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Human and Ecological Risk Assessment: An International Journal最新文献

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Ecological security evaluation for Changtan Reservoir in Taizhou City, East China, based on the DPSIR model 基于DPSIR模型的台州市长滩水库生态安全评价
Pub Date : 2023-07-19 DOI: 10.1080/10807039.2023.2236713
Lingxi Li, Peiyue Li, Song He, Rui Duan, Fei Xu
Abstract Reservoirs supply drinking water to many major cities in China, and their ecological security ensures the economic development, drinking water safety and ecological balance of cities. Based on Driver-Pressure-State-Impact-Response (DPSIR) model, this study evaluated the ecological security of Changtan Reservoir in Taizhou City, East China. The ecological security evaluation system was constructed, including 17 s-level evaluation factors, which included 36 third-level evaluation indices. By combining the expert scoring method with the entropy method, the weights of each index can be calculated effectively. Finally, the ecological security index (ESI) was obtained according to the DPSIR model. The results show that the ESI of the Changtan Reservoir is 75.78, which suggests that the Changtan Reservoir is in a relatively safe state. However, the soil erosion intensity index is in a poor state in most areas. Therefore, soil and water conservation management should be strengthened. The aquatic biodiversity in the watershed of the reservoir is also poor, especially the benthos with a single species. Hence, the ecological conservation of the reservoir watershed should also be enhanced. The study also proposes that centralized treatment of urban domestic sewages and rural domestic sewages around the reservoir should be greatly improved by enhancing the sewage treatment facilities and pipelines.
水库为中国许多大城市提供饮用水,水库生态安全是城市经济发展、饮用水安全和生态平衡的重要保障。基于驱动-压力-状态-影响-响应(DPSIR)模型,对台州市长滩水库生态安全进行了评价。构建了包含17个s级评价因子、36个三级评价指标的生态安全评价体系。将专家评分法与熵值法相结合,可以有效地计算出各指标的权重。最后,根据DPSIR模型得到生态安全指数(ESI)。结果表明,长滩水库的ESI值为75.78,表明长滩水库处于相对安全状态。然而,大部分地区的土壤侵蚀强度指数处于较差状态。因此,应加强水土保持管理。水库流域的水生生物多样性也较差,尤其是底栖动物种类单一。因此,也应加强水库流域的生态保护。研究还提出,通过加强污水处理设施和管道,大幅度改善水库周边城市生活污水和农村生活污水的集中处理。
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引用次数: 1
Spatial distribution modeling of radiometric analysis and radiation dose estimations in drinking water and soil samples from Siirt city in Türkiye 新疆锡尔特市饮用水和土壤样品辐射分析的空间分布模型和辐射剂量估算
Pub Date : 2023-07-06 DOI: 10.1080/10807039.2023.2231549
N. Damla, Ahmet Altun, C. M. Yeşilkanat, H. Taşkın, Ayhan Kara, U. Isik
Abstract In this study, the spatial distribution model has been aimed to characterize the radiometric parameters in drinking water and soil samples of Siirt City in Türkiye using the geostatistical method. The gross α and β measurements in the water samples and radiometric measurements in the soil samples were performed using a gas proportional α/β counter (Berthold, LB 770 model) and a gamma spectroscopy system (HPGe-detector), respectively. The spatial distribution maps, covering the whole region using the ordinary kriging method, were created visually. The gross α and β activities in the water samples varied from 9 to 40 and from 21 to 252 mBq L−1. The corresponding arithmetic average of the annual effective dose of gross α and β of drinking water was estimated to be 5.3 and 52.3 μSv y−1, respectively. In soil samples, the arithmetic average values of 238U, 232Th, 40K, and 137Cs radionuclides were 17 ± 6, 20 ± 7, 445 ± 166, and 4 ± 6 Bq kg−1, respectively. The arithmetic average absorbed dose rate (D), annual effective dose (AED), and excess lifetime cancer risk (ELCR) values in soil samples were calculated as 38 nGy h−1, 0.05 mSv y−1, and 0.165 × 10−3, respectively, for soil samples. The radiometric parameters of the sample were lower than those of the guideline levels recommended in the literature. Furthermore, the interpolation maps were evaluated in terms of the soil structure of the region.
摘要本文采用地统计学方法,建立了基耶尔省锡尔特市饮用水和土壤样品中辐射参数的空间分布模型。水样中的总α和β测量和土壤样品中的辐射测量分别使用气体比例α/β计数器(Berthold, LB 770型号)和伽马能谱系统(hpge检测器)进行。利用普通克里格法绘制了覆盖整个区域的空间分布图。水样中α和β的总活性分别为9 ~ 40和21 ~ 252 mBq L−1。饮用水中总α和β年有效剂量的算术平均值分别为5.3和52.3 μSv y−1。土壤样品中238U、232Th、40K和137Cs的算术平均值分别为17±6、20±7、445±166和4±6 Bq kg−1。计算得到土壤样品的算术平均吸收剂量率(D)、年有效剂量(AED)和过量终身癌症风险(ELCR)值分别为38 nGy h−1、0.05 mSv y−1和0.165 × 10−3。样品的放射学参数低于文献中推荐的指导水平。此外,根据该地区的土壤结构对插值图进行了评价。
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引用次数: 1
Potential contamination of microplastic from plastic recycling enterprises in Ho Chi Minh City, Vietnam 来自越南胡志明市塑料回收企业的微塑料潜在污染
Pub Date : 2023-07-04 DOI: 10.1080/10807039.2023.2228414
Minh Le Tran, Ha Thi Van Nguyen, Vu Phuong Thai, Thiep Ngoc Nguyen
Abstract The widespread presence of microplastics (MPs) in water raises serious concerns on a global scale due to the negative effects on human health and ecosystems. Wastewater and sludge from preliminary plants of recycled plastic pellets are a significant continuous source of MP discharged into the environment. Wastewater and sludge samples were collected from three plastic recycling plants and analyzed for MPs (size from 0.15–5 mm). The average rate of MP emission was approximately 5.8–6.6% of the total investigations. The MP in water ranged from 14.3410 to 19.3395 g/l, of which 40% with size 2–5 mm, 32% (1–2 mm), 5% (0.5–1 mm), 14% (0.15–0.5 mm), and 9% with size less than 0.15 mm in average. MP in sludge varied from 472.2031 to 644.7620 g/kg, of which, 37% with size 2–5 mm, 24% (1–2 mm), 9% (0.5–1 mm), 12% (0.15–0.5 mm) and 18% less than 0.15 mm. In average, 2,695 particles/l and 287,600 particles/kg of MP size 0.15–5 mm was found in wastewater and sludge, which may have a potential risk to aquatic fauna and humans. Therefore, control microplastic emission from those sources will contribute significantly to reducing microplastics entering the surrounding environment.
由于对人类健康和生态系统的负面影响,微塑料(MPs)在全球范围内广泛存在,引起了严重关注。再生塑料颗粒初步厂的废水和污泥是排放到环境中的重要的连续MP来源。从三个塑料回收厂收集废水和污泥样本,并分析MPs(大小从0.15-5毫米)。MP的平均排放率约为总调查的5.8-6.6%。其中,粒径为2-5 mm的占40%,1-2 mm的占32%,0.5-1 mm的占5%,0.15 - 0.5 mm的占14%,小于0.15 mm的占9%。污泥中MP含量为472.2031 ~ 644.7620 g/kg,其中2-5 mm占37%,1-2 mm占24%,0.5-1 mm占9%,0.15 - 0.5 mm占12%,小于0.15 mm占18%。在废水和污泥中,平均发现粒径0.15-5 mm的颗粒/升为2695个,颗粒/公斤为287600个,可能对水生动物和人类产生潜在风险。因此,控制这些来源的微塑料排放将大大有助于减少进入周围环境的微塑料。
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引用次数: 1
Risk assessment of toxic metals and groundwater quality assessment in an industrial hotspot of Bengaluru, India – case study 印度班加罗尔工业热点地区有毒金属风险评价及地下水质量评价——个案研究
Pub Date : 2023-06-23 DOI: 10.1080/10807039.2023.2223651
B. Prathima, G. S. Sivakumar Babu, S. Ullas, H. K. Lokesh
Abstract The present study was conducted across 28 sampling locations in an industrial zone (Peenya) of Bengaluru city to characterize the various chemical parameters of groundwater. Groundwater chemistry was evaluated using Water Quality Index (WQI) and Piper plots. The WQI results showed that around 78% of sampling points were unfit for drinking water consumption. Results of Piper plots categorized groundwater samples principally into Ca·Mg-HCO3 type (39%) and mixed Ca·Mg − Cl · SO4 type (53.5%). The study used principal component analysis and hierarchical cluster analysis to evaluate possible sources of water pollution. The five major principal components were extracted, and it showed that the water quality in the study area was likely influenced by both natural geogenic and anthropogenic sources. Water was not typically used for drinking purposes, but was used for various industrial uses. Human health risk assessment showed that in most sampling locations (86%), values of the Hazard Index were greater than 1, which indicated that water was not suitable for drinking because of its potential to cause non-carcinogenic health effects in adults and children. Long-term monitoring of contamination in the study area revealed that the concentration of Cr(VI) still existed at concerning levels in groundwater. Thus, the current study aids in identifying risks associated with heavy metal contamination and serves as a foundation for developing a remediation plan to address environmental issues.
本研究在班加罗尔市工业区(Peenya)的28个采样点进行,以表征地下水的各种化学参数。采用水质指数(WQI)和Piper样地对地下水化学进行评价。水质指数结果显示,约78%的采样点不适合饮用。Piper样地将地下水样品主要分为Ca·Mg- hco3型(39%)和Ca·Mg−Cl·SO4混合型(53.5%)。采用主成分分析法和层次聚类分析法对可能的污染源进行评价。提取了5个主要主成分,表明研究区水质可能同时受到自然地质和人为因素的影响。水通常不用于饮用,而是用于各种工业用途。人类健康风险评估表明,在大多数采样地点(86%),危害指数值大于1,这表明水不适合饮用,因为它可能对成人和儿童造成非致癌的健康影响。长期污染监测表明,研究区地下水中Cr(VI)浓度仍处于适宜水平。因此,目前的研究有助于确定与重金属污染有关的风险,并为制定解决环境问题的补救计划奠定基础。
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引用次数: 0
How does environmental relative performance evaluation work? The case of China’s urban air quality ranking 环境相对绩效评价是如何工作的?中国城市空气质量排名案例
Pub Date : 2023-06-22 DOI: 10.1080/10807039.2023.2225622
Qingduo Mao, Haojie Cheng, Jia-lian Shi, Lei Zhou
Abstract Adapting to the situation of one principal versus several agents, the Relative Performance Evaluation (RPE) is an effective incentive tool to motivate subordinates. The Chinese central government has adopted RPE to combat intractable air pollution, which is the Urban Air Quality Ranking (UAQR) system. This study uses a series of econometric methods including regression discontinuity design to examine its effectiveness in environmental governance. The results show that (1) since the implementation of UAQR, the overall air quality of cities has improved; (2) air quality of the bottom 3 cities in the ranking will improve in the coming month compared with their counterparts; (3) while top 3 cities in the ranking do not experience such change in air quality. Therefore, this paper argues that the activating based RPE does not stimulate effective competition, whereas competency based RPE does. UAQR with credible incentive commitment can be a useful measure to motivate local authorities to strengthen air pollution reduction. In this study, the results of the empirical analysis enrich the theoretical framework of RPE, and an innovative theoretical framework is adopted to explain the UAQR system. However, as a top-down environmental monitoring system, such ranking institution could mainly eliminate centralized discharged pollutants. A sound judicial system is the fundamental guarantee for sustainable development.
相对绩效评价(RPE)是一种有效的激励下属的工具,它适应于一个委托人对多个代理人的情况。中国中央政府采用城市空气质量排名(UAQR)系统来对抗棘手的空气污染。本研究运用包括回归不连续设计在内的一系列计量经济学方法来检验其在环境治理中的有效性。结果表明:(1)实施城市空气质量qr以来,城市整体空气质量有所改善;(2)未来一个月,排名倒数3位的城市空气质量将较其他城市有所改善;(3)而排名前3位的城市则没有出现这样的空气质量变化。因此,本文认为基于激活的RPE不能激发有效竞争,而基于胜任力的RPE则能。具有可信激励承诺的空气质量指标可成为激励地方当局加强减少空气污染的有用措施。在本研究中,实证分析的结果丰富了RPE的理论框架,并采用了一个创新的理论框架来解释UAQR系统。然而,作为一种自上而下的环境监测制度,这种排名制度主要可以消除集中排放的污染物。健全的司法制度是可持续发展的根本保障。
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引用次数: 1
Thoracic limb activity of Simocephalus vetulus and its descendants is shaped by the combination of delafloxacin and calcium 德拉沙星和钙的联合作用影响了黄头猴及其后代的胸肢活动
Pub Date : 2023-06-19 DOI: 10.1080/10807039.2023.2225625
T. Nguyen, T. Itayama, N. Iwami, K. Shimizu, T. Dao, T. Pham, H. Maseda
Abstract Due to its robust antibacterial activity in acidic environments and effectiveness against old fluoroquinolone-resistant bacterial strains, the use of delafloxacin (DFX) is projected to increase in the coming years. Here, we investigated the effect on the thoracic limb rate (TLR) of the water flea Simocephalus vetulus under the combined exposure of DFX (0, 100, 200, and 400 µg L−1) and calcium (Ca) (26 and 78 mg L−1) using Bayesian statistics-based linear models. The findings showed unexpected increases and decreases in the TLR of maternal S. vetulus exposed to DFX in the 26 mg Ca L−1. In the 78 mg Ca L−1 condition, we found a clearer decrease in TLR during DFX treatments. In addition, in the 26 mg Ca L−1, elusive changes in the TLR of neonatal S. vetulus whose mothers were exposed to DFX were observed, whereas the reduced TLR of the neonate, whose mother was exposed to 400 µg DFX L−1, was apparent in the higher Ca condition. While the elevated Ca content did not appear to have a clear effect on organisms’ TLR, it acted as a synergist in conjunction with DFX, leading to a reduction in TLR, the underlying mechanism of which remains poorly understood. The results of our study indicate that DFX may pose an ecological risk as a xenobiotic; therefore, taking into account the abundance of Ca in specific aquatic environments, a comprehensive ecological risk assessment should be conducted. Moreover, the inclusion of Bayesian statistics in ecotoxicological studies is highly recommended to improve data analysis and interpretation.
由于德拉沙星在酸性环境中具有强大的抗菌活性,并且对旧的氟喹诺酮耐药菌株有效,预计未来几年德拉沙星(DFX)的使用将会增加。本研究采用基于贝叶斯统计的线性模型,研究了DFX(0、100、200和400µg L−1)和Ca(26和78 mg L−1)联合暴露对水蚤Simocephalus vetulus胸肢率(TLR)的影响。结果显示,在26 mg Ca L−1的DFX环境中,母鼠的TLR出现了意想不到的上升和下降。在78 mg Ca L−1的情况下,我们发现DFX治疗期间TLR下降更明显。此外,在26 mg Ca L−1条件下,母鼠暴露于DFX的新生儿的TLR发生了难以捉摸的变化,而当母鼠暴露于400µg DFX L−1条件下,新生儿的TLR明显降低。虽然Ca含量升高似乎对生物体的TLR没有明显的影响,但它与DFX一起起协同作用,导致TLR减少,其潜在机制尚不清楚。本研究结果表明,DFX作为一种外源生物可能具有生态风险;因此,应综合考虑特定水生环境中Ca的丰度,进行综合生态风险评估。此外,强烈建议将贝叶斯统计纳入生态毒理学研究,以改善数据分析和解释。
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引用次数: 1
Nexus of pesticide exposure, personal preventive measures and farm workers’ health safety in cotton production 棉花生产中农药暴露、个人预防措施与农场工人健康安全的关系
Pub Date : 2023-06-12 DOI: 10.1080/10807039.2023.2218940
H. M. Yousaf, K. Bakhsh, A. Masood
Abstract The aim of the present study is to assess the prevalence and possible predictors of health hazards and their effects on health cost of pesticide applicators and non-applicators. This cross-sectional study was conducted on 580 farm households using multistage sampling technique. The pesticide applicators and non-applicators involved in cotton production were interviewers by the survey team. The prevalence of occupational hazards was higher among the pesticide applicators than non-applicators. Logit regression analysis revealed that the more educated, well trained workers were relatively less vulnerable. Similarly, personal protective measures such as wearing boots and protective handkerchief, and taking bath after pesticide application reduced probability of health risk. Prolonged exposure to pesticide, distance from hospital, and smoking habits were risk factors for development of occupational hazards among the pesticide applicators and non-applicators. The total mean score of health cost resulting from occupational hazards was significantly lower in pesticide non-applicators than pesticide applicators. Workers involved in pesticide application are at higher risk for developing occupational hazards that adversely affects general health and quality of life. The study urges policymakers to formulate programs for proper training of farm workers, encouraging the use of personal preventive measures and the provision of health facilities to farm workers. This will not only improve health of workers but also save undue expenses on medical treatment.
摘要本研究的目的是评估农药施药者和非施药者健康危害的流行程度和可能的预测因素及其对健康成本的影响。本研究采用多阶段抽样方法对580户农户进行横断面调查。参与棉花生产的施药人员和不施药人员由调查队进行访谈。施药者的职业危害发生率高于非施药者。Logit回归分析显示,受教育程度高、训练有素的工人相对不那么脆弱。同样,个人防护措施,如穿靴子和防护手帕,并在施用农药后洗澡,降低了健康风险的可能性。长期接触农药、距离医院较远、吸烟习惯是施药人员和未施药人员职业危害发生的危险因素。职业危害健康成本的总平均得分在未施用农药者显著低于施用农药者。从事农药施用的工人发生对一般健康和生活质量产生不利影响的职业危害的风险较高。该研究敦促决策者制定适当培训农场工人的方案,鼓励使用个人预防措施,并为农场工人提供卫生设施。这不仅可以改善工人的健康状况,还可以节省不必要的医疗费用。
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引用次数: 0
Molybdenum is not a risk factor for changes in serum testosterone 钼不是血清睾酮变化的危险因素
Pub Date : 2023-06-05 DOI: 10.1080/10807039.2023.2218935
K. Klipsch, L. Cox, Shanna L. Clark, M. Rahim, S. Carey
Abstract Molybdenum is a bio-essential trace nutrient, and elevated urinary molybdenum has been implicated as correlating with lower testosterone levels in men. To properly address the contention that molybdenum constitutes a potential health risk factor, we reviewed statistical research findings on molybdenum exposure and somatic levels in humans in a biological plausibility context, which is an indispensable component of reliable risk factor determination. Our analysis applied advanced nonparametric statistical modeling that expands linear regressions to include more potential variables and common confounders. The analysis shows that previously published negative molybdenum-testosterone associations no longer retain statistical relevance. In place of molybdenum as a stressor responsible for lowered testosterone levels, body mass index, age, related hormone variability, and underlying global downward trends in testosterone are shown to be the factors responsible for this effect.
钼是一种生物必需的微量营养素,尿钼升高与男性睾酮水平降低有关。为了正确地解决钼构成潜在健康风险因素的争论,我们回顾了在生物合理性背景下关于钼暴露和人体水平的统计研究结果,这是可靠的风险因素确定不可或缺的组成部分。我们的分析应用了先进的非参数统计模型,将线性回归扩展到包括更多潜在变量和常见混杂因素。分析表明,先前公布的钼-睾酮负相关不再具有统计相关性。钼不再是导致睾酮水平降低的压力源,体重指数、年龄、相关激素变异以及潜在的全球睾酮下降趋势被证明是造成这种影响的因素。
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引用次数: 0
Biogenic synthesis of CuO nanoparticles for efficient photocatalytic degradation of industrial pollutants 生物合成纳米氧化铜用于工业污染物的高效光催化降解
Pub Date : 2023-05-10 DOI: 10.1080/10807039.2023.2210223
Rohit Kumar, J. Kaur, Mohit Rawat, Abdullah A. Alarfaj, Roberto Acevedo, M. Cascione, Valeria De Matteis, Jagpreet Singh
Abstract The issue of industrial dyes has risen to the forefront of environmental concerns, as they are now recognized as a prevalent form of industrial waste that pollutes our surroundings. As such, it is imperative that efforts be made to address their toxicity, with a view to safeguarding the environment and public health. To this end, the application of nanotechnologies presents a promising solution to the challenge of mitigating the harmful effects of industrial dyes on our environment. Copper oxide nanoparticles (CuO NPs) have been found to possess strong photocatalytic properties and are effective in degrading toxic dyes in polluted water and industrial effluents. In this experimental work, CuO NPs were synthesized using Citrus limon leaves extract as source of bioactive molecules to obtain stable NPs. Microscopic and spectroscopic analyses confirmed the formation of CuO NPs with size range of 20–25 nm with spherical shape. In addition, the prepared NPs utilized as photocatalyst against Remazol Brilliant Blue R (RBBR) dye, which shows remarkable potency within 180 min with degradation efficiency ∼90%. Thus, CuO NPs can be used as sustainable, cost-effective and efficient alternative for the removal of toxic industrial effluents from water bodies.
工业染料的问题已经上升到环境问题的前沿,因为它们现在被认为是一种普遍的工业废物,污染我们的环境。因此,必须努力解决其毒性问题,以保护环境和公众健康。为此,纳米技术的应用为减轻工业染料对环境的有害影响提供了一个有希望的解决方案。氧化铜纳米颗粒(CuO NPs)具有较强的光催化性能,可有效降解废水和工业废水中的有毒染料。本实验以柑橘柠檬叶提取物为生物活性分子来源,合成CuO NPs,获得稳定的NPs。显微镜和光谱分析证实形成了尺寸在20 ~ 25 nm之间的球形CuO纳米颗粒。此外,所制备的NPs作为光催化剂对Remazol Brilliant Blue R (RBBR)染料的降解效果显著,在180 min内降解效率达到90%。因此,废液可以作为可持续的、成本效益高的和高效的替代方案,用于从水体中去除有毒工业废水。
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引用次数: 2
Evaluation of glyphosate exposure on testosterone among U.S. adult men 草甘膦暴露对美国成年男性睾酮的影响
Pub Date : 2023-04-25 DOI: 10.1080/10807039.2023.2195005
F. Glover, D. Barr, Jasmin A. Eatman, W. Muncey, F. del Giudice, F. Belladelli, N. Seranio, M. Eisenberg
ABSTRACT Glyphosate is one of the most commonly used herbicide globally. It is considered an endocrine-disrupting chemical (EDC) that can affect the production and function of various hormones including testosterone. Testosterone is an important sex hormone in men that governs sexual development, function, metabolism, and reproduction. Glyphosate has been associated with testosterone impairment in a number of experimental studies; however, the association between glyphosate exposure and testosterone among U.S. adult men in the general population is currently unknown. Data was leveraged from the National Health and Nutrition Examination Survey (NHANES), which is an annually conducted, population-based cross-sectional study. Urinary levels of glyphosate were quantified as measures of exposure. Total testosterone was quantified from the serum of adult men ages 18+, and a serum value of <300 ng/dL was used to define low testosterone. Chi-square, analysis of variance (ANOVA), and multivariable, weighted linear and logistic regression analyses were used to compare sociodemographic and biological characteristics between quartiles of glyphosate exposure, identify risk factors for glyphosate exposure and low testosterone, and to analyze the relationship between glyphosate and testosterone. A total of 441 adults were included in final analyses, representing 18,345,154 individuals after survey weighting. The geometric mean of glyphosate was 0.58 ng/mL (IQR: 0.26–0.66). Race/ethnicity was significantly associated with glyphosate exposure, where white men had higher mean glyphosate exposure compared to black men (β = 0.11, p = .04). Analysis of total glyphosate modeled as a continuous variable was not significantly associated with testosterone (β = 10.93, p = .75). Similarly, no significant associations were observed when categorizing urinary glyphosate into quartiles when evaluating continuous testosterone (β = 3.46 p = .85, β = −6.74 p = .78, β = 10.22 p = .75 for quartiles 2–4, respectively), and categorical testosterone (i.e. normal/low) (OR = 2.29 95% CI [0.61,8.58], OR = 0.88 95% CI [0.18,4.08], OR = 1.14 95% CI [0.39,3.30]) for quartiles 2–4, respectively. We present the first evaluation of population-based urinary glyphosate levels on testosterone among U.S. adult men. We observed no significant associations between glyphosate and testosterone levels. Future studies are warranted to corroborate these findings, and to test these associations in prospective studies and within populations exposed to high levels of glyphosate.
草甘膦是全球最常用的除草剂之一。它被认为是一种内分泌干扰化学物质(EDC),可以影响包括睾酮在内的各种激素的产生和功能。睾酮是男性中一种重要的性激素,控制着性发育、功能、新陈代谢和生殖。在许多实验研究中,草甘膦与睾丸激素损伤有关;然而,在普通美国成年男性中,草甘膦暴露与睾酮之间的关系目前尚不清楚。数据来自国家健康和营养检查调查(NHANES),这是一项每年进行的、以人群为基础的横断面研究。尿中草甘膦水平被量化作为暴露的测量。从18岁以上成年男性的血清中定量测定总睾酮,血清值<300 ng/dL为睾酮水平低。采用卡方、方差分析(ANOVA)、多变量、加权线性和逻辑回归分析比较草甘膦暴露四分位数之间的社会人口学和生物学特征,确定草甘膦暴露和低睾酮的危险因素,并分析草甘膦和睾酮之间的关系。在调查加权后,共有441名成年人被纳入最终分析,代表18,345,154人。草甘膦的几何平均值为0.58 ng/mL (IQR: 0.26 ~ 0.66)。种族/民族与草甘膦暴露显著相关,白人男性草甘膦暴露的平均水平高于黑人男性(β = 0.11, p = 0.04)。将草甘膦总量建模为连续变量的分析与睾酮无显著相关性(β = 10.93, p = 0.75)。同样,当评估持续睾酮时,将尿草甘膦分类为四分位数时,没有观察到显著的关联(β = 3.46 p =。85, β = - 6.74 p =。78、β = 10.222-4四分位数分别为75)和分类睾酮(即正常/低)(OR = 2.29 95% CI [0.61,8.58], OR = 0.88 95% CI [0.18,4.08], OR = 1.14 95% CI[0.39,3.30])。我们首次对美国成年男性基于人群的尿中草甘膦水平对睾酮的影响进行了评估。我们没有观察到草甘膦和睾酮水平之间的显著关联。未来的研究有必要证实这些发现,并在前瞻性研究和暴露于高水平草甘膦的人群中测试这些关联。
{"title":"Evaluation of glyphosate exposure on testosterone among U.S. adult men","authors":"F. Glover, D. Barr, Jasmin A. Eatman, W. Muncey, F. del Giudice, F. Belladelli, N. Seranio, M. Eisenberg","doi":"10.1080/10807039.2023.2195005","DOIUrl":"https://doi.org/10.1080/10807039.2023.2195005","url":null,"abstract":"ABSTRACT Glyphosate is one of the most commonly used herbicide globally. It is considered an endocrine-disrupting chemical (EDC) that can affect the production and function of various hormones including testosterone. Testosterone is an important sex hormone in men that governs sexual development, function, metabolism, and reproduction. Glyphosate has been associated with testosterone impairment in a number of experimental studies; however, the association between glyphosate exposure and testosterone among U.S. adult men in the general population is currently unknown. Data was leveraged from the National Health and Nutrition Examination Survey (NHANES), which is an annually conducted, population-based cross-sectional study. Urinary levels of glyphosate were quantified as measures of exposure. Total testosterone was quantified from the serum of adult men ages 18+, and a serum value of <300 ng/dL was used to define low testosterone. Chi-square, analysis of variance (ANOVA), and multivariable, weighted linear and logistic regression analyses were used to compare sociodemographic and biological characteristics between quartiles of glyphosate exposure, identify risk factors for glyphosate exposure and low testosterone, and to analyze the relationship between glyphosate and testosterone. A total of 441 adults were included in final analyses, representing 18,345,154 individuals after survey weighting. The geometric mean of glyphosate was 0.58 ng/mL (IQR: 0.26–0.66). Race/ethnicity was significantly associated with glyphosate exposure, where white men had higher mean glyphosate exposure compared to black men (β = 0.11, p = .04). Analysis of total glyphosate modeled as a continuous variable was not significantly associated with testosterone (β = 10.93, p = .75). Similarly, no significant associations were observed when categorizing urinary glyphosate into quartiles when evaluating continuous testosterone (β = 3.46 p = .85, β = −6.74 p = .78, β = 10.22 p = .75 for quartiles 2–4, respectively), and categorical testosterone (i.e. normal/low) (OR = 2.29 95% CI [0.61,8.58], OR = 0.88 95% CI [0.18,4.08], OR = 1.14 95% CI [0.39,3.30]) for quartiles 2–4, respectively. We present the first evaluation of population-based urinary glyphosate levels on testosterone among U.S. adult men. We observed no significant associations between glyphosate and testosterone levels. Future studies are warranted to corroborate these findings, and to test these associations in prospective studies and within populations exposed to high levels of glyphosate.","PeriodicalId":13141,"journal":{"name":"Human and Ecological Risk Assessment: An International Journal","volume":"45 1","pages":"902 - 915"},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75244717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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Human and Ecological Risk Assessment: An International Journal
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