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Erratum to: Abstract 313, “Is Acute Clozapine-Induced Hypersensitivity Myocarditis Over-Diagnosed in Australia?” [Heart, Lung and Circulation, Volume 33, Supplement 4, August 2024, Page S158, (Abstracts for the 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, 1–4 August 2024, Perth, Australia)].
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.11.008
H. Slifirski , S. Toukhsati , D. Hare , K. Huang
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引用次数: 0
Knowledge of Acute Coronary Syndrome Symptoms and the Intention to Call Emergency Medical Services in Culturally and Linguistically Diverse Australians 具有不同文化和语言背景的澳大利亚人对急性冠状动脉综合征症状的了解以及拨打紧急医疗服务电话的意愿。
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.07.008
Ararso Baru Olani MSc, MHS , Kathryn Eastwood PhD , Stuart Howell PhD , Amanda Buttery PhD , Janet E. Bray PhD

Background

Prompt recognition of symptoms and response to acute coronary syndrome (ACS) are crucial for reducing pre-hospital delay. This study compares culturally and linguistically diverse (CALD) and non-CALD Australian populations in terms of their (i) ACS symptom knowledge and (ii) intention to call emergency medical services (EMS) for ACS.

Method

This cross-sectional study used data from HeartWatch, an online survey collected by the National Heart Foundation of Australia between 2018 and 2020 for Australian adults aged ≥18 years. CALD respondents were defined as non-Indigenous individuals who reported speaking a language other than English at home. Characteristics associated with ACS symptom knowledge and EMS calling intentions were analysed using multivariable logistic regression.

Results

Of 31,919 respondents, 16.3% were from CALD backgrounds (n=5,212). Compared with non-CALD, CALD respondents were less likely to name any ACS symptom (63.0% vs 76.0%; adjusted odds ratio [AOR] 0.66; 95% confidence interval [CI] 0.61–0.70) and were less likely to state that they would call an ambulance for ACS (50.2% vs 72.1%; AOR 0.53; 95% CI 0.50–0.57). Almost one-quarter (23.0%) of CALD respondents reported not knowing what they would do. In both groups, males, individuals aged ≤60 years, and those with diabetes were less likely to name an ACS symptom and had lower intention to call an ambulance. Those unable to list a single ACS symptom also had a lower intention to call an ambulance.

Conclusions

Knowledge of ACS symptoms and intention to call an ambulance were lower among CALD respondents. The demographics of those with low ACS symptom knowledge and EMS calling intention were similar in the two groups. Future education efforts in Australia should focus on promoting ACS symptom knowledge and EMS use and should target these groups.
背景:对急性冠状动脉综合征(ACS)症状的及时识别和应对是减少院前延误的关键。本研究比较了澳大利亚不同文化和语言群体(CALD)和非CALD群体在以下两方面的情况:(i) ACS症状知识;(ii) ACS呼叫紧急医疗服务(EMS)的意向:这项横断面研究使用了澳大利亚国家心脏基金会(National Heart Foundation of Australia)在 2018 年至 2020 年期间针对年龄≥18 岁的澳大利亚成年人收集的在线调查 "心脏观察"(HeartWatch)数据。CALD受访者被定义为报告在家中讲英语以外语言的非土著人。采用多变量逻辑回归分析了与ACS症状知识和EMS呼叫意向相关的特征:在31,919名受访者中,16.3%来自CALD背景(n=5,212)。与非 CALD 受访者相比,CALD 受访者不太可能说出任何 ACS 症状(63.0% vs 76.0%;调整赔率[AOR] 0.66;95% 置信区间[CI] 0.61-0.70),也不太可能表示会为 ACS 叫救护车(50.2% vs 72.1%;AOR 0.53;95% CI 0.50-0.57)。近四分之一(23.0%)的 CALD 受访者表示不知道自己会怎么做。在两组受访者中,男性、年龄≤60 岁者和糖尿病患者不太可能说出 ACS 症状,呼叫救护车的意愿也较低。无法说出单个冠状动脉综合征症状的人呼叫救护车的意愿也较低:结论:CALD受访者对ACS症状的了解程度和呼叫救护车的意愿均较低。两组中对 ACS 症状了解较少的受访者的人口统计学特征和 EMS 召唤意愿相似。澳大利亚未来的教育工作应侧重于促进对 ACS 症状的了解和 EMS 的使用,并应以这些群体为目标。
{"title":"Knowledge of Acute Coronary Syndrome Symptoms and the Intention to Call Emergency Medical Services in Culturally and Linguistically Diverse Australians","authors":"Ararso Baru Olani MSc, MHS ,&nbsp;Kathryn Eastwood PhD ,&nbsp;Stuart Howell PhD ,&nbsp;Amanda Buttery PhD ,&nbsp;Janet E. Bray PhD","doi":"10.1016/j.hlc.2024.07.008","DOIUrl":"10.1016/j.hlc.2024.07.008","url":null,"abstract":"<div><h3>Background</h3><div>Prompt recognition of symptoms and response to acute coronary syndrome (ACS) are crucial for reducing pre-hospital delay. This study compares culturally and linguistically diverse (CALD) and non-CALD Australian populations in terms of their (i) ACS symptom knowledge and (ii) intention to call emergency medical services (EMS) for ACS.</div></div><div><h3>Method</h3><div>This cross-sectional study used data from HeartWatch, an online survey collected by the National Heart Foundation of Australia between 2018 and 2020 for Australian adults aged ≥18 years. CALD respondents were defined as non-Indigenous individuals who reported speaking a language other than English at home. Characteristics associated with ACS symptom knowledge and EMS calling intentions were analysed using multivariable logistic regression.</div></div><div><h3>Results</h3><div>Of 31,919 respondents, 16.3% were from CALD backgrounds (n=5,212). Compared with non-CALD, CALD respondents were less likely to name any ACS symptom (63.0% vs 76.0%; adjusted odds ratio [AOR] 0.66; 95% confidence interval [CI] 0.61–0.70) and were less likely to state that they would call an ambulance for ACS (50.2% vs 72.1%; AOR 0.53; 95% CI 0.50–0.57). Almost one-quarter (23.0%) of CALD respondents reported not knowing what they would do. In both groups, males, individuals aged ≤60 years, and those with diabetes were less likely to name an ACS symptom and had lower intention to call an ambulance. Those unable to list a single ACS symptom also had a lower intention to call an ambulance.</div></div><div><h3>Conclusions</h3><div>Knowledge of ACS symptoms and intention to call an ambulance were lower among CALD respondents. The demographics of those with low ACS symptom knowledge and EMS calling intention were similar in the two groups. Future education efforts in Australia should focus on promoting ACS symptom knowledge and EMS use and should target these groups.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Pages 1659-1669"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends in Sudden Unexpected Deaths in an Australian Population: Impact of the COVID-19 Pandemic 澳大利亚人口的意外猝死趋势:COVID-19 大流行的影响。
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.07.009
James Healy MD , Andrew M. Youssef MD, PhD , Sonia Sawant MD , Jessica J. Orchard MPH, PhD , Rajan Rehan MD , Rianie Van Vuuren MD , John W. Orchard MBBS, PhD , Christopher Semsarian MBBS, PhD , Rajesh Puranik MBBS, PhD

Background & Aim

SARS-CoV-2 infection is associated with increased cardiovascular (CV) morbidity and mortality, manifesting as increased adverse outcomes in the first 30 days, extending to 12 months. This study aimed to investigate trends in sudden unexpected deaths between 2018 and 2022, with a focus on CV deaths.

Method

A retrospective analysis was performed on autopsy reports (n=9,330) obtained from New South Wales Coroners Court, Australia, specifically targeting cases of unexplained deaths that occurred between 2018 and 2022. Statistical analysis was conducted using chi-square tests and a post hoc analysis with Bonferroni correction, as well as analysis of variance with multiple comparisons.

Results

There were 349 (18.3%) CV deaths in 2018, 346 (18.0%) in 2019, 338 (17.5%) in 2020, 395 (21.9%) in 2021, and (23.4%) 413 in 2022 (p=0.0002). Among CV deaths, the number of deaths from sudden arrhythmic death syndrome were 25 (7.2%) in 2018, 26 (7.5%) in 2019, 18 (5.3%) in 2020, 52 (13.2%) in 2021, and 80 (19.4%) in 2022 (p=0.0001). Atherosclerosis was the most common cause of death among all CV categories; there were 196 (56.2%) atherosclerosis deaths in 2018, 207 (59.8%) in 2019, 192 (56.8%) in 2020, 221 (56.0%) in 2021, and 197 (47.7%) in 2022 (p=0.43). The average age of death from sudden arrhythmic death syndrome (42.8±19.1 years) across 2018–2022 was younger than atherosclerosis (56.2±12.4 years) and total groups (53.1±15.1 years) (p<0.001). Males comprised 76% of all CV deaths from 2018 to 2022 (p<0.0001).

Conclusions

Compared with pre-pandemic data, a noteworthy increase in CV deaths was observed in occurrence with the escalation in COVID-19 cases in Australia. This may be attributed to direct or indirect factors, such as lifestyle modifications, disrupted access to routine cardiac care, or COVID-19 infection–triggered CV deaths.
背景和目的:SARS-CoV-2感染与心血管(CV)发病率和死亡率的增加有关,表现为最初30天内不良后果的增加,并可延长至12个月。本研究旨在调查 2018 年至 2022 年间意外猝死的趋势,重点关注 CV 死亡:对从澳大利亚新南威尔士州验尸官法庭获得的尸检报告(n=9330)进行了回顾性分析,特别针对2018年至2022年间发生的不明原因死亡病例。统计分析采用卡方检验和经Bonferroni校正的事后分析,以及多重比较的方差分析:2018年有349例(18.3%)CV死亡,2019年有346例(18.0%),2020年有338例(17.5%),2021年有395例(21.9%),2022年有413例(23.4%)(P=0.0002)。在心血管疾病死亡病例中,死于心律失常猝死综合征的人数在2018年为25人(7.2%),2019年为26人(7.5%),2020年为18人(5.3%),2021年为52人(13.2%),2022年为80人(19.4%)(P=0.0001)。动脉粥样硬化是所有心血管疾病类别中最常见的死因;2018年有196人(56.2%)死于动脉粥样硬化,2019年有207人(59.8%),2020年有192人(56.8%),2021年有221人(56.0%),2022年有197人(47.7%)(P=0.43)。2018-2022年心律失常猝死综合征的平均死亡年龄(42.8±19.1岁)比动脉粥样硬化组(56.2±12.4岁)和总体组(53.1±15.1岁)更年轻(P结论:2018-2022年心律失常猝死综合征的平均死亡年龄比动脉粥样硬化组(56.2±12.4岁)和总体组(53.1±15.1岁)更年轻:与大流行前的数据相比,随着澳大利亚 COVID-19 病例的增加,观察到心血管疾病死亡人数显著增加。这可能归因于直接或间接因素,如生活方式的改变、常规心脏护理的中断或 COVID-19 感染引发的心血管疾病死亡。
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引用次数: 0
Multimodality Imaging Evaluation of Tumour Peeking Its Head Into the Right Atrium 肿瘤头部探入右心房的多模态成像评估
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.06.1039
Kouta Nakamura MT , Akinobu Miyazaki MT , Masahiro Suzuki MD , Ken-ichi Imasaka MD, PhD , Kisho Ohtani MD, PhD
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引用次数: 0
Reply to Letter to the Editor “Addressing Gaps in Post-MI Medication Use Study” regarding: “Patterns of 12-Month Post-Myocardial Infarction Medication Use According to Revascularisation Strategy: Analysis of 15,339 Admissions in Victoria, Australia” 回复致编辑的信 "弥补心肌梗死后用药研究的不足",内容涉及"心肌梗塞后 12 个月用药模式取决于血管重建策略:对澳大利亚维多利亚州 15,339 例入院患者的分析"。
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.10.007
Adam C. Livori MClinPharm , Zanfina Ademi MPH, PhD , Jenni Ilomäki PhD , Adam J. Nelson MBBS, MPH, MBA, PhD , J. Simon Bell PhD , Jedidiah I. Morton PhD
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引用次数: 0
Atrial Fibrillation is an Important String to our Surgical Bow: Lets do More! 心房颤动是我们外科弓的重要一环:让我们做得更多!
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.11.004
Jaishankar Raman MMed, PhD, FRACS , John Alvarez FRACS
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引用次数: 0
Perforation of the Septal Perforators: A Case Series and Proposed Management Paradigm 房间隔穿孔:一个病例系列和拟议的治疗范例。
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.09.006
Daniel G. Brieger FRACP , Aditya Bhat DrPH, FRACP , Ravinay Bhindi PhD, FRACP, FCSANZ , Michael R. Ward PhD, FRACP, FCSANZ
Septal artery perforations are an uncommon complication of percutaneous coronary intervention. Unlike epicardial vessels, septal perforations do not result in pericardial effusions but rather produce septal haematomas. While most can be managed expectantly, a small proportion requires active management to prevent rapid haematoma expansion resulting in compromise of right ventricular filling and ‘dry tamponade’. We present two cases of septal artery perforation during percutaneous coronary intervention and propose a management approach that takes into account the unique haemodynamic consequences of this complication.
室间隔动脉穿孔是经皮冠状动脉介入治疗中一种不常见的并发症。与心外膜血管不同,室间隔穿孔不会导致心包积液,而是产生室间隔血肿。虽然大多数情况下可以预期处理,但也有一小部分情况需要积极处理,以防止血肿迅速扩大,导致右心室充盈受损和 "干性填塞"。我们介绍了两例经皮冠状动脉介入手术中室间隔动脉穿孔的病例,并提出了一种考虑到这种并发症独特血流动力学后果的处理方法。
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引用次数: 0
Atrial Fibrillation Surgery in Australia: Are We Doing Enough? 澳大利亚的心房颤动手术:我们做得够不够?
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.07.007
Frazer Kirk MBBS, MSurg , Matthew S. Yong PhD, FRACS , Lavinia Tran BMedSc, PhD , Andrew Newcomb FRACS , Cheng He BMedSc, FRACS , Andrie Stroebel MBChB, MMed, FRACS

Aim

This study aimed to examine contemporary burden and treatment trends of atrial fibrillation (AF) in patients undergoing cardiac surgery in Australia and New Zealand. This allows comparison of contemporary practice with the Society of Thoracic Surgeons guideline recommendations for the surgical treatment of AF in patients undergoing cardiac surgery.

Method

A 10-year retrospective review of the Australian & New Zealand Society of Cardiac & Thoracic Surgeons National Cardiac Surgery Database was performed, examining all adult cardiac surgery patients from 2011 to 2021. Patients were grouped by the presence or absence of AF, and simple descriptive statistical analysis was performed to assess baseline demographics and premorbid condition of the patients. The incidence of AF was analysed by type of surgery. Trends for surgical treatment of AF were then analysed using simple descriptive statistics, examining isolated left atrial appendage ligation, isolated surgical ablation, and combined ligation and ablation.

Results

In the last 10 years, the Australian & New Zealand Society of Cardiac & Thoracic Surgeons database has recorded 140,680 patients who underwent cardiac surgery. Atrial fibrillation (AF) was present in 21,077 patients (14%). Patients with AF were generally older (72.25 vs 66.65 years; p<0.001). Among patients undergoing cardiac surgery, AF was more common in female than in male patients (18% vs 13%, respectively). Patients with AF more often had a higher classification of dyspnoea according to the New York Heart Association and lower ejection fractions compared with their AF-free counterparts. The incidence of AF as a comorbid condition was more frequent in patients undergoing mitral valve surgery or combined coronary artery bypass grafting and valve surgery (aortic, mitral, or both) compared with those undergoing isolated coronary or aortic surgery. Only 11.90% (n=2,509) of patients with AF received a combined ablation and left atrial appendage ligation, and 19.54% (n=693) of those received a Cox-Maze IV ablation.

Conclusions

The burden of concomitant AF in patients undergoing cardiac surgery in Australia is higher than previously reported (14% vs 5%–11%). Despite strong recommendation for the surgical management of AF in patients undergoing cardiac surgery and clear evidence of its benefit, both left atrial appendage ligation and surgical ablation independently or concomitantly remain heavily underutilised in this cohort.
目的:本研究旨在探讨澳大利亚和新西兰接受心脏手术的患者心房颤动(AF)的当代负担和治疗趋势。这样就可以将当代做法与胸外科医师协会关于心脏手术患者房颤手术治疗的指南建议进行比较:方法:对澳大利亚和新西兰心脏与胸外科医师学会国家心脏手术数据库进行了为期 10 年的回顾性审查,检查了 2011 年至 2021 年期间的所有成人心脏手术患者。根据是否存在房颤对患者进行分组,并进行简单的描述性统计分析,以评估患者的基线人口统计学特征和病前状况。心房颤动的发生率按手术类型进行分析。然后使用简单的描述性统计对房颤手术治疗的趋势进行了分析,检查了单独的左心房阑尾结扎术、单独的手术消融术以及结扎和消融联合术:在过去 10 年中,澳大利亚和新西兰心脏与胸外科医师协会数据库记录了 140,680 名接受心脏手术的患者。21,077名患者(14%)存在心房颤动(AF)。心房颤动患者的年龄普遍较大(72.25 岁对 66.65 岁;P结论:在澳大利亚接受心脏手术的患者中,合并房颤的比例高于之前的报道(14% 对 5%-11% )。尽管强烈建议对接受心脏手术的患者进行房颤手术治疗,而且也有明确证据表明手术治疗房颤有益,但在这一人群中,单独或同时进行左心房阑尾结扎和手术消融的患者仍严重不足。
{"title":"Atrial Fibrillation Surgery in Australia: Are We Doing Enough?","authors":"Frazer Kirk MBBS, MSurg ,&nbsp;Matthew S. Yong PhD, FRACS ,&nbsp;Lavinia Tran BMedSc, PhD ,&nbsp;Andrew Newcomb FRACS ,&nbsp;Cheng He BMedSc, FRACS ,&nbsp;Andrie Stroebel MBChB, MMed, FRACS","doi":"10.1016/j.hlc.2024.07.007","DOIUrl":"10.1016/j.hlc.2024.07.007","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to examine contemporary burden and treatment trends of atrial fibrillation (AF) in patients undergoing cardiac surgery in Australia and New Zealand. This allows comparison of contemporary practice with the Society of Thoracic Surgeons guideline recommendations for the surgical treatment of AF in patients undergoing cardiac surgery.</div></div><div><h3>Method</h3><div>A 10-year retrospective review of the Australian &amp; New Zealand Society of Cardiac &amp; Thoracic Surgeons National Cardiac Surgery Database was performed, examining all adult cardiac surgery patients from 2011 to 2021. Patients were grouped by the presence or absence of AF, and simple descriptive statistical analysis was performed to assess baseline demographics and premorbid condition of the patients. The incidence of AF was analysed by type of surgery. Trends for surgical treatment of AF were then analysed using simple descriptive statistics, examining isolated left atrial appendage ligation, isolated surgical ablation, and combined ligation and ablation.</div></div><div><h3>Results</h3><div>In the last 10 years, the Australian &amp; New Zealand Society of Cardiac &amp; Thoracic Surgeons database has recorded 140,680 patients who underwent cardiac surgery. Atrial fibrillation (AF) was present in 21,077 patients (14%). Patients with AF were generally older (72.25 vs 66.65 years; p&lt;0.001). Among patients undergoing cardiac surgery, AF was more common in female than in male patients (18% vs 13%, respectively). Patients with AF more often had a higher classification of dyspnoea according to the New York Heart Association and lower ejection fractions compared with their AF-free counterparts. The incidence of AF as a comorbid condition was more frequent in patients undergoing mitral valve surgery or combined coronary artery bypass grafting and valve surgery (aortic, mitral, or both) compared with those undergoing isolated coronary or aortic surgery. Only 11.90% (n=2,509) of patients with AF received a combined ablation and left atrial appendage ligation, and 19.54% (n=693) of those received a Cox-Maze IV ablation.</div></div><div><h3>Conclusions</h3><div>The burden of concomitant AF in patients undergoing cardiac surgery in Australia is higher than previously reported (14% vs 5%–11%). Despite strong recommendation for the surgical management of AF in patients undergoing cardiac surgery and clear evidence of its benefit, both left atrial appendage ligation and surgical ablation independently or concomitantly remain heavily underutilised in this cohort.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"33 12","pages":"Pages 1627-1637"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice: Adherence to Cardiac Medications in Patients With Atrial Fibrillation: A Pilot Study 撤回通知:心房颤动患者心脏药物依从性:一项试点研究:[心脏,肺和循环,第29卷,第7期,2020年7月,页e131-e139]。
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.11.009
Adrienne Pacleb BN , Nicole Lowres PhD , Sue Randall PhD , Lis Neubeck PhD , Robyn Gallagher PhD
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引用次数: 0
Sex-Related Differences in Outcome of Patients Treated With Microaxial Percutaneous Left Ventricular Assist Device for Cardiogenic Shock 使用微轴经皮左心室辅助装置治疗心源性休克的患者预后中与性别有关的差异
IF 2.2 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-12-01 DOI: 10.1016/j.hlc.2024.07.010
Johannes Mierke MD, Thomas Nowack MD, Frederike Poege MD, Marie Celine Schuster MD, Krunoslav Michael Sveric MD, Stefanie Jellinghaus MD, Felix J. Woitek MD, Stephan Haussig MD, Axel Linke MD, Norman Mangner MD

Background

The use of microaxial percutaneous left ventricular assist devices (pLVADs) in cardiogenic shock (CS) has increased in recent years, despite limited evidence, and data on sex disparities are particularly scarce. This study aimed to compare short-term outcomes between males and females.

Methods

Data were retrospectively collected from the Dresden Impella Registry, which is a large, prospective, single-centre registry that consecutively enrolled patients who received microaxial pLVAD. Inclusion criteria were CS due to left ventricular failure with serum lactate >4 mM. Patients with pLVAD other than Impella CP were excluded. The primary endpoint was the composite of all-cause mortality at 30 days or requirement of renal replacement therapy (RRT). Secondary endpoints were the components of the primary endpoint alone. Propensity score matched (PSM) analysis was used to adjust for baseline characteristics.

Results

A total of 319 male (69 years; body mass index, 26.7 kg/m2) and 113 female patients (74 years; 27.9 kg/m2) were included in the study. The primary composite endpoint occurred less frequently in female patients in the unmatched analysis (♂ 75.9% [n=239] vs ♀ 64.4% [n=72]; p=0.040) but not in the PSM analysis (♂ 81.1% [n=73] vs ♀ 68.9% [n=42]; p=0.056). However, females less frequently required RRT in both analyses (♂ 48.2% [n=126] vs ♀ 25.9% [n=25]; p=0.001; PSM: ♂ 49.1% [n=36] vs ♀ 23.3% [n=12]; p=0.007). All-cause mortality did not differ between the cohorts.

Conclusions

This study showed no differences in all-cause mortality at 30 days between male and female patients receiving microaxial pLVAD in CS. Larger studies are required to confirm whether female sex is associated with reduced requirement of RRT in CS treated with microaxial pLVAD.
背景:尽管证据有限,但近年来在心源性休克(CS)中使用微轴向经皮左心室辅助装置(pLVAD)的情况有所增加,而有关性别差异的数据尤其稀少。本研究旨在比较男性和女性的短期疗效:德累斯顿Impella登记处是一个大型、前瞻性、单中心登记处,连续登记了接受微轴pLVAD的患者。纳入标准为左心室衰竭导致的 CS,血清乳酸大于 4 mM。不包括使用 Impella CP 以外的 pLVAD 的患者。主要终点是30天内全因死亡率或肾脏替代疗法(RRT)需求的复合终点。次要终点是主要终点的单独组成部分。采用倾向评分匹配(PSM)分析来调整基线特征:共有 319 名男性患者(69 岁;体重指数 26.7 kg/m2)和 113 名女性患者(74 岁;体重指数 27.9 kg/m2)参与了研究。在非配对分析中,女性患者的主要复合终点发生率较低(♂ 75.9% [n=239] vs ♀ 64.4% [n=72]; p=0.040),但在 PSM 分析中,女性患者的主要复合终点发生率较低(♂ 81.1% [n=73] vs ♀ 68.9% [n=42]; p=0.056)。然而,在这两项分析中,女性需要 RRT 的频率较低(♂ 48.2% [n=126] vs ♀ 25.9% [n=25]; p=0.001;PSM:♂ 49.1% [n=36] vs ♀ 23.3% [n=12]; p=0.007)。两组患者的全因死亡率没有差异:本研究显示,在CS中接受微轴pLVAD的男性和女性患者在30天内的全因死亡率没有差异。需要进行更大规模的研究,以确认女性是否与接受微轴pLVAD治疗的CS患者对RRT的需求减少有关。
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引用次数: 0
期刊
Heart, Lung and Circulation
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