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IAEA Safety Standards - One Step Toward Harmonized System of Radiation Protection Applied in Practice. 国际原子能机构安全标准——迈向辐射防护协调体系的一步。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1097/HP.0000000000002095
Miroslav Pinak, Jasminka Joksic, Hildegarde Vandenhove

The International Atomic Energy Agency (IAEA) has played a critical role in the development and establishment of contemporary radiation safety standards, beginning with its safety standards program launched in 1958. These standards have been developed and/or reviewed in continuous cooperation with the International Commission on Radiological Protection (ICRP) and United Nations Scientific Committee on the Effects of Atomic Radiation. This long-lasting partnership ensures that the latest scientific findings are integrated into international safety standards, fostering global harmonization. In 2021, the ICRP announced a review and potential revision of the system of radiological protection, which could lead an update of 2007 Recommendations (ICRP Publication 103) and called for cooperation and discussion among all relevant international stakeholders. Since then, numerous discussions among radiation protection professionals worldwide have taken place at key international meetings and events, focusing on the proposed changes and highlighting the need for further dialogue and cooperation in potential future revision. Any changes to the system will have consequences that must be carefully considered and justified. Potential revisions should be thoroughly evaluated to ensure they enhance the safety for the public, workers, patients, and the environment, while maintaining the system's stability and respecting national and regional specificities. The IAEA's work on providing for application of the current set of IAEA safety standards in its Member States aims to ensure that safety standards remain relevant, effective, and also adaptable to emerging challenges. It is important to stress the need for cooperation among all relevant international stakeholders to maintain the system's global applicability. Reviews of this work indicate that the current system is robust and effective, but with challenges primarily related to the way and feasibility of implementation and interpretation of safety standards rather than associated with the system itself.

国际原子能机构(IAEA)从1958年启动的安全标准项目开始,在制定和建立当代辐射安全标准方面发挥了关键作用。这些标准是在与国际辐射防护委员会和联合国原子辐射影响问题科学委员会不断合作下制定和(或)审查的。这种长期的伙伴关系确保将最新的科学发现纳入国际安全标准,促进全球统一。2021年,ICRP宣布对辐射防护体系进行审查和可能的修订,这可能导致对2007年建议(ICRP第103号出版物)进行更新,并呼吁所有相关国际利益攸关方进行合作和讨论。从那时起,世界各地的辐射防护专业人员在重要的国际会议和活动中进行了大量讨论,重点关注拟议的变化,并强调在未来可能的修订中进一步对话和合作的必要性。对系统的任何改变都将产生后果,必须仔细考虑并证明是合理的。应彻底评估潜在的修订,以确保它们提高公众、工作人员、患者和环境的安全,同时保持系统的稳定性并尊重国家和地区的特殊性。原子能机构在其成员国实施原子能机构现行安全标准方面的工作旨在确保安全标准保持相关性和有效性,并适应新出现的挑战。必须强调所有有关的国际利益攸关方之间必须进行合作,以维持该制度的全球适用性。对这项工作的回顾表明,目前的系统是健全和有效的,但挑战主要与安全标准的实施和解释的方式和可行性有关,而不是与系统本身有关。
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引用次数: 0
Sustainability and NORM - The Practitioner's Perspective. 可持续性和规范——实践者的视角。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1097/HP.0000000000002104
Rainer Gellermann, Analia Canoba, Douglas Chambers, Jim Hondros, Stéphane Pepin

This paper aims to discuss some of the challenges (and opportunities) associated with NORM and sustainability. Practical examples are used to demonstrate that the strict application of operational quantities, such as exemption values or surface contamination limits, can restrict the use of products that could be used in an unrestricted manner from a risk-based perspective. This can lead to the devaluation of material goods, such as phosphogypsum, radioactively contaminated scrap, and lead-containing 210Pb, among others, which clash with the objectives of the circular economy and thus also sustainability. The paper exemplifies the linkages between radiation protection and sustainability and aims to open a discussion on the adverse social and economic effects of the current practice. This is particularly relevant given the further development of the radiation protection system initiated by ICRP. Some preliminary ideas for this discussion are described.

本文旨在讨论与规范和可持续性相关的一些挑战(和机遇)。用实际的例子来证明,严格应用操作数量,如豁免值或表面污染限值,可以从基于风险的角度限制可以不受限制地使用的产品的使用。这可能导致物质商品贬值,如磷石膏、放射性污染废料和含铅210Pb等,这与循环经济的目标和可持续性相冲突。本文举例说明了辐射防护与可持续性之间的联系,并旨在就目前做法的不利社会和经济影响展开讨论。考虑到ICRP发起的辐射防护系统的进一步发展,这一点尤为重要。本文对本文的讨论提出了一些初步的设想。
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引用次数: 0
Radiological Justification Criteria of Pediatric Computed Tomography in Kenya. 肯尼亚儿童计算机断层扫描的放射学证明标准。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1097/HP.0000000000002089
Lonah Moraa Ong'ayo, Hyun Suk Yoon

Computed tomography is acknowledged as the most widely used imaging technique in both adults and children. Although computed tomography offers valuable diagnostic information, it contributes to a high radiation dose and poses relatively high risks of stochastic effects to patients. Stochastic risks are of special concern in pediatric imaging since children are more vulnerable to effects of ionizing radiation than adults. Therefore, the justification of pediatric computed tomography examinations is of paramount importance to critically weigh the benefits of computed tomography against the individual detriment. This study evaluates the current radiological justification for pediatric computed tomography in Kenya and propose strategies to enhance justification. An extensive literature review on pediatric computed tomography justification was explored based on the international guidelines of ICRP and IAEA and individual publications. The foundation of the review focused on the 3 A's: awareness, appropriateness, and audits as tools to ensure proper justification. The recommendations and guidelines proposed in this study can guide in the implementation of the 3 A's in the country.

计算机断层扫描被认为是成人和儿童中使用最广泛的成像技术。尽管计算机断层扫描提供了有价值的诊断信息,但它的辐射剂量高,对患者造成相对较高的随机效应风险。由于儿童比成人更容易受到电离辐射的影响,因此在儿童成像中需要特别关注随机风险。因此,儿童计算机断层扫描检查的理由是至关重要的,以批判性地权衡计算机断层扫描的好处和个人损害。本研究评估了目前肯尼亚儿童计算机断层扫描的放射学合理性,并提出了增强合理性的策略。根据ICRP和国际原子能机构的国际准则以及个别出版物,对儿童计算机断层扫描的合理性进行了广泛的文献回顾。审查的基础集中在3a:意识、适当性和审计作为确保适当证明的工具。本研究提出的建议和指导方针可以指导在该国实施3a。
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引用次数: 0
The Systems of Radiological Protection for Ionizing and Non-Ionizing Radiation. 电离和非电离辐射的辐射防护系统。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1097/HP.0000000000002109
Sara Dumit, Christopher Clement, John O'Hagan, Rodney Croft, Werner Rühm, Sigurður M Magnússon, Emilie van Deventer, Kathryn A Higley

This paper summarizes the presentations and panel discussion held at Plenary Session 1 of the 16th IRPA International Congress/69th Health Physics Society Annual Meeting, in Orlando, FL, in July 2024. Plenary Session 1 discussed the basics of the systems of radiological protection (RP) for ionizing radiation (IR) and non-ionizing radiation (NIR) and included five presentations and a panel discussion. Rodney Croft, Chair of the International Commission on Non-Ionizing Radiation Protection (ICNIRP), delivered the first presentation. Croft introduced the System of RP for NIR and provided an overview of ICNIRP's coverage and current areas of work. Werner Rühm, Chair of the International Commission on Radiological Protection (ICRP), delivered the second presentation. He gave an overview of the System of RP for IR and covered the key principles of justification, optimization, and dose limitation, including the current plans of ICRP toward the envisaged revision of the System of RP. The third speaker, Sigurður Magnús Magnússon, from the International Radiation Protection Association (IRPA), provided the perspective of the RP professionals on the development of the Systems of RP for IR and NIR. Emilie van Deventer, from the World Health Organization (WHO), presented WHO's views of both Systems of RP and discussed the relevant current activities of WHO with regard to IR and NIR. Kathryn Higley, President of the National Council on Radiation Protection and Measurements (NCRP), delivered the final presentation. Higley outlined the history of NCRP, the differences between ICRP and NCRP, and discussed the role of the NCRP in the System of RP, including NCRP's role to analyze mechanisms of interaction of NIR with biological systems, including humans. The session concluded with a fruitful panel discussion, where the audience had the opportunity to ask the five invited speakers questions.

本文总结了2024年7月在佛罗里达州奥兰多举行的第16届IRPA国际大会/第69届健康物理学会年会第1次全体会议上的演讲和小组讨论。全体会议1讨论了电离辐射(IR)和非电离辐射(NIR)辐射防护系统(RP)的基础知识,包括五场演讲和一次小组讨论。国际非电离辐射防护委员会(ICNIRP)主席罗德尼·克罗夫特(Rodney Croft)作了第一次介绍。Croft介绍了NIR的RP系统,并概述了ICNIRP的覆盖范围和当前的工作领域。国际放射防护委员会(ICRP)主席Werner r hm作了第二次介绍。他概述了针对IR的RP系统,并涵盖了论证、优化和剂量限制的关键原则,包括ICRP对RP系统的设想修订的当前计划。第三位发言者Sigurður Magnús Magnússon来自国际辐射防护协会(IRPA),他从RP专业人员的角度阐述了IR和NIR RP系统发展的观点。来自世界卫生组织(世卫组织)的Emilie van Deventer介绍了世卫组织对两个RP系统的看法,并讨论了世卫组织目前在IR和NIR方面的相关活动。国家辐射防护和测量委员会(NCRP)主席凯瑟琳·希格利(Kathryn Higley)作了最后的介绍。Higley概述了NCRP的历史、ICRP与NCRP的区别,并讨论了NCRP在RP系统中的作用,包括NCRP在分析NIR与生物系统(包括人类)相互作用机制中的作用。会议以富有成果的小组讨论结束,听众有机会向五位受邀演讲者提问。
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引用次数: 0
Use of the Linear No-threshold (LNT) Model in Radiological Protection: An Update. 线性无阈值(LNT)模型在放射防护中的应用研究进展。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1097/HP.0000000000002063
Dominique Laurier, Yann Billarand, Dmitry Klokov, Michael Tichauer

The linear no-threshold (LNT) model was introduced into the radiological protection system by the International Commission on Radiological Protection (ICRP) in 1966. The appropriateness of this model is still hotly debated today. Based on a recently published article, we summarize recent results in radiobiology and epidemiology and discuss their impact on the use of the LNT model regarding radiological protection. The scientific results published in radiobiology and epidemiology have strengthened our scientific knowledge of cancer risks associated with low dose and/or low dose-rate radiation exposure. In radiobiology, early stages of mutational carcinogenesis are considered to play a key role in carcinogenesis, with linear responses at doses as low as 10 mGy. Today, some non-mutation mechanisms appear clearly as non-linear, but their impact on the overall carcinogenesis process remains difficult to assess. In epidemiology, excess cancer risk has been observed at dose levels of 100 mGy or less. Some findings suggest that for some cancers, non-linear dose relationships may exist, but overall, the LNT model does not seem to seriously overestimate the risks of cancer at low doses. Overall, current results in radiobiology or epidemiology do not demonstrate the existence of a dose threshold below which the risk of radiation-induced cancer would be zero. Uncertainties remain, but if such a dose threshold existed for all solid cancers, it could not be greater than a few tens of mGy. In conclusion, we consider that the recent scientific knowledge does not call into question the use of the LNT model to assess cancer risks associated with exposure to ionizing radiation for the purpose of radiological protection. Today, the use of this model seems reasonable, and no other dose-response model seems to be more appropriate or justified for radiological protection purposes.

线性无阈值(LNT)模型于1966年由国际放射防护委员会(ICRP)引入放射防护系统。这种模式的适用性至今仍在激烈争论。基于最近发表的一篇文章,我们总结了放射生物学和流行病学的最新研究结果,并讨论了它们对使用LNT模型进行放射防护的影响。发表在《放射生物学和流行病学》上的科学结果加强了我们对与低剂量和/或低剂量率辐射照射有关的癌症风险的科学认识。在放射生物学中,突变性癌变的早期阶段被认为在癌变中起关键作用,在低至10毫戈瑞的剂量下具有线性反应。今天,一些非突变机制显然是非线性的,但它们对整个致癌过程的影响仍然难以评估。在流行病学中,已观察到在100毫戈瑞或更低的剂量水平下有过高的癌症风险。一些研究结果表明,对于某些癌症,可能存在非线性剂量关系,但总体而言,LNT模型似乎没有严重高估低剂量下的癌症风险。总体而言,目前放射生物学或流行病学的研究结果并未证明存在一个剂量阈值,低于该阈值,辐射诱发癌症的风险将为零。不确定性仍然存在,但如果对所有实体癌症都存在这样的剂量阈值,它不可能超过几十毫戈瑞。总之,我们认为,最近的科学知识并不质疑使用LNT模型来评估与电离辐射暴露相关的癌症风险,以达到辐射防护的目的。今天,这个模型的使用似乎是合理的,没有其他剂量-反应模型似乎更适合或更合理地用于辐射防护目的。
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引用次数: 0
Stakeholder Support for Regulatory Harmonization and Expanded Nuclear Power: Outcomes of HPS/NCRP Open Forums. 利益相关者支持监管协调和扩大核电:HPS/NCRP公开论坛的成果。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-01-14 DOI: 10.1097/HP.0000000000002056
C A Wilson, E M Brackett, K A Higley, E A Caffrey

On June 9th and 10th, 2025 the Health Physics Society (HPS) and National Council on Radiation Protection and Measurements (NCRP) jointly sponsored two open forums with the hopes of discussing and responding to constituent beliefs regarding a series of nuclear-related Executive Orders (EOs). The HPS and NCRP leaders were joined by members from the American Academy of Physicists in Medicine (AAPM), and the Conference of Radiation Control Program Directors (CRCPD) as panelists to help respond and moderate the forums. The forums focused on three of the nine relevant EOs, and, while varying opinions were shared, three common themes were strongly supported: First, many of the constituents support change, particularly regulatory harmonization (205/212, 97%), and the time to make changes [now] is appropriate due to these EOs. Second, the constituents believe that these EOs will have a significant impact on the nuclear fields (420/468, 90%). Third, the constituents strongly support the United States in increasing its use of nuclear power (236/245, 96%).

2025年6月9日和10日,健康物理学会(HPS)和国家辐射防护和测量委员会(NCRP)联合主办了两个公开论坛,希望讨论和回应有关一系列核相关行政命令(EOs)的组成信念。美国医学物理学家学会(AAPM)和辐射控制项目主任会议(CRCPD)的成员加入了HPS和NCRP的领导人,作为小组成员帮助回应和主持论坛。论坛集中讨论了九个相关EOs中的三个,虽然分享了不同的意见,但有三个共同的主题得到了强烈支持:首先,许多成员支持变革,特别是监管协调(205/212,97%),并且由于这些EOs,[现在]进行变革的时间是合适的。其次,参与者认为这些EOs将对核领域产生重大影响(420/468,90%)。第三,选民强烈支持美国增加核能的使用(236/ 245,96 %)。
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引用次数: 0
Effect of Water-Absorbent Polymers on Iodine Volatilization Control during the Heat Drying of Radioactive-iodine-containing Wastewater. 吸水聚合物对放射性含碘废水热干燥过程中碘挥发控制的影响。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-01-14 DOI: 10.1097/HP.0000000000002069
Masahiro Hirota, Tamaki Otani, Kodai Nishi, Shogo Higaki

The accidental ingestion of radioactive iodine is known to increase the risk of thyroid cancer and thyroid dysfunction; hence, strict radiation safety measures are required when handling it. In a previous study, we demonstrated that absorbing radioactive-iodine-containing wastewater using a water-absorbent polymer with cyclic oligosaccharides that selectively capture iodine, followed by natural drying, effectively separates at least 80% of the iodine from the wastewater. However, because natural drying requires approximately 2 wk, faster processing is essential to improve the efficiency of this wastewater treatment. Hence, we propose a method for quickly separating iodine from wastewater via heat drying. This study aimed to compare radioactive iodine volatilization levels between samples subjected to heat-drying- and natural-drying-based iodine and water separation. Na125I was added to purified water and artificial urine to prepare simulated waste liquids containing iodine at concentrations equivalent to those in the urine of patients undergoing radioactive iodine treatment. The prepared simulated waste liquids were poured into containers containing a superabsorbent polymer, dried in a thermostatic dryer set at 100 °C for 9 h, and subsequently stored for 90 d. The iodine residual rate in the simulated waste liquids was determined by measuring 125I radioactivity. At the end of the heat-drying process, the iodine residual rates in the simulated waste liquids prepared with purified water and artificial urine were 0.452 and 0.783, respectively. When absorbed in 1 g of superabsorbent polymer, the residual rates increased to 0.956 and 0.952, respectively. Over the following 82 d, the residual rates decreased by approximately 10%. Thus, by absorbing radioactive-iodine-containing wastewater into a highly water-absorbent polymer and then applying heat drying, iodine can be effectively separated from the wastewater while limiting its volatilization to less than 15%.

已知意外摄入放射性碘会增加患甲状腺癌和甲状腺功能障碍的风险;因此,在处理时必须采取严格的辐射安全措施。在之前的一项研究中,我们证明了使用含有环状低聚糖的吸水聚合物选择性地捕获碘,然后自然干燥,有效地从废水中分离出至少80%的碘。然而,由于自然干燥需要大约2周,因此更快的处理对于提高这种废水处理的效率至关重要。因此,我们提出了一种通过热干燥快速分离废水中碘的方法。这项研究的目的是比较放射性碘挥发水平的样品经受热干燥和自然干燥为基础的碘和水分离。将Na125I添加到纯净水和人工尿液中,以制备含碘浓度与接受放射性碘治疗的患者尿液中的浓度相当的模拟废液。将制备好的模拟废液倒入含有高吸水性聚合物的容器中,在100°C的恒温干燥器中干燥9 h,随后储存90 d。通过测量125I放射性来确定模拟废液中的碘残留率。在热干燥过程结束时,纯化水和人工尿液制备的模拟废液中碘残留率分别为0.452和0.783。在1 g高吸水性聚合物中吸附时,残留率分别提高到0.956和0.952。在接下来的82 d中,残留率下降了约10%。因此,通过将含放射性碘的废水吸收到高吸水性聚合物中,然后进行热干燥,可以有效地将碘从废水中分离出来,同时将其挥发率限制在15%以下。
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引用次数: 0
Radiation Protection Policy in a Nuclear Era -Recommendations from Health Physicists in Response to EO 14300. 核时代的辐射防护政策——健康物理学家响应EO 14300的建议。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-01-14 DOI: 10.1097/HP.0000000000002050
Emily A Caffrey, Charles A Wilson, Amir A Bahadori, Shaheen A Dewji
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引用次数: 0
Development and Clinical Implementation of an Integrated Information System for Occupational Radiation Exposure. 职业辐射暴露综合信息系统的开发与临床应用。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-01-14 DOI: 10.1097/HP.0000000000002038
Kengo Tanaka, Rikuta Ishigaki, Misaki Kamogawa, Noboru Niki, Yoshiki Kawata

Conventional occupational radiation exposure monitoring relies on cumulative dose data from personal dosimeters without providing information on when, where, or under what conditions exposure occurs. This lack of context limits analysis of causal factors, evaluation of protective behaviors, and the effectiveness of safety education. This study aimed to develop and clinically implement an integrated information system for occupational radiation exposure by combining dose data, spatiotemporal movement records, and angiography-related radiation information. We also assessed its utility and potential for improving radiation safety management. The system was implemented for 1 mo in a clinical angiography suite. It integrated (1) personal digital dosimeters recording dose and time, (2) Bluetooth Low Energy beacons tracking healthcare workers' positions and movements, and (3) Radiation Dose Structured Reports providing exposure details. Data were synchronized to reconstruct when, where, and under what conditions exposure occurred. The system identified high-risk positions near x-ray tubes (Beacon IDs 1-3), where exposure was greatest. Avoidance behaviors were also detected, such as movement to low-risk areas (e.g., Beacon ID 8) before irradiation. We successfully developed, implemented, and evaluated the system, demonstrating its utility for improving radiation safety management. The insights gained support targeted interventions and the refinement of safety protocols, with potential for broader use in diverse radiation-controlled settings.

传统的职业辐射照射监测依赖于个人剂量计的累积剂量数据,而不提供有关照射发生的时间、地点或条件的信息。这种背景的缺乏限制了对原因的分析、对保护行为的评价以及安全教育的有效性。本研究旨在结合剂量数据、时空运动记录和血管造影相关辐射信息,开发并临床实施职业辐射暴露综合信息系统。我们还评估了它在改善辐射安全管理方面的效用和潜力。该系统在临床血管造影套件中实施了1个月。它集成了(1)个人数字剂量计记录剂量和时间,(2)蓝牙低能量信标跟踪医护人员的位置和运动,以及(3)辐射剂量结构化报告提供照射细节。数据被同步以重建暴露发生的时间、地点和条件。系统识别出x射线管附近的高风险位置(Beacon id 1-3),那里的暴露程度最高。还检测到回避行为,例如在照射前移动到低风险区域(例如,信标ID 8)。我们成功地开发、实施和评估了该系统,证明了它在提高辐射安全管理方面的作用。获得的见解支持有针对性的干预措施和安全协议的改进,具有在各种辐射控制环境中更广泛使用的潜力。
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引用次数: 0
Organ Dosimetry in Radionuclide Therapy: Biokinetics of 131I and Dose with a Healthy Thyroid and after Thyroidectomy Using MCNP6. 放射性核素治疗中的器官剂量学:使用MCNP6检测健康甲状腺和甲状腺切除术后131I的生物动力学和剂量。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-01-08 DOI: 10.1097/HP.0000000000002044
Claudia Villalpando-Hernández, Fernando De La Torre Aguilar, Fernando Mireles-García, Eric Reyes-Rivera, Carlos Ríos-Martínez, José Luis Pinedo-Vega

An accurate internal dosimetry is important in 131I radionuclide therapy. In patients who have undergone a thyroidectomy, organs other than the thyroid absorb higher doses as the radionuclide is transported through the body because most of the thyroid gland is removed, and it cannot retain the 131I. The primary objective of this study is to compare the absorbed doses in at-risk organs due to intake of 131I after thyroidectomy vs. a healthy thyroid scenario. The biokinetic model of internal dosimetry for healthy thyroid as proposed by the International Commission on Radiological Protection (ICRP) in Publication 137 and a radiation transport simulation in Monte Carlo N-Particle 6 (MCNP6) were used. From the biokinetic model, average activities of 131I over a 30 h period were obtained, and these activities were used as source terms in MCNP6 simulations transporting gamma rays and beta particles to estimate absorbed doses in at-risk organs. The use of average activities is a new approach proposed in this study. Once the internal dosimetry model for a healthy thyroid was complete and functional, it was adapted for the scenario following thyroidectomy. This involved changing the transfer coefficients connected with the thyroid in the biokinetic model to constants proposed by Taprogge et al. in 2021. With this adjusted model, average activities of 131I over a 30-h period were obtained again and used as source terms in MCNP6 simulations of a patient following thyroidectomy, and from this simulation, absorbed doses in at-risk organs were estimated. These coefficients had not been used to estimate organ doses using MCNP. The 131I activity in the thyroid gland was found to be 20.4% of the initial administered dose in the scenario with a healthy thyroid vs. 0.64% following thyroidectomy. After thyroidectomy, all organs other than the thyroid absorbed higher radiation doses compared to the scenario with a healthy thyroid. The results of this study allow comparison of the absorbed doses between the scenarios of a healthy thyroid and after thyroidectomy, showing substantial differences between the modeled scenarios, which underscores the need to consider the larger context when assessing radiological impact on at-risk organs during 131I therapy.

准确的内剂量测定在131I放射性核素治疗中很重要。在接受甲状腺切除术的患者中,当放射性核素在体内运输时,甲状腺以外的器官吸收的剂量更高,因为大部分甲状腺被切除了,它不能保留131。本研究的主要目的是比较甲状腺切除术后与健康甲状腺情况下摄入131I在危险器官中的吸收剂量。采用国际放射防护委员会(ICRP)在第137号出版物中提出的健康甲状腺内剂量学生物动力学模型和蒙特卡罗n粒子6 (MCNP6)辐射输运模拟。从生物动力学模型中,获得了131I在30小时内的平均活度,这些活度被用作MCNP6模拟的源项,用于运输伽马射线和β粒子,以估计危险器官的吸收剂量。使用平均活动是本研究提出的一种新方法。一旦健康甲状腺的内部剂量学模型是完整和功能的,它就适用于甲状腺切除术后的情况。这涉及将生物动力学模型中与甲状腺相关的传递系数更改为Taprogge等人于2021年提出的常数。通过调整后的模型,再次获得了131I在30小时内的平均活性,并将其作为源项用于甲状腺切除术后患者的MCNP6模拟,并从该模拟中估计出危险器官的吸收剂量。这些系数未用于使用MCNP估计器官剂量。在甲状腺健康的情况下,甲状腺中的131I活性为初始给药剂量的20.4%,而甲状腺切除术后为0.64%。甲状腺切除术后,除甲状腺外的所有器官吸收的辐射剂量都高于甲状腺健康的情况。本研究的结果允许比较健康甲状腺和甲状腺切除术后情景之间的吸收剂量,显示了模拟情景之间的实质性差异,这强调了在评估131 - i治疗期间对危险器官的放射影响时需要考虑更大的背景。
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