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Coronary artery motion estimation and compensation: A feasibility study 冠状动脉运动估计和补偿:可行性研究
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5874307
M. Iatrou, J. Pack, R. Bhagalia, D. Beque, John Seamans
High temporal resolution and high spatial resolution are required to image the coronary arteries without motion artifacts. Several approaches have been pursued to achieve better temporal resolution including faster rotational speeds, and dual tube systems. In this paper, we present an alternative approach using motion estimation and compensation. The results demonstrate that the proposed methods can significantly reduce motion artifacts in coronary artery imaging.
冠状动脉成像需要高时间分辨率和高空间分辨率,以避免运动伪影。为了获得更好的时间分辨率,人们采用了几种方法,包括更快的旋转速度和双管系统。在本文中,我们提出了一种使用运动估计和补偿的替代方法。结果表明,该方法能显著降低冠状动脉成像中的运动伪影。
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引用次数: 8
Requirements on the instrumentation of a prompt gamma measuring device 快速伽马测量装置的仪器要求
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5873926
F. Fiedler, T. Kormoll, A. Müller, W. Enghardt
RADIATION therapy is an important treatment modality in cancer therapy and new radiation species, like protons and light ions have the potential of increasing tumor conformality of irradiation. Such high precision radiotherapy treatment requires efficient quality assurance techniques. Therefore, the objective of these investigations is the development of a real time invivo dosimetry system for proton and ion beams. Proton and ion beams offer advantages over conventional treatment modalities, such as photons. Because of the way these particles deposit their energy on their path through tissue they allow for an increased dose deposition in the tumor volume and reduce the damage of the surrounding healthy tissue. However, the parameters of the ion beams must be calculated from models. Small changes in the irradiated volume will lead to a mismatch of the deposited dose maximum and the tumor. This causes missing dose in the tumor volume and potential damage to healthy tissue. Therefore, a dose monitoring system is highly desirable. Until now, the only clinically applied in-vivo dosimetry method for ion beams is Positron Emission Tomography (PET) [1]. Between 1997 and 2008, the in-beam PET method was used at the GSI Helmholtzzentrum f ¨ur Schwerionenforschung, Darmstadt, Germany, for monitoring the dose delivered by 12C beams. Due to inherent limitations of this method, a direct quantification of the delivered dose is not feasible. Therefore, another approach currently under investigation monitors the dose via the detection of prompt gamma rays. It has been shown by several groups [2], [3], [4] that monitoring of an ion beam treatment via photon measurement is possible. Because of the high energy of the produced gamma rays and the required spatial resolution, the favored technical solution is a Compton camera system. The project is aimed to design and construct such a camera, and evaluate if it could lead to clinical applications.
放射治疗是肿瘤治疗中的一种重要治疗方式,质子、光离子等新的放射物质具有提高肿瘤辐照合规性的潜力。这种高精度的放射治疗需要有效的质量保证技术。因此,这些研究的目的是开发一个实时体内剂量测定系统的质子和离子束。质子和离子束比传统的治疗方式(如光子)有优势。由于这些粒子在其通过组织的路径上沉积能量的方式,它们允许在肿瘤体积中增加剂量沉积,并减少对周围健康组织的损害。然而,离子束的参数必须从模型中计算出来。辐照体积的微小变化将导致最大沉积剂量与肿瘤的不匹配。这会导致肿瘤体积的剂量缺失和对健康组织的潜在损害。因此,剂量监测系统是非常需要的。到目前为止,临床上唯一应用的离子束体内剂量测定方法是正电子发射断层扫描(PET)[1]。1997年至2008年间,束内PET方法在德国达姆施塔特的GSI Helmholtzzentrum f¨Schwerionenforschung使用,用于监测12C光束的剂量。由于该方法固有的局限性,无法对所给剂量进行直接定量。因此,目前正在研究的另一种方法是通过探测提示伽马射线来监测剂量。几个研究小组[2],[3],[4]表明,通过光子测量来监测离子束处理是可能的。由于所产生的伽马射线的高能量和所需的空间分辨率,最受欢迎的技术解决方案是康普顿相机系统。该项目旨在设计和建造这样一个相机,并评估它是否可以导致临床应用。
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引用次数: 3
Improved data acquisition system for brain PET using GAPD arrays 改进的GAPD阵列脑PET数据采集系统
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5874426
Wei Hu, Yong Choi, K. Hong, Jihoon Kang, Y. Huh, H. Lim, Sang Su Kim, Jiwoong Jung, Kyu Bom Kim, Byung-Tae Kim
We have previously reported that a brain PET using GAPD arrays was successfully developed. The brain PET consisted of 72 4 × 4 GAPD arrays combined with LYSO crystals (single pixel size: 3 mm × 3 mm). Each 4 GAPD arrays' output signals were sent to a 64:1 position decoder circuit (PDC) which detects the fastest gamma signal of 64 input channels. To further improve the PET system performance, several modifications were performed on the DAQ system: PET data from 3 DAQ cards were transferred and saved on one SDRAM module by rapid channel communication; parallel processing and multiplexing based FPGA algorithm was developed to detect true PET signals by real time; a more user-friendly GUI DAQ control program was developed to control 3 DAQ cards simultaneously; an accurate and fast coincidence sorting method containing 3 discrimination approaches (time, energy and line of response discriminations) was developed to improve image quality. To evaluate the improved DAQ system, several experiments were performed such as sensitivity measurement using a 25 μά Na-22 point source, spatial resolution measurement using ten F-18 line sources with different source-to-center distances (−8 cm, −6 cm, −4 cm, −2 cm, 0, 2 cm, 4 cm, 6 cm, 8 cm and 10 cm), PET images acquisition of hot rod phantom and Hoffman brain phantom. Experimental results showed that PET sensitivity of 2594 cps/ MBq at 30% energy window (350–650 kev) was achieved. Spatial resolution from 2.9 mm (center) to 5 mm (25 cm off-center) was acquired for ten different source-to-center distances. PET images of hot rod phantom and Hoffman brain phantom were successfully acquired with improved image quality. The DAQ system developed in this study allows to acquiring high quality PET images using GAPD arrays.
我们之前已经报道了使用GAPD阵列的脑PET成功开发。脑PET由72个4 × 4 GAPD阵列结合LYSO晶体组成(单像素尺寸:3mm × 3mm)。每个4个GAPD阵列的输出信号被送到64:1位置解码电路(PDC),该电路检测64个输入通道中最快的伽马信号。为了进一步提高PET系统的性能,对数据采集系统进行了一些改进:通过快速通道通信将3个数据采集卡的PET数据传输并保存在一个SDRAM模块上;开发了基于并行处理和复用的FPGA算法,实时检测PET真实信号;开发了更加用户友好的GUI数据采集控制程序,可同时控制3个数据采集卡;为了提高图像质量,提出了一种包含时间、能量和响应线3种识别方法的准确、快速的符合排序方法。为了评价改进后的DAQ系统,采用25 μά Na-22点源进行了灵敏度测量,采用10个不同源中心距离(- 8 cm、- 6 cm、- 4 cm、-2 cm、0、2 cm、4 cm、6 cm、8 cm和10 cm)的F-18线源进行了空间分辨率测量,并对热杆模体和Hoffman脑模体进行了PET图像采集。实验结果表明,在30%能量窗(350 ~ 650 kev)下,PET的灵敏度达到2594 cps/ MBq。在10种不同的源到中心距离下获得2.9 mm(中心)至5 mm(离中心25 cm)的空间分辨率。成功地获得了热杆幻像和霍夫曼脑幻像的PET图像,提高了图像质量。在本研究中开发的DAQ系统允许使用GAPD阵列获取高质量的PET图像。
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引用次数: 0
New daily detector uniformity quality control methodology for cardiac SPECT using solid-state detectors 使用固态检测器的心脏SPECT新的每日检测器均匀性质量控制方法
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5874158
C. Bai, R. Conwell
Detector non-uniformity can potentially introduce detectable artifacts into SPECT images. The degree of non-uniformity and the position of the non-uniform area on the detector surface determine the position and severity of the introduced artifacts. The commonly used daily uniformity quality control (QC) procedure follows the NEMA methodology but acquires fewer counts than the latter specifies. It has three major drawbacks: (1) it does not report the locations and extension of the non-uniform areas on the detector surface; (2) it may report a non-uniformity value that is lower than the true value due to the use of a 9-point filter, and it makes the reported non-uniformity value vary with the extension of the nonuniform area. These two drawbacks are inherited from the NEMA methodology. The third drawback is that the noise due to the relatively low counts collected in daily uniformity QC does not allow the measurement of certain degrees of non-uniformity with adequate statistical significance, yet such non-uniformity can potentially introduce observable artifacts. In this work we propose a new methodology for daily uniformity QC for cardiac SPECT imaging using solid-state detectors. The new QC largely overcomes the above drawbacks of NEMA QC. In addition, the new procedure (1) can catch some detectors that pass the NEMA-based daily uniformity QC but can be nonuniform enough to introduce detectable artifacts and (2) reports the locations and extension of the non-uniform areas of the detectors, therefore, may allow a detector that fails the NEMA-based daily QC to be used for imaging without introducing artifacts in certain situations.
检测器的不均匀性可能会在SPECT图像中引入可检测的伪影。不均匀程度和不均匀区域在探测器表面的位置决定了引入伪像的位置和严重程度。常用的每日均匀性质量控制(QC)程序遵循NEMA方法,但获得的计数少于后者规定的计数。它有三个主要缺点:(1)不能报告探测器表面非均匀区域的位置和延伸;(2)由于使用9点滤波器,可能会报告低于真实值的不均匀性值,并使报告的不均匀性值随着不均匀区域的扩展而变化。这两个缺点是从NEMA方法继承下来的。第三个缺点是,由于在日常均匀性QC中收集的相对较低的计数而产生的噪声不允许测量具有足够统计显著性的一定程度的非均匀性,然而这种非均匀性可能会引入可观察到的伪像。在这项工作中,我们提出了一种新的方法,用于心脏SPECT成像的日常均匀性QC使用固态探测器。新的QC在很大程度上克服了NEMA QC的上述缺点。此外,新程序(1)可以捕获一些通过基于nema的日常均匀性QC的检测器,但可能不均匀到足以引入可检测的伪像;(2)报告检测器非均匀区域的位置和扩展,因此,可能允许未通过基于nema的日常QC的检测器用于成像,而不会在某些情况下引入伪像。
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引用次数: 2
Development of 3D tracking detectors in the DCBA experiment for studies of double beta decays 双衰变DCBA实验中三维跟踪探测器的研制
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5873873
H. Igarashi, T. Sumiyoshi, N. Ishihara, H. Iwase, T. Inagaki, T. Ohama, Y. Kato, Y. Kondou, Kasuke Takahashi, S. Takeda, T. Haruyama, Y. Makida, Yoshikazu Yamada, M. Kawai, T. Ishizuka, S. Kitamura, Y. Teramoto, Y. Sakamoto, I. Nakano, Y. Nagasaka, N. Tamura, Koichi Tanaka, R. Ito, M. Tonooka
DCBA(Drift Chamber Beta-ray Analyzer) experiment is aiming to search for neutrinoless double beta decay (0νββ). The DCBA detector is a momentum analyzer to measure individual electron energy from double beta decays. Since 0νββ is extremely rare, the detector must be low background and accommodate a lot of decays source. And also the excellent energy resolution is required at the Q-value to distinguish 0νββ from two-neutrino double beta decay (2νββ). The DCBA detector consists of drift chambers, a magnet and cosmic-ray veto counters. A test prototype DCBA-T2 has been constructed and operated with natural Mo source containing 9.6% 100Mo in order to solve operation problems. Another new prototype called DCBA-T3 is under construction at KEK. DCBA-T3 will have better performance than DCBA-T2 in view points of the energy resolution and the source accommodation volume. The results of the DCBA-T2 test operation and the DCBA-T3 status are described together with the future plan temporarily called Magnetic Tracking Detector (MTD), which is designed based on the experiences of DCBA-T2 and T3.
DCBA(Drift Chamber beta -ray Analyzer)实验旨在寻找中微子双β衰变(0νββ)。DCBA探测器是一种动量分析仪,用于测量双β衰变产生的单个电子能量。由于0νββ极为罕见,探测器必须具有低本底并能容纳大量的衰减源。在q值处,要区分0νββ和双中微子双β衰变(2νββ),还需要优异的能量分辨率。DCBA探测器由漂移室、磁铁和宇宙射线计数器组成。为了解决运行问题,在含9.6% 100Mo的天然Mo源下,构建了DCBA-T2试验样机并进行了运行。另一种名为DCBA-T3的新原型正在KEK建造中。在能量分辨率和源容纳体积方面,dba - t3的性能优于dba - t2。介绍了dgba - t2的试验运行结果和dgba -T3的状态,以及基于dgba - t2和T3的经验设计的未来计划暂称为磁跟踪检测器(MTD)。
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引用次数: 0
Test results and irradiation performances of 3-D circuits developed in the framework of ATLAS hybrid pixel upgrade 在ATLAS混合像元升级框架下开发的三维电路的测试结果和辐照性能
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5874036
P. Pangaud, D. Arutinov, M. Barbero, P. Breugnon, B. Chantepie, J. Clémens, R. Fei, D. Fougeron, M. Garcia-Sciveres, S. Godiot, T. Hemperek, M. Karagounis, H. Kruger, A. Mekkaoui, L. Perrot, S. Rozanov, N. Wermes
Vertex detectors for High Energy Physics experiments require pixel detectors featuring high spatial resolution, very good signal to noise ratio and radiation hardness. A way to face new challenges of ATLAS/SLHC future hybrid pixel vertex detectors is to use the emerging 3-D Integrated Technologies. However, commercial offers of such technologies are only very few and the 3-D designer's choice is then hardly constrained. Moreover, as radiation hardness and specially SEU tolerance of configuration registers is a crucial issue for SLHC vertex detectors and, as commercial data on this point are always missing, a reliable qualification program is to be developed for any candidate technology. We will present the design and test (including radiation tests with 70 kV, 60W X-Ray source and 24 GeV protons) of Chartered, 130nm Low Power 2-D chips realized for this qualification.
用于高能物理实验的顶点检测器要求像素检测器具有较高的空间分辨率、良好的信噪比和辐射硬度。面对ATLAS/SLHC未来混合像素顶点探测器的新挑战,一种方法是使用新兴的3-D集成技术。然而,这种技术的商业供应很少,3d设计师的选择几乎没有限制。此外,由于配置寄存器的辐射硬度和特殊的SEU公差是SLHC顶点检测器的关键问题,并且由于这一点上的商业数据总是缺失,因此需要为任何候选技术开发可靠的资格认证程序。我们将介绍为本次资质而实现的特许130nm低功耗二维芯片的设计和测试(包括70kv, 60W x射线源和24gev质子的辐射测试)。
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引用次数: 3
Simulation of charge multiplication and trap-assisted tunneling in irradiated planar pixel sensors 辐照平面像素传感器中电荷倍增和阱辅助隧穿的模拟
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5873832
M. Benoit, A. Lounis, N. Dinu
We present a model for the TCAD simulation of charge multiplication and trap-to-band tunneling to explain the discrepancies between the experimentally observed charge collection in highly irradiated planar pixel sensors and the predictions made using the Hamburg model. DC and transient TCAD simulations of one dimensional n-in-p diodes were performed and reproduce well the observed behavior of diode irradiated to fluences of the order of 1015–16 neq cm−2. The results of the simulations show that impact ionization and de-trapping due to tunneling qualitatively explain the behavior of irradiated sensors observed experimentally.
我们提出了一个电荷倍增和陷阱到带隧道的TCAD模拟模型,以解释在高辐照平面像素传感器中实验观察到的电荷收集与使用汉堡模型做出的预测之间的差异。对一维n-in-p二极管进行了直流和瞬态TCAD模拟,并很好地再现了在1015-16 neq cm−2量级的影响下二极管的观察行为。模拟结果表明,隧穿引起的冲击电离和脱陷定性地解释了实验观察到的辐照传感器的行为。
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引用次数: 6
Evaluation of the radiation hardness and Charge Summing Mode of a Medipix3-based detector with synchrotron radiation 基于medipix3的同步辐射探测器的辐射硬度和电荷求和模式评价
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5874120
E. Gimenez, R. Ballabriga, M. Campbell, I. Dolbnya, I. Horswell, X. Llopart, J. Marchal, K. Sawhney, N. Tartoni, D. Turecek
Synchrotron applications such as coherent X-ray diffraction and X-ray photon-correlation spectroscopy require detectors with a pixel pitch of 50 μm as highlighted by a survey with beamline scientists of Diamond Light Source synchrotron. Furthermore, the detector should also have a high frame rate, large dynamic range and large detection efficiency. The Medipix3 readout chip with a pixel pitch of 55 μm emerged as a good candidate to develop a new detector for the aforementioned applications. Additionally, it implements a new operating mode, referred to as Charge Summing Mode (CSM), with the purpose of eliminating charge-shared events. This mode can be very useful in this case, since the charge-sharing effect increases as the detector pixel size decreases. Also, its design is expected to be more radiation hard that its predecessor Medipix2. The present work focuses on the evaluation of the radiation hardness and the CSM operating mode of a Medipix3-based detector in order to develop a large area detector for synchrotron applications.
同步加速器的应用,如相干x射线衍射和x射线光子相关光谱,需要探测器的像素间距为50 μm,金刚石光源同步加速器的光束线科学家的调查突出了这一点。此外,检测器还应具有高帧率、大动态范围和高检测效率。像素间距为55 μm的Medipix3读出芯片成为开发上述应用的新检测器的良好候选者。此外,它还实现了一种新的操作模式,称为电荷求和模式(CSM),目的是消除电荷共享事件。这种模式在这种情况下非常有用,因为电荷共享效应随着探测器像素大小的减小而增加。此外,它的设计预计将比其前身Medipix2更具抗辐射能力。本文对基于medipix3的探测器的辐射硬度和CSM工作模式进行了评估,以期开发出用于同步加速器的大面积探测器。
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引用次数: 2
The butterfly effect: Correlations between modeling in nuclear-particle physics and socioeconomic factors 蝴蝶效应:核粒子物理模型与社会经济因素之间的相关性
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5873851
M. Pia, T. Basaglia, Z. Bell, P. Dressendorfer
A scientometric analysis has been performed on selected physics journals to estimate the presence of simulation and modeling in physics literature in the past fifty years. Correlations between the observed trends and several social and economical factors have been evaluated.
对选定的物理期刊进行了科学计量学分析,以估计在过去五十年中物理文献中模拟和建模的存在。对观测到的趋势与若干社会和经济因素之间的相关性进行了评价。
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引用次数: 0
Beam hardening correction for fan-beam CT imaging with multiple materials 多材料扇束CT成像的光束硬化校正
Pub Date : 2010-10-01 DOI: 10.1109/NSSMIC.2010.5874473
Yanbo Zhang, X. Mou, Shao-jie Tang
In X-ray CT, Beam hardening (BH) effect, which is caused by polychromatic X-ray beam and energy-dependent attenuation coefficients, always introduces cupping and streak artifacts. Most of correction methods can only deal with beam hardening artifacts for a single material or dual-material object, but fail to correct in case of a multi-material object since the correction complexity and instability increase with the increase of the kinds of materials. In this paper, we proposed a multimaterial BH correction method. A binary Legendre polynomial is adopted to correct BH based on bi-parameter imaging physical model, and the Helgasson-Ludwig consistency condition (H-L consistency condition) is introduced to optimally determine the bi-parameters of all materials. In the simulation experiments showed that the proposed method can suppress the artifacts greatly. The corrected values approach very closely to the ideal ones.
在x射线CT中,由多色x射线光束和能量相关衰减系数引起的光束硬化(BH)效应总是会引入拔罐和条纹伪影。由于校正的复杂性和不稳定性随着材料种类的增加而增加,大多数校正方法只能处理单材料或双材料对象的光束硬化伪像,而不能处理多材料对象的光束硬化伪像。本文提出了一种多材料BH校正方法。基于双参数成像物理模型,采用二元Legendre多项式对黑洞进行校正,并引入Helgasson-Ludwig一致性条件(H-L一致性条件)对所有材料的双参数进行最优确定。仿真实验表明,该方法能较好地抑制伪影。修正值非常接近于理想值。
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引用次数: 12
期刊
IEEE Nuclear Science Symposuim & Medical Imaging Conference
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