swallowing study, swallowing water function test. The study of electro-acupuncture treatment for post-stroke dysphagia needs to be standardized and high-quality study models should be introduced.
{"title":"Literature Review of Clinical Research Electro-Acupuncture Treatment on Post-stroke Dysphagia","authors":"성범 변, 주희 유, 아지 문, 봉우 박, 선엽 이, 종민 윤, 병순 문","doi":"10.15188/KJOPP.2014.06.28.3.280","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.06.28.3.280","url":null,"abstract":"The aim of this study was to collect and analyze clinical studies on electro-acupuncture therapies of post-stroke dysphagia to suggest the methods of the study about electro-acupuncture therapy. In this study, electronic searches were performed with searching sites. Searched words such as ‘중풍’, ‘뇌졸중’, ‘연하장애’, ‘전침’, ‘stroke’, ‘dysphagia’, ‘deglutition disorders’, ‘electro-acupuncture’ were used as a single keyword or in combinations. Through searching, 27 studies were selected and analyzed. In comparison of results before and after electro-acupuncture treatment, there were statistically significant improvement in 26 studies by using assessment such as video fluoroscopy swallowing study, swallowing water function test. The study of electro-acupuncture treatment for post-stroke dysphagia needs to be standardized and high-quality study models should be introduced. ","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117237487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-06-30DOI: 10.15188/KJOPP.2014.06.28.3.359
Soo Jin Lee, Chae-jeong Han
The purpose of this study was to validate the Sasang Digestive function Inventory (SDFI) and Sasang Personality Questionnaire (SPQ) which measures the pathophysiolgoical symptoms and temperament of each Sasang types. The SDFI, SPQ along with Questionnaire for Sasang Constitution Classification II (QSCCII) were measured with 191 College students. The correlation coefficient was measured with Pearson correlation between SDFI and SPQ. The SDFI and SPQ subscale score of each Sasang constitution groups based on QSCCII were compared using analysis of variance and profile analysis. The SDFI and SPQ total score of So-Eum Sasang type were significantly (p 0.05) between SDFI and SPQ total score, however the SDFI-Digestion scale showed significant correlation with SPQ subscales. We found that the SDFI and SPQ can measure the Sasang type-specific pathophysiological symptoms and temperaments, and it would be useful for the clinical application and interdisciplinary research when combined together.
{"title":"Study on Sasang Typology Based on the Type-Specific Characteristics with Type-Specific Pathophysiological Symptom and Temperament","authors":"Soo Jin Lee, Chae-jeong Han","doi":"10.15188/KJOPP.2014.06.28.3.359","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.06.28.3.359","url":null,"abstract":"The purpose of this study was to validate the Sasang Digestive function Inventory (SDFI) and Sasang Personality Questionnaire (SPQ) which measures the pathophysiolgoical symptoms and temperament of each Sasang types. The SDFI, SPQ along with Questionnaire for Sasang Constitution Classification II (QSCCII) were measured with 191 College students. The correlation coefficient was measured with Pearson correlation between SDFI and SPQ. The SDFI and SPQ subscale score of each Sasang constitution groups based on QSCCII were compared using analysis of variance and profile analysis. The SDFI and SPQ total score of So-Eum Sasang type were significantly (p 0.05) between SDFI and SPQ total score, however the SDFI-Digestion scale showed significant correlation with SPQ subscales. We found that the SDFI and SPQ can measure the Sasang type-specific pathophysiological symptoms and temperaments, and it would be useful for the clinical application and interdisciplinary research when combined together. ","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130629295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-06-30DOI: 10.15188/KJOPP.2014.06.28.3.317
김지아, Chul-Won Lee, Lee BooKyun, Lee Jang Cheon, A. Gun
Amyloid-β protein (Aβ) is a pathological component of Alzheimer’s disease (AD) by participating in the senile plaque formation in the patient’s brain. Although the exact mechanism of Aβ toxicity is not fully elucidated, it is considered to be closely related to its fibrillation process. For prevention of AD, recent studies have suggested various small molecules which inhibit Aβ fibrillation. In this report, β-asarone found in acorus plant has been investigated as an anti-amyloid molecule. β-Asarone was demonstrated to prevent in vitro fibrillation of Aβ by inducing the oligomer formation that obviously decreased cytotoxicity. Therefore, β-asarone could be suggested as an inhibitory agent of Aβ fibrillation and toxicity, which would help us not only to understand underlying principle of amyloidogenesis mechanism but also to develop a controlling strategy toward AD.
Amyloid-β protein (Aβ) is a pathological component of Alzheimer’s disease (AD) by participating in the senile plaque formation in the patient’s brain. Although the exact mechanism of Aβ toxicity is not fully elucidated, it is considered to be closely related to its fibrillation process. For prevention of AD, recent studies have suggested various small molecules which inhibit Aβ fibrillation. In this report, β-asarone found in acorus plant has been investigated as an anti-amyloid molecule. β-Asarone was demonstrated to prevent in vitro fibrillation of Aβ by inducing the oligomer formation that obviously decreased cytotoxicity. Therefore, β-asarone could be suggested as an inhibitory agent of Aβ fibrillation and toxicity, which would help us not only to understand underlying principle of amyloidogenesis mechanism but also to develop a controlling strategy toward AD.
{"title":"Inhibition of Aβ42 Fibrillation and Toxicity with β-Asarone","authors":"김지아, Chul-Won Lee, Lee BooKyun, Lee Jang Cheon, A. Gun","doi":"10.15188/KJOPP.2014.06.28.3.317","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.06.28.3.317","url":null,"abstract":"Amyloid-β protein (Aβ) is a pathological component of Alzheimer’s disease (AD) by participating in the senile plaque formation in the patient’s brain. Although the exact mechanism of Aβ toxicity is not fully elucidated, it is considered to be closely related to its fibrillation process. For prevention of AD, recent studies have suggested various small molecules which inhibit Aβ fibrillation. In this report, β-asarone found in acorus plant has been investigated as an anti-amyloid molecule. β-Asarone was demonstrated to prevent in vitro fibrillation of Aβ by inducing the oligomer formation that obviously decreased cytotoxicity. Therefore, β-asarone could be suggested as an inhibitory agent of Aβ fibrillation and toxicity, which would help us not only to understand underlying principle of amyloidogenesis mechanism but also to develop a controlling strategy toward AD. ","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114187138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-06-30DOI: 10.15188/KJOPP.2014.06.28.3.251
Misun Park, Y. Kim
This article is for understanding dementia with the perspective of Korean Medicine through research on syndrome differentiations of dementia clinically applied and relations between modern diseases and Korean Medicine pattern types of dementia. clinical papers were searched in China Academic Journals(CAJ) of China National Knowledge Infrastructure(CNKI) from 2012 to 2013. Conclusions are as follows. First, dementia was expressed in many ways such as imbecility, stupidity, fatuity, idiocy, vacuity, etc and was related with amnesia, forgetfulness, speech not in the right order, depressive psychosis(quiet insanity), manic psychosis, depression syndrome. Second, prescriptions such as QiFuYin and ZuoGuiWan from JingYueQuanShu, XiXinTang and ZhiMiTang from BianZhengLu, TongQiaoHuoXueTang, XueFuZhuYuTang and BuYangHaiWuTang from YiLinGaiCuo, HaiShaoDan from YiFangJiJie, HuangLianJieDuTang from WaiTaiMiYao were suggested for dementia. Third, syndrome differentiation pattern types of dementia are kidney deficiency and marrow decrease, qi-blood depletion, liver-kidney depletion, spleen-kidney depletion, heart-spleen deficiency as deficiency patterns and effulgent heart-liver fire, ascendant hyperactivity of liver yang, qi stagnation and blood stasis, phlegm turbidity obstructing orifice, phlegm-blood stasis obstructing orifice, intense heat toxin as excess patterns and qi deficiency with blood stasis, yin deficiency with yang hyperactivity as deficiency-excess complex patterns. Major pattern types are kidney deficiency and marrow decrease, phlegm-blood stasis obstructing orifice, qi stagnation and blood stasis, liver-kidney depletion, phlegm turbidity obstructing orifice.
{"title":"Study on syndrome differentiation of dementia","authors":"Misun Park, Y. Kim","doi":"10.15188/KJOPP.2014.06.28.3.251","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.06.28.3.251","url":null,"abstract":"This article is for understanding dementia with the perspective of Korean Medicine through research on syndrome differentiations of dementia clinically applied and relations between modern diseases and Korean Medicine pattern types of dementia. clinical papers were searched in China Academic Journals(CAJ) of China National Knowledge Infrastructure(CNKI) from 2012 to 2013. Conclusions are as follows. First, dementia was expressed in many ways such as imbecility, stupidity, fatuity, idiocy, vacuity, etc and was related with amnesia, forgetfulness, speech not in the right order, depressive psychosis(quiet insanity), manic psychosis, depression syndrome. Second, prescriptions such as QiFuYin and ZuoGuiWan from JingYueQuanShu, XiXinTang and ZhiMiTang from BianZhengLu, TongQiaoHuoXueTang, XueFuZhuYuTang and BuYangHaiWuTang from YiLinGaiCuo, HaiShaoDan from YiFangJiJie, HuangLianJieDuTang from WaiTaiMiYao were suggested for dementia. Third, syndrome differentiation pattern types of dementia are kidney deficiency and marrow decrease, qi-blood depletion, liver-kidney depletion, spleen-kidney depletion, heart-spleen deficiency as deficiency patterns and effulgent heart-liver fire, ascendant hyperactivity of liver yang, qi stagnation and blood stasis, phlegm turbidity obstructing orifice, phlegm-blood stasis obstructing orifice, intense heat toxin as excess patterns and qi deficiency with blood stasis, yin deficiency with yang hyperactivity as deficiency-excess complex patterns. Major pattern types are kidney deficiency and marrow decrease, phlegm-blood stasis obstructing orifice, qi stagnation and blood stasis, liver-kidney depletion, phlegm turbidity obstructing orifice. ","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116604097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-06-30DOI: 10.15188/KJOPP.2014.06.28.3.330
Yu Hsia
This study aimed at examining the anti-inflammatory effects of Scutellariae Radix & Lonicerae Caulis water extract(SC). RAW 264.7 mouse macrophage cells were treated with 25∼200μg/ml SC for 24 hours. Cell viability was then measured using MTT assays. The nitric oxide(NO) production and the creation of several cytokines in LPS-stimulated RAW 264.7 cells were investigated. SC inhibited significantly increasing the production of NO in LPS-induced RAW 264.7 cell at the density of 25, 50 and 200 μg/ml. SC inhibited significantly the TNF-α of the RAW 264.7 cell induced by LPS at the density of 50μg/ml. SC inhibited significantly the MIP-1α of the RAW 264.7 cell induced by LPS at the density of 25, 50 and 100μg/ml. SC inhibited significantly the MIP-1β, MIP-2 at the density of 50, 100μg/ml in the RAW 264.7 cell increased by LPS, respectively. SC did not affect the production levels of VEGF in RAW 264.7 cell. As a result, SC significantly inhibited the inductions of MIP-1α, MIP-1β, MIP-2 and NO in LPS-induced RAW 264.7 cell without causing the toxicity. These results signify that SC has anti-inflammatory effects on controlling the over inflammatory reaction on the RAW 264.7 cell.
{"title":"Anti-inflammatory Effect of Combination of Scutellariae Radix and Lonicerae Caulis Water Extract","authors":"Yu Hsia","doi":"10.15188/KJOPP.2014.06.28.3.330","DOIUrl":"https://doi.org/10.15188/KJOPP.2014.06.28.3.330","url":null,"abstract":"This study aimed at examining the anti-inflammatory effects of Scutellariae Radix & Lonicerae Caulis water extract(SC). RAW 264.7 mouse macrophage cells were treated with 25∼200μg/ml SC for 24 hours. Cell viability was then measured using MTT assays. The nitric oxide(NO) production and the creation of several cytokines in LPS-stimulated RAW 264.7 cells were investigated. SC inhibited significantly increasing the production of NO in LPS-induced RAW 264.7 cell at the density of 25, 50 and 200 μg/ml. SC inhibited significantly the TNF-α of the RAW 264.7 cell induced by LPS at the density of 50μg/ml. SC inhibited significantly the MIP-1α of the RAW 264.7 cell induced by LPS at the density of 25, 50 and 100μg/ml. SC inhibited significantly the MIP-1β, MIP-2 at the density of 50, 100μg/ml in the RAW 264.7 cell increased by LPS, respectively. SC did not affect the production levels of VEGF in RAW 264.7 cell. As a result, SC significantly inhibited the inductions of MIP-1α, MIP-1β, MIP-2 and NO in LPS-induced RAW 264.7 cell without causing the toxicity. These results signify that SC has anti-inflammatory effects on controlling the over inflammatory reaction on the RAW 264.7 cell. ","PeriodicalId":129371,"journal":{"name":"Korean Journal of Oriental Physiology & Pathology","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131225685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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