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CaF2(Eu): An “Old” scintillator revisited CaF2(Eu):一个“古老”的闪烁体
Pub Date : 2013-06-14 DOI: 10.1088/1748-0221/8/06/P06010
C. Plettner, G. Pausch, F. Scherwinski, C. Herbach, R. Lentering, Y. Kong, K. Romer, J. Stein, T. Szczesniak, M. Grodzicka, J. Iwanowska, M. Moszynski
Homeland security applications demand high performance Compton-camera systems, with high detector efficiency, good nuclide identification and able to operate in-field conditions. A low-Z scintillator has been proposed and studied as a promising candidate for use in the scattering plane of a scintillator-based Compton camera: CaF2(Eu). All the relevant properties for the application of this scintillator in a mobile Compton camera system have been addressed: the energy resolution and the non-linearity at room temperature and in the temperature range of −20°C to +55°C, the photoelectron yield and the relative light yield in the relevant temperature range. A new method of inferring the relative light output of scintillators as a function of temperature has been proposed.
国土安全应用需要高性能康普顿相机系统,具有高探测器效率,良好的核素识别能力,能够在现场条件下运行。一种低z闪烁体(CaF2(Eu))已被提出并研究,作为一种有希望用于基于闪烁体的康普顿相机散射面的候选体。讨论了该闪烁体在移动康普顿相机系统中应用的所有相关特性:在室温和−20°C至+55°C温度范围内的能量分辨率和非线性,在相关温度范围内的光电子产率和相对光产率。提出了一种推断闪烁体相对光输出随温度变化的新方法。
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引用次数: 11
Evaluation of the accuracy and robustness of a motion correction algorithm for PET using a novel phantom approach 一种基于幻像的PET运动校正算法的精度和鲁棒性评估
Pub Date : 2012-01-26 DOI: 10.1109/NSSMIC.2010.5874232
S. Wollenweber, Girish Gopalakrishnan, K. Thielemans, R. Manjeshwar
We introduce the use of a novel physical phantom to quantify the performance of a motion-correction algorithm. The goal of the study was to assess a PET-PET image registration, the final output of which is a motion-corrected high-statistics PET image volume, a procedure called Reconstruct, Register and Average (RRA). Methods: A phantom was constructed using 5 ∼2mL Ge-68 filled spheres suspended in a water-filled tank via lightweight fishing line and driven by a periodic motion. Comparison of maximum and mean concentration and sphere volume was performed. Ground truth data were measured using no-motion. With motion, five replicate datasets of 3-minute phase-gated data for each of 3 different periods of motion were acquired. Gated PET images were registered using a multi-resolution level-sets-based non-rigid registration (NRR). The NRR images were then averaged to form a motion-corrected, high-statistics image volume. Spheres from all images were segmented and compared across the imaging conditions. Results: The average center-of-mass range of motion was 7.35, 5.83 and 2.66 mm for the spheres over the three periods of 8, 6 and 4 seconds. The center-of-mass for all spheres in all conditions was corrected to within 1mm on average using NRR as compared to the gated data. For the RRA data, the sphere maximum activity concentration (MAC) was on average 40.2% higher (−4.0% to 116.7%) and sphere volume was on average 12.0% smaller (−8.2% to 28.1%) as compared to the un-gated data with motion. The RRA results for MAC were on average 70% more accurate and for sphere volume 80% more accurate as compared to the un-gated data. Conclusions: The results show that the novel phantom setup and analysis methods are a promising evaluation technique for the assessment of motion correction algorithms. Benefits include the ability to compare against ground truth data without motion but with control of the statistical data quality and background variability. Use of a nonmoving object adjacent to spheres in motion, the spatial extent of the motion correction algorithm was confirmed to be local to the induced motion and to not affect the stationary object. A further benefit of the assessment technique is the use of ground truth data.
我们介绍了使用一种新的物理幻影来量化运动校正算法的性能。本研究的目的是评估PET-PET图像配准,其最终输出是一个运动校正的高统计量PET图像体积,该过程称为重构,配准和平均(RRA)。方法:用5 ~ 2mL充满Ge-68的球体,通过轻型钓鱼线悬浮在一个装满水的水箱中,并由周期运动驱动,构建一个幽灵。比较了最大浓度和平均浓度及球体积。地面真值数据采用无运动测量。在运动中,获得了5个重复数据集,每个数据集为3个不同的运动周期的3分钟相位门控数据。门控PET图像使用基于多分辨率水平集的非刚性配准(NRR)进行配准。然后对NRR图像进行平均,形成运动校正后的高统计量图像体积。对所有图像中的球体进行分割,并在不同的成像条件下进行比较。结果:在8、6、4秒三个周期内,球的平均质心运动范围分别为7.35、5.83、2.66 mm。与门控数据相比,在所有条件下,使用NRR将所有球体的质心校正到平均1mm以内。对于RRA数据,与带运动的非门控数据相比,球体最大活性浓度(MAC)平均高40.2%(- 4.0% ~ 116.7%),球体体积平均小12.0%(- 8.2% ~ 28.1%)。与非门控数据相比,MAC的RRA结果平均精度提高了70%,球体体积的RRA结果平均精度提高了80%。结论:该方法是一种很有前途的运动校正算法评价方法。其好处包括能够在没有变动的情况下与地面真实数据进行比较,但可以控制统计数据质量和背景可变性。利用与运动球体相邻的非运动物体,确定了运动校正算法的空间范围局部于诱导运动且不影响静止物体。评估技术的另一个好处是使用了地面真值数据。
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引用次数: 18
The performance of GridPix detectors GridPix探测器的性能
Pub Date : 2011-06-13 DOI: 10.1109/NSSMIC.2010.5873901
Y. Bilevych, V. Carballo, M. Fransen, H. van der Graaf, N. de Groot, F. Hartjes, N. Hessey, A. Konig, W. Koppert, M. Rogers, J. Schmitz, R. Schon, J. Timmermans, J. Visschers
A GridPix detector is a gaseous detector capable of detecting individual single primary electrons from ionizing particles. Such a detector consists of a pixel chip as active anode covered with a thin layer of silicon rich silicon nitride (SiRN) for protection against discharges, an integrated amplification grid (InGrid), applied on top of the chip by wafer post processing techniques, and a cathode plane. The drift region is between the grid and cathode while the gas gain occurs between the chip and the grid. The discharge quenching properties of the SiRN layer have been determined as well as the relation on grid capacitance, grid voltage and gas mixture. Part of the detectors in this report were of the type Gossip, a GridPix detector with a drift gap of ∼1 mm. Using such thin drift layer, one may consider this detector as a replacement for a silicon pixel detector. The performance of three Gossip detectors has been investigated by measurements in a test beam at CERN.
GridPix探测器是一种气体探测器,能够从电离粒子中检测单个初级电子。这种探测器包括一个像素芯片作为主动阳极,上面覆盖一层薄薄的富硅氮化硅(SiRN)以防止放电,一个集成放大栅格(InGrid),通过晶圆后处理技术应用于芯片顶部,以及一个阴极平面。漂移区在栅极和阴极之间,而气体增益发生在芯片和栅极之间。测定了sin层的放电淬火性能以及与栅极电容、栅极电压和气体混合物的关系。本报告中的部分探测器为Gossip类型,这是一种GridPix探测器,漂移间隙为1 mm。利用这种薄的漂移层,可以把这种检测器看作硅像素检测器的替代品。在欧洲核子研究中心的测试光束中测量了三个八卦探测器的性能。
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引用次数: 0
Development of an 8-channel time based readout ASIC for PET applications 用于PET应用的8通道基于时间的读出ASIC的开发
Pub Date : 2010-12-01 DOI: 10.1109/NSSMIC.2010.5874061
Z. Deng, A. K. Lan, Xishan Sun, C. Bircher, Yinong Liu, Y. Shao
An eight-channel readout ASIC has been developed for reading out signals from Silicon Photomultiplier (SiPM) for PET applications. It converts both signal charge and occurring time to digital timing pulses and only needs TDC. It has the advantages of simplified circuit design, reduced power consumption and suitable for large number of readout channels. The ASIC uses a fully current mode preamplifier to obtain high bandwidth (>100MHz) with a few mW/ch power consumption. The dynamic range for charge measurement is adjustable and can be extended up to 103 pC. The chip has been fabricated in 0.35μm 2P4M CMOS technology. A test prototype board for ASIC evaluation has been developed and the preliminary tests show the time jitter is 150ps (rms) by electronics only with injected 30 ns rise time signals, and the coincidence timing is about 1.7 ns (FWHM) for 511 keV photo peak events with LYSO/SiPM detectors. The charge dynamic range is measured to be ∼10bit for electronics only, and better than 1% for detector signals. A simple theoretic analysis shows that the timing and charge resolutions are limited dominately by the detector dark noise in our test and will be studied further. Preliminary evaluations show that the ASIC's functionalities and performance targets have been successfully achieved.
开发了一种八通道读出专用集成电路,用于读取PET应用中硅光电倍增管(SiPM)的信号。它将信号电荷和发生时间转换为数字定时脉冲,只需要TDC。它具有简化电路设计、降低功耗、适合大量读出通道的优点。ASIC采用全电流模式前置放大器,以几mW/ch的功耗获得高带宽(>100MHz)。电荷测量的动态范围是可调的,可以扩展到103 pC。该芯片采用0.35μm 2P4M CMOS工艺制造。初步测试结果表明,LYSO/SiPM探测器在511 keV光峰值事件下,仅注入30 ns上升时间信号时,电子器件的时间抖动为150ps (rms),重合时间约为1.7 ns (FWHM)。电荷动态范围仅测量为电子器件的~ 10bit,检测器信号的电荷动态范围优于1%。简单的理论分析表明,在我们的测试中,时间和电荷分辨率主要受到探测器暗噪声的限制,这将进一步研究。初步评估表明,ASIC的功能和性能目标已经成功实现。
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引用次数: 3
FPGA based TDC using Virtex-4 ISERDES blocks 基于FPGA的TDC使用Virtex-4 ISERDES块
Pub Date : 2010-12-01 DOI: 10.1109/NSSMIC.2010.5874005
G. Hegyesi, G. Kalinka, J. Molnár, F. Nagy, J. Imrek, I. Valastyán, Z. Szabó
We report on the implementation of an interleaving TDC architecture based on Virtex-4 ISERDES blocks. Multiple ISERDES blocks are used for each input channel in a split-phase arrangement. The architecture has moderate resolution (312 ps in this implementation), it is not sensitive to PVT variations, requires only limited FPGA resources, and thus suitable for high channel counts.
我们报告了基于Virtex-4 ISERDES块的交错TDC架构的实现。在分相安排中,每个输入通道使用多个ISERDES块。该架构具有中等分辨率(在本实现中为312 ps),对PVT变化不敏感,只需要有限的FPGA资源,因此适合高通道计数。
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引用次数: 2
Energy and timing measurement of a PET detector with time-based readout electronics 带时间读出电子器件的PET检测器的能量和定时测量
Pub Date : 2010-12-01 DOI: 10.1109/NSSMIC.2010.5874238
Y. Shao, Xishan Sun, K. Lan, C. Bircher, Z. Deng, Yinong Liu
New time-based readout (TBR) electronics has been developed and evaluated for its performance and application for PET detectors. It consists of a leading edge (LE) timing threshold for timing pickoff that provides a signal timing t1; a charge integration followed by a constant discharge between two specific timings t2 and t3 that are used to directly measure the signal energy. The timing-walk error caused by LE from signals of different amplitudes can be measured with t1 as a function of different signal amplitudes that is proportional to the time difference between t2 and t3. With this pre-calibration, timing-walk error can be accurately corrected. Therefore, both signal timing and energy can be accurately measured with digital timing signals without using CFD and ADC. These timing signals were controlled and in principle can be measured by an FPGA that can apply many signal logic and data correction algorithms. A single channel discrete component TBR circuit has been implemented in PC board, and 8-channel ASIC chips have been developed for feasibility evaluations and PET detector applications. Initial functionality and performance evaluations have been conducted. Signal amplitude measurement accuracy and linearity are very good; the measured timing accuracy from a pulse is the same as a standard CFD and reaches to ∼100 ps resolution with the test setup. Both suitable energy and coincidence timing resolutions (∼17% and ∼1.0–2.0 ns) were achieved with PMT or Solid-State PM (SSPM) array based PET detectors. Initial studies to acquire flood source crystal identification map has demonstrated the advantages of applying parallel readout with TBR electronics that read out and process signals from each pixel of SSPM array independently. With its relatively simple circuit and low cost, TBR electronics is expected to provide suitable front-end signal readout electronics for compact photon detectors such as SSPM array that require large number of output channels and demand high performance in energy and timing.
新的基于时间的读出(TBR)电子器件已经被开发出来,并对其性能和在PET探测器中的应用进行了评估。它包括用于时序拾取的前沿(LE)时序阈值,该阈值提供信号时序t1;两个特定时间t2和t3之间的电荷积分,随后是恒定放电,用于直接测量信号能量。不同幅值信号的LE引起的时序行走误差可以用t1作为不同信号幅值的函数,与t2和t3的时间差成正比。通过这种预校准,可以精确地校正定时行走误差。因此,在不使用CFD和ADC的情况下,可以使用数字定时信号精确测量信号时序和能量。这些时序信号被控制,原则上可以通过FPGA测量,FPGA可以应用许多信号逻辑和数据校正算法。在PC板上实现了单通道离散元件TBR电路,并开发了8通道ASIC芯片,用于可行性评估和PET检测器应用。已经进行了初步的功能和业绩评价。信号幅度测量精度和线性度都很好;测量到的脉冲时序精度与标准CFD相同,使用测试装置可达到~ 100 ps的分辨率。基于PMT或固态PM (SSPM)阵列的PET探测器可以获得合适的能量和符合时间分辨率(~ 17%和~ 1.0-2.0 ns)。初步研究表明,采用TBR并行读出技术对SSPM阵列中每个像素的信号进行独立读出和处理,可以获得洪水源晶体识别图。由于其相对简单的电路和低成本,TBR电子器件有望为紧凑的光子探测器(如SSPM阵列)提供合适的前端信号读出电子器件,这些光子探测器需要大量的输出通道,并且需要高性能的能量和时序。
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引用次数: 5
Evaluation of equivalence of upslope method-derived myocardial perfusion index and transfer constant based on two-compartment tracer kinetic model 基于双室示踪动力学模型的上坡法心肌灌注指数和传递常数等效性评价
Pub Date : 2010-12-01 DOI: 10.1109/NSSMIC.2010.5874200
T. Ichihara, R. George, J. Lima, Y. Ikeda, A. Lardo
The purpose of this study was to describe the upslope method-derived myocardial perfusion index using the parameters based on a tracer kinetic model of iodixanol contrast agent and to validate this theoretically derived relationship using an ischemic canine model. The established modified Kety model was used to describe the extravascular diffusion of iodixanol contrast agent, which undergoes no cellular uptake or metabolism. This model consists of two functional compartments, one describing the vascular compartment and the second representing all myocardial capillaries, interstitium, and cells. These compartments are connected by two rate constants, K1 and k2, which represent the first-order transfer constants from the left ventricular (LV) blood to myocardium and from myocardium to the vascular system, respectively. In the early phase after the arrival of contrast agent in the myocardium, the relationship between K1 and the concentrations of iodixanol contrast agent in the myocardium and arterial blood (LV blood) is described by K1 = {dCmyo(tpeak)/dt}/Ca(tpeak) (Eq. 1), where Cmyo(t) is the relative concentration of iodixanol contrast agent in the myocardium at time t, Ca(t) is the relative concentration of iodixanol contrast agent in the LV blood, and tpeak is the time at the peak of Ca(t) and maximum upslope of Cmyo(t). Six canine models of left anterior descending (LAD) artery stenosis were prepared and underwent first-pass contrast-enhanced mult-detector row computed tomography (MDCT) perfusion imaging during adenosine infusion (0.14–0.21 mg/kg/min) to study a wide range of flow rates. K1 was measured using the Patlak plot method and upslope method applied to time-attenuation curve data of the LV blood pool and myocardium. The results were compared against microsphere myocardial blood flow measurements. The Patlak plot-derived K1 and upslope method-derived K1 showed a good linear association. Regional K1 can be measured accurately using the upslope method-derived myocardial perfusion index based on a compartment model.
本研究的目的是利用基于碘二沙醇造影剂示踪动力学模型的参数来描述上坡法衍生的心肌灌注指数,并利用缺血犬模型验证这一理论推导的关系。采用所建立的改良Kety模型描述碘沙醇造影剂不经细胞摄取和代谢的血管外扩散。该模型由两个功能室组成,一个描述血管室,第二个代表所有心肌毛细血管、间质和细胞。这些室室由两个速率常数K1和k2连接,这两个速率常数分别代表从左心室(LV)血液到心肌和从心肌到血管系统的一级传递常数。在造影剂到达心肌后的早期,K1与心肌和动脉血(左室血)中碘二沙醇造影剂浓度的关系为K1 = {dCmyo(tpeak)/dt}/Ca(tpeak)(式1),其中Cmyo(t)为t时刻心肌中碘二沙醇造影剂的相对浓度,Ca(t)为左室血中碘二沙醇造影剂的相对浓度,tpeak为Ca(t)峰值和Cmyo(t)最大上坡时间。制备6只犬左前降支(LAD)狭窄模型,在腺苷输注(0.14 ~ 0.21 mg/kg/min)过程中进行第一遍对比增强多排计算机断层扫描(MDCT)灌注成像,研究大范围血流速率。采用Patlak图法和上斜率法测量左室血池和心肌时间衰减曲线数据。将结果与微球心肌血流量测量结果进行比较。Patlak图导出的K1和上坡法导出的K1表现出良好的线性相关性。基于室室模型的上斜法心肌灌注指数可以准确测量区域K1。
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引用次数: 5
The nanometer beam size monitor (Shintake monitor) at ATF2 ATF2的纳米光束尺寸监视器(Shintake监视器)
Pub Date : 2010-12-01 DOI: 10.1109/NSSMIC.2010.5874041
M. Oroku, Y. Yamaguchi, Jaqueline Yan, T. Yamanaka, Y. Kamiya, T. Suehara, S. Komamiya, T. Okugi, N. Terunuma, T. Tauchi, S. Araki, J. Urakawa
My presentation focuses on the Shintake (Beamsize) Monitor which can measure nanometer electron beam sizes. The Shintake Monitor is installed in the Accelerator Test Facility 2 (ATF2) at KEK, Japan. ATF2 is a realistic scaled down model of the final focus system for the International Linear Collider. The final focusing scheme named the Local Chromaticity Correction will be tested for the first time in the world. The vertical design beam size at the focal point (virtual interaction point) is 37 nm. Shintake monitor has been designed to measure a beamsize down to 20 nm. It employs the interference pattern made by splitting laser beams and crossing them at the focal point of the electron beam. In their intersecting region, the electromagnetic fields of the two laser beams form a standing wave (interference fringe). The probability of the Compton scattering varies according to the phase of the standing wave where the electrons pass through. Then the total energy of photons from the Compton scattering is measured in a multi-layered ganma ray detector located downstream from the interaction point. This scheme was originally proposed by T. Shintake whose team measured a beamsize of approximately 65 nm with 10 percent resolution at FFTB, SLAC, a former test facility for the ILC. We upgraded this monitor to measure the even smaller beam sizes to be available at ATF2. The laser wavelength has been modified from 1064 nm to 532 nm using a second harmonics generator. The laser optics was newly designed and constructed by implementing a laser wire scheme to measure a larger horizontal beam size, and by enabling different crossing angles of split laser beams to measure a wide (diverse) range of vertical beam sizes. The gamma detector for Shintake monitor has also been newly developed. We evaluated the performance of Shintake monitor with a beam of several microns in size and confirmed its consistency with wire scanner measurements. The expected performance of the Shintake monitor and the current status of the electron beam at ATF, achieved a record in beam size history and near future plan for 37 nm beam size measurement will be mentioned.
我的演讲重点是Shintake(束尺寸)监视器,它可以测量纳米电子束尺寸。Shintake Monitor安装在日本KEK的加速器测试设施2 (ATF2)中。ATF2是国际线性对撞机最终聚焦系统的现实缩小模型。最终的聚焦方案被命名为局部色度校正,将在世界上首次进行测试。在焦点(虚拟相互作用点)处的垂直设计光束尺寸为37 nm。Shintake监测器的设计目的是测量光束尺寸低至20纳米。它采用由分裂激光束并在电子束的焦点处交叉而成的干涉图样。在它们的相交区域,两束激光的电磁场形成驻波(干涉条纹)。康普顿散射的概率根据电子经过的驻波的相位而变化。然后在位于相互作用点下游的多层伽玛射线探测器中测量康普顿散射光子的总能量。该方案最初是由T. Shintake提出的,他的团队在FFTB, SLAC (ILC的前测试设施)以10%的分辨率测量了大约65 nm的光束尺寸。我们升级了这台监视器,以测量ATF2可用的更小的光束尺寸。使用第二个谐波发生器将激光波长从1064 nm修改为532 nm。激光光学系统是通过采用激光线方案来测量更大的水平光束尺寸,以及通过允许不同的分裂激光束交叉角度来测量更大范围的垂直光束尺寸而新设计和构建的。新武监测器的伽马探测器也是新开发的。我们用几微米大小的光束评估了Shintake监视器的性能,并证实了其与线扫描仪测量结果的一致性。Shintake显示器的预期性能和ATF电子束的现状,在束流尺寸历史上创下了记录,并将提到不久的将来37nm束流尺寸测量计划。
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引用次数: 0
Automation tools in the software development of the TOTEM Detector Control System 自动化工具软件开发中的TOTEM探测器控制系统
Pub Date : 2010-12-01 DOI: 10.1109/NSSMIC.2010.5873774
Ivan Atannasov, F. L. Rodríguez, P. Palazzi, F. Ravotti, Sami Stockell, J. Sziklai, V. Tulimaki
The TOTEM experiment at the CERN LHC consists of three different subdetectors. Its Detector Control System (DCS) is built with the industry-supplied PVSS system and extended with components developed at CERN through the Joint Controls Project (JCOP). In view of minimizing the development effort and improving reliability, the TOTEM DCS team has developed various technologies to automate the software development process to a large extent. A unified automatic development for all the three subde-tectors of the experiment saves time, produces more reliable software, and makes maintenance less expensive. The automation process described here may be reused in other industrial automation applications.
欧洲核子研究中心大型强子对撞机的TOTEM实验由三个不同的子探测器组成。它的探测器控制系统(DCS)采用工业提供的PVSS系统,并通过联合控制项目(JCOP)扩展了CERN开发的组件。为了尽量减少开发工作量和提高可靠性,TOTEM DCS团队开发了各种技术,在很大程度上实现了软件开发过程的自动化。对实验的三个子探测器进行统一的自动化开发,节省了时间,产生了更可靠的软件,降低了维护成本。这里描述的自动化过程可以在其他工业自动化应用程序中重用。
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引用次数: 1
Comparison of the GEANT4 releases 8.2 and 9.2 in terms of a pCT reduced calibration curve GEANT4版本8.2和9.2在pCT简化校准曲线方面的比较
Pub Date : 2010-12-01 DOI: 10.1109/NSSMIC.2010.5874220
O. Yevseyeva, Joaquim Teixeira de Assis, E. Milhoretto, I. Evseev, H. Schelin, F. Ahmann, S. Paschuk, J. Setti, V. Denyak, K. S. Diaz, J. M. Hormaza, R. Lopes
The GEANT4 simulations are essential for the development of medical tomography with proton beams — pCT. In the case of thin absorbers the latest releases of GEANT4 generate very similar final spectra which agree well with the results of other popular Monte Carlo codes like TRIM/SRIM, or MCNPX. For thick absorbers, however, the disagreements became evident. In a part, these disagreements are due to the known contradictions in the NIST PSTAR and SRIM reference data. Therefore, it is interesting to compare the GEANT4 results with each other, with experiment, and with diverse code results in a reduced form, which is free from this kind of doubts. In this work such comparison is done within the Reduced Calibration Curve concept elaborated for the proton beam tomography.
GEANT4模拟对于质子束医学断层扫描(pCT)的发展至关重要。在薄吸收体的情况下,最新版本的GEANT4生成非常相似的最终光谱,与其他流行的蒙特卡罗代码(如TRIM/SRIM或MCNPX)的结果非常一致。然而,对于吸收能力强的人来说,分歧变得很明显。在某种程度上,这些分歧是由于NIST PSTAR和SRIM参考数据中已知的矛盾。因此,将GEANT4结果与其他结果、与实验结果以及与各种简化形式的代码结果进行比较是很有趣的,这样就不会有这种疑问。在这项工作中,这种比较是在质子束断层成像的简化校准曲线概念内完成的。
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引用次数: 1
期刊
IEEE Nuclear Science Symposuim & Medical Imaging Conference
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