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Comment on "Reappraisal of the impact of resection margin on outcomes after hepatectomy and perioperative treatment for alveolar echinococcosis: a single center experience" by Notte et al. (HPB 2025;27:1284). Notte等人对“重新评估切除边缘对肺泡包虫病肝切除术和围手术期治疗结果的影响:单中心经验”的评论(HPB 2025;27:1284)。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-26 DOI: 10.1016/j.hpb.2025.12.034
İlgin Özden
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引用次数: 0
Objective assessment of remnant pancreatic perfusion using intraoperative indocyanine green angiography: a novel technique to predict postoperative pancreatic fistula. 术中吲哚菁绿血管造影评估残余胰腺灌注:一种预测术后胰瘘的新技术。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-26 DOI: 10.1016/j.hpb.2025.12.036
Tutku Tüfekçi, Sena Azamat, Ergün Tiryaki, Samet Yığman, Emre Bozkurt, Orhan Bilge, Gürkan Tellioğlu

Background: Postoperative pancreatic fistula (POPF) remains a major complication following pancreaticoduodenectomy (PD). Indocyanine green (ICG) fluorescence angiography offers real-time perfusion assessment but is underutilized in pancreatic surgery. Although pancreatic stump hypoperfusion has been suggested as a risk factor for POPF, but its role remains underexplored.

Objective: To evaluate whether quantitative perfusion parameters derived from ICG fluorescence angiography are associated with POPF.

Methods: In this prospective cohort study, 30 patients undergoing PD were assessed using ICG near-infrared fluorescence angiography. Fluorescence intensity-time curves were generated using a Python-based algorithm and analyzed for intensity and flow parameters. Associations between perfusion metrics and POPF, classified by ISGPS criteria, were statistically evaluated.

Results: Clinically relevant POPF (CR-POPF) occurred in 30 % of patients. Significant associations were observed between CR-POPF and perfusion parameters including higher fluorescence distribution heterogeneity (p = 0.032) and a slower slope of fluorescence increase (p = 0.008).

Conclusions: Quantitative ICG fluorescence angiography provides objective metrics that correlate with POPF development. Parameters such as slope, peak intensity and fluorescence heterogeneity may serve as intraoperative indicators of perfusion adequacy, supporting surgical decision-making during PD. Larger, multicenter studies are warranted to validate these findings.

背景:术后胰瘘(POPF)仍然是胰十二指肠切除术(PD)后的主要并发症。吲哚菁绿(ICG)荧光血管造影提供实时灌注评估,但在胰腺手术中应用不足。虽然胰腺残端灌注不足已被认为是POPF的危险因素,但其作用仍未得到充分探讨。目的:评价ICG荧光血管造影定量灌注参数与POPF的相关性。方法:在这项前瞻性队列研究中,使用ICG近红外荧光血管造影对30例PD患者进行评估。采用基于python的算法生成荧光强度-时间曲线,并对强度和流量参数进行分析。灌注指标与POPF之间的关联,按ISGPS标准分类,进行统计学评估。结果:临床相关POPF (CR-POPF)发生率为30%。CR-POPF与灌注参数之间存在显著相关性,荧光分布异质性较高(p = 0.032),荧光增加斜率较慢(p = 0.008)。结论:定量ICG荧光血管造影提供了与POPF发展相关的客观指标。斜率、峰强度、荧光异质性等参数可作为PD术中灌注充分性的指标,支持手术决策。需要更大规模的多中心研究来验证这些发现。
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引用次数: 0
Efficacy and safety of TRIANGLE operation for pancreatic head and body cancer: a systematic review and meta-analysis. 三角手术治疗胰头体癌的疗效和安全性:系统回顾和荟萃分析。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-24 DOI: 10.1016/j.hpb.2025.12.030
Rui Cao, Yuerong Xuan, Xiaowen Gong, Chengshuai Pang, Chenyang Dong, Chaojie Liang

Background: Despite growing adoption of the Heidelberg TRIANGLE operation for pancreatic head/body tumors, comprehensive analysis of its safety and outcomes remains lacking.

Methods: Systematic searches using predefined criteria (inception-May 2024) across PubMed, Cochrane, Web of Science, Embase, Medline, CNKI and Wan-Fang databases identified eligible studies. Primary outcomes were R0 resection rates and survival; secondary outcomes were complications and recurrence. Meta-analysis utilized Stata 18.0.

Results: This meta-analysis included 8 studies (1,106 patients). Compared to standard resection, the TRIANGLE group had longer operative times and higher postoperative diarrhea rates (P < 0.001), but demonstrated reduced 1-year (P = 0.001) and 3-year recurrence (P = 0.036), lower perioperative mortality (P = 0.032), and more extensive lymph node dissection (P = 0.004). No differences were observed in R0 rates (P = 0.171), survival (1-year P = 0.730; 3-year P = 0.136), or primary complications. Overall survival (P = 0.075) and recurrence rates (P = 0.137) showed no statistical significance.

Conclusion: TRIANGLE operation reduces 1/3-year recurrence rates vs standard resection but increases postoperative diarrhea, while achieving similar R0/R1 rates and survival outcomes. Its clinical benefits require validation through large multicenter RCTs.

背景:尽管越来越多的人采用Heidelberg三角手术治疗胰腺头/体肿瘤,但对其安全性和结果的综合分析仍然缺乏。方法:使用预定义标准(inception- 2024年5月)在PubMed、Cochrane、Web of Science、Embase、Medline、CNKI和万方数据库中进行系统搜索,确定符合条件的研究。主要结局为R0切除率和生存率;次要结果为并发症和复发。meta分析采用Stata 18.0。结果:本荟萃分析包括8项研究(1106例患者)。与标准切除相比,TRIANGLE组手术时间更长,术后腹泻率更高(P < 0.001),但1年(P = 0.001)和3年复发率(P = 0.036)降低,围手术期死亡率(P = 0.032)降低,淋巴结清扫更广泛(P = 0.004)。R0率(P = 0.171)、生存率(1年P = 0.730; 3年P = 0.136)、原发性并发症均无差异。总生存率(P = 0.075)和复发率(P = 0.137)差异无统计学意义。结论:与标准手术相比,三角手术减少了1/3年的复发率,但增加了术后腹泻,同时获得了相似的R0/R1率和生存结果。其临床益处需要通过大型多中心随机对照试验验证。
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引用次数: 0
Liver resection extended to adjacent structures for advanced hepatoblastoma - a 25 year tertiary hepatobiliary and transplant center experience. 晚期肝母细胞瘤的肝切除术扩展到邻近结构- 25年三级肝胆和移植中心的经验。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-23 DOI: 10.1016/j.hpb.2025.12.033
Víola B Weeda, Khalid Sharif, Girish Gupte, Prabal Mishra, David Hobin, Pat McKiernan, James Bennett, Peter Bromley, Evelyn Ong, Thamara Perera, Bruce Morland, Darius F Mirza

Background: Refinement in perioperative chemotherapy coupled with surgical innovation improves prognosis in children with very high risk hepatoblastoma. Our aim was to evaluate and identify prognostic factors contributing to recurrence in hepatoblastoma resected along with adjacent structures.

Methods: An audit was conducted of patients surgically treated for hepatoblastoma at our center over 25 years.

Results: Thirty-six of 202 patients underwent resection of structures adjacent to the liver for suspected tumor spread. Over half (21/36) of patients underwent hepatectomy with resection of adjacent structures, and orthotopic liver or multi-visceral transplantation. Adjacent structures including lymph nodes, vascular structures, diaphragm, spleen, omentum, and stomach, showed viable tumor tissue in nineteen patients. Both overall survival and recurrence free survival were 75 % at a mean follow up of 113 months. Survival improved with a negative resection margin. Recurrence free survival decreased with tumor viability. Pathology subtypes showed distinct influence on survival.

Conclusion: This series shows favorable survival with aggressive surgical treatment. Adverse histology subtype, lung metastases, and resistance to chemotherapy are associated with higher risk of recurrence. Management at specialist centers with simultaneous hepatic resection and transplantation readily available, achieves optimum outcomes in this niche subgroup of children with advanced hepatoblastoma.

背景:围手术期化疗的改进和手术的创新改善了高危肝母细胞瘤患儿的预后。我们的目的是评估和确定导致肝母细胞瘤及邻近结构切除后复发的预后因素。方法:对我院25年来接受肝母细胞瘤手术治疗的患者进行回顾性分析。结果:202例患者中有36例因怀疑肿瘤扩散而行肝旁结构切除。超过一半(21/36)的患者行肝切除术并切除邻近结构,原位肝或多脏器移植。19例患者的邻近结构包括淋巴结、血管结构、横膈膜、脾脏、大网膜和胃显示活的肿瘤组织。在平均113个月的随访中,总生存率和无复发生存率均为75%。阴性切缘提高了生存率。无复发生存率随肿瘤生存而降低。病理亚型对生存率有明显影响。结论:通过积极的手术治疗,本病例具有良好的生存率。不良组织学亚型、肺转移和化疗耐药与较高的复发风险相关。在专科中心进行同时肝切除和移植的治疗,在晚期肝母细胞瘤患儿这一小众亚群中获得了最佳结果。
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引用次数: 0
Smarter minutes, faster meetings: evaluating AI medical scribe utilisation in hepatobiliary multidisciplinary team meetings, a comparative performance study. 更智能的会议记录,更快的会议:评估人工智能医疗记录仪在肝胆多学科团队会议中的使用情况,一项比较绩效研究。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-22 DOI: 10.1016/j.hpb.2025.12.032
Marwan Idrees, Sami Rahmeh, Kin Ng, Ruth Blanco Colino, James Mcallister, Shahid Farid
{"title":"Smarter minutes, faster meetings: evaluating AI medical scribe utilisation in hepatobiliary multidisciplinary team meetings, a comparative performance study.","authors":"Marwan Idrees, Sami Rahmeh, Kin Ng, Ruth Blanco Colino, James Mcallister, Shahid Farid","doi":"10.1016/j.hpb.2025.12.032","DOIUrl":"https://doi.org/10.1016/j.hpb.2025.12.032","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of subtotal cholecystectomy from a large tertiary New Zealand hospital. 新西兰一家大型三级医院胆囊次全切除术的结果。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-17 DOI: 10.1016/j.hpb.2025.12.029
Hannah Kim, Jing Goh, Isaac Tranter-Entwistle, Saxon Connor

Background: Subtotal cholecystectomy (StC) is a recognised bail-out strategy for difficult cholecystectomy. The aim of the study was to analyse technical aspects and outcomes associated with subtypes of StC.

Method: All perioperative data of patients who underwent StC at Christchurch Hospital between June 2015 to September 2023 were retrospectively identified and analysed. The subtypes were classified as reconstituting (rStC), fenestrating (fStC), and remnant posterior wall (pwStC) subtotal cholecystectomy.

Results: Of the 6251 patients who underwent cholecystectomy, 422 (6.8 %) underwent StC, and 132 (31.3 %), 115 (27.3 %), 175 (41.5 %) underwent rStC, fStC and pwStC respectively.pwStC was generally associated with superior, and fStC inferior outcomes. In patients who had fStC, rStC and pwStC; 38 (33.0 %), 12 (9.1 %), 6 (3.4 %) developed bile leak (p < 0.001), 20 (17.4 %), 12 (9.1 %), 3 (1.7 %) developed intraabdominal collections (p < 0.001), and 28 (24.3 %), 10 (7.6 %) and 9 (5.1 %) required post-operative ERCP (p < 0.001), respectively. No difference in rates of delayed post-op biliary events including cholecystitis and choledocholithiasis were noted across the subgroups (p = 0.775).

Conclusion: There are technical variations of StC with different complication profiles. Surgeons should be aware of these nuances, as it may help inform decision making when faced with need to perform StC.

背景:胆囊次全切除术(StC)是一种公认的困难胆囊切除术的救助策略。该研究的目的是分析与StC亚型相关的技术方面和结果。方法:回顾性分析2015年6月至2023年9月在基督城医院接受StC手术的所有患者围手术期资料。亚型分为重建型(rStC)、开窗型(fStC)和残余后壁型(pwStC)胆囊次全切除术。结果:6251例胆囊切除术患者中,422例(6.8%)行StC,其中rStC 132例(31.3%),fStC 115例(27.3%),pwStC 175例(41.5%)。pwStC通常与预后较好相关,而fStC则与预后较差相关。fStC、rStC和pwStC患者;38例(33.0%)、12例(9.1%)、6例(3.4%)发生胆漏(p < 0.001)、20例(17.4%)、12例(9.1%)、3例(1.7%)发生腹腔内收集(p < 0.001),术后需要ERCP的分别为28例(24.3%)、10例(7.6%)、9例(5.1%)(p < 0.001)。术后迟发性胆道事件(包括胆囊炎和胆管结石)发生率在各亚组间无差异(p = 0.775)。结论:StC有不同并发症的技术变异。外科医生应该意识到这些细微差别,因为它可能有助于在面临需要进行StC时做出决策。
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引用次数: 0
Integrating clinical, genomic, and transcriptomic data improves post-resection prognostication in hepatocellular carcinoma. 整合临床、基因组和转录组数据可改善肝细胞癌切除术后的预后。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-17 DOI: 10.1016/j.hpb.2025.12.028
Piyush Gupta, Pejman Radkani, Thomas Fishbein, Dimitrios Moris
{"title":"Integrating clinical, genomic, and transcriptomic data improves post-resection prognostication in hepatocellular carcinoma.","authors":"Piyush Gupta, Pejman Radkani, Thomas Fishbein, Dimitrios Moris","doi":"10.1016/j.hpb.2025.12.028","DOIUrl":"https://doi.org/10.1016/j.hpb.2025.12.028","url":null,"abstract":"","PeriodicalId":13229,"journal":{"name":"Hpb","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Charlson comorbidity index as a predictor of postoperative complications in patients with hepatic cystic echinococcosis. A nested case-control study. 评价Charlson合并症指数作为肝囊性包虫病患者术后并发症的预测指标。巢式病例对照研究。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-17 DOI: 10.1016/j.hpb.2025.12.025
Carlos Manterola, Josue Rivadeneira, Luis Alvarado, Luis Grande

Background: Postoperative complications (POC) in surgery for hepatic cystic echinococcosis (HCE) still being frequent. Comorbidities as a risk factor has not yet been studied. The aim of this study was to evaluate the predictive value of CCI for POC in surgically treated HCE patients.

Methods: Nested case-control study. Patients undergoing elective surgery for HCE between 2011 and 2019; matched (1:1) by sex, cyst diameter and time follow-up were included. Cases were patients with CCI≥3; and controls, patients with CCI≤2. Primary outcome was POC. Descriptive statistics and bivariate analyses were applied. Logistic regression was used, odds ratios (OR) and their respective 95 % confidence intervals (CI95 %), were calculated.

Results: 226 patients (113 cases and 113 controls) were analyzed. Significant differences were verified between cases and controls in frequency of evolutionary complications of HCE (OR: 5.5; p = 0.0003); and major rate of ASA I-II in controls (OR: 0.07; p < 0.0001). A great rate of POC (OR: 3.58; p = 0.0002); and Clavien ≥ IIIb POC more frequent in cases were found (OR: 7.00; p = 0.031). Applying logistic regression model, CCI score≥3 was identified as an independent prognostic factor for POC (OR: 6.29 [CI95 %: 2.1-18.8; p < 0.01]).

Conclusion: In this study, cases showed higher frequency and severity of POC than controls.

背景:肝囊性包虫病(HCE)手术术后并发症(POC)仍较为常见。合并症作为一种危险因素尚未得到研究。本研究的目的是评估CCI对手术治疗的HCE患者POC的预测价值。方法:巢式病例对照研究。2011年至2019年期间接受HCE选择性手术的患者;按性别、囊肿直径及随访时间进行1:1匹配。病例为CCI≥3的患者;对照组为CCI≤2的患者。主要结局为POC。采用描述性统计和双变量分析。采用Logistic回归,计算比值比(OR)和各自的95%可信区间(ci95%)。结果:226例患者,其中113例为病例,113例为对照组。HCE进化并发症的发生频率在病例和对照组之间存在显著差异(OR: 5.5; p = 0.0003);对照组ASA I-II主要发生率(OR: 0.07; p < 0.0001)。高POC率(OR: 3.58; p = 0.0002);且Clavien≥IIIb的POC发生率更高(OR: 7.00; p = 0.031)。应用logistic回归模型,CCI评分≥3是POC的独立预后因素(OR: 6.29 [CI95 %: 2.1 ~ 18.8; p < 0.01])。结论:本研究中,POC的发生率和严重程度均高于对照组。
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引用次数: 0
Validation of postoperative period of care and textbook outcome as quality measures regarding gallstone surgery. 验证术后护理期和教科书结果作为胆结石手术的质量指标。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-16 DOI: 10.1016/j.hpb.2025.12.023
Linda N Nilsson, Agnieszka Popowicz, Folke Hammarqvist, Gabriel Sandblom

Background: A universally accepted quality measure for gallstone surgery is lacking. In this retrospective study, we evaluated the duration of postoperative care, completion with laparoscopic approach, absence of procedure-related complications, and no readmission as criteria for Textbook Outcome (TO).

Methods: Data was collected from the Swedish National Register for Gallstone Surgery (GallRiks) 2007-2022. We analyzed postoperative stay as exposure and postoperative complications as outcome using Receiver Operation Characteristic (ROC). TO was defined as laparoscopically completed operations, discharge within three days after surgery, no postoperative complication > Clavien-Dindo 2, no contact with the care provider or new readmission/intervention within 30 days post-surgery. The outcome of TO was further validated based on patients 6 months postoperatively answering SF-36.

Results: A total of 193 201 cholecystectomies were analyzed. Using discharge within three days postoperatively as threshold, the sensitivity was 50 % and the specificity 87 % for predicting a surgery-related complication. The rate of TO in the entire cohort was 79,4 %. Those who met the TO criteria rated notably higher on physical and mental scoring 6 months postoperatively (both p < 0.05) than those who did not.

Conclusion: The postoperative period of care and TO are robust outcome measures for evaluating results after gallstone surgery.

背景:缺乏一种普遍接受的胆结石手术质量衡量标准。在这项回顾性研究中,我们评估了术后护理的持续时间,腹腔镜入路的完成,无手术相关并发症,无再入院作为教科书结局(TO)的标准。方法:数据收集自2007-2022年瑞典国家胆结石手术登记处(GallRiks)。我们使用受试者操作特征(ROC)分析术后停留时间和术后并发症。TO定义为腹腔镜下完成手术,术后3天内出院,无术后并发症> Clavien-Dindo 2,术后30天内无与护理人员联系或新的再入院/干预。基于患者术后6个月的SF-36应答,进一步验证了TO的结果。结果:共分析了193 201例胆囊切除术。以术后三天内出院为阈值,预测手术相关并发症的敏感性为50%,特异性为87%。整个队列中TO的发生率为79.4%。符合TO标准的患者在术后6个月的身体和精神评分明显高于不符合TO标准的患者(p < 0.05)。结论:术后护理期和TO是评价胆结石术后疗效的可靠指标。
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引用次数: 0
Effect of duration of neoadjuvant therapy on pancreatic cancer outcomes: a systematic review and meta-analysis. 新辅助治疗持续时间对胰腺癌预后的影响:系统回顾和荟萃分析。
IF 2.4 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Hpb
Pub Date : 2025-12-16 DOI: 10.1016/j.hpb.2025.12.018
Shahin Hajibandeh, Shahab Hajibandeh, Syed S Raza, David C Bartlett, Bobby V M Dasari, Nikolaos Chatzizacharias, Ravi Marudanayagam, Robert P Sutcliffe, Keith J Roberts

Background: The aim of theis study was toevaluate impact of duration of neoadjuvant treatment (NAT) on surgical resection rate, resection margin, response to treatment, and survival in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods: All randomised controlled trials (RCTs) of NAT in patients with PDAC were included. Effect sizes were determined for surgical resection rate, R0 resection, radiological response to NAT and 1- to 5-years survival.

Results: Twenty-three RCTs (1880 patients) were included. NAT duration≤8 weeks was associated with significantly higher surgical resection rate [66.7 % (95 % CI 57.4 %-76.1 %)] compared with NAT duration >8 weeks [33.5 % (95 % CI 22.1 %-45.0 %)]. The difference remained significant when only resectable [73.9 % (95 % CI 64.3 %-83.5 %) vs 44.7 % (95 % CI 15.9 %-60.6.%)], borderline resectable [66.4 % (95 % CI 46.6 %-86.1 %) vs 22.5 % (95 % CI 18.2 %-26.8 %)], or mixed borderline resectable/locally advanced PDAC [60.6 % (95 % CI 48.2 %-73.0 %) vs 35.0 % (95 % CI 27.6 %-42.4 %)] were considered. Moreover, when only NAT with chemotherapy considered, resection rate remained significant in favour of NAT duration≤8. No significant difference was found in R0 resection rate, partial response, stable disease, or disease progression between two groups. Intention-to-treat respected 1-, 3-, 5-years survival were comparable.

Conclusions: NAT duration >8 weeks may be associated with a reduced surgical resection rate and no apparent improvement in negative resection margin in patients with PDAC, particularly borderline resectable cases. However, it may have comparable survival to NAT duration ≤8 weeks. Future randomised evidence is needed to overcome the limitations associated with current evidence.

背景:本研究的目的是评估新辅助治疗时间(NAT)对胰腺导管腺癌(PDAC)患者手术切除率、切除边缘、治疗反应和生存的影响。方法:纳入所有PDAC患者的NAT随机对照试验(rct)。确定手术切除率、R0切除率、放射学对NAT的反应和1至5年生存率的效应量。结果:共纳入23项随机对照试验(rct),共1880例患者。与NAT持续时间≤8周[33.5% (95% CI 22.1% - 45.0%)]相比,NAT持续时间≤8周[66.7% (95% CI 57.4% - 76.1%)]的手术切除率显著高于NAT持续时间≤8周[66.7% (95% CI 57.4% - 76.1%)]。当仅可切除时,差异仍然显著[73.9% (95% CI 64.3% - 83.5%) vs 44.7% (95% CI 15.9% -60.6)]。考虑边缘可切除[66.4% (95% CI 46.6% - 86.1%) vs 22.5% (95% CI 18.2% - 26.8%)],或混合边缘可切除/局部晚期PDAC [60.6% (95% CI 48.2% - 73.0%) vs 35.0% (95% CI 27.6% - 42.4%)]。此外,当仅考虑NAT与化疗时,切除率仍然显著,有利于NAT持续时间≤8。两组在R0切除率、部分缓解、疾病稳定或疾病进展方面无显著差异。意向治疗的1、3、5年生存率具有可比性。结论:NAT持续时间bbbb8周可能与PDAC患者手术切除率降低和阴性切缘无明显改善有关,特别是边缘可切除的病例。然而,它的生存期可能与NAT相当,持续时间≤8周。需要未来的随机证据来克服与当前证据相关的局限性。
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引用次数: 0
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