首页 > 最新文献

Hpb最新文献

英文 中文
Sociodemographic variation in the utilization of minimally invasive surgical approaches for pancreatic cancer 利用微创手术治疗胰腺癌的社会人口学差异
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-10-01 DOI: 10.1016/j.hpb.2024.07.403
Andy Tran , Richard Zheng , Fabian Johnston , Jin He , William R. Burns , Christopher Shubert , Kelly Lafaro , Richard A. Burkhart

Background

Minimally invasive pancreatic surgery (MIPS), when selectively utilized, has been shown to hasten recovery with outcomes comparable to open approaches, but access may not be equitable. This study explored variation in utilization of MIPS for pancreatic cancer.

Methods

The National Cancer Database was queried to identify patients diagnosed with a primary pancreatic neoplasm from 2010 to 2020. Study participants had diagnoses of clinical or pathologic stage 1–3 disease and received curative-intent surgery. Multivariable analyses assessed the association between surgical approach and patient and disease factors.

Results

Inclusion criteria identified 73,137 patients: 51,408 underwent open surgery and 21,729 received MIPS. In our multivariable analysis, Black race was associated with reduced odds of MIPS (AOR 0.88; p = 0.02), while older age (AOR 1.17; p = 0.01), later year of diagnosis (AOR 1.57; p < 0.001), and private insurance coverage (AOR 1.30; p = 0.05) were associated with increased odds. When patients with adenocarcinoma were analyzed in isolation, disparities in MIPS utilization persisted even when controlling for disease stage.

Conclusion

Sociodemographic factors like age, race, and insurance coverage appear to vary in the utilization of MIPS technologies for the treatment of pancreatic malignancy. Addressing variation with robust mixed methods approaches in the future is proposed to incorporate prospective interventions with highly annotated outcomes for additional study.
背景有选择地使用微创胰腺手术(MIPS)已被证明可加快康复,其效果与开放式手术相当,但使用机会可能并不公平。本研究探讨了胰腺癌微创胰腺手术(MIPS)利用率的差异。方法通过查询美国国家癌症数据库,确定了2010年至2020年期间诊断为原发性胰腺肿瘤的患者。研究参与者被诊断为临床或病理 1-3 期疾病,并接受了治愈性手术。多变量分析评估了手术方式与患者和疾病因素之间的关联:51,408人接受了开放手术,21,729人接受了MIPS手术。在我们的多变量分析中,黑人种族与 MIPS 的几率降低有关(AOR 0.88;P = 0.02),而年龄较大(AOR 1.17;P = 0.01)、诊断年份较晚(AOR 1.57;P <;0.001)和私人保险覆盖范围(AOR 1.30;P = 0.05)与几率增加有关。结论年龄、种族和保险范围等社会人口因素似乎在利用 MIPS 技术治疗胰腺恶性肿瘤方面存在差异。建议今后采用稳健的混合方法来解决差异问题,以纳入具有高度注释结果的前瞻性干预措施,进行更多研究。
{"title":"Sociodemographic variation in the utilization of minimally invasive surgical approaches for pancreatic cancer","authors":"Andy Tran ,&nbsp;Richard Zheng ,&nbsp;Fabian Johnston ,&nbsp;Jin He ,&nbsp;William R. Burns ,&nbsp;Christopher Shubert ,&nbsp;Kelly Lafaro ,&nbsp;Richard A. Burkhart","doi":"10.1016/j.hpb.2024.07.403","DOIUrl":"10.1016/j.hpb.2024.07.403","url":null,"abstract":"<div><h3>Background</h3><div><span>Minimally invasive pancreatic surgery (MIPS), when selectively utilized, has been shown to hasten recovery with outcomes comparable to open approaches, but access may not be equitable. This study explored variation in utilization of MIPS for </span>pancreatic cancer.</div></div><div><h3>Methods</h3><div>The National Cancer Database was queried to identify patients diagnosed with a primary pancreatic neoplasm from 2010 to 2020. Study participants had diagnoses of clinical or pathologic stage 1–3 disease and received curative-intent surgery. Multivariable analyses assessed the association between surgical approach and patient and disease factors.</div></div><div><h3>Results</h3><div>Inclusion criteria identified 73,137 patients: 51,408 underwent open surgery and 21,729 received MIPS. In our multivariable analysis, Black race was associated with reduced odds of MIPS (AOR 0.88; p = 0.02), while older age (AOR 1.17; p = 0.01), later year of diagnosis (AOR 1.57; p &lt; 0.001), and private insurance coverage (AOR 1.30; p = 0.05) were associated with increased odds. When patients with adenocarcinoma were analyzed in isolation, disparities in MIPS utilization persisted even when controlling for disease stage.</div></div><div><h3>Conclusion</h3><div>Sociodemographic factors like age, race, and insurance coverage appear to vary in the utilization of MIPS technologies for the treatment of pancreatic malignancy. Addressing variation with robust mixed methods approaches in the future is proposed to incorporate prospective interventions with highly annotated outcomes for additional study.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"26 10","pages":"Pages 1280-1290"},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta analysis of radiofrequency ablation versus surgical resection in small and large nodule of hepatocellular carcinoma 射频消融与手术切除治疗肝细胞癌小结节和大结节的 Meta 分析
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-10-01 DOI: 10.1016/j.hpb.2024.06.009
Rino A. Gani, Maria Teressa, Refael A. Budiman, Kemal F. Kalista, Cosmas Rinaldi A. Lesmana

Introduction

Although studies have indicated comparable outcomes between RFA and surgical resection in early HCC, there is still unclear evidence of benefit in larger tumor sizes. This study aimed to assess the efficacy and safety of RFA versus surgical resection in HCC patients, considering nodule size with a cutoff at 3 cm.

Methods

A comprehensive search of multiple databases was conducted. The systematic review and meta-analysis followed the PRISMA guidelines.

Result

Surgical resection showed superior OS (HR = 1.18, 95% CI: 1.11–1.27, p = 0.008) and RFS (HR = 1.17, 95% CI: 1.11–1.25, p < 0.00001), compared to RFA. For nodules less than 3 cm or larger than 5 cm, the OS and RFS in the surgical resection group were significantly higher than those in the RFA group, while no significant differences were observed for nodules sized 3–5 cm. However, significantly more adverse events occurred following surgical resection (OR = 0.43, 95% CI: 0.33–0.56, P < 0.00001).

Conclusion

Surgical resection has better OS and RFS compared to RFA for liver tumors less than 3 cm or larger than 5 cm. For liver tumors sized 3–5 cm, RFA and surgical resection yield similar findings. RFA may become a preferable option in these 3–5 cm tumors due to its comparable efficacy and fewer adverse events for patients unsuitable for surgery.
尽管有研究表明,在早期 HCC 中,RFA 和手术切除的疗效相当,但对于肿瘤较大的患者,其获益证据仍不明确。本研究旨在评估 RFA 与手术切除对 HCC 患者的疗效和安全性,考虑到结节的大小,以 3 厘米为分界线。研究人员对多个数据库进行了全面检索。系统回顾和荟萃分析遵循了 PRISMA 指南。与 RFA 相比,手术切除显示出更佳的 OS(HR = 1.18,95% CI:1.11-1.27,p = 0.008)和 RFS(HR = 1.17,95% CI:1.11-1.25,p < 0.00001)。对于小于3厘米或大于5厘米的结节,手术切除组的OS和RFS明显高于RFA组,而对于3-5厘米的结节则无明显差异。然而,手术切除后发生的不良事件明显增多(OR = 0.43,95% CI:0.33-0.56,P < 0.00001)。对于小于3厘米或大于5厘米的肝脏肿瘤,手术切除的OS和RFS均优于RFA。对于 3-5 厘米的肝脏肿瘤,RFA 和手术切除的结果相似。对于不适合手术的患者来说,RFA的疗效相当,不良反应较少,因此可能成为这些3-5厘米肿瘤的首选。
{"title":"Meta analysis of radiofrequency ablation versus surgical resection in small and large nodule of hepatocellular carcinoma","authors":"Rino A. Gani,&nbsp;Maria Teressa,&nbsp;Refael A. Budiman,&nbsp;Kemal F. Kalista,&nbsp;Cosmas Rinaldi A. Lesmana","doi":"10.1016/j.hpb.2024.06.009","DOIUrl":"10.1016/j.hpb.2024.06.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Although studies have indicated comparable outcomes between RFA and surgical resection in early HCC, there is still unclear evidence of benefit in larger tumor sizes. This study aimed to assess the efficacy and safety of RFA versus surgical resection in HCC patients, considering nodule size with a cutoff at 3 cm.</div></div><div><h3>Methods</h3><div>A comprehensive search of multiple databases was conducted. The systematic review and meta-analysis followed the PRISMA guidelines.</div></div><div><h3>Result</h3><div>Surgical resection showed superior OS (HR = 1.18, 95% CI: 1.11–1.27, p = 0.008) and RFS (HR = 1.17, 95% CI: 1.11–1.25, p &lt; 0.00001), compared to RFA. For nodules less than 3 cm or larger than 5 cm, the OS and RFS in the surgical resection group were significantly higher than those in the RFA group, while no significant differences were observed for nodules sized 3–5 cm. However, significantly more adverse events occurred following surgical resection (OR = 0.43, 95% CI: 0.33–0.56, P &lt; 0.00001).</div></div><div><h3>Conclusion</h3><div>Surgical resection has better OS and RFS compared to RFA for liver tumors less than 3 cm or larger than 5 cm. For liver tumors sized 3–5 cm, RFA and surgical resection yield similar findings. RFA may become a preferable option in these 3–5 cm tumors due to its comparable efficacy and fewer adverse events for patients unsuitable for surgery.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"26 10","pages":"Pages 1216-1228"},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141612210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of liver surgery and fluid strategy on renin activity and aldosterone and anti-diuretic hormone levels: a secondary analysis of the GALILEO trial 肝脏手术和输液策略对肾素活性、醛固酮和抗利尿激素水平的影响:GALILEO 试验的二次分析
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-10-01 DOI: 10.1016/j.hpb.2024.06.005

Background

It is unknown whether liver surgery leads to increased RAAS activity and anti-diuretic hormone (ADH) levels and subsequent fluid accumulation. Furthermore, it is unknown whether the peri-operative fluid strategy changes this effect.

Methods

This is a pre-planned post hoc analysis of a randomised controlled trial which compared restrictive (n = 20) versus liberal fluid strategy (n = 20) in patients undergoing liver surgery. Primary outcomes for the current study were the difference in hormone levels after anaesthesia induction and after liver resection. Fluid overload was defined as a ≥10% increase in weight.

Results

Renin activity (6 [2.1–15.5] vs. 12 [4.6–33.5]) and ADH levels (6.0 [1.7–16.3] vs. 3.8 [1.6–14.7]) did not differ significantly before and after resection. However, aldosterone levels were significantly higher after resection (0.30 [0.17–0.49] vs. 0.69 [0.31–1.21] ). Renin activity and aldosterone levels did not differ between the groups. ADH was significantly higher in the restrictive strategy group (1.6 [1.1–2.1] vs 5.9 [3.8–16.0]). No differences in hormone levels were found in patients with and without fluid overload.

Discussion

Aldosterone levels increased after liver surgery but renin activity and ADH levels did not. ADH levels were higher in the restrictive group. Development of post-operative fluid overload was not associated with RAAS activity or ADH levels.
肝脏手术是否会导致 RAAS 活性和抗利尿激素(ADH)水平升高,进而导致液体积聚,目前尚不清楚。此外,围手术期输液策略是否会改变这种影响也不得而知。这是对一项随机对照试验进行的预先计划的事后分析,该试验比较了肝脏手术患者的限制性输液策略(= 20)和自由输液策略(= 20)。本次研究的主要结果是麻醉诱导后和肝脏切除术后激素水平的差异。液体超负荷的定义是体重增加≥10%。肾素活性(6 [2.1-15.5] vs. 12 [4.6-33.5])和ADH水平(6.0 [1.7-16.3] vs. 3.8 [1.6-14.7])在切除前后没有显著差异。但是,切除术后醛固酮水平明显升高(0.30 [0.17-0.49] vs. 0.69 [0.31-1.21] )。肾素活性和醛固酮水平在各组之间没有差异。限制性策略组的 ADH 水平明显更高(1.6 [1.1-2.1] vs 5.9 [3.8-16.0])。体液超负荷和无体液超负荷患者的激素水平没有差异。肝脏手术后醛固酮水平升高,但肾素活性和ADH水平没有升高。限制性组的 ADH 水平更高。术后体液超负荷与 RAAS 活性或 ADH 水平无关。
{"title":"The effect of liver surgery and fluid strategy on renin activity and aldosterone and anti-diuretic hormone levels: a secondary analysis of the GALILEO trial","authors":"","doi":"10.1016/j.hpb.2024.06.005","DOIUrl":"10.1016/j.hpb.2024.06.005","url":null,"abstract":"<div><h3>Background</h3><div>It is unknown whether liver surgery leads to increased RAAS activity and anti-diuretic hormone (ADH) levels and subsequent fluid accumulation. Furthermore, it is unknown whether the peri-operative fluid strategy changes this effect.</div></div><div><h3>Methods</h3><div>This is a pre-planned post hoc analysis of a randomised controlled trial which compared restrictive (<em>n</em> = 20) versus liberal fluid strategy (<em>n</em> = 20) in patients undergoing liver surgery. Primary outcomes for the current study were the difference in hormone levels after anaesthesia induction and after liver resection. Fluid overload was defined as a ≥10% increase in weight.</div></div><div><h3>Results</h3><div>Renin activity (6 [2.1–15.5] vs. 12 [4.6–33.5]) and ADH levels (6.0 [1.7–16.3] vs. 3.8 [1.6–14.7]) did not differ significantly before and after resection. However, aldosterone levels were significantly higher after resection (0.30 [0.17–0.49] vs. 0.69 [0.31–1.21] ). Renin activity and aldosterone levels did not differ between the groups. ADH was significantly higher in the restrictive strategy group (1.6 [1.1–2.1] vs 5.9 [3.8–16.0]). No differences in hormone levels were found in patients with and without fluid overload.</div></div><div><h3>Discussion</h3><div>Aldosterone levels increased after liver surgery but renin activity and ADH levels did not. ADH levels were higher in the restrictive group. Development of post-operative fluid overload was not associated with RAAS activity or ADH levels.</div></div>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"26 10","pages":"Pages 1248-1253"},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141501400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional outcomes & complications of hepatic artery infusion pumps by device manufacturer 按设备制造商分列的肝动脉输注泵的功能结果和并发症
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-10-01 DOI: 10.1016/j.hpb.2024.07.404
Jason M. Aubrey, Hordur M. Kolbeinsson, Pavitra Attanayake, Allison Swider, Hannah R. Liefeld, Mathew Chung, M. Mura Assifi, G. Paul Wright
{"title":"Functional outcomes & complications of hepatic artery infusion pumps by device manufacturer","authors":"Jason M. Aubrey,&nbsp;Hordur M. Kolbeinsson,&nbsp;Pavitra Attanayake,&nbsp;Allison Swider,&nbsp;Hannah R. Liefeld,&nbsp;Mathew Chung,&nbsp;M. Mura Assifi,&nbsp;G. Paul Wright","doi":"10.1016/j.hpb.2024.07.404","DOIUrl":"10.1016/j.hpb.2024.07.404","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"26 10","pages":"Pages 1302-1304"},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: Predictive score for identifying intrahepatic cholangiocarcinoma patients without lymph node metastasis: a basis for omitting lymph node dissection 致编辑的信:识别无淋巴结转移的肝内胆管癌患者的预测评分:省略淋巴结清扫的依据。
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-10-01 DOI: 10.1016/j.hpb.2024.07.406
Yu-Le Luo , Hai-Su Dai , Ting Yu, Zhi-Yu Chen, Zhi-Peng Liu
{"title":"Letter to the editor: Predictive score for identifying intrahepatic cholangiocarcinoma patients without lymph node metastasis: a basis for omitting lymph node dissection","authors":"Yu-Le Luo ,&nbsp;Hai-Su Dai ,&nbsp;Ting Yu,&nbsp;Zhi-Yu Chen,&nbsp;Zhi-Peng Liu","doi":"10.1016/j.hpb.2024.07.406","DOIUrl":"10.1016/j.hpb.2024.07.406","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":"26 10","pages":"Page 1308"},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is robotic liver resection feasible in patients with lesions in close proximity to major vessels? A propensity score matching analysis. 病变靠近大血管的患者是否可行机器人肝脏切除术?倾向得分匹配分析
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-09-29 DOI: 10.1016/j.hpb.2024.09.010
Edoardo M Muttillo, Leonardo L Chiarella, Francesca Ratti, Paolo Magistri, Andrea Belli, Giammauro Berardi, Giuseppe M Ettorre, Graziano Ceccarelli, Francesco Izzo, Marcello G Spampinato, Nicola De Angelis, Patrick Pessaux, Tullio Piardi, Fabrizio Di Benedetto, Luca Aldrighetti, Riccardo Memeo

Introduction: Robotic surgery is widely diffused in the surgical field and is becoming increasingly prevalent, however several aspects need more detailed assessment. One of them concerns the role of robotic liver surgery for lesions in contact with major vascular (CMV) pedicles. The aim of our study is to evaluate and compare intra and post operative outcomes in patients undergoing robotic liver resections between lesions in contact or free from major vessels.

Methods: A multicentric retrospective study was performed including 1030 patients who underwent robotic liver resection. Patients were divided into two groups according to vascular contact. Intra and post-operative outcomes were compared between the groups before and after Propensity Score Matching.

Results: After propensity score matching 889 patients were included in the study. Among these lesions, 595 were not in contact with major vessels (NCMV) and 294 were in contact with major vessels (CMV). Use of Pringle Manoeuvre was more associated with CMV resections (49.8 % vs 31.2 %, p = 0,0001). No differences in terms of operative time, conversion rate, morbidity and type of complications were observed after PSM.

Conclusion: The presents study shows how robotic surgery is a valid and safe technique also for resection of tumors close to vascular pedicles.

导言:机器人手术已广泛应用于外科领域,并日益普及,但有几个方面需要更详细的评估。其中一个方面涉及到机器人肝脏手术在治疗与大血管(CMV)血管蒂接触的病变方面的作用。我们的研究旨在评估和比较接受机器人肝脏切除术的患者在接触或不接触大血管的病变中的术中和术后效果:我们进行了一项多中心回顾性研究,包括 1030 名接受机器人肝脏切除术的患者。根据血管接触情况将患者分为两组。比较了倾向得分匹配前后两组患者的术中和术后结果:经过倾向评分匹配后,889 名患者被纳入研究。在这些病变中,595 例未与大血管接触(NCMV),294 例与大血管接触(CMV)。使用普林格尔手法(Pringle Manoeuvre)与CMV切除术更相关(49.8% vs 31.2%,p = 0,0001)。PSM术后在手术时间、转换率、发病率和并发症类型方面均无差异:本研究表明,机器人手术对于切除靠近血管蒂的肿瘤也是一种有效而安全的技术。
{"title":"Is robotic liver resection feasible in patients with lesions in close proximity to major vessels? A propensity score matching analysis.","authors":"Edoardo M Muttillo, Leonardo L Chiarella, Francesca Ratti, Paolo Magistri, Andrea Belli, Giammauro Berardi, Giuseppe M Ettorre, Graziano Ceccarelli, Francesco Izzo, Marcello G Spampinato, Nicola De Angelis, Patrick Pessaux, Tullio Piardi, Fabrizio Di Benedetto, Luca Aldrighetti, Riccardo Memeo","doi":"10.1016/j.hpb.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.hpb.2024.09.010","url":null,"abstract":"<p><strong>Introduction: </strong>Robotic surgery is widely diffused in the surgical field and is becoming increasingly prevalent, however several aspects need more detailed assessment. One of them concerns the role of robotic liver surgery for lesions in contact with major vascular (CMV) pedicles. The aim of our study is to evaluate and compare intra and post operative outcomes in patients undergoing robotic liver resections between lesions in contact or free from major vessels.</p><p><strong>Methods: </strong>A multicentric retrospective study was performed including 1030 patients who underwent robotic liver resection. Patients were divided into two groups according to vascular contact. Intra and post-operative outcomes were compared between the groups before and after Propensity Score Matching.</p><p><strong>Results: </strong>After propensity score matching 889 patients were included in the study. Among these lesions, 595 were not in contact with major vessels (NCMV) and 294 were in contact with major vessels (CMV). Use of Pringle Manoeuvre was more associated with CMV resections (49.8 % vs 31.2 %, p = 0,0001). No differences in terms of operative time, conversion rate, morbidity and type of complications were observed after PSM.</p><p><strong>Conclusion: </strong>The presents study shows how robotic surgery is a valid and safe technique also for resection of tumors close to vascular pedicles.</p>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hospital charge and resource use analysis of extended-spectrum penicillin antibiotic therapy after pancreatoduodenectomy in intermediate- and high-risk patients. 中高危患者胰十二指肠切除术后延长谱青霉素抗生素治疗的住院费用和资源使用分析。
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-09-28 DOI: 10.1016/j.hpb.2024.09.011
Alexander Loftus, Victoria S Wu, Mohamedraed Elshami, Jonathan J Hue, Lee M Ocuin

Background: We previously reported that an extended antibiotic mitigation pathway following pancreatoduodenectomy in patients with intermediate-/high-risk glands is associated with 83 % lower odds of clinically relevant postoperative pancreatic fistula (CR-POPF). We now describe associations between the pathway, resource utilization, and hospital charges.

Methods: We performed a retrospective cohort study of patients who underwent elective pancreatoduodenectomy with soft gland texture and fistula risk score (FRS) ≥3 who received standard or extended antibiotics. Hospital charges and resource utilization within 90 days of surgery were compared by CR-POPF status and antibiotic pathway.

Results: A total of 34 patients received extended antibiotics and 53 received standard antibiotics. In patients with CR-POPF, patients who received extended antibiotics had lower likelihood of surgical or percutaneous reintervention (75.0 % vs. 100.0 %, p = 0.022). Ninety-day postoperative charges associated with CR-POPF were higher than no CR-POPF ($60,527 vs. $25,631, p = 0.028). Our risk-based model predicted a $15,825 decrease in hospital charges per patient receiving extended antibiotics.

Conclusions: CR-POPF is associated with higher 90-day hospital charges. Extended antibiotic therapy following pancreatoduodenectomy in patients with soft gland texture and FRS ≥3 is associated with fewer reinterventions in patients who develop CR-POPF. These outcomes will be formally tested in a randomized controlled trial (NCT05753735).

背景:我们以前曾报道过,对中/高危腺体患者进行胰十二指肠切除术后延长抗生素缓解路径可降低 83% 的临床相关术后胰瘘 (CR-POPF) 发生几率。现在,我们将介绍该路径、资源利用率和住院费用之间的关联:我们对接受择期胰十二指肠切除术、腺体质地较软、瘘管风险评分(FRS)≥3、接受标准或延长抗生素治疗的患者进行了回顾性队列研究。根据 CR-POPF 状态和抗生素使用途径比较了手术后 90 天内的住院费用和资源使用情况:结果:共有 34 名患者接受了扩展抗生素治疗,53 名患者接受了标准抗生素治疗。在 CR-POPF 患者中,接受延长抗生素治疗的患者接受手术或经皮再介入治疗的可能性较低(75.0% 对 100.0%,P = 0.022)。与 CR-POPF 相关的术后九十天费用高于未使用 CR-POPF 的费用(60,527 美元对 25,631 美元,p = 0.028)。我们基于风险的模型预测,每位接受延长抗生素治疗的患者住院费用将减少 15,825 美元:结论:CR-POPF 与较高的 90 天住院费用有关。对于腺体质地较软、FRS ≥3的患者,胰十二指肠切除术后延长抗生素疗程可减少发生CR-POPF患者的再次干预。这些结果将在随机对照试验(NCT05753735)中进行正式检验。
{"title":"Hospital charge and resource use analysis of extended-spectrum penicillin antibiotic therapy after pancreatoduodenectomy in intermediate- and high-risk patients.","authors":"Alexander Loftus, Victoria S Wu, Mohamedraed Elshami, Jonathan J Hue, Lee M Ocuin","doi":"10.1016/j.hpb.2024.09.011","DOIUrl":"https://doi.org/10.1016/j.hpb.2024.09.011","url":null,"abstract":"<p><strong>Background: </strong>We previously reported that an extended antibiotic mitigation pathway following pancreatoduodenectomy in patients with intermediate-/high-risk glands is associated with 83 % lower odds of clinically relevant postoperative pancreatic fistula (CR-POPF). We now describe associations between the pathway, resource utilization, and hospital charges.</p><p><strong>Methods: </strong>We performed a retrospective cohort study of patients who underwent elective pancreatoduodenectomy with soft gland texture and fistula risk score (FRS) ≥3 who received standard or extended antibiotics. Hospital charges and resource utilization within 90 days of surgery were compared by CR-POPF status and antibiotic pathway.</p><p><strong>Results: </strong>A total of 34 patients received extended antibiotics and 53 received standard antibiotics. In patients with CR-POPF, patients who received extended antibiotics had lower likelihood of surgical or percutaneous reintervention (75.0 % vs. 100.0 %, p = 0.022). Ninety-day postoperative charges associated with CR-POPF were higher than no CR-POPF ($60,527 vs. $25,631, p = 0.028). Our risk-based model predicted a $15,825 decrease in hospital charges per patient receiving extended antibiotics.</p><p><strong>Conclusions: </strong>CR-POPF is associated with higher 90-day hospital charges. Extended antibiotic therapy following pancreatoduodenectomy in patients with soft gland texture and FRS ≥3 is associated with fewer reinterventions in patients who develop CR-POPF. These outcomes will be formally tested in a randomized controlled trial (NCT05753735).</p>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocol for a national, multicentre prospective study of acute pancreatitis management and outcomes: the PANORAMA study. 全国性多中心急性胰腺炎管理和预后前瞻性研究:PANORAMA 研究协议。
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-09-26 DOI: 10.1016/j.hpb.2024.09.008

Aim: The primary aim of this study is to determine compliance with key quality performance indicators (QPIs) for the management of acute pancreatitis. The secondary aim is to examine the relationship between compliance to QPIs and clinical outcomes with factors that influence this.

Methods: This prospective cohort study will be conducted via the trainee-led STRATA collaborative network. All public hospitals in Aotearoa New Zealand will be eligible to participate. Data will be collected on all adult patients who are diagnosed with acute pancreatitis over a 3 month period. The primary outcome is compliance with the QPIs for the different domains of acute pancreatitis management. Secondary outcomes include early (30-days from index admission) clinical outcomes including incidence of locoregional complications, interventions, organ failure, and mortality.

Conclusion: This protocol describes the methodology for a nationwide prospective cohort study in Aotearoa New Zealand to evaluate compliance based on QPIs derived from the literature. These data will lay the foundation for future registry studies, clinical trials, and quality improvement initiatives.

目的:本研究的主要目的是确定急性胰腺炎治疗过程中关键质量绩效指标(QPI)的达标情况。次要目的是研究遵守 QPI 与临床结果之间的关系以及影响因素:这项前瞻性队列研究将通过受训人员领导的 STRATA 合作网络进行。新西兰奥特亚罗瓦的所有公立医院均有资格参与。将在 3 个月内收集所有被诊断为急性胰腺炎的成年患者的数据。主要结果是急性胰腺炎管理不同领域的 QPI 达标情况。次要结果包括早期(入院 30 天后)临床结果,包括局部并发症、干预、器官衰竭和死亡率的发生率:本方案介绍了在新西兰奥特亚罗瓦开展全国性前瞻性队列研究的方法,以评估基于文献中得出的 QPIs 的依从性。这些数据将为未来的登记研究、临床试验和质量改进计划奠定基础。
{"title":"Protocol for a national, multicentre prospective study of acute pancreatitis management and outcomes: the PANORAMA study.","authors":"","doi":"10.1016/j.hpb.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.hpb.2024.09.008","url":null,"abstract":"<p><strong>Aim: </strong>The primary aim of this study is to determine compliance with key quality performance indicators (QPIs) for the management of acute pancreatitis. The secondary aim is to examine the relationship between compliance to QPIs and clinical outcomes with factors that influence this.</p><p><strong>Methods: </strong>This prospective cohort study will be conducted via the trainee-led STRATA collaborative network. All public hospitals in Aotearoa New Zealand will be eligible to participate. Data will be collected on all adult patients who are diagnosed with acute pancreatitis over a 3 month period. The primary outcome is compliance with the QPIs for the different domains of acute pancreatitis management. Secondary outcomes include early (30-days from index admission) clinical outcomes including incidence of locoregional complications, interventions, organ failure, and mortality.</p><p><strong>Conclusion: </strong>This protocol describes the methodology for a nationwide prospective cohort study in Aotearoa New Zealand to evaluate compliance based on QPIs derived from the literature. These data will lay the foundation for future registry studies, clinical trials, and quality improvement initiatives.</p>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence in the detection of choledocholithiasis: a systematic review. 人工智能在胆总管结石检测中的应用:系统综述。
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-09-25 DOI: 10.1016/j.hpb.2024.09.009
Joshua Blum, Lewis Wood, Richard Turner

Importance: Choledocholithiasis is a potentially life-threatening manifestation of acute biliary dysfunction (ABD) often requiring magnetic resonance cholangiopancreatography (MRCP) for diagnosis when standard investigation findings are inconclusive. Machine learning models (MLMs) may offer alternatives to diagnose choledocholithiasis.

Objective: This systematic review seeks to evaluate the performance of MLMs in predicting choledocholithiasis and to compare this performance with the American Society of Gastrointestinal Endoscopy (ASGE) guidelines.

Review: This review adhered to PRISMA guidelines. Four databases were searched for relevant records published between January 2000 and April 2024. Two researchers appraised records. MLM performance and ASGE guideline efficacy were compared, and the clinical utility of MLMs was assessed.

Findings: 408 records were screened; eight were eligible. Model accuracy ranged from 19 % to 97 %. Several records demonstrated a moderate-to-high risk of bias; of those featuring low risk of bias, peak accuracies ranged from 70 % to 85 %. Most MLMs outperformed ASGE guidelines. Important predictor variables included age, total bilirubin, and common bile duct diameter.

Conclusions: MLMs outperform ASGE guidelines in predicting choledocholithiasis. Nonetheless, biases in study design and reporting limit their prospective applicability. Current MLMs do not yet rival MRCP in detecting choledocholithiasis. Future guideline development should consider MLM-driven insights for better risk prediction.

重要性:胆总管结石是急性胆道功能障碍(ABD)的一种可能危及生命的表现,当标准检查结果不确定时,往往需要进行磁共振胆胰管造影(MRCP)来诊断。机器学习模型(MLM)可作为诊断胆总管结石的替代方法:本系统综述旨在评估机器学习模型在预测胆总管结石方面的性能,并将其与美国消化内镜学会(ASGE)指南进行比较:本综述遵循 PRISMA 指南。我们在四个数据库中搜索了2000年1月至2024年4月期间发表的相关记录。两名研究人员对记录进行了评估。比较了MLM的性能和ASGE指南的有效性,并评估了MLM的临床实用性:筛选了 408 条记录,其中 8 条符合条件。模型准确率从 19% 到 97% 不等。一些记录显示存在中度到高度的偏倚风险;在偏倚风险较低的记录中,峰值准确率介于 70% 到 85% 之间。大多数 MLM 都优于 ASGE 指南。重要的预测变量包括年龄、总胆红素和胆总管直径:结论:MLM 在预测胆总管结石方面优于 ASGE 指南。尽管如此,研究设计和报告中的偏差限制了其前瞻性的适用性。在检测胆总管结石方面,目前的多导睡眠监测尚不能与 MRCP 相媲美。未来的指南制定应考虑以 MLM 为导向,以更好地预测风险。
{"title":"Artificial intelligence in the detection of choledocholithiasis: a systematic review.","authors":"Joshua Blum, Lewis Wood, Richard Turner","doi":"10.1016/j.hpb.2024.09.009","DOIUrl":"https://doi.org/10.1016/j.hpb.2024.09.009","url":null,"abstract":"<p><strong>Importance: </strong>Choledocholithiasis is a potentially life-threatening manifestation of acute biliary dysfunction (ABD) often requiring magnetic resonance cholangiopancreatography (MRCP) for diagnosis when standard investigation findings are inconclusive. Machine learning models (MLMs) may offer alternatives to diagnose choledocholithiasis.</p><p><strong>Objective: </strong>This systematic review seeks to evaluate the performance of MLMs in predicting choledocholithiasis and to compare this performance with the American Society of Gastrointestinal Endoscopy (ASGE) guidelines.</p><p><strong>Review: </strong>This review adhered to PRISMA guidelines. Four databases were searched for relevant records published between January 2000 and April 2024. Two researchers appraised records. MLM performance and ASGE guideline efficacy were compared, and the clinical utility of MLMs was assessed.</p><p><strong>Findings: </strong>408 records were screened; eight were eligible. Model accuracy ranged from 19 % to 97 %. Several records demonstrated a moderate-to-high risk of bias; of those featuring low risk of bias, peak accuracies ranged from 70 % to 85 %. Most MLMs outperformed ASGE guidelines. Important predictor variables included age, total bilirubin, and common bile duct diameter.</p><p><strong>Conclusions: </strong>MLMs outperform ASGE guidelines in predicting choledocholithiasis. Nonetheless, biases in study design and reporting limit their prospective applicability. Current MLMs do not yet rival MRCP in detecting choledocholithiasis. Future guideline development should consider MLM-driven insights for better risk prediction.</p>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artisential®-assisted pancreatoduodenectomy: a comparative analysis with Robot(Da Vinci®)-assisted pancreatoduodenectomy. Artisential®辅助胰十二指肠切除术:与机器人(达芬奇®)辅助胰十二指肠切除术的比较分析。
IF 2.7 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2024-09-19 DOI: 10.1016/j.hpb.2024.09.006
Su Hyeong Park, Seoung Yoon Rho, Munseok Choi, Seung Soo Hong, Sung Hyun Kim, Chang Moo Kang

Background: Robot-assisted pancreaticoduodenectomy (R-PD) helps further improve the safety and efficacy of minimally invasive pancreaticoduodenectomy. However, it faces challenges such as high costs and limitations in availability at different centers, making it difficult for patients to access. In this study, we evaluate the initial experience of Artisential®-assisted PD (A-PD) and compare its perioperative outcomes with R-PD, discussing the clinical applicability of A-PD.

Methods: This study reviewed cases of R-PD and A-PD conducted between 2022 and 2023. A total of 34 patients underwent R-PD, while 26 patients underwent A-PD. Statistical analysis was conducted based on factors related to the patient's surgical procedure and postoperative prognostic indicators.

Results: There were no significant differences observed between the two groups in terms of surgical factors. There were also no differences in the occurrence of postoperative complications. However, there was a significant difference in the length of hospital stay, with the Artisential® group having an average of 11.50 ± 5.54 days and the Robot group having 15.06 ± 5.34 days (p = 0.001).

Conclusions: R-PD and A-PD showed no differences in procedures or outcomes. Using a multi-articulated device is beneficial where robot use is challenging.

背景:机器人辅助胰十二指肠切除术(R-PD)有助于进一步提高微创胰十二指肠切除术的安全性和有效性。然而,它面临着高成本和不同中心可用性的限制等挑战,使患者难以使用。在本研究中,我们评估了Artisential®辅助胰十二指肠切除术(A-PD)的初步经验,并将其围手术期结果与R-PD进行了比较,探讨了A-PD的临床适用性:本研究回顾了2022年至2023年间进行的R-PD和A-PD病例。共有 34 名患者接受了 R-PD,26 名患者接受了 A-PD。根据患者的手术方式和术后预后指标等相关因素进行了统计分析:结果:两组患者在手术因素方面无明显差异。结果:两组患者的手术因素无明显差异,术后并发症发生率也无差异。然而,两组患者的住院时间存在明显差异,Artisential®组平均住院时间为(11.50 ± 5.54)天,而机器人组平均住院时间为(15.06 ± 5.34)天(P = 0.001):结论:R-PD 和 A-PD 在手术过程和结果上没有差异。在机器人使用具有挑战性的情况下,使用多关节装置是有益的。
{"title":"Artisential®-assisted pancreatoduodenectomy: a comparative analysis with Robot(Da Vinci®)-assisted pancreatoduodenectomy.","authors":"Su Hyeong Park, Seoung Yoon Rho, Munseok Choi, Seung Soo Hong, Sung Hyun Kim, Chang Moo Kang","doi":"10.1016/j.hpb.2024.09.006","DOIUrl":"https://doi.org/10.1016/j.hpb.2024.09.006","url":null,"abstract":"<p><strong>Background: </strong>Robot-assisted pancreaticoduodenectomy (R-PD) helps further improve the safety and efficacy of minimally invasive pancreaticoduodenectomy. However, it faces challenges such as high costs and limitations in availability at different centers, making it difficult for patients to access. In this study, we evaluate the initial experience of Artisential®-assisted PD (A-PD) and compare its perioperative outcomes with R-PD, discussing the clinical applicability of A-PD.</p><p><strong>Methods: </strong>This study reviewed cases of R-PD and A-PD conducted between 2022 and 2023. A total of 34 patients underwent R-PD, while 26 patients underwent A-PD. Statistical analysis was conducted based on factors related to the patient's surgical procedure and postoperative prognostic indicators.</p><p><strong>Results: </strong>There were no significant differences observed between the two groups in terms of surgical factors. There were also no differences in the occurrence of postoperative complications. However, there was a significant difference in the length of hospital stay, with the Artisential® group having an average of 11.50 ± 5.54 days and the Robot group having 15.06 ± 5.34 days (p = 0.001).</p><p><strong>Conclusions: </strong>R-PD and A-PD showed no differences in procedures or outcomes. Using a multi-articulated device is beneficial where robot use is challenging.</p>","PeriodicalId":13229,"journal":{"name":"Hpb","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142345818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Hpb
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1