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The Radiopharmaceutical Industry in Morocco: An Analytical Overview of Constraints and Developmental Prospects. 摩洛哥的放射性制药工业:制约因素和发展前景的分析概述。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-02 DOI: 10.1097/HP.0000000000002080
Hasnae Guerrouj, Ayat Mouaden, Mustapha Bouatia, Majdouline Bel Lakhdar

The Moroccan radiopharmaceutical industry is currently under development. The country has two operational cyclotrons capable of producing fluorine-18-labeled radiopharmaceuticals (RPs), primarily for PET imaging, while all other therapeutic and SPECT-dedicated RPs are imported. Importation processes are administratively complex and subject to fluctuations in global supply chains. The RP industry also faces additional challenges, including a stringent regulatory framework, limited accessibility, reimbursement barriers, and a scarcity of trained professionals in radiopharmacy and nuclear medicine more broadly. Furthermore, limited education and awareness among referring clinicians hinder the integration of some nuclear medicine procedures into routine clinical practice. Despite these challenges, Morocco has significant potential for localized RP production. Strategic investment and partnerships with key international agencies could enhance radiopharmacy infrastructure, streamline regulatory pathways for local manufacturing, and foster the development of new training programs for professionals in Morocco and other African countries.

摩洛哥的放射性制药工业目前正在发展中。该国有两个可操作的回旋加速器,能够生产氟-18标记的放射性药物,主要用于PET成像,而所有其他治疗和spect专用的rp都是进口的。进口过程管理复杂,并受全球供应链波动的影响。RP行业还面临着额外的挑战,包括严格的监管框架、有限的可及性、报销障碍以及在更广泛的范围内缺乏经过培训的放射药学和核医学专业人员。此外,转诊临床医生的教育和认识有限,阻碍了一些核医学程序融入常规临床实践。尽管存在这些挑战,摩洛哥仍具有本地化RP生产的巨大潜力。战略投资和与主要国际机构的伙伴关系可以加强放射性药物基础设施,简化当地生产的监管途径,并促进为摩洛哥和其他非洲国家的专业人员制定新的培训计划。
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引用次数: 0
Using a Retrospective Analysis to Conduct Prospective Dose Evaluations for Medical Health Physics Programs. 使用回顾性分析对医学健康物理项目进行前瞻性剂量评估。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-02 DOI: 10.1097/HP.0000000000002120
Jason D Hout, James Kyle Underwood, James Holland, Glenn M Sturchio

In radiation safety programs, particularly in large healthcare systems, personal dosimetry is often issued conservatively, leading to unnecessary monitoring of individuals with minimal exposure risk. This study describes a structured approach implemented at Mayo Clinic to evaluate the necessity and exchange frequency of dosimeters using two years of retrospective radiation dose data. Personnel were grouped based on job type and workplace conditions, then dosimetry data was analyzed at the 50th percentile, 95th percentile, and maximum levels against conservative thresholds. Regulatory requirements and managerial input were incorporated throughout the decision-making process. From 2020 to 2024, this method resulted in the reduction of dosimeter frequency for 82 individuals and complete removal for 1,067: reducing dosimeter issuance by 4,912 each year. The approach enabled a more efficient use of resources, allowing radiation safety efforts to be directed toward higher-risk groups and activities without compromising compliance or worker protection. This model provides a conservative, scalable framework for optimizing dosimetry programs in healthcare and potentially other radiation-using industries.

在辐射安全项目中,特别是在大型医疗保健系统中,个人剂量测定通常是保守的,导致对暴露风险最小的个人进行不必要的监测。本研究描述了在梅奥诊所实施的一种结构化方法,利用两年的回顾性辐射剂量数据来评估剂量计的必要性和交换频率。根据工作类型和工作条件对人员进行分组,然后对剂量学数据进行第50百分位,第95百分位和保守阈值的最大水平分析。在整个决策过程中纳入了监管要求和管理投入。从2020年到2024年,该方法减少了82人使用剂量计的频率,完全取消了1,067人,每年减少了4,912个剂量计的发放。这种方法能够更有效地利用资源,使辐射安全工作能够针对高风险群体和活动,而不会损害合规或工人保护。该模型为优化医疗保健和潜在的其他辐射使用行业的剂量学计划提供了一个保守的、可扩展的框架。
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引用次数: 0
Distribution of Natural Radionuclides at the Nevada National Security Site. 内华达国家安全基地天然放射性核素的分布。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-02 DOI: 10.1097/HP.0000000000002111
Xianan Liu, Ronald W Warren

According to the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) publications, contributions of terrestrial gamma doses are mainly from the presence of 40K, and of 238U and 232Th together with their progeny in various rocks and soils. A survey of soil distributions of radionuclides 40K, 238U, and 232Th was performed at the Nevada National Security Site (NNSS) using in situ gamma-ray spectrometry with a high-purity germanium (HPGe) detector. The average activity concentrations of 40K, 238U, and 232Th in natural soils at the NNSS are 867 Bq kg-1 (range from 150 ± 8 to 1297 ± 56 Bq kg-1), 50 Bq kg-1 (range from 29 ± 3 to 74 ± 8 Bq kg-1), and 56 Bq kg-1 (range from 11 ± 2 to 96 ± 10 Bq kg-1), respectively. The concentration at each location is significantly associated with its geological lithology. The terrestrial gamma dose rates around the NNSS were estimated from 26 to 144 nSv h-1 with mean value of 93 nSv h-1. Our results provide useful information about the natural background radiation and radiological effects of naturally occurring radionuclides at the NNSS.

根据联合国原子辐射影响科学委员会(UNSCEAR)的出版物,地面伽马剂量的贡献主要来自各种岩石和土壤中40K、238U和232Th及其后代的存在。在内华达州国家安全基地(NNSS),利用高纯度锗(HPGe)探测器的原位伽玛射线能谱法对放射性核素40K、238U和232Th的土壤分布进行了调查。自然土壤中40K、238U和232Th的平均活性浓度分别为867 Bq kg-1(范围150±8 ~ 1297±56 Bq kg-1)、50 Bq kg-1(范围29±3 ~ 74±8 Bq kg-1)和56 Bq kg-1(范围11±2 ~ 96±10 Bq kg-1)。在每个地点的浓度与它的地质岩性显著相关。NNSS周围的地面伽马剂量率估计为26 ~ 144 nSv h-1,平均值为93 nSv h-1。我们的研究结果提供了有关NNSS天然本底辐射和天然放射性核素辐射效应的有用信息。
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引用次数: 0
Tissue Substitutes for the Livermore Torso Phantom Suitable for a Continuous Spectrum of Low-energy Photons. 适合低能光子连续光谱的利弗莫尔躯干幻影的组织替代品。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-02 DOI: 10.1097/HP.0000000000002051
Henry Spitz, Jimmy Stringer, Samuel Glover, Mary Kathryn Hoffman, Ethan Howell

Substitute materials that accurately reproduce the radiological properties of human tissues are required for direct in vivo measurement of internally deposited radioactive materials to estimate associated health risk, especially for the respiratory tract. The Livermore torso phantom, the de facto standard for calibrating detector systems that measure radioactive materials deposited in the lungs, liver, and thoracic lymph nodes, was designed with tissue substitute materials that match the density and attenuation coefficient exhibited by natural human tissue when exposed to single low-energy x rays associated with the decay of plutonium. In this study, we evaluated the radiometric tissue equivalence of new tissue substitutes for muscle, rib, sternum, lung, and cartilage that are suitable for a continuous low photon energy spectrum from approximately 30 to 120 keV. The formulation for each of the tissue substitutes was developed using a novel method that determines the optimized quantity of base material and additives to produce a material that best matches the density and photon transmission exhibited by the natural human tissue present in the thoracic cavity. Measurements of the mass attenuation coefficient (i.e., ) from approximately 30 keV up to 120 keV for each substitute tissue were within 8% or better to expected values calculated using the photon cross section database XCOM from the National Institute for Standards and Technology.

为了直接在体内测量体内沉积的放射性物质,以估计相关的健康风险,特别是呼吸道的健康风险,需要能够准确再现人体组织放射特性的替代材料。利弗莫尔躯干模型是测量肺部、肝脏和胸部淋巴结中沉积的放射性物质的校准探测器系统的事实上的标准,它是用组织替代材料设计的,这些材料与自然人体组织暴露在与钚衰变有关的单次低能x射线下所表现出的密度和衰减系数相匹配。在这项研究中,我们评估了肌肉、肋骨、胸骨、肺和软骨的新组织替代品的放射组织等效性,这些替代品适用于大约30至120 keV的连续低光子能谱。每种组织替代品的配方都是使用一种新方法开发的,该方法确定了基础材料和添加剂的最佳数量,以产生最符合胸腔中存在的天然人体组织所表现出的密度和光子传输的材料。每个替代组织的质量衰减系数(即)从大约30 keV到120 keV的测量值与使用美国国家标准与技术研究所的光子截面数据库XCOM计算的期望值在8%以内或更好。
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引用次数: 0
The Key Role of Objective Experience in Enhancing the Knowledge of Ionizing Radiation for Pre-interns and Residents. 客观经验在提高实习医师和住院医师电离辐射知识中的关键作用。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-02 DOI: 10.1097/HP.0000000000002036
Vahideh Nazari, Vahid Ghaderi, Leili Tapak

Due to the widespread use of ionizing radiation in diagnosis and therapy and its associated risks, this study seeks to evaluate the radiation knowledge of pre-interns and residents and find key factors in this regard. This research was conducted at an educational hospital involving 56 pre-interns and 42 radiotherapy and radiology residents. The questionnaire contained fifteen questions about radiobiology, radiation knowledge basics, and ionizing radiation protection principles. The findings revealed that pre-interns had a mean score of 60.48 ± 11.69, whereas radiology and radiotherapy residents had mean scores of 55.75 ± 9.11 and 82.00 ± 13.06, respectively. The knowledge level of radiotherapy residents was significantly higher than other groups in every section (P-value<0.0001), with no significant difference found based on gender. The mean level of knowledge varies by academic degree. Pre-interns scored significantly lower than residents (P-value<0.05). The higher level of radiation knowledge within the cohort of radiotherapy residents underscores the pivotal role of continuous learning through objective experience. Given their professional focus on the use of ionizing radiation, this group is objectively in ongoing training.

由于电离辐射在诊断和治疗中的广泛使用及其相关的风险,本研究旨在评估实习生和住院医生的辐射知识,并找到这方面的关键因素。本研究在一家教育医院进行,涉及56名实习医师和42名放射治疗和放射学住院医师。问卷内容包括放射生物学、辐射知识基础、电离辐射防护原理等15个问题。结果显示,实习医师的平均得分为60.48±11.69,而放射科和放疗住院医师的平均得分分别为55.75±9.11和82.00±13.06。放疗住院患者的知识水平在各剖面上均显著高于其他组(p值)
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引用次数: 0
Single-Center, Open-Label, Randomized Controlled Trial on the Reduction of Scattered Radiation Exposure to the Primary Operator in Radial, Femoral, and Pectoral Cath Lab Procedures Using a Radiation Protection Drape. 单中心、开放标签、随机对照试验:使用辐射防护罩减少桡骨、股动脉和胸动脉导管实验室操作中主要操作者的散射辐射暴露。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-02 DOI: 10.1097/HP.0000000000002100
Shodhan R Aithal, Hermohander Singh Isser, Zubair Farooq, Sandeep Bansal, Puneet Gupta

Radiation exposure in the catheterization laboratory poses a significant occupational hazard for primary operators. This single-center, open-label, randomized controlled trial conducted at Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, evaluated scattered radiation exposure to the primary operator during procedures via radial, femoral, and pectoral vascular access sites and the effectiveness of radiation protection drapes in reducing this exposure. A total of 216 patients (72 in each vascular access group) were randomized using coin flipping to receive either standard radiation protection or additional shielding with a radiation protection drape. The primary operator's scattered radiation dose was assessed in comparison to the radiation emitted during the procedure, with normalization to procedural radiation parameters including air kerma (AK), dose area product (DAP), and cine-adjusted screen time (CAST). Pectoral access was associated with the highest operator exposure (96.75 µSv) compared to femoral (45.72 µSv) and radial (49.06 µSv) access, despite lower AK values. Radiation protection drapes significantly reduced operator exposure across all access sites, with radial access showing reductions of 51% (DAP), 48% (AK), and 53% (CAST); femoral access showing reductions of 82% (DAP), 74% (AK), and 63% (CAST); and pectoral access showing reductions of 62% (DAP), 49% (AK), and 52% (CAST), all statistically significant (P < 0.05). No adverse events were reported. The findings provide strong support for the routine use of radiation protection drapes to minimize primary operator radiation exposure during catheterization procedures, especially when using the pectoral access site.

导管室的辐射暴露对主要操作人员构成了重大的职业危害。这项在新德里Vardhman Mahavir医学院和Safdarjung医院进行的单中心、开放标签、随机对照试验评估了手术过程中主要操作者通过桡骨、股动脉和胸动脉血管的散射辐射暴露,以及辐射防护罩在减少这种暴露方面的有效性。共有216名患者(每个血管通路组72名)随机接受标准辐射防护或额外的辐射防护罩。将主要操作者的散射辐射剂量与手术过程中发射的辐射进行比较,并将其归一化为手术辐射参数,包括空气可达度(AK)、剂量面积积(DAP)和电影调整屏幕时间(CAST)。尽管AK值较低,与股骨(45.72µSv)和桡骨(49.06µSv)入路相比,胸侧入路的操作人员暴露量最高(96.75µSv)。辐射防护帘显著降低了所有接入点的操作人员暴露量,其中径向接入点降低了51% (DAP)、48% (AK)和53% (CAST);股骨通路显示82% (DAP)、74% (AK)和63% (CAST)的减少;胸通径降低62% (DAP)、49% (AK)、52% (CAST),均有统计学意义(P < 0.05)。无不良事件报告。研究结果为常规使用辐射防护布提供了强有力的支持,以减少导管过程中主要操作人员的辐射暴露,特别是在使用胸侧通路部位时。
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引用次数: 0
Revisiting the System of Radiological Protection: The Principle of Justification. 再论辐射防护制度:正当性原则。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1097/HP.0000000000002078
Nobuhiko Ban

The principle of justification is intended to ensure the net benefit of a proposed activity that would alter radiation exposure. While the concept is simple and easy to understand, its application, including the basis for judgments and the process for reaching a decision, is not straightforward. It has been demonstrated in the last decades that the decision-making process in radiological protection and safety requires not only scientific and technical rationality but also consideration of stakeholder views to appropriately reflect societal and ethical values. In view of these emerging challenges, the International Commission on Radiological Protection created Task Group 124 for the purpose of revisiting and modernizing the principle of justification. The Task Group collected various views and opinions of radiation protection experts through an online workshop and an international conference. They were examined to identify areas that need further clarification and to extract ideas that were not given sufficient consideration in the past. The Task Group is working to compile a report that identifies essential elements and key perspectives in the decision-making process for justification. It aims to clarify what "do more good than harm" means in society today and on what basis the judgment should be made.

正当性原则旨在确保将改变辐射照射的拟议活动的净效益。虽然这一概念简单易懂,但其应用,包括判断的基础和作出决定的过程,并不直截了当。过去几十年的经验表明,辐射防护和安全决策过程不仅需要科学和技术合理性,还需要考虑利益相关者的意见,以适当反映社会和道德价值观。鉴于这些新出现的挑战,国际放射防护委员会设立了第124工作队,目的是重新审查辩解原则并使之现代化。专责小组透过网上研讨会及国际会议,收集辐射防护专家的不同意见。对它们进行了审查,以确定需要进一步澄清的领域,并提取过去没有得到充分考虑的想法。工作队正在编写一份报告,确定决策过程中的基本要素和关键观点,以供证明理由。它旨在澄清“利大于弊”在当今社会的含义,以及应该在什么基础上做出判断。
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引用次数: 0
Rapid Radiation Dose Estimation Techniques for Initial Patient Triage. 初步病人分诊的快速辐射剂量估计技术。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1097/HP.0000000000002061
Meghan M Dieffenthaller, Joshua M Hayes, James D Vogt, Adayabalam S Balajee, Carol J Iddins

Emergency responders and health physicists need to make quick decisions on initial analyses and observations when responding to a radiological or nuclear emergency. Health physicists use complicated mathematical equations and dose calculation algorithms to create precise and detailed dose reconstructions, but this is dependent upon the release of information regarding the exposure or contamination scenario. The Radiation Emergency Assistance Center/Training Site employs and teaches certain "rules of thumb" dose estimation techniques for both internal and external exposures, which may help in early phase dose reconstruction and for predicting health outcomes by health care providers. This includes using the point source equation and inverse square law to estimate a person's exposure from a source at a given distance, assessing internal inhalation intakes, and estimating internal deposition based on initial uptake measurements from wound or nasal contamination. Biodosimetry techniques can be used to estimate the absorbed dose, with dicentric chromosome assay being the gold standard. Other biodosimetry techniques include evaluating symptoms of acute radiation syndrome and cutaneous radiation injury. The intent for these initial dose reconstruction techniques is not to replace the existing dosimetry techniques but to allow rapid initial patient triage, so that life-saving interventions may be employed immediately.

在应对放射性或核紧急情况时,应急人员和卫生物理学家需要对初步分析和观察迅速作出决定。卫生物理学家使用复杂的数学方程和剂量计算算法来创建精确和详细的剂量重建,但这取决于有关暴露或污染情景的信息的发布。辐射紧急援助中心/培训地点采用并教授某些针对内部和外部照射的“经验法则”剂量估计技术,这可能有助于早期剂量重建和卫生保健提供者预测健康结果。这包括使用点源方程和平方反比定律来估计一个人在给定距离处的暴露量,评估内部吸入摄入量,以及根据伤口或鼻腔污染的初始摄取测量来估计内部沉积。生物剂量测定技术可用于估计吸收剂量,以双中心染色体测定为金标准。其他生物剂量测定技术包括评估急性辐射综合征和皮肤辐射损伤的症状。这些初始剂量重建技术的目的不是取代现有的剂量测定技术,而是允许快速的初始患者分诊,以便立即采取挽救生命的干预措施。
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引用次数: 0
HEALTH PHYSICS SOCIETY . 2026 AFFILIATE MEMBERS. 健康物理学会。2026个附属会员。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1097/01.HP.0001177644.51858.44
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引用次数: 0
Topical Issues for the Future of Radiation Protection. 未来辐射防护的热门议题。
IF 1.4 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1097/HP.0000000000002107
Kevin Nelson, Renate Czarwinski, Charles Wilson, Bernard LeGuen, Jing Chen, Hildegarde Annie Vandenhove, Shengli Niu, Thierry Schneider, John Damilakis, Peter Alfred Bryant

This paper summarizes the presentations and panel discussion provided at Plenary Panel #2 on the first day of the 16th World Congress of the International Radiation Protection Association (IRPA) jointly organized with the 69th Annual Meeting of the Health Physics Society (HPS) in Orlando/Florida in July 2024. International organizations that play a key role in radiation protection and are close in contact with IRPA by official agreements or even MoU's (Memorandum of Understanding) presented highlights of their projects in radiation protection as well as results. Topical issues on their current work program as seen in a list of statements, including future efforts, were presented and discussed. The needs of practitioners were stressed for recognition by the representatives of the international organizations to be included in their projects. Requested and presented topics were: • Key challenges for radiation protection practitioners in the next 10 y. • Potential effects of emerging science on radiation protection. • Challenges for implementation of IAEA Safety Standards in low- and middle-income countries. • Challenges in occupational radiation protection. • Broadening the process of optimization. • Impact of emerging technologies on radiation protection. • Ensuring radiation protection workforce for the future.

本文总结了国际辐射防护协会(IRPA)与健康物理学会(HPS)第69届年会(2024年7月在佛罗里达州奥兰多举行)联合举办的第16届世界大会第一天全体小组#2的演讲和小组讨论。在辐射防护方面扮演重要角色,并与IRPA有正式协议甚至谅解备忘录(MoU)密切联系的国际组织,介绍了他们在辐射防护方面的重点项目和成果。会议提出并讨论了关于其当前工作计划的专题问题,如发言清单所示,包括今后的努力。与会者强调了从业人员的需要,以便得到国际组织代表的承认,并将其列入其项目。请求和提出的主题是:•未来10年辐射防护从业人员面临的主要挑战。•新兴科学对辐射防护的潜在影响。•在中低收入国家实施国际原子能机构安全标准的挑战。•职业辐射防护面临的挑战。•拓宽优化过程。•新兴技术对辐射防护的影响。•确保未来的辐射防护劳动力。
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引用次数: 0
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