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Absolute Method for Measuring Environmental Radioactive Materials Using Imaging Plates. 使用成像板测量环境放射性物质的绝对方法。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-06-29 DOI: 10.1097/HP.0000000000001818
Mori Yutaro, Isobe Tomonori, Takei Hideyuki, Yoshimura Yosuke, Ide Yasuwo, Sugaya Keito, Sajyrau Gudetyjum, Sakae Takeji

Abstract: We had previously developed a measurement method using an imaging plate (IP) to evaluate and address surface contamination caused by the release of radioactive materials during the Fukushima nuclear accident. The measurement units for the surface contamination density were in relative values [described as relative luminescence levels measured in luminescence arbitrary units (LAU)], but the evaluation was required in absolute values, such as Bq cm -2 , to enable appropriate control of exposure doses. This study establishes a method for converting the IP measurements of surface contamination density due to environmental radioactivity into absolute values. Soil contaminated with radioactive materials from the Fukushima nuclear accident was collected to create a working reference material (WRM). The conversion coefficient for surface contamination density was calculated using the WRM values measured with an IP and high-purity germanium detectors. The IP measurement values were converted into the surface contamination density using the conversion coefficient. The WRM values measured with the IP and high-purity germanium detectors were 324.1 LAU and 32.22 ± 2.27 Bq cm -2 , respectively. The surface contamination density conversion factor was calculated as 0.0994. The surface contamination density on the roof of the Tsukuba City facility was re-evaluated using the conversion factor. The average value of 29,972 Bq m -2 matched the amount of radioactive material fallen in Tsukuba City. By standardizing the measurement conditions for surface contamination when using IPs, we successfully quantified the surface contamination density with an accuracy comparable to that of conventional methods. This method is expected to make a significant contribution to efficient radiation safety management.

摘要:我们之前开发了一种使用成像板(IP)的测量方法,用于评估和处理福岛核事故期间放射性物质释放造成的表面污染。表面污染密度的测量单位是相对值[描述为以发光任意单位(LAU)测量的相对发光水平],但评估需要绝对值,如 Bq cm-2,以便适当控制照射剂量。本研究建立了一种方法,可将环境放射性导致的地表污染密度的 IP 测量值转换为绝对值。收集了福岛核事故中受到放射性物质污染的土壤,以创建工作参考材料(WRM)。使用 IP 和高纯锗探测器测量的 WRM 值计算了表面污染密度的转换系数。使用转换系数将 IP 测量值转换为表面污染密度。使用 IP 和高纯锗探测器测得的表面污染密度值分别为 324.1 LAU 和 32.22 ± 2.27 Bq cm-2。经计算,表面污染密度换算系数为 0.0994。使用转换系数重新评估了筑波市设施屋顶的表面污染密度。29,972 Bq m-2 的平均值与筑波市放射性物质的降落量相符。通过在使用 IPs 时对表面污染的测量条件进行标准化,我们成功地量化了表面污染密度,其精确度与传统方法相当。这种方法有望为高效的辐射安全管理做出重大贡献。
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引用次数: 0
Decontamination of Actinide-contaminated Injured Skin with Ca-DTPA Products Using an Ex Vivo Rat Skin Model. 使用 Ca-DTPA 产品对放线菌污染的损伤皮肤进行净化,并使用体内大鼠皮肤模型。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-05-17 DOI: 10.1097/HP.0000000000001827
Anne Van der Meeren, Karine Devilliers, Nina Griffiths, Anne-Sophie Chaplault, Martine Defrance, Gaëtan Ducouret, Michaël Pasteur, Pierre Laroche, François Caire-Maurisier

Abstract: Skin contamination by α-emitting actinides such as plutonium and americium is a risk for workers during nuclear fuel production and reactor decommissioning. Decontamination of skin is an important medical countermeasure to limit potential internal contamination, particularly in the case of injured skin. Current recommendations include undressing of the victim followed by skin washing using soap or chelating agents, such as diethylene triamine pentaacetic acid (DTPA). The goal of the present work is to assess the efficacy of a novel Ca-DTPA loaded gel to decontaminate injured skin exposed to plutonium or americium as compared to recommended treatments. For decontaminant testing on injured skin, whole body skin was obtained from euthanized rats and lesions created using a metallic brush. Delimited test areas were contaminated with plutonium or americium solutions of known properties. Various protocols were tested including time before contamination, duration of gel application, washing steps, as well as the concomitant addition or not of dressings. Activity was measured in each decontamination product and in skin. Data indicate that healthy skin was easier to decontaminate than damaged skin. On injured skin, we demonstrated an increased decontamination efficacy of the Ca-DTPA gel formulation as compared to the solution. Importantly, gel application alone was effective, and further gel applications could be used for residual activity.

摘要:在核燃料生产和反应堆退役过程中,钚和镅等α发射锕系元素对工人的皮肤造成污染是一种风险。皮肤去污是限制潜在内部污染的重要医疗对策,尤其是在皮肤受伤的情况下。目前的建议包括脱掉受害者的衣服,然后使用肥皂或螯合剂(如二乙三胺五乙酸(DTPA))清洗皮肤。本研究的目的是评估一种新型的钙-DTPA 负载凝胶与建议的处理方法相比,对暴露于钚或镅的受伤皮肤的去污效果。在对受伤皮肤进行去污测试时,从安乐死的大鼠身上获取全身皮肤,并使用金属刷造成损伤。用已知性质的钚或镅溶液污染划定的测试区域。对各种方案进行了测试,包括污染前的时间、涂抹凝胶的持续时间、清洗步骤以及是否同时添加敷料。对每种去污产品和皮肤的活性进行了测量。数据表明,健康皮肤比受损皮肤更容易去污。在受损皮肤上,我们发现 Ca-DTPA 凝胶配方的去污效果比溶液更好。重要的是,单独使用凝胶就能产生效果,进一步使用凝胶还能产生剩余活性。
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引用次数: 0
Research on Detection Efficiency of Imaging Plates for Alpha Particles Using Two Types of Imaging Plate. 使用两种成像板检测阿尔法粒子的成像板检测效率研究。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-06-17 DOI: 10.1097/HP.0000000000001828
Fengdi Qin, Zhengzhong He, Zhongkai Fan, Kejun Lu, Haoxuan Li, Yizhe Luo, Xiyu Yang, Tianyu Deng, Xiangming Cai, Cong Sun, Jian Shan

Abstract: Imaging plates can measure isotopes with alpha decay (such as radon and its progeny, americium, and so on). However, the detection efficiency of imaging plates is affected by alpha particle energy, types of imaging plates, and the overlapping effect. In this study, simulations were performed to analyze the relationship between detection efficiency and these three influence factors. The research findings suggest that BAS-TR and BAS-MS are well-suited for the detection of alpha particles with energy levels below 6.83 MeV and above, respectively. The track overlap effect correction method proposed in this study is applicable to both BAS-TR and BAS-MS image plates. The measurement results of radon progeny demonstrate that the correction method enhances the detection efficiency from 0.203 to 0.288. This study presents a valuable approach for selecting the appropriate image plate and correcting the track overlap effect in the measurement of alpha radioactive material concentration and other related information.

摘要:成像板可以测量具有α衰变的同位素(如氡及其后代、镅等)。然而,成像板的探测效率受α粒子能量、成像板类型和重叠效应的影响。本研究对探测效率与这三个影响因素之间的关系进行了模拟分析。研究结果表明,BAS-TR 和 BAS-MS 分别非常适合检测能量水平低于 6.83 MeV 和高于 6.83 MeV 的阿尔法粒子。本研究提出的轨道重叠效应校正方法适用于 BAS-TR 和 BAS-MS 图像板。氡后代的测量结果表明,校正方法可将检测效率从 0.203 提高到 0.288。这项研究为在测量α放射性物质浓度和其他相关信息时选择合适的图像板和校正轨道重叠效应提供了一种有价值的方法。
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引用次数: 0
Uranium Body Clearance Kinetics-A Long-term Follow-up Study of Retired Nuclear Fuel Workers. 铀体清除动力学--退休核燃料工人的长期跟踪研究。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1097/HP.0000000000001861
Ibtisam Yusuf, Edvin Hansson, Mats Eriksson, Patric Lindahl, Håkan B L Pettersson
<p><strong>Abstract: </strong>Nuclear industry workers exposed to uranium aerosols may risk kidney damage and radiation-induced cancer. This warrants the need for well-established dose and risk assessments, which can be greatly improved by using material-specific absorption parameters in the ICRP Human Respiratory Tract Model. The present study focuses on the evaluation of the slow dissolution rate ( s s , d -1 ), a parameter that is difficult to quantify with in vitro dissolution studies, especially for more insoluble uranium compounds. A long-term follow-up of urinary excretion after the cessation of chronic inhalation exposure can provide a better estimate of the slow-rate dissolution. In this study, two workers, previously working for >20 y at a nuclear fuel fabrication plant, provided urine samples regularly for up to 6 y. One individual had worked at the pelletizing workshop with the known presence of uranium dioxide (UO 2 ) and triuranium octoxide (U 3 O 8 ). The second individual worked at the conversion workshop where multiple compounds, including uranium hexafluoride (UF 6 ), uranium dioxide (UO 2 ), ammonium uranyl carbonate, and AUC [UO 2 CO 3 ·2(NH 4 ) 2 CO 3 ], are present. Data on uranium concentration in urine during working years were also available for both workers. The daily excretion of uranium by urine was characterized by applying non-linear least square regression fitting to the urinary data. Material-specific parameters, such as the activity median aerodynamic diameter (AMAD), the respiratory tract absorption parameters, rapid fraction ( f r ,), rapid dissolution rate ( s r , d -1 ), and slow dissolution rate ( s s , d -1 ) and alimentary tract transfer factor ( f A ) acquired from previous work along with default absorption types, were applied to urine data, and the goodness of fit was evaluated. Thereafter intake estimates and dose calculations were performed. For the ex-pelletizing worker, a one-compartment model with a clearance half-time of 662 ± 100 d ( s s = 0.0010 d -1 ) best represented the urinary data. For the ex-conversion worker, a two-compartment model with a major [93% of the initial urinary excretion (A 0 )] fast compartment with a clearance half-time of 1.3 ± 0.4 d ( s r = 0.5 d -1 ) and a minor (7% of A 0 ) slow compartment with a half-time of 394 ± 241 d ( s s = 0.002 d -1 ) provided the best fit. The results from the data-fitting of urinary data to biokinetic models for the ex-conversion worker demonstrated that in vitro derived experimental parameters (AMAD = 20 μm, f r = 0.32, s r = 27 d -1 , s s = 0.0008 d -1 , f A = 0.005) from our previous work best represented the urinary data. This resulted in an estimated intake rate of 0.66 Bq d -1 . The results from the data-fitting of urinary data to biokinetic models for the ex-pelletizing worker indicated that the experimental parameters (AMAD = 10 μm and 20 μm, f r = 0.008, s r = 12 d -1 , f A = 0.00019) from our previous dissolution studies with the slow
摘要:暴露于铀气溶胶的核工业工人可能面临肾脏损伤和辐射诱发癌症的风险。因此,需要进行完善的剂量和风险评估,而在国际放射防护委员会人体呼吸道模型中使用特定材料的吸收参数,可以大大提高评估结果的准确性。本研究的重点是评估缓慢溶解速率(ss,d-1),这是一个很难通过体外溶解研究进行量化的参数,尤其是对于较难溶解的铀化合物。在停止慢性吸入接触后,对尿液排泄进行长期跟踪可以更好地估计缓慢溶解率。在这项研究中,两名曾在核燃料制造厂工作超过 20 年的工人定期提供了长达 6 年的尿样。其中一人曾在造粒车间工作,已知存在二氧化铀(UO2)和八氧化三铀(U3O8)。第二个人曾在转化车间工作,该车间存在多种化合物,包括六氟化铀 (UF6)、二氧化铀 (UO2)、碳酸铀铵和 AUC [UO2CO3-2(NH4)2CO3]。这两名工人在工作期间尿液中铀浓度的数据也已获得。通过对尿液数据进行非线性最小平方回归拟合,确定了尿液中铀的日排泄量。将特定材料参数,如活动中值空气动力学直径 (AMAD)、呼吸道吸收参数、快速组分 (fr,)、快速溶解率 (sr, d-1) 和慢速溶解率 (ss, d-1) 以及消化道转移因子 (fA) 与默认吸收类型一起应用于尿液数据,并评估拟合的良好性。然后进行摄入量估计和剂量计算。对于前造粒工人,清除半衰期为 662 ± 100 d(ss = 0.0010 d-1)的单室模型最能体现尿液数据。对于前转化工人,二室模型的拟合效果最好,其中主要的快速室(占初始尿排泄量(A0)的 93%)的清除半衰期为 1.3 ± 0.4 d(ssr = 0.5 d-1),次要的慢速室(占 A0 的 7%)的清除半衰期为 394 ± 241 d(ss = 0.002 d-1)。将尿液数据与前转化工人的生物动力学模型进行数据拟合的结果表明,我们以前工作中得出的体外实验参数(AMAD = 20 μm,fr = 0.32,sr = 27 d-1,ss = 0.0008 d-1,f A = 0.005)最能代表尿液数据。因此,估计摄入率为 0.66 Bq d-1。将尿液数据与生物动力学模型进行拟合的结果表明,先前溶解研究中的实验参数(AMAD = 10 μm 和 20 μm,fr = 0.008,sr = 12 d-1,fA = 0.00019)与根据尿液数据逐步优化的慢速率参数(ss = 0.0008 d-1)的拟合效果最佳。因此,估计摄入率为 5 Bq d-1。从体外溶解研究中得出的实验参数为从转炉车间退休的受试者提供了最佳拟合参数,可以假定他吸入的是可溶气溶胶(如AUC、UF6)和相对不溶气溶胶(如二氧化铀)的混合物。对于在造粒车间工作而退休的受试者,由于其暴露于相对不溶性的气溶胶(二 氧化铀和八氧化三铀),ss 值比溶解度研究中获得的要高得多,这更好地反映了尿液 数据,并且与其他研究中报告的二氧化铀和八氧化三铀的ss 值相当。这意味着不溶性材料的体外溶解研究可能存在不确定性。在评估尿液数据的回顾性拟合结果时,停止接触后获得的尿液样本显然波动较小。停止接触后对铀排泄的长期跟踪是确定吸收参数的一个很好的替代方法,可被视为确定较难溶解物质缓慢吸收率的最可行方法。
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引用次数: 0
A Compendium of Radiation Safety Practices That Can Complement Organizational Worker Well-being Initiatives. 辐射安全措施简编,可补充组织工人福利计划。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-05-26 DOI: 10.1097/HP.0000000000001835
R J Emery, J M Gutierrez, M K Zwick

Abstract: Organizations are learning that efforts to protect the health and safety of their workers from risks both at work and outside of work yield great dividends in the form of increased productivity, morale, and reduced healthcare costs. This realization has given rise to a variety of worker well-being initiatives that span far beyond the typical boundaries of traditional workplace health and safety programs. Examples include providing information and services on diet, exercise, personal habits, and mental health issues. Interestingly, the radiation safety profession has been historically involved with a series of progressive worker well-being practices that perhaps are not fully appreciated by the broader well-being community. These include the ability to comprehensively track occupational doses, training regarding doses arising from outside the workplace (such as medical procedures and environmental exposures), and fetal protection policies, to name a few. Described here is the shift in perspective from health and safety merely for the workplace to a more holistic approach, but the degree to which the actions may be implemented varies. Included then is a compendium of radiation safety practices that may be possibly folded into the discussion of larger organizational well-being efforts.

摘要:各组织正在认识到,努力保护工人的健康和安全,使其免受工作场所和工作场所以外风险的影响,可以带来巨大的收益,如提高生产率、士气和降低医疗成本。这种认识催生了各种工人福利计划,其范围远远超出了传统工作场所健康与安全计划的典型界限。例如,提供有关饮食、运动、个人习惯和心理健康问题的信息和服务。有趣的是,辐射安全专业在历史上曾参与过一系列进步的工人福利实践,而这些实践也许并没有得到更广泛的福利社区的充分重视。这些措施包括全面跟踪职业剂量的能力、关于工作场所外产生的剂量(如医疗程序和环境暴露)的培训,以及胎儿保护政策等等。这里描述的是从仅仅关注工作场所的健康和安全到更全面的视角的转变,但这些行动的实施程度各不相同。其中包括辐射安全实践简编,这些实践可能会被纳入更广泛的组织福利工作的讨论中。
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引用次数: 0
Comparison of MCNP and Microshield Dose Savings Determinations for Remote Methods of Transuranic Contamination Characterization. 跨铀污染特征描述远程方法中 MCNP 和微屏蔽剂量节省测定的比较。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-10-01 Epub Date: 2024-05-26 DOI: 10.1097/HP.0000000000001829
Justina A M Freilich, Camille J Palmer

The maturation of robotic and remote systems presents opportunities to expand the use of technologies that have typically been restricted to high-dose/high-risk nuclear work for moderate- or low-risk work to further reduce radiation exposure to workers. This study quantifies the potential dose savings achieved through the use of robotic techniques for characterizing transuranic-contaminated waste items and compares dose estimates from a simplistic, user-friendly deterministic radiation transport code and a more robust, complex Monte Carlo code. Three scenarios of transuranic-contaminated waste items described in published reports are modeled using representative source geometries in MicroShield and MCNP radiation transport codes. Estimated dose rates are determined at points ranging from 30 cm to 300 cm from the face of the waste item to represent the increase in distance allowed by robotic or remote system implementation for characterization activities. The dose rate savings are then converted to detriment cost savings using a dollar-per-person-dose conversion factor to provide a financial context. The radiation transport simulations show no consistent bias in estimated dose rate by varying simulation methodology or using geometrical simplifications-in some cases, MicroShield produces higher dose rate estimates while MCNP estimates are higher in other cases. In the MCNP simulations, the volume source geometry consistently produces a higher dose rate than the slab source geometry, but the MicroShield dose rate estimates do not display the same trend. Dose savings range from 1.60 × 10-5 μSv h-1 to 1.75 × 101 μSv h-1 with associated detriment cost savings from < 0.010 USD/person-h to 14 USD/person-h.

机器人和远程系统的成熟为将通常仅限于高剂量/高风险核工作的技术扩大用于中度或低风险工作提供了机会,从而进一步减少工人受到的辐射照射。本研究量化了通过使用机器人技术表征受跨铀污染的废物物项而实现的潜在剂量节省,并比较了来自简单、用户友好的确定性辐射传输代码和更强大、更复杂的蒙特卡洛代码的剂量估计值。利用微屏蔽和 MCNP 辐射传输代码中具有代表性的源几何形状,对已发表报告中描述的三种受超铀污染的废物进行建模。估算的剂量率是在距离废物表面 30 厘米到 300 厘米之间的点上确定的,以表示机器人或远程系统实施特征描述活动时允许增加的距离。然后,使用美元/人剂量转换系数将节省的剂量率转换为节省的损害成本,以提供财务背景。辐射传输模拟表明,不同的模拟方法或使用几何简化方法对估计剂量率的偏差并不一致--在某些情况下,微护盾得出的估计剂量率更高,而在其他情况下,MCNP 得出的估计剂量率更高。在 MCNP 模拟中,体积源几何形状产生的剂量率始终高于板状源几何形状,但 MicroShield 的剂量率估计值没有显示出相同的趋势。节省的剂量从 1.60 × 10-5 μSv h-1 到 1.75 × 101 μSv h-1 不等,节省的相关损害成本从 < 0.010 美元/人-小时到 14 美元/人-小时不等。
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引用次数: 0
INTDOSKIT: An R-Code for Calculation of Dose Coefficients and Studying Their Uncertainties. INTDOSKIT:用于计算剂量系数和研究其不确定性的 R 代码。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-13 DOI: 10.1097/HP.0000000000001833
Bastian Breustedt, Niranjan Chavan, Thomas Makumbi

Abstract: An R-code, which allows the calculation of the time dependent activity distribution based on ICRP reference models, the number of decays in a commitment period, and the dose coefficients for tissues and organs of the human body, has been developed. R Language was chosen due to its powerful mathematical and statistical modeling features, as well as its graphical capabilities. The developed set of functions and constants (called "INTDOSKIT") can be sourced in R-scripts that define or import the models and calculations to be performed. The code has been tested on models of several radionuclides and was successfully validated against reference data taken from ICRP OIR Data Viewer software. Furthermore, the code has been tested and verified on the modeling of the radioactivity of decay chains using data of the 233Ra model presented by Höllriegl and colleagues. The results of calculations with INTDOSKIT demonstrated that the code is able to reproduce the ICRP bioassay data and dose coefficients. Deviations are a few percent only and are due mainly to rounding in the original data. Lastly, the code is able to handle uncertainty and sensitivity studies as demonstrated by the results in a pilot study of injection of 241Am, which estimated geometric standard deviations (GSD) for dose coefficients ranging between 1.25 (bone-surface) and 1.66 (testes); these results are consistent with those obtained from similar studies done by other researchers who reported GSD values ranging from 1.13 to 1.73.

摘要:我们开发了一种 R 代码,可以根据国际放射防护委员会的参考模型计算随时间变化的放射性活度分布、承诺期内的衰变次数以及人体组织和器官的剂量系数。之所以选择 R 语言,是因为它具有强大的数学和统计建模功能以及图形功能。开发的函数和常量集(称为 "INTDOSKIT")可在 R 脚本中使用,以定义或导入要执行的模型和计算。该代码已在几种放射性核素的模型上进行了测试,并成功地与来自 ICRP OIR Data Viewer 软件的参考数据进行了验证。此外,还利用 Höllriegl 及其同事提供的 233Ra 模型数据,对该代码进行了衰变链放射性建模测试和验证。使用 INTDOSKIT 计算的结果表明,该代码能够再现 ICRP 的生物测定数据和剂量系数。偏差仅为百分之几,主要是由于原始数据的四舍五入造成的。最后,该代码能够处理不确定性和敏感性研究,对注入 241Am 的试验研究结果证明了这一点,该研究估计剂量系数的几何标准偏差(GSD)在 1.25(骨表面)和 1.66(睾丸)之间;这些结果与其他研究人员进行的类似研究得出的结果一致,其他研究人员报告的 GSD 值在 1.13 至 1.73 之间。
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引用次数: 0
Effects of High Temperature and High Humidity on the Degree of Ocular Damage Caused by 60 GHz Millimeter Wave Exposure. 高温和高湿对 60 GHz 毫米波暴露造成的眼损伤程度的影响。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-02 DOI: 10.1097/HP.0000000000001843
Masami Kojima, Takafumi Tasaki, Toshio Kamijo, Aki Hada, Yukihisa Suzuki, Masateru Ikehata, Hiroshi Sasaki

Abstract: Millimeter waves (MMW) are pervasive in society; however, studies on the biological effects of MMW exposure are usually performed in laboratory settings not reflecting global environmental diversity. We investigated the effects of a 6-min exposure to 60 GHz MMW (wavelength, 5.0 mm) at incident power densities of 200 and 300 mW cm-2 in eyes (exposed right eyes vs. unexposed left eyes) under various ambient temperature/relative humidity environments (24 °C/50%, 45 °C/20%, and 45 °C/80%) using an in vivo rabbit model. Correlations were examined with adverse ocular events, including corneal epithelial damage (assessed using fluorescein staining), corneal opacity (evaluated by slit-lamp microscopy), and corneal thickness (measured via optical coherence tomography). Our findings indicate that higher temperatures and humidity tend to exacerbate MMW-induced ocular damage, albeit not significantly in the present study. Further research with a larger sample size is warranted. Incident power density emerged as a factor that was directly linked to the ocular damage threshold. High ambient temperature and humidity tended to exacerbate ocular damage from MMW exposure, although the effect was secondary. Ocular damage in a high-temperature (45 °C), high-humidity (80%) environment was increased to the same extent as that by incident power density increased by approximately 100 mW cm-2 in an ocular damage model in a standard environment (24 °C, 50%). In a high-humidity environment, the internal ocular tissue temperature increased at a high ambient temperature of 45 °C, suggesting that the eyeball may respond differently compared to other tissues.

摘要:毫米波(MMW)在社会中无处不在;然而,有关接触毫米波对生物影响的研究通常是在实验室环境中进行的,不能反映全球环境的多样性。我们利用活体兔子模型,研究了在不同的环境温度/相对湿度环境(24 °C/50%、45 °C/20%和 45 °C/80%)下,入射功率密度为 200 和 300 mW cm-2 的 60 GHz 毫米波(波长 5.0 mm)对眼睛(暴露的右眼与未暴露的左眼)的 6 分钟暴露影响。研究了不良眼部事件与角膜上皮损伤(通过荧光素染色评估)、角膜不透明(通过裂隙灯显微镜评估)和角膜厚度(通过光学相干断层扫描测量)之间的相关性。我们的研究结果表明,较高的温度和湿度往往会加剧 MMW 引起的眼部损伤,尽管在本研究中并不明显。我们有必要进行样本量更大的进一步研究。入射功率密度是与眼损伤阈值直接相关的一个因素。高环境温度和湿度往往会加剧微功率辐射对眼睛的损伤,尽管这种影响是次要的。在高温(45 °C)、高湿度(80%)环境中,眼损伤的加重程度与标准环境(24 °C,50%)中眼损伤模型的入射功率密度增加约 100 mW cm-2 的程度相同。在高湿度环境中,眼球内部组织温度在 45 ℃ 的高环境温度下升高,这表明眼球的反应可能与其他组织不同。
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引用次数: 0
Feasibility of Treatment Agents in Radioactive Iodine Separation from Waste Liquids. 从废液中分离放射性碘的处理剂的可行性。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-01 Epub Date: 2024-01-10 DOI: 10.1097/HP.0000000000001780
Masahiro Hirota, Shogo Higaki, Yoshiyuki Ishida, Daisuke Nakata, Keiji Terao, Shigeki Ito

Abstract: To discharge waste liquid containing radioactive iodine into sewage systems, long-term storage or dilution with a large amount of water may be required until the radioactivity concentration reduces below the standard value. Processing the waste liquid could be easier if radioactive iodine could be separated from the water. This study verified the effectiveness of superabsorbent polymer and α-cyclodextrin as treatment agents to separate radioactive iodine from waste liquids. Sodium iodide (Na 125 I) was added to purified water and artificial urine to prepare simulated waste liquids containing iodine equivalent to the urine of patients treated with radioactive iodine. The as-prepared simulated waste liquid was poured into a container with superabsorbent polymer and left for 90 d. The residual iodine rate in the simulated waste liquid was estimated by measuring 125 I radioactivity. When the water was sufficiently dried, residual iodine rates on day 15 were 0.102 and 0.884 in the simulated waste liquids comprising purified water and artificial urine, respectively. The simulated waste liquid comprising purified water with 5% α-cyclodextrin absorbed by 1 g of superabsorbent polymer had a residual rate of 0.980. Moreover, the residual rate of simulated waste liquid comprising artificial urine with 2% α-cyclodextrin absorbed by 1 g of SAP was 0.949. Superabsorbent polymer combined with α-cyclodextrin was an effective treatment agent for separating radioactive iodine from waste liquids.

摘要:要将含有放射性碘的废液排入污水系统,可能需要长期储存或用大量水稀释,直到放射性浓度降低到标准值以下。如果能将放射性碘从水中分离出来,废液的处理就会变得更容易。这项研究验证了超吸收聚合物和 α-环糊精作为处理剂从废液中分离放射性碘的有效性。将碘化钠(Na125I)添加到纯净水和人工尿液中,制备出含碘量相当于接受放射性碘治疗的患者尿液的模拟废液。将制备好的模拟废液倒入装有超吸收聚合物的容器中,静置 90 d。当水充分干燥后,在第 15 天,由纯净水和人工尿液组成的模拟废液中的碘残留率分别为 0.102 和 0.884。由纯净水和 5%α-环糊精组成的模拟废液被 1 克超吸收聚合物吸收后,残留率为 0.980。此外,1 克 SAP 吸收含有 2% α-环糊精的人工尿液模拟废液的残留率为 0.949。结合了 α-环糊精的超强吸收聚合物是一种从废液中分离放射性碘的有效处理剂。
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引用次数: 0
Feasibility of Liver Transplantation after 90 Y Radioembolization: Lessons from a Radiation Protection Incident. 90Y 放射性栓塞术后肝移植的可行性:从辐射防护事故中吸取的教训。
IF 1 4区 医学 Q4 ENVIRONMENTAL SCIENCES Pub Date : 2024-09-01 Epub Date: 2024-03-26 DOI: 10.1097/HP.0000000000001814
Marine Soret, Jacques-Antoine Maisonobe, Philippe Maksud, Stéphane Payen, Manon Allaire, Eric Savier, Charles Roux, Charlotte Lussey-Lepoutre, Aurélie Kas

Abstract: Radioembolization using 90 Y is a growing procedure in nuclear medicine for treating hepatocellular carcinoma. Current guidelines suggest postponing liver transplantation or surgical resection for a period of 14 to 30 d after radioembolization to minimize surgeons' exposure to ionizing radiation. In light of a radiation protection incident, we reevaluated the minimum delay required between radioembolization and subsequent liver transplantation. A patient with a hepatocellular carcinoma underwent a liver transplantation 44 h after undergoing radioembolization using 90 Y (860 MBq SIR-Spheres). No specific radioprotection measures were followed during surgery and pathological analysis. We subsequently (1) evaluated the healthcare professionals' exposure to ionizing radiation by conducting dose rate measurements from removed liver tissue and (2) extrapolated the recommended interval to be observed between radioembolization and surgery/transplantation to ensure compliance with the radiation dose limits for worker safety. The surgeons involved in the transplantation procedure experienced the highest radiation exposure, with whole-body doses of 2.4 mSv and extremity doses of 24 mSv. The recommended delay between radioembolization and liver transplantation was 8 d when using SIR-Spheres and 15 d when injecting TheraSphere. This delay can be reduced further when considering the specific 90 Y activity administered during radioembolization. This dosimetric study suggests the feasibility of shortening the delay for liver transplantation/surgery after radioembolization from the 8th or 15th day after using SIR-Spheres or TheraSphere, respectively. This delay can be decreased further when adjusted to the administrated activity while upholding radiation protection standards for healthcare professionals.

摘要:使用 90Y 进行放射栓塞是核医学中治疗肝细胞癌的一种新兴方法。目前的指南建议在放射性栓塞术后 14 至 30 d 内推迟肝移植或手术切除,以尽量减少外科医生暴露于电离辐射的时间。鉴于发生了一起辐射防护事件,我们重新评估了放射栓塞术与随后的肝移植手术之间所需的最短延迟时间。一名肝细胞癌患者在接受 90Y(860 MBq SIR-Spheres)放射栓塞术 44 小时后接受了肝移植手术。手术和病理分析期间没有采取任何特殊的放射防护措施。随后,我们(1)通过对取出的肝脏组织进行剂量率测量,评估了医护人员暴露于电离辐射的情况;(2)推断了放射栓塞与手术/移植之间的建议间隔时间,以确保符合工人安全的辐射剂量限制。参与移植手术的外科医生受到的辐射量最高,全身剂量为 2.4 mSv,四肢剂量为 24 mSv。使用 SIR-Spheres 时,建议放射栓塞与肝移植手术之间的延迟时间为 8 天,注射 TheraSphere 时为 15 天。如果考虑到放射性栓塞期间施用的特定 90Y 活性,这一延迟时间还可以进一步缩短。这项剂量学研究表明,在使用 SIR-Spheres 或 TheraSphere 放射栓塞后,将肝移植/手术的延迟时间分别从第 8 天或第 15 天开始缩短是可行的。在坚持医护人员辐射防护标准的前提下,根据所施放的放射性活度进行调整,可以进一步缩短延迟时间。
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