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Discovery of the Novel HLA-DRB4*01:03:01:21 Allele by Third-Generation HLA-Targeted Sequencing Technology 利用第三代hla靶向测序技术发现新的HLA-DRB4*01:03:01:21等位基因。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-18 DOI: 10.1111/tan.70004
Zihang Li, Guangbo Tang, Tingjie Wang, Peng Gao, Pengcheng He

HLA-DRB4*01:03:01:21 differs from DRB4*01:03:01:11 by two nucleotide changes in intron 1 and intron 2.

HLA-DRB4*01:03:01:21与DRB4*01:03:01:11的区别在于内含子1和内含子2的两个核苷酸变化。
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引用次数: 0
Characterisation of Four Novel HLA-B Alleles From Russian Registry 俄罗斯4个HLA-B等位基因的特征分析。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-18 DOI: 10.1111/tan.15808
Maria Loginova, Daria Smirnova, Igor Paramonov

Four novel HLA-B alleles are described from bone marrow volunteers of Russian Registry.

从俄罗斯登记的骨髓志愿者中描述了四个新的HLA-B等位基因。
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引用次数: 0
Four Novel HLA-DRB1 Alleles Were Identified by Next-Generation Sequencing 新一代测序技术鉴定了4个新的HLA-DRB1等位基因。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-18 DOI: 10.1111/tan.15807
Maria Loginova, Olga Makhova, Igor Paramonov

Identification of four novel HLA-DRB1 alleles by next-generation sequencing.

新一代测序鉴定4个HLA-DRB1等位基因。
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引用次数: 0
The Novel Allele, HLA-C*06:391, Identified by Next Generation Sequencing in a Saudi Individual 新等位基因HLA-C*06:39 91在沙特个体中被下一代测序鉴定
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-18 DOI: 10.1111/tan.70007
Dalal AlAbduladheem, Hassan Alharbi, Saber AlZahrani, Amani Mohammed, Mohammad Awaji

A single nucleotide substitution in exon 2 of HLA-C*06:02:01:01 results in the novel allele, HLA-C*06:391.

HLA-C*06:02:01:01外显子2的单核苷酸替换产生新的等位基因HLA-C*06:391。
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引用次数: 0
Characterisation of the Novel HLA-G*01:06:01:02 Allele in a Tribal Individual From Western Maharashtra, India 印度马哈拉施特拉邦西部部落个体HLA-G*01:06:01:02等位基因的特征
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-12 DOI: 10.1111/tan.15805
Yogini Mujumdar, Shramika Vasant Thakur, Vikrant M. Bhor, Ragini Nitin Kulkarni, Itta Krishna Chaaithanya

HLA-G*01:06:02:01 differs from HLA-G*01:06:01:01 by one nucleotide substitution in intron 4 at position 1921 (C to T).

HLA-G*01:06:02:01与HLA-G*01:06:01:01的不同之处在于在第4内含子1921位（C到T）有一个核苷酸替换。
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引用次数: 0
Identification of the Novel HLA-DPA1*02:143 Allele by Next-Generation Sequencing 新HLA-DPA1*02:143等位基因的新一代测序鉴定
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-12 DOI: 10.1111/tan.15806
Jong Kwon Lee, Sohyeon Eom, Jun Woo Park, Jina Lee, Eun-Suk Kang

HLA-DPA1*02:143 is identical to HLA-DPA1*02:02:02:01 except for a single nucleotide substitution in exon 1.

HLA-DPA1* 02:02:143与HLA-DPA1*02:02:02:01完全相同，除了外显子1有一个单核苷酸替换。
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引用次数: 0
Three Fields Allelic Haplotype Frequencies of HLA-DPA1 and -DPB1 Typed by Next Generation Sequencing of 563 Families in Chinese Han Population 中国汉族 563 个家庭的下一代测序所测出的 HLA-DPA1 和 -DPB1 的三个基因组单倍型频率
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-12 DOI: 10.1111/tan.15810
Jian-Ling Wang, Jun-Bo He, Zhi-Min Li, Ya-Nan Zhu, DaJiang Cao, Hong-Lei Fu, Xian Zhang, Marcelo A. Fernández-Viña, Erik Rozemuller, XiangJun Liu

The present study investigated the HLA-DPA1 and -DPB1 allele and haplotype frequencies in the Chinese Han population. A total of 563 families, which have been typed for the purpose of haematopoietic stem cell transplantation, were included, and three-field allelic resolution typing of HLA-DPA1 and -DPB1 of all individuals were defined by the next-generation sequencing method. HLA-DPA1~DPB1 haplotypes were determined by allele segregation within a nuclear family. A total of 9 HLA-DPA1 and 39 HLA-DPB1 alleles, and 62 HLA-DPA1~DPB1 haplotypes were identified. The three most frequent alleles at HLA-DPA1 locus are HLA-DPA1*02:02:02 (46.581%), HLA-DPA1*01:03:01 (36.456%) and HLA-DPA1*02:01:01 (12.167%); and the three most frequent HLA-DPB1 alleles are HLA-DPB1*05:01:01 (34.014%), HLA-DPB1*02:01:02 (18.428%) and HLA-DPB1*04:01:01 (10.124%). The three most frequent haplotypes are HLA-DPA1*02:02:02~DPB1*05:01:01 (32.327%), HLA-DPA1*01:03:01 ~ DPB1*02:01:02 (14.654%) and HLA-DPA1*01:03:01~DPB1*04:01:01 (9.458%). The HLA-DPA1*02:01~DPB1*02:02 and HLA-DPA1*04:01~DPB1*05:01 haplotypes appear to be unique in Han Chinese. Strong global linkage disequilibrium (LD) between HLA-DPA1 and -DPB1 was confirmed (D′ = 0.848, Wn = 0.684). Moreover, the haplotype frequencies based on the family study were compared with the frequencies estimated by the expectation–maximisation algorithm, and the equivalent results were obtained except for haplotypes with very low frequencies. Our data provide a solid base for HLA-DP dimer association studies and useful information for transplantation and disease association studies.

本研究调查了中国汉族人群HLA-DPA1和-DPB1等位基因和单倍型频率。共纳入563个为造血干细胞移植目的分型的家族，并通过下一代测序方法确定所有个体HLA-DPA1和-DPB1的三场等位基因分辨率分型。HLA-DPA1~DPB1单倍型由核心家族内的等位基因分离确定。共鉴定出9个HLA-DPA1和39个HLA-DPB1等位基因，以及62个HLA-DPA1~DPB1单倍型。HLA-DPA1位点最常见的3个等位基因分别是HLA-DPA1*02:02:02（46.581%）、HLA-DPA1*01:03:01（36.456%）和HLA-DPA1*02:01:01 (12.167%)；HLA-DPB1最常见的等位基因为HLA-DPB1*05:01:01（34.014%）、HLA-DPB1*02:01:02（18.428%）和HLA-DPB1*04:01:01（10.124%）。最常见的三种单倍型分别是HLA-DPA1*02:02:02~DPB1*05:01:01（32.327%）、HLA-DPA1*01:03:01~DPB1* 02:01:02（14.654%）和HLA-DPA1*01:03:01~DPB1*04:01:01（9.458%）。HLA-DPA1*02:01~DPB1*02:02和HLA-DPA1*04:01~DPB1*05:01两种单倍型在汉族人群中具有独特性。证实HLA-DPA1与-DPB1之间存在强烈的全局连锁不平衡（LD） （D ' = 0.848, Wn = 0.684）。此外，将基于家族研究的单倍型频率与期望最大化算法估计的频率进行比较，除频率极低的单倍型外，均获得等效结果。我们的数据为HLA-DP二聚体关联研究提供了坚实的基础，并为移植和疾病关联研究提供了有用的信息。
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引用次数: 0
The Novel HLA-C*03:656 Allele Identified by Next-Generation Sequencing 新一代测序鉴定HLA-C*03:656等位基因
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-12 DOI: 10.1111/tan.15801
Manli Shen, Jo-Ellen Jennemann, Patricia Willey, Chang Liu

HLA-C*03:656 differs from HLA-C*03:04:01:02 by a single missense nucleotide substitution in codon 342 in exon 7.

HLA-C*03:04:01:02与HLA-C* 03:04:656的区别在于外显子7密码子342的单错义核苷酸替换。
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引用次数: 0
Identification of the Novel HLA-DRB3*02:185 Allele by Next-Generation Sequencing in a Post-Transplant Renal Patient 新一代测序技术鉴定肾移植后患者HLA-DRB3*02:185等位基因
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-12 DOI: 10.1111/tan.15804
He Zhao, Destinie Webster, Karey Gorkoff, Ahmed Shoker, Ahmed Mostafa

The novel allele HLA-DRB3*02:185 differs from HLA-DRB3*02:02:01:02 by one nucleotide substitution in codon 191 of exon 4.

新等位基因HLA-DRB3*02:185与HLA-DRB3*02:02:01:02在第4外显子191密码子上有一个核苷酸替换。
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引用次数: 0
Description of the Novel HLA-B*48:01:14 Allele Identified in a Northern Chinese Han Individual 中国北方汉族新HLA-B*48:01:14等位基因的描述
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-12-12 DOI: 10.1111/tan.15793
Yu Han, Li-Xin Jiao, Fan Yang

Identification of the novel HLA-B*48:01:14 allele, which differs from HLA-B*48:01:01 at one position.

新HLA-B*48:01:14等位基因的鉴定，该等位基因与HLA-B*48:01:01有一个位点的差异。
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引用次数: 0
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